{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:04:39Z","timestamp":1786118679502,"version":"build-2736575974"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["310691\/2022-2"],"award-info":[{"award-number":["310691\/2022-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["304484\/ 2022\\u20139"],"award-info":[{"award-number":["304484\/ 2022\\u20139"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007762","name":"National Institute of Translational Science and Technology in Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["18\/04899-1"],"award-info":[{"award-number":["18\/04899-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2021\/10014-5"],"award-info":[{"award-number":["2021\/10014-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.neulet.2026.138668","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:07:24Z","timestamp":1782749244000},"page":"138668","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Role of nNOS\/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats"],"prefix":"10.1016","volume":"883","author":[{"given":"Melissa T.","family":"Goulart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane","family":"Busnardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivaldo J.A.","family":"Bel\u00e9m-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Fassini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana C.","family":"Ventris-Godoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime Eduardo","family":"Cec\u00edlio Hallak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando M.A.","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos C.","family":"Crestani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4401-6170","authenticated-orcid":false,"given":"Fernando H.F.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2026.138668_b0005","doi-asserted-by":"crossref","first-page":"R429","DOI":"10.1152\/ajpregu.00051.2015","article-title":"Central mechanisms regulating coordinated cardiovascular and respiratory function during stress and arousal","volume":"309","author":"Dampney","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neulet.2026.138668_b0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.physbeh.2016.10.015","article-title":"Corticolimbic regulation of cardiovascular responses to stress","volume":"172","author":"Myers","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neulet.2026.138668_b0015","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.820398","article-title":"Cortical-hypothalamic integration of autonomic and endocrine stress responses","volume":"13","author":"Schaeuble","year":"2022","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neulet.2026.138668_b0020","doi-asserted-by":"crossref","first-page":"R580","DOI":"10.1016\/j.cub.2017.05.010","article-title":"The insular cortex","volume":"27","author":"Gogolla","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.neulet.2026.138668_b0025","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/B978-0-444-53860-4.00007-6","article-title":"The insular cortex: a review","volume":"195","author":"Nieuwenhuys","year":"2012","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neulet.2026.138668_b0030","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0165-0173(96)00011-2","article-title":"Circuitry and functional aspects of the insular lobe in primates including humans","volume":"22","author":"Augustine","year":"1996","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.neulet.2026.138668_b0035","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrn3857","article-title":"Salience processing and insular cortical function and dysfunction","volume":"16","author":"Uddin","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brainres.2010.03.077","article-title":"The insular cortex modulates cardiovascular responses to acute restraint stress in rats","volume":"1333","author":"Alves","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2026.138668_b0045","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1111\/ejn.12210","article-title":"Involvement of the insular cortex in the consolidation and expression of contextual fear conditioning","volume":"38","author":"Alves","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2013.11.045","article-title":"Repeated forced swim stress enhances CFA-evoked thermal hyperalgesia and affects the expressions of pCREB and c-Fos in the insular cortex","volume":"259","author":"Imbe","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2026.138668_b0055","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.4103\/1673-5374.162757","article-title":"Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction","volume":"10","author":"Ahn","year":"2015","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neulet.2026.138668_b0060","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1093\/cercor\/bhu069","article-title":"Correlation between activation of the prelimbic cortex, basolateral amygdala, and agranular insular cortex during taste memory formation","volume":"25","author":"Uematsu","year":"2015","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.neulet.2026.138668_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2020.100274","article-title":"Infralimbic cortical glutamate output is necessary for the neural and behavioral consequences of chronic stress","volume":"13","author":"Pace","year":"2020","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.neulet.2026.138668_b0070","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/cne.903190202","article-title":"Proportion of glutamate- and aspartate-immunoreactive neurons in the efferent pathways of the rat visual cortex varies according to the target","volume":"319","author":"Dori","year":"1992","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neulet.2026.138668_b0075","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/336385a0","article-title":"Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain","volume":"336","author":"Garthwaite","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.neulet.2026.138668_b0080","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1146\/annurev.ph.57.030195.003423","article-title":"Nitric oxide synthases: properties and catalytic mechanism","volume":"57","author":"Griffith","year":"1995","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.neulet.2026.138668_b0085","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1749-6632.2002.tb04058.x","article-title":"Glial-neuronal transfer of arginine and S-nitrosothiols in nitric oxide transmission","volume":"962","author":"Do","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neulet.2026.138668_b0090","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/bph.14532","article-title":"NO as a multimodal transmitter in the brain: discovery and current status","volume":"176","author":"Garthwaite","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neulet.2026.138668_b0095","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1111\/bph.14800","article-title":"Nitric oxide signalling in the brain and its control of bodily functions","volume":"177","author":"Chachlaki","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neulet.2026.138668_b0100","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1016\/j.cell.2022.06.010","article-title":"Nitric oxide signaling in health and disease","volume":"185","author":"Lundberg","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.neulet.2026.138668_b0105","doi-asserted-by":"crossref","first-page":"9344","DOI":"10.1523\/JNEUROSCI.1902-09.2009","article-title":"More than a retrograde messenger: nitric oxide needs two cGMP pathways to induce hippocampal long-term potentiation","volume":"29","author":"Taqatqeh","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0110","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3389\/fncel.2013.00190","article-title":"The role of nitric oxide in pre-synaptic plasticity and homeostasis","volume":"7","author":"Hardingham","year":"2013","journal-title":"Front. Cell. Neurosci."},{"issue":"1312","key":"10.1016\/j.neulet.2026.138668_bib381","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1098\/rstb.1994.0096","article-title":"Localization of nitric oxide synthase in the adult rat brain","volume":"345","author":"Rodrigo","year":"1994","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.neulet.2026.138668_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2022.110598","article-title":"NMDA receptors in the insular cortex modulate cardiovascular and autonomic but not neuroendocrine responses to restraint stress in rats","volume":"119","author":"Goulart","year":"2022","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2026.138668_b0120","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.autneu.2008.12.015","article-title":"N-methyl-D-aspartate receptors in the insular cortex modulate baroreflex in unanesthetized rats","volume":"147","author":"Alves","year":"2009","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.147037","article-title":"Nitric oxide in the insular cortex modulates baroreflex responses in a cGMP-independent pathway","volume":"1747","author":"Ferreira-Junior","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2026.138668_b0130","series-title":"The rat brain in stereotaxic coodinates","author":"Paxinos","year":"1997"},{"key":"10.1016\/j.neulet.2026.138668_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.autneu.2026.103403","article-title":"Site-specific role of CRF(1) receptors along the rostrocaudal axis of the insular cortex in cardiovascular responses evoked by acute and repeated restraint stress in rats","volume":"265","author":"Reis-Silva","year":"2026","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0140","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1111\/bph.13560","article-title":"Involvement of endocannabinoid neurotransmission in the bed nucleus of stria terminalis in cardiovascular responses to acute restraint stress in rats","volume":"173","author":"Gomes-de-Souza","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neulet.2026.138668_b0145","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.euroneuro.2019.03.001","article-title":"GABAA but not GABAB receptors in the lateral hypothalamus modulate the tachycardic response to emotional stress in rats","volume":"29","author":"Gomes-de-Souza","year":"2019","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neulet.2026.138668_b0150","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.878927","article-title":"Site-specific regulation of stress responses along the rostrocaudal axis of the insular cortex in rats","volume":"16","author":"Tomeo","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0155","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1080\/10253890.2018.1532992","article-title":"Habituation of the cardiovascular responses to restraint stress in male rats: influence of length, frequency and number of aversive sessions","volume":"22","author":"Benini","year":"2019","journal-title":"Stress"},{"key":"10.1016\/j.neulet.2026.138668_b0160","doi-asserted-by":"crossref","DOI":"10.1242\/jeb.219501","article-title":"Habituation of the cardiovascular response to restraint stress is inhibited by exposure to other stressor stimuli and exercise training","volume":"223","author":"Benini","year":"2020","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.neulet.2026.138668_b0165","doi-asserted-by":"crossref","DOI":"10.1111\/psyp.70062","article-title":"Role of sex and Age on cardiovascular and autonomic responses during acute and repeated restraint stress in rats","volume":"62","author":"Benini","year":"2025","journal-title":"Psychophysiology"},{"key":"10.1016\/j.neulet.2026.138668_b0170","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1007\/s00424-020-02451-9","article-title":"Spontaneous recovery, time course, and circadian influence on habituation of the cardiovascular responses to repeated restraint stress in rats","volume":"472","author":"Santos","year":"2020","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.neulet.2026.138668_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110404","article-title":"Role of endocannabinoid neurotransmission in the insular cortex on cardiovascular, autonomic and behavioral responses evoked by acute restraint stress in rats","volume":"271","author":"Belem-Filho","year":"2025","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2026.138668_b0180","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.brainres.2010.05.023","article-title":"Cardiovascular responses to L-glutamate microinjection into the hypothalamic paraventricular nucleus are mediated by a local nitric oxide-guanylate cyclase mechanism","volume":"1344","author":"Busnardo","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.neulet.2026.138668_b0185","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pnpbp.2018.11.001","article-title":"Nitrergic neurotransmission in the paraventricular nucleus of the hypothalamus modulates autonomic, neuroendocrine and behavioral responses to acute restraint stress in rats","volume":"90","author":"Busnardo","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neulet.2026.138668_b0190","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1177\/0269881117691468","article-title":"Both N-methyl-D-aspartate and non-N-methyl-D-aspartate glutamate receptors in the bed nucleus of the stria terminalis modulate the cardiovascular responses to acute restraint stress in rats","volume":"31","author":"Adami","year":"2017","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.neulet.2026.138668_b0195","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1523\/JNEUROSCI.4301-06.2007","article-title":"Bed nucleus of the stria terminalis subregions differentially regulate hypothalamic-pituitary-adrenal axis activity: implications for the integration of limbic inputs","volume":"27","author":"Choi","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0200","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.autneu.2010.06.003","article-title":"Paraventricular nucleus modulates autonomic and neuroendocrine responses to acute restraint stress in rats","volume":"158","author":"Busnardo","year":"2010","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0205","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.psyneuen.2018.07.014","article-title":"Influence of pre-existing hypertension on neuroendocrine and cardiovascular changes evoked by chronic stress in female rats","volume":"97","author":"Vieira","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neulet.2026.138668_b0210","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.neubiorev.2009.05.004","article-title":"Restraint stress in biobehavioral research: recent developments","volume":"33","author":"Buynitsky","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2026.138668_b0215","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3389\/fphys.2016.00251","article-title":"Emotional stress and cardiovascular complications in animal models: a review of the influence of stress type","volume":"7","author":"Crestani","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neulet.2026.138668_b0220","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jash.2010.05.001","article-title":"The insular cortex and cardiovascular system: a new insight into the brain-heart axis","volume":"4","author":"Nagai","year":"2010","journal-title":"J. Am. Soc. Hypertens."},{"key":"10.1016\/j.neulet.2026.138668_b0225","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/j.2040-4603.2016.tb00691.x","article-title":"The insular cortex and the regulation of cardiac function","volume":"6","author":"Oppenheimer","year":"2016","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.neulet.2026.138668_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2022.114006","article-title":"Evaluation of the posterior insular cortex involvement in anxiogenic response to emotional stress in male rats: functional topography along the rostrocaudal axis","volume":"258","author":"Vitorio","year":"2023","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neulet.2026.138668_b0235","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1111\/j.1460-9568.2005.04073.x","article-title":"Changes in cutaneous and body temperature during and after conditioned fear to context in the rat","volume":"21","author":"Vianna","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0240","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10571-017-0518-9","article-title":"AT1 and AT2 receptors in the prelimbic cortex modulate the cardiovascular response evoked by acute exposure to restraint stress in rats","volume":"38","author":"Brasil","year":"2018","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.neulet.2026.138668_b0245","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.neuroscience.2013.11.022","article-title":"Involvement of dorsal hippocampus glutamatergic and nitrergic neurotransmission in autonomic responses evoked by acute restraint stress in rats","volume":"258","author":"Moraes-Neto","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2026.138668_b0250","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/j.2040-4603.2016.tb00694.x","article-title":"Regulation of the hypothalamic-pituitary-adrenocortical stress response","volume":"6","author":"Herman","year":"2016","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.neulet.2026.138668_b0255","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0896-6273(00)80310-4","article-title":"(S)NO signals: translocation, regulation, and a consensus motif","volume":"18","author":"Stamler","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2026.138668_b0260","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/978-3-540-74805-2_16","article-title":"NO\/cGMP-dependent modulation of synaptic transmission","author":"Feil","year":"2008","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.neulet.2026.138668_b0265","article-title":"Nitric oxide signalling in the brain and its control of bodily functions","author":"Chachlaki","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neulet.2026.138668_b0270","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1146\/annurev.ne.17.030194.001101","article-title":"Nitric oxide and synaptic function","volume":"17","author":"Schuman","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0275","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1126\/science.8080500","article-title":"Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity","volume":"263","author":"Zhang","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.neulet.2026.138668_b0280","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1101\/lm.3.5.414","article-title":"Modification of hippocampal synaptic proteins by nitric oxide-stimulated ADP ribosylation","volume":"3","author":"Sullivan","year":"1997","journal-title":"Learn. Mem."},{"key":"10.1016\/j.neulet.2026.138668_b0285","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.molcel.2005.12.006","article-title":"A nitric oxide signaling pathway controls CREB-mediated gene expression in neurons","volume":"21","author":"Riccio","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neulet.2026.138668_b0290","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0896-6273(00)80055-0","article-title":"Direct activation of the olfactory cyclic nucleotide-gated channel through modification of sulfhydryl groups by NO compounds","volume":"16","author":"Broillet","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2026.138668_b0295","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0896-6273(00)80334-7","article-title":"Beta subunits of the olfactory cyclic nucleotide-gated channel form a nitric oxide activated Ca2+ channel","volume":"18","author":"Broillet","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.neulet.2026.138668_b0300","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/35055104","article-title":"Protein S-nitrosylation: a physiological signal for neuronal nitric oxide","volume":"3","author":"Jaffrey","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neulet.2026.138668_b0305","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nrn2555","article-title":"How do you feel\u2013now? The anterior insula and human awareness","volume":"10","author":"Craig","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0310","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1126\/science.7569892","article-title":"Acetylcholine receptors: too many channels, too few functions","volume":"269","author":"Sivilotti","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.neulet.2026.138668_b0315","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1523\/JNEUROSCI.21-03-00771.2001","article-title":"Synaptically driven calcium transients via nicotinic receptors on somatic spines","volume":"21","author":"Shoop","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0320","doi-asserted-by":"crossref","first-page":"16418","DOI":"10.1523\/JNEUROSCI.1537-15.2015","article-title":"Cholinergic neurotransmission in the posterior insular cortex is altered in preclinical models of neuropathic pain: key role of muscarinic m2 receptors in donepezil-induced antinociception","volume":"35","author":"Ferrier","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0325","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1523\/JNEUROSCI.2340-15.2016","article-title":"Opposing roles of cholinergic and gabaergic activity in the insular cortex and nucleus basalis magnocellularis during novel recognition and familiar taste memory retrieval","volume":"36","author":"Rodriguez-Garcia","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0330","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1111\/ejn.13857","article-title":"Nicotinic activity layer specifically modulates synaptic potentiation in the mouse insular cortex","volume":"50","author":"Toyoda","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0335","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.job.2018.12.001","article-title":"Role of nicotinic acetylcholine receptors for modulation of microcircuits in the agranular insular cortex","volume":"61","author":"Toyoda","year":"2019","journal-title":"J. Oral Biosci."},{"key":"10.1016\/j.neulet.2026.138668_b0340","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/j.1476-5381.2010.01124.x","article-title":"Central nicotinic acetylcholine receptor involved in Ca(2+) -calmodulin-endothelial nitric oxide synthase pathway modulated hypotensive effects","volume":"163","author":"Cheng","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neulet.2026.138668_b0345","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1471-4159.2002.01147.x","article-title":"Nicotinic-acetylcholine receptors are functionally coupled to the nitric oxide\/cGMP-pathway in insect neurons","volume":"83","author":"Zayas","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neulet.2026.138668_b0350","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neulet.2003.08.064","article-title":"Nicotinic receptor mediated stimulation of NO-generation in neurons of rat thoracic dorsal root ganglia","volume":"361","author":"Papadopolou","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2026.138668_b0355","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1124\/jpet.106.112474","article-title":"Nicotine-induced norepinephrine release in hypothalamic paraventricular nucleus and amygdala is mediated by N-methyl-D-aspartate receptors and nitric oxide in the nucleus tractus solitarius","volume":"320","author":"Zhao","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neulet.2026.138668_b0360","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/jnr.23537","article-title":"The prelimbic cortex muscarinic M(3) receptor-nitric oxide-guanylyl cyclase pathway modulates cardiovascular responses in rats","volume":"93","author":"Fassini","year":"2015","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neulet.2026.138668_b0365","doi-asserted-by":"crossref","first-page":"5849","DOI":"10.1111\/ejn.16527","article-title":"The influence of paraventricular nucleus of the hypothalamus soluble guanylate cyclase on autonomic and neuroendocrine responses to acute restraint stress in rats","volume":"60","author":"Busnardo","year":"2024","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neulet.2026.138668_b0370","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuropharm.2015.10.018","article-title":"Dissociation in control of physiological and behavioral responses to emotional stress by cholinergic neurotransmission in the bed nucleus of the stria terminalis in rats","volume":"101","author":"Gouveia","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2026.138668_b0375","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.physbeh.2017.03.030","article-title":"Role of the lateral preoptic area in cardiovascular and neuroendocrine responses to acute restraint stress in rats","volume":"175","author":"Duarte","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neulet.2026.138668_b0380","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.55585","article-title":"A whole-brain connectivity map of mouse insular cortex","volume":"9","author":"Gehrlach","year":"2020","journal-title":"Elife"}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394026001680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394026001680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:26:49Z","timestamp":1786033609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394026001680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":77,"alternative-id":["S0304394026001680"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2026.138668","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of nNOS\/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2026.138668","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"138668"}}