{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:03:06Z","timestamp":1786118586330,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T00:00:00Z","timestamp":1781308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010249","name":"School of Medicine, Indiana University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010249","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC017147"],"award-info":[{"award-number":["DC017147"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC018785"],"award-info":[{"award-number":["DC018785"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.neulet.2026.138660","type":"journal-article","created":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T18:19:18Z","timestamp":1781461158000},"page":"138660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["CCDC181, a kinocilium-localization protein, is dispensable for hair bundle development and auditory perception"],"prefix":"10.1016","volume":"883","author":[{"given":"Chang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renat","family":"Nahornyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Il","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2881-5714","authenticated-orcid":false,"given":"Bo","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2026.138660_b0005","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.742391","article-title":"Conserved and divergent principles of planar polarity revealed by hair cell development and function","volume":"15","author":"Deans","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neulet.2026.138660_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2019.134373","article-title":"New insights into regulation and function of planar polarity in the inner ear","volume":"709","author":"Tarchini","year":"2019","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2026.138660_b0015","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/wdev.202","article-title":"Developmental regulation of planar cell polarity and hair-bundle morphogenesis in auditory hair cells: lessons from human and mouse genetics","volume":"5","author":"Lu","year":"2016","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.neulet.2026.138660_b0020","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ng.2007.54","article-title":"Ciliary proteins link basal body polarization to planar cell polarity regulation","volume":"40","author":"Jones","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neulet.2026.138660_b0025","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1242\/dev.060061","article-title":"Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain","volume":"138","author":"Webb","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.neulet.2026.138660_b0030","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1083\/jcb.109.6.3367","article-title":"The microtubule binding domain of microtubule-associated protein MAP1B contains a repeated sequence motif unrelated to that of MAP2 and tau","volume":"109","author":"Noble","year":"1989","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neulet.2026.138660_b0035","doi-asserted-by":"crossref","first-page":"6366","DOI":"10.1523\/JNEUROSCI.5126-14.2015","article-title":"Gene Expression by Mouse inner Ear Hair Cells during Development","volume":"35","author":"Scheffer","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2026.138660_b0040","doi-asserted-by":"crossref","first-page":"42079","DOI":"10.1038\/srep42079","article-title":"Gfi1(Cre) mice have early onset progressive hearing loss and induce recombination in numerous inner ear non-hair cells","volume":"7","author":"Matern","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neulet.2026.138660_b0045","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.24272\/j.issn.2095-8137.2024.075","article-title":"CCDC181 is required for sperm flagellum biogenesis and male fertility in mice","volume":"45","author":"Zhang","year":"2024","journal-title":"Zool. Res."},{"key":"10.1016\/j.neulet.2026.138660_b0050","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.jgg.2024.07.010","article-title":"CCDC181 is required for proper spermiogenesis in mice","volume":"51","author":"Zi","year":"2024","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.neulet.2026.138660_b0055","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ejcb.2017.02.003","article-title":"Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia","volume":"96","author":"Schwarz","year":"2017","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.neulet.2026.138660_b0060","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1038\/nprot.2014.168","article-title":"Using injectoporation to deliver genes to mechanosensory hair cells","volume":"9","author":"Xiong","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neulet.2026.138660_b0065","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.celrep.2018.09.063","article-title":"GRXCR2 Regulates Taperin Localization critical for Stereocilia Morphology and Hearing","volume":"25","author":"Liu","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.neulet.2026.138660_b0070","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10163","article-title":"A conditional knockout resource for the genome-wide study of mouse gene function","volume":"474","author":"Skarnes","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2026.138660_b0075","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1093\/nar\/23.24.5080","article-title":"A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells","volume":"23","author":"Schwenk","year":"1995","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neulet.2026.138660_b0080","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.heares.2004.12.002","article-title":"Initial characterization of kinocilin, a protein of the hair cell kinocilium","volume":"203","author":"Leibovici","year":"2005","journal-title":"Hear. Res."},{"key":"10.1016\/j.neulet.2026.138660_b0085","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.4161\/cc.9.20.13387","article-title":"Role of a novel coiled-coil domain-containing protein CCDC69 in regulating central spindle assembly","volume":"9","author":"Pal","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.neulet.2026.138660_b0090","doi-asserted-by":"crossref","DOI":"10.1111\/febs.70533","article-title":"Coiled-coil centrosomal proteins facilitate tubulin concentration via polyKR motifs","author":"Lin","year":"2026","journal-title":"FEBS J."},{"key":"10.1016\/j.neulet.2026.138660_b0095","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/BF01179815","article-title":"The kinocilium of auditory hair cells and evidence for its morphogenetic role during the regeneration of stereocilia and cuticular plates","volume":"24","author":"Sobkowicz","year":"1995","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.neulet.2026.138660_b0100","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3389\/fnmol.2018.00326","article-title":"Deletion of Kncn does not Affect Kinocilium and Stereocilia Bundle Morphogenesis and Mechanotransduction in Cochlear Hair Cells","volume":"11","author":"Hu","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neulet.2026.138660_b0105","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202408026","article-title":"Taperin bundles F-actin at stereocilia pivot points enabling optimal lifelong mechanosensitivity","volume":"224","author":"Belyantseva","year":"2025","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neulet.2026.138660_b0110","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.14222","article-title":"Murine Fam65b forms ring-like structures at the base of stereocilia critical for mechanosensory hair cell function","volume":"5","author":"Zhao","year":"2016","journal-title":"Elife"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394026001606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394026001606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:26:26Z","timestamp":1786033586000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394026001606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":22,"alternative-id":["S0304394026001606"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2026.138660","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CCDC181, a kinocilium-localization protein, is dispensable for hair bundle development and auditory perception","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2026.138660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"138660"}}