{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:13:57Z","timestamp":1788556437957,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013318","name":"Shanxi Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2023BKS07"],"award-info":[{"award-number":["2023BKS07"]}],"id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013318","name":"Shanxi Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2013131022"],"award-info":[{"award-number":["2013131022"]}],"id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013318","name":"Shanxi Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["202303021221159"],"award-info":[{"award-number":["202303021221159"]}],"id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013318","name":"Shanxi Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["202504010931029"],"award-info":[{"award-number":["202504010931029"]}],"id":[{"id":"10.13039\/501100013318","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017605","name":"Shaanxi University of Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.neulet.2026.138681","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:22:13Z","timestamp":1783639333000},"page":"138681","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The role of dorsal striatal DNMT3b in alcohol seeking behavior after withdrawal"],"prefix":"10.1016","volume":"884","author":[{"given":"Jian-Jun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Dan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Cheng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Haghparast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ling","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Bin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.neulet.2026.138681_b0005","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41583-020-0289-z","article-title":"The transition to compulsion in addiction","volume":"21","author":"L\u00fcscher","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"issue":"11","key":"10.1016\/j.neulet.2026.138681_b0010","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1111\/j.1530-0277.2006.00238.x","article-title":"Relationship between ghrelin levels, alcohol seeking, and nutritional status in current alcoholic patients","volume":"30","author":"Addolorato","year":"2006","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"5","key":"10.1016\/j.neulet.2026.138681_b0015","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/ajad.12465","article-title":"Review: DNA methylation and alcohol use disorders: Progress and challenges","volume":"26","author":"Zhang","year":"2017","journal-title":"Am. J. Addict."},{"issue":"9","key":"10.1016\/j.neulet.2026.138681_b0020","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s00702-005-0413-2","article-title":"Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism","volume":"113","author":"B\u00f6nsch","year":"2006","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"10","key":"10.1016\/j.neulet.2026.138681_b0025","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1111\/j.1530-0277.2011.01520.x","article-title":"Striatal involvement in human alcoholism and alcohol consumption, and withdrawal in animal models","volume":"35","author":"Chen","year":"2011","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"10","key":"10.1016\/j.neulet.2026.138681_b0030","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1038\/npp.2011.99","article-title":"Identifying neurobiological phenotypes associated with alcohol use disorder severity","volume":"36","author":"Claus","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"10","key":"10.1016\/j.neulet.2026.138681_b0035","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1111\/j.1360-0443.2010.03022.x","article-title":"Initial, habitual and compulsive alcohol use is characterized by a shift of cue processing from ventral to dorsal striatum","volume":"105","author":"Vollst\u00e4dt-Klein","year":"2010","journal-title":"Addiction"},{"issue":"11","key":"10.1016\/j.neulet.2026.138681_b0040","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1038\/nn1579","article-title":"Neural systems of reinforcement for drug addiction: from actions to habits to compulsion","volume":"8","author":"Everitt","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"6\u20137","key":"10.1016\/j.neulet.2026.138681_b0045","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.euroneuro.2006.10.006","article-title":"Drug addiction: pathways to the disease and pathophysiological perspectives","volume":"17","author":"Le Moal","year":"2007","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neulet.2026.138681_b0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fnint.2010.00017","article-title":"Instrumental uncertainty as a determinant of behavior under interval schedules of reinforcement","volume":"4","author":"Derusso","year":"2010","journal-title":"Front. Integr. Neurosci."},{"issue":"5\u20136","key":"10.1016\/j.neulet.2026.138681_b0055","first-page":"731","article-title":"Compulsive drug use and its neural substrates","volume":"23","author":"Lesscher","year":"2012","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neulet.2026.138681_b0060","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3389\/fnbeh.2014.00301","article-title":"Habitual responding for alcohol depends upon both AMPA and D2 receptor signaling in the dorsolateral striatum","volume":"8","author":"Corbit","year":"2014","journal-title":"Front. Behav. Neurosci."},{"issue":"33","key":"10.1016\/j.neulet.2026.138681_b0065","doi-asserted-by":"crossref","first-page":"11634","DOI":"10.1523\/JNEUROSCI.0003-15.2015","article-title":"Alcohol Elicits Functional and Structural Plasticity Selectively in Dopamine D1 Receptor-Expressing Neurons of the Dorsomedial Striatum","volume":"35","author":"Wang","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neulet.2026.138681_b0070","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1146\/annurev.neuro.29.051605.112851","article-title":"Habits, rituals and the evaluative brain","volume":"31","author":"Graybiel","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"issue":"8","key":"10.1016\/j.neulet.2026.138681_b0075","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.tins.2004.06.006","article-title":"Putting a spin on the dorsal-ventral divide of the striatum","volume":"27","author":"Voorn","year":"2004","journal-title":"Trends Neurosci."},{"issue":"6","key":"10.1016\/j.neulet.2026.138681_b0080","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrn1919","article-title":"The role of the basal ganglia in habit formation","volume":"7","author":"Yin","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"issue":"12","key":"10.1016\/j.neulet.2026.138681_b0085","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.tins.2022.10.001","article-title":"Convergent actions of stress and stimulants via epigenetic regulation of neural circuitry","volume":"45","author":"Murphy","year":"2022","journal-title":"Trends Neurosci."},{"issue":"1","key":"10.1016\/j.neulet.2026.138681_b0090","doi-asserted-by":"crossref","DOI":"10.1111\/adb.13251","article-title":"Lack of amygdala habituation to negative emotional faces in alcohol use disorder and the relation to adverse childhood experiences","volume":"28","author":"Gerhardt","year":"2023","journal-title":"Addict. Biol."},{"key":"10.1016\/j.neulet.2026.138681_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2025.154315","article-title":"The role of DNA methylation in alcohol-mediated neurodevelopmental toxicity","volume":"519","author":"Gao","year":"2026","journal-title":"Toxicology"},{"issue":"11","key":"10.1016\/j.neulet.2026.138681_b0100","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.euroneuro.2019.09.002","article-title":"DNA-methylation of the dopamin receptor 2 gene is altered during alcohol withdrawal","volume":"29","author":"Hillemacher","year":"2019","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"4","key":"10.1016\/j.neulet.2026.138681_b0105","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00702-010-0378-7","article-title":"DNA methylation of the POMC gene promoter is associated with seeking in alcohol dependence","volume":"117","author":"Muschler","year":"2010","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.neulet.2026.138681_b0110","doi-asserted-by":"crossref","unstructured":"June, H. L., & Gilpin, N. W. (2010). Operant self-administration models for testing the neuropharmacological basis of ethanol consumption in rats. Current protocols in neuroscience, Chapter 9, Unit\u20139.12.26.","DOI":"10.1002\/0471142301.ns0912s51"},{"key":"10.1016\/j.neulet.2026.138681_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108759","article-title":"Astrocyte-neuron interaction in the dorsal striatum-pallidal circuits and alcohol-seeking behaviors","volume":"198","author":"Hong","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neulet.2026.138681_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110646","article-title":"Abstinence and extinction drive opposing changes in striatal activity and dopamine signaling during alcohol relapse","volume":"279","author":"Xie","year":"2025","journal-title":"Neuropharmacology"},{"issue":"1\u20132","key":"10.1016\/j.neulet.2026.138681_b0125","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0166-4328(98)00107-7","article-title":"Effects of medial and lateral caudate-putamen lesions on place- and cue-guided behaviors in the water maze: relation to thigmotaxis","volume":"100","author":"Devan","year":"1999","journal-title":"Behav. Brain Res."},{"issue":"5","key":"10.1016\/j.neulet.2026.138681_b0130","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.jmb.2005.02.044","article-title":"Profound flanking sequence preference of DNMT3a and DNMT3b mammalian DNA methyltransferases shape the human epigenome","volume":"348","author":"Handa","year":"2005","journal-title":"J. Mol. Biol."},{"issue":"10","key":"10.1016\/j.neulet.2026.138681_b0135","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1002\/cbic.201000673","article-title":"Approaches to enzyme and substrate design of the murine DNMT3a DNA methyltransferase","volume":"12","author":"Jurkowska","year":"2011","journal-title":"Chembiochem"},{"issue":"3","key":"10.1016\/j.neulet.2026.138681_b0140","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1128\/MCB.22.3.704-723.2002","article-title":"Murine de novo methyltransferase DNMT3a demonstrates strand asymmetry and site preference in the methylation of DNA in vitro","volume":"22","author":"Lin","year":"2002","journal-title":"Mol. Cell Biol."},{"issue":"9","key":"10.1016\/j.neulet.2026.138681_b0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001106","article-title":"DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo","volume":"6","author":"Wienholz","year":"2010","journal-title":"PLoS Genet."},{"issue":"2","key":"10.1016\/j.neulet.2026.138681_b0150","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbr.2005.07.012","article-title":"Inactivation of dorsolateral striatum enhances sensitivity to changes in the action-outcome contingency in instrumental conditioning","volume":"166","author":"Yin","year":"2006","journal-title":"Behav. Brain Res."},{"issue":"7546","key":"10.1016\/j.neulet.2026.138681_b0155","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nature14176","article-title":"Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation","volume":"520","author":"Baubec","year":"2015","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.neulet.2026.138681_b0160","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.stem.2014.06.018","article-title":"DNMT3a and DNMT3b have overlapping and distinct functions in hematopoietic stem cells","volume":"15","author":"Challen","year":"2014","journal-title":"Cell Stem Cell"},{"issue":"16","key":"10.1016\/j.neulet.2026.138681_b0165","doi-asserted-by":"crossref","first-page":"5594","DOI":"10.1128\/MCB.23.16.5594-5605.2003","article-title":"Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by DNMT3a and DNMT3b","volume":"23","author":"Chen","year":"2003","journal-title":"Mol. Cell Biol."},{"issue":"20","key":"10.1016\/j.neulet.2026.138681_b0170","doi-asserted-by":"crossref","first-page":"15098","DOI":"10.3390\/ijms242015098","article-title":"Sex differences in Brain Region-specific Activation of c-Fos following Kappa Opioid Receptor Stimulation or Acute stress in mice","volume":"24","author":"Ma","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neulet.2026.138681_b0175","article-title":"Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain","volume":"6(26):eaba0154","author":"De Santis","year":"2020","journal-title":"Sci. Adv."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394026001813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394026001813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:30:26Z","timestamp":1788553826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394026001813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":35,"alternative-id":["S0304394026001813"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2026.138681","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of dorsal striatal DNMT3b in alcohol seeking behavior after withdrawal","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2026.138681","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"138681"}}