{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:40:01Z","timestamp":1793508001999,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"US Department of War","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Letters"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.neulet.2026.138711","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:43:40Z","timestamp":1787849020000},"page":"138711","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Microtubule and cytoskeletal destabilization gene expression in the brain vasculature after experimental diffuse traumatic brain injury: Implications for neurodegenerative disease later in life"],"prefix":"10.1016","volume":"886","author":[{"given":"Diego F.","family":"Mastroeni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Nolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yining","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1697-8284","authenticated-orcid":false,"given":"Karisa A.","family":"Louangprasert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Emerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Karamanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.Matthew","family":"Law","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Q.","family":"Migrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4398-6493","authenticated-orcid":false,"given":"Jonathan","family":"Lifshitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neulet.2026.138711_b0005","doi-asserted-by":"crossref","first-page":"16084","DOI":"10.1038\/nrdp.2016.84","article-title":"Traumatic brain injuries","volume":"2","author":"Blennow","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.neulet.2026.138711_b0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mcn.2015.03.001","article-title":"Epidemiology of mild traumatic brain injury and neurodegenerative disease","volume":"66","author":"Gardner","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neulet.2026.138711_b0015","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0925-4927(03)00109-4","article-title":"Cerebral blood flow in chronic symptomatic mild traumatic brain injury","volume":"124","author":"Bonne","year":"2003","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neulet.2026.138711_b0020","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuroscience.2012.08.058","article-title":"Morphological and genetic activation of microglia after diffuse traumatic brain injury in the rat","volume":"225","author":"Cao","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.neulet.2026.138711_b0025","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/2051-5960-2-67","article-title":"Selective vulnerability of the cerebral vasculature to blast injury in a rat model of mild traumatic brain injury","volume":"2","author":"Gama Sosa","year":"2014","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neulet.2026.138711_b0030","doi-asserted-by":"crossref","DOI":"10.1089\/neu.2022.0015","article-title":"Chronic Cognitive and Cerebrovascular Function following Mild Traumatic Brain Injury in Rats","author":"Griffiths","year":"2022","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neulet.2026.138711_b0035","article-title":"Blood brain barrier dysfunction and delayed neurological deficits in mild traumatic brain injury induced by blast shock waves","volume":"8","author":"Shetty","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neulet.2026.138711_b0040","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1042\/CS20120259","article-title":"Impaired cerebral haemodynamic function associated with chronic traumatic brain injury in professional boxers","volume":"124","author":"Bailey","year":"2013","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.neulet.2026.138711_b0045","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/j.nano.2018.06.004","article-title":"Blood\u2013brainbarrier disruption dictates nanoparticle accumulation following experimental brain injury","volume":"14","author":"Bharadwaj","year":"2018","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.neulet.2026.138711_b0050","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/109980040100200303","article-title":"Cerebral autoregulation and outcome in acute brain injury","volume":"2","author":"Kirkness","year":"2001","journal-title":"Biol. Res. Nurs."},{"key":"10.1016\/j.neulet.2026.138711_b0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pscychresns.2011.12.007","article-title":"Regional cerebral blood flow differences in patients with mild cognitive impairment between those who did and did not develop Alzheimer's disease","volume":"203","author":"Park","year":"2012","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.neulet.2026.138711_b0060","doi-asserted-by":"crossref","unstructured":"Giordano, K. R. & Lifshitz, J. in Traumatic Brain Injury: Science, Practice, Evidence and Ethics (eds Stephen Honeybul & Angelos G. Kolias) 13-18 (Springer International Publishing, 2021).","DOI":"10.1007\/978-3-030-78075-3_2"},{"key":"10.1016\/j.neulet.2026.138711_b0065","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1136\/jnnp-2017-317557","article-title":"Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia","volume":"90","author":"Graham","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neulet.2026.138711_b0070","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/jemt.10250","article-title":"Microfilaments and microtubules maintain endothelial integrity","volume":"60","author":"Lee","year":"2003","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.neulet.2026.138711_b0075","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.mvr.2008.06.003","article-title":"The role of cytoskeleton in the regulation of vascular endothelial barrier function","volume":"76","author":"Bogatcheva","year":"2008","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.neulet.2026.138711_b0080","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1249\/MSS.0b013e31819fcd1b","article-title":"Brain injury forces of moderate magnitude elicit the fencing response","volume":"41","author":"Hosseini","year":"2009","journal-title":"Med. Sci. Sports Exerc."},{"key":"10.1016\/j.neulet.2026.138711_b0085","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1080\/02699052.2016.1193628","article-title":"Clinical relevance of midline fluid percussion brain injury: Acute deficits, chronic morbidities and the utility of biomarkers","volume":"30","author":"Lifshitz","year":"2016","journal-title":"Brain Inj."},{"key":"10.1016\/j.neulet.2026.138711_b0090","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/978-1-4939-3816-2_13","article-title":"Midline (Central) Fluid Percussion Model of Traumatic Brain Injury","volume":"1462","author":"Rowe","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.neulet.2026.138711_b0095","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neurobiolaging.2018.02.018","article-title":"Upregulation of histone deacetylase 2 in laser capture nigral microglia in Parkinson's disease","volume":"68","author":"Tan","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2026.138711_b0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191382","article-title":"Correction: ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity","volume":"13","author":"Mastroeni","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.neulet.2026.138711_b0105","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neurobiolaging.2017.10.019","article-title":"Laser-captured microglia in the Alzheimer's and Parkinson's brain reveal unique regional expression profiles and suggest a potential role for hepatitis B in the Alzheimer's brain","volume":"63","author":"Mastroeni","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neulet.2026.138711_b0110","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.jalz.2017.12.005","article-title":"Oligomeric amyloid beta preferentially targets neuronal and not glial mitochondrial-encoded mRNAs","volume":"14","author":"Mastroeni","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neulet.2026.138711_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2018.04.003","article-title":"Peripheral complement interactions with amyloid beta peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1","author":"Johansson","year":"2018","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.neulet.2026.138711_b0120","doi-asserted-by":"crossref","DOI":"10.1117\/1.NPh.9.3.031916","article-title":"Unbiased analysis of mouse brain endothelial networks from two- or three-dimensional fluorescence images","volume":"9","author":"Freitas-Andrade","year":"2022","journal-title":"Neurophotonics"},{"key":"10.1016\/j.neulet.2026.138711_b0125","doi-asserted-by":"crossref","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"Embnet.journal"},{"key":"10.1016\/j.neulet.2026.138711_b0130","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.neulet.2026.138711_b0135","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.neulet.2026.138711_b0140","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (camb)"},{"key":"10.1016\/j.neulet.2026.138711_b0145","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1101\/gad.11.23.3143","article-title":"Targeted inactivation of plectin reveals essential function in maintaining the integrity of skin, muscle, and heart cytoarchitecture","volume":"11","author":"Andra","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.neulet.2026.138711_b0150","doi-asserted-by":"crossref","first-page":"E2841","DOI":"10.1073\/pnas.1401777111","article-title":"Cep164 triggers ciliogenesis by recruiting Tau tubulin kinase 2 to the mother centriole","volume":"111","author":"Cajanek","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neulet.2026.138711_b0155","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1212\/WNL.0000000000000616","article-title":"Traumatic brain injury and risk of dementia in older veterans","volume":"83","author":"Barnes","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.neulet.2026.138711_b0160","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S1474-4422(12)70226-0","article-title":"Cognitive decline in older adults with a history of traumatic brain injury","volume":"11","author":"Moretti","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neulet.2026.138711_b0165","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neulet.2016.06.066","article-title":"Traumatic brain injury accelerates amyloid-beta deposition and impairs spatial learning in the triple-transgenic mouse model of Alzheimer's disease","volume":"629","author":"Shishido","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neulet.2026.138711_b0170","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.neubiorev.2012.02.013","article-title":"Traumatic brain injury: a risk factor for Alzheimer's disease","volume":"36","author":"Sivanandam","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neulet.2026.138711_b0175","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.tcb.2019.07.004","article-title":"Microtubule-Associated Proteins: Structuring the Cytoskeleton","volume":"29","author":"Bodakuntla","year":"2019","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.neulet.2026.138711_b0180","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/cm.20388","article-title":"Cytoskeletal pathologies of Alzheimer disease","volume":"66","author":"Bamburg","year":"2009","journal-title":"Cell Motil. Cytoskeleton"},{"key":"10.1016\/j.neulet.2026.138711_b0185","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s40035-021-00272-z","article-title":"New perspectives on cytoskeletal dysregulation and mitochondrial mislocalization in amyotrophic lateral sclerosis","volume":"10","author":"Theunissen","year":"2021","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.neulet.2026.138711_b0190","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00018-016-2351-6","article-title":"Back to the tubule: microtubule dynamics in Parkinson's disease","volume":"74","author":"Pellegrini","year":"2017","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neulet.2026.138711_b0195","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202105146","article-title":"Plectin-mediated cytoskeletal crosstalk controls cell tension and cohesion in epithelial sheets","volume":"221","author":"Prechova","year":"2022","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neulet.2026.138711_b0200","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202201054","article-title":"Plectin pulls it together, coupling the cortical actin and intermediate filament cytoskeletons","volume":"221","author":"Broussard","year":"2022","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neulet.2026.138711_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.115209","article-title":"Plectin stabilizes microtubules during osteoclastic bone resorption by acting as a scaffold for Src and Pyk2","volume":"132","author":"Matsubara","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.neulet.2026.138711_b0210","first-page":"4138","article-title":"Plectin reinforces vascular integrity by mediating crosstalk between the vimentin and the actin networks","volume":"128","author":"Osmanagic-Myers","year":"2015","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.neulet.2026.138711_b0215","article-title":"Identification of risk genes for Alzheimer's disease by gene embedding","volume":"2","author":"Lagisetty","year":"2022","journal-title":"Cell Genom"},{"key":"10.1016\/j.neulet.2026.138711_b0220","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/nan.12635","article-title":"Plectin dysfunction in neurons leads to tau accumulation on microtubules affecting neuritogenesis, organelle trafficking, pain sensitivity and memory","volume":"47","author":"Valencia","year":"2021","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.neulet.2026.138711_b0225","doi-asserted-by":"crossref","first-page":"12358","DOI":"10.1038\/s41598-020-69096-7","article-title":"Transcriptomic comparison of human and mouse brain microvessels","volume":"10","author":"Song","year":"2020","journal-title":"Sci. Rep."}],"container-title":["Neuroscience Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394026002119?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0304394026002119?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:24:03Z","timestamp":1791865443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0304394026002119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":45,"alternative-id":["S0304394026002119"],"URL":"https:\/\/doi.org\/10.1016\/j.neulet.2026.138711","relation":{},"ISSN":["0304-3940"],"issn-type":[{"value":"0304-3940","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microtubule and cytoskeletal destabilization gene expression in the brain vasculature after experimental diffuse traumatic brain injury: Implications for neurodegenerative disease later in life","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neulet.2026.138711","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"138711"}}