{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:25:48Z","timestamp":1786994748376,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.neulet.2026.138649","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:38:53Z","timestamp":1780641533000},"page":"138649","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["BAI attenuates depression by inhibiting P2X7R and NOX2: Insights from a pharmacological animal study"],"prefix":"10.1016","volume":"882","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1771-5814","authenticated-orcid":false,"given":"Baban S.","family":"Thawkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7340-2150","authenticated-orcid":false,"given":"Nisarg S.","family":"Sawant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsh","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10312","key":"10.1016\/j.neulet.2026.138649_b0005","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0140-6736(21)02143-7","article-title":"Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic","volume":"398","author":"Santomauro","year":"2021","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.neulet.2026.138649_b0010","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report","volume":"163","author":"Rush","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.neulet.2026.138649_b0015","article-title":"Chronic stress, neuroinflammation, and depression: an overview of pathophysiological mechanisms and emerging anti-inflammatories","volume":"14","author":"Hassamal","year":"2023","journal-title":"Front. Psych."},{"key":"10.1016\/j.neulet.2026.138649_b0020","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbi.2020.02.010","article-title":"Inflammatory markers in depression: a meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls","volume":"87","author":"Osimo","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neulet.2026.138649_b0025","doi-asserted-by":"crossref","unstructured":"Haroon, E., Fleischer, C. C., Felger, J. C., Chen, X., Woolwine, B. J., Patel, T., Hu, X. P., & Miller, A. H. (2016). Conceptual convergence: increased inflammation is associated with increased basal ganglia glutamate in patients with major depression. Molecular Psychiatry 2016 21:10, 21(10), 1351\u20131357. https:\/\/doi.org\/10.1038\/mp.2015.206.","DOI":"10.1038\/mp.2015.206"},{"key":"10.1016\/j.neulet.2026.138649_b0030","doi-asserted-by":"crossref","DOI":"10.1177\/17590914231181037","article-title":"How Oxidative stress Induces Depression?","volume":"15","author":"Ji","year":"2023","journal-title":"ASN Neuro"},{"key":"10.1016\/j.neulet.2026.138649_b0035","doi-asserted-by":"crossref","unstructured":"Wang, H., He, Y., Sun, Z., Ren, S., Liu, M., Wang, G., & Yang, J. (2022). Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression. Journal of Neuroinflammation 2022 19:1, 19(1), 132-. https:\/\/doi.org\/10.1186\/S12974-022-02492-0.","DOI":"10.1186\/s12974-022-02492-0"},{"key":"10.1016\/j.neulet.2026.138649_b0040","doi-asserted-by":"crossref","unstructured":"Yue, N., Huang, H., Zhu, X., Han, Q., Wang, Y., Li, B., Liu, Q., Wu, G., Zhang, Y., & Yu, J. (2017). Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors. Journal of Neuroinflammation 2017 14:1, 14(1), 102-. https:\/\/doi.org\/10.1186\/S12974-017-0865-Y.","DOI":"10.1186\/s12974-017-0865-y"},{"issue":"1","key":"10.1016\/j.neulet.2026.138649_b0045","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.bbr.2008.10.018","article-title":"Behavioral profile of P2X7 receptor knockout mice in animal models of depression and anxiety: Relevance for neuropsychiatric disorders","volume":"198","author":"Basso","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neulet.2026.138649_b0050","doi-asserted-by":"crossref","unstructured":"Guo, L. T., Wang, S. Q., Su, J., Xu, L. X., Ji, Z. Y., Zhang, R. Y., Zhao, Q. W., Ma, Z. Q., Deng, X. Y., & Ma, S. P. (2019). Baicalin ameliorates neuroinflammation-induced depressive-like behavior through inhibition of toll-like receptor 4 expression via the PI3K\/AKT\/FoxO1 pathway. Journal of Neuroinflammation 2019 16:1, 16(1), 95-. https:\/\/doi.org\/10.1186\/S12974-019-1474-8.","DOI":"10.1186\/s12974-019-1474-8"},{"key":"10.1016\/j.neulet.2026.138649_b0055","doi-asserted-by":"crossref","unstructured":"Apolloni, S., Parisi, C., Pesaresi, M. G., Rossi, S., Carr\u00ec, M. T., Cozzolino, M., Volont\u00e9, C., & D\u2019Ambrosi, N. (2013). The NADPH oxidase pathway is dysregulated by the P2X7 receptor in the SOD1-G93A microglia model of amyotrophic lateral sclerosis. Journal of Immunology (Baltimore, Md.\u00a0: 1950), 190(10), 5187\u20135195. https:\/\/doi.org\/10.4049\/JIMMUNOL.1203262.","DOI":"10.4049\/jimmunol.1203262"},{"issue":"4","key":"10.1016\/j.neulet.2026.138649_b0060","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neulet.2026.138649_b0065","doi-asserted-by":"crossref","unstructured":"Fritz, M., Fakhoury, M., Markov, D. D., & Novosadova, E. V. (2022). Chronic Unpredictable Mild Stress Model of Depression: Possible Sources of Poor Reproducibility and Latent Variables. Biology 2022, Vol. 11, Page 1621, 11(11), 1621. https:\/\/doi.org\/10.3390\/BIOLOGY11111621.","DOI":"10.3390\/biology11111621"},{"key":"10.1016\/j.neulet.2026.138649_b0070","doi-asserted-by":"crossref","unstructured":"Xin, H., Su, S., Wu, R., Wei, L., Su, N., Qi, L., Wu, R., A, R., Tong, L., Wang, W., Zhang, J., Hu, R., & Li, L. (2023). Chronic Unpredictable Mild Stress in Rats based on the Mongolian medicine. JoVE (Journal of Visualized Experiments), (200), e65889. https:\/\/doi.org\/10.3791\/65889.","DOI":"10.3791\/65889"},{"issue":"1","key":"10.1016\/j.neulet.2026.138649_b0075","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/ame2.12107","article-title":"Optimization of food deprivation and sucrose preference test in SD rat model undergoing chronic unpredictable mild stress","volume":"3","author":"He","year":"2020","journal-title":"Anim. Models Exp. Med."},{"issue":"1","key":"10.1016\/j.neulet.2026.138649_b0080","doi-asserted-by":"crossref","first-page":"16","DOI":"10.4183\/aeb.2018.16","article-title":"Chronic unpredictable mild stress progressively disturbs glucose metabolism and appetite hormones in rats","volume":"14","author":"L\u00f3pez L\u00f3pez","year":"2018","journal-title":"Acta Endocrinol. (bucharest)"},{"key":"10.1016\/j.neulet.2026.138649_b0085","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.euroneuro.2023.08.496","article-title":"Sucrose preference test: a systematic review of protocols for the assessment of anhedonia in rodents","volume":"77","author":"Primo","year":"2023","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neulet.2026.138649_b0090","doi-asserted-by":"crossref","unstructured":"V\u00f5ikar, V., & Stanford, S. C. (2023). The Open Field Test. Neuromethods, 190, 9\u201329. https:\/\/doi.org\/10.1007\/978-1-0716-2748-8_2.","DOI":"10.1007\/978-1-0716-2748-8_2"},{"issue":"2","key":"10.1016\/j.neulet.2026.138649_b0095","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3758\/s13415-024-01171-2","article-title":"Rodent tests of depression and anxiety: Construct validity and translational relevance","volume":"24","author":"Gencturk","year":"2024","journal-title":"Cognit. Affect. Behav. Neurosci."},{"issue":"4\u20135","key":"10.1016\/j.neulet.2026.138649_b0100","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2026.138649_b0105","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neubiorev.2020.01.034","article-title":"Revisiting the validity of the mouse tail suspension test: Systematic review and meta-analysis of the effects of prototypic antidepressants","volume":"112","author":"Stukalin","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6","key":"10.1016\/j.neulet.2026.138649_b0110","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/sj.npp.1300406","article-title":"Total sleep deprivation decreases immobility in the forced-swim test","volume":"29","author":"Lopez-Rodriguez","year":"2004","journal-title":"Neuropsychopharmacology"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394026001497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394026001497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:18:28Z","timestamp":1783397908000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394026001497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":22,"alternative-id":["S0304394026001497"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2026.138649","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BAI attenuates depression by inhibiting P2X7R and NOX2: Insights from a pharmacological animal study","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2026.138649","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"138649"}}