{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:22:27Z","timestamp":1773289347005,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1016\/j.neures.2006.02.010","type":"journal-article","created":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T07:07:13Z","timestamp":1144393633000},"page":"123-133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells"],"prefix":"10.1016","volume":"55","author":[{"given":"Takumi","family":"Misaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohide","family":"Murate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushi","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Kubo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2006.02.010_bib1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/79944","article-title":"OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28","volume":"26","author":"Alexander","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neures.2006.02.010_bib2","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/jemt.1070270303","article-title":"Dynamics of mitochondria in living cells: shape changes, dislocations, fusion, and fission of mitochondria","volume":"27","author":"Bereiter-Hahn","year":"1994","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.neures.2006.02.010_bib3","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/13014","article-title":"The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast","volume":"1","author":"Bleazard","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neures.2006.02.010_bib4","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.ceb.2003.10.015","article-title":"Mitochondrial fission in apoptosis, neurodegeneration and aging","volume":"15","author":"Bossy-Wetzel","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.neures.2006.02.010_bib5","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1091\/mbc.12.2.309","article-title":"Division of mitochondria requires a novel DMN1-interacting protein, Net2p","volume":"12","author":"Cerveny","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neures.2006.02.010_bib6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1083\/jcb.200211046","article-title":"Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development","volume":"160","author":"Chen","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neures.2006.02.010_bib7","doi-asserted-by":"crossref","first-page":"26185","DOI":"10.1074\/jbc.M503062200","article-title":"Disruption of fusion results in mitochondrial heterogeneity and dysfunction","volume":"280","author":"Chen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2006.02.010_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3550001","article-title":"Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signalling","volume":"355","author":"Chiesa","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.neures.2006.02.010_bib9","doi-asserted-by":"crossref","first-page":"15927","DOI":"10.1073\/pnas.0407043101","article-title":"OPA1 requires mitofusin 1 to promote mitochondrial fusion","volume":"101","author":"Cipolat","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neures.2006.02.010_bib10","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1083\/jcb.127.4.915","article-title":"Induction of mutant dynamin specifically blocks endocytic coated vesicle formation","volume":"127","author":"Damke","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neures.2006.02.010_bib11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/79936","article-title":"Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy","volume":"26","author":"Delettre","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.neures.2006.02.010_bib12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1006\/mgme.2001.3278","article-title":"OPA1 (Kjer type) dominant optic atrophy: a novel mitochondrial disease","volume":"75","author":"Delettre","year":"2002","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.neures.2006.02.010_bib13","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1083\/jcb.151.2.333","article-title":"Gag3p, an outer membrane protein required for fission of mitochondrial tubules","volume":"151","author":"Fekkes","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neures.2006.02.010_bib14","doi-asserted-by":"crossref","first-page":"18792","DOI":"10.1074\/jbc.M400920200","article-title":"Loss of the intermembrane space protein Mgm1\/Opa1 induces swelling and localized constrictions along the lengths of mitochondria","volume":"279","author":"Griparic","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2006.02.010_bib15","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0092-8674(00)80319-0","article-title":"Developmentally regulated mitochondrial fusion mediated by a conserved, novel, predicted GTPase","volume":"90","author":"Hales","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.neures.2006.02.010_bib16","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1083\/jcb.143.2.359","article-title":"Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p","volume":"143","author":"Hermann","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neures.2006.02.010_bib17","first-page":"1190","article-title":"Linkage analysis in dominant optic atrophy","volume":"35","author":"Kivlin","year":"1983","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neures.2006.02.010_bib18","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1755-3768.1983.tb01424.x","article-title":"Histopathology of eye, optic nerve and brain in a case of dominant optic atrophy","volume":"61","author":"Kjer","year":"1983","journal-title":"Acta Ophthalmol. (Copenh.)"},{"key":"10.1016\/j.neures.2006.02.010_bib19","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/S1097-2765(00)80391-3","article-title":"C. elegans dynamin-related protein DRP-1 controls severing of the mitochondrial outer membrane","volume":"4","author":"Labrousse","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.neures.2006.02.010_bib20","doi-asserted-by":"crossref","first-page":"15834","DOI":"10.1074\/jbc.M109260200","article-title":"Primary structure of a dynamin-related mouse mitochondrial GTPase and its distribution in brain, subcellular localization, and effect on mitochondrial morphology","volume":"277","author":"Misaka","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2006.02.010_bib21","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1083\/jcb.151.2.367","article-title":"Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p","volume":"151","author":"Mozdy","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neures.2006.02.010_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","article-title":"Efficient selection for high-expression transfectants with a novel eukaryotic vector","volume":"108","author":"Niwa","year":"1991","journal-title":"Gene"},{"key":"10.1016\/j.neures.2006.02.010_bib23","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0014-5793(02)02985-X","article-title":"The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space","volume":"523","author":"Olichon","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neures.2006.02.010_bib24","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1074\/jbc.C200677200","article-title":"Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosis","volume":"278","author":"Olichon","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2006.02.010_bib25","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1242\/jcs.112.22.4151","article-title":"Fission yeast Msp1 is a mitochondrial dynamin-related protein","volume":"112","author":"Pelloquin","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.neures.2006.02.010_bib26","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/hmg\/10.13.1359","article-title":"OPA1 mutations in patients with autosomal dominant optic atrophy and evidence for semi-dominant inheritance","volume":"10","author":"Pesch","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neures.2006.02.010_bib27","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1242\/jcs.115.8.1663","article-title":"Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo","volume":"115","author":"Rojo","year":"2002","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.neures.2006.02.010_bib28","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1242\/jcs.114.5.867","article-title":"Control of mitochondrial morphology by a human mitofusin","volume":"114","author":"Santel","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.neures.2006.02.010_bib29","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0006-291X(02)02874-7","article-title":"Differential sublocalization of the dynamin-related protein OPA1 isoforms in mitochondria","volume":"300","author":"Satoh","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neures.2006.02.010_bib30","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1083\/jcb.147.4.699","article-title":"Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape","volume":"147","author":"Sesaki","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neures.2006.02.010_bib31","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0962-8924(01)02246-2","article-title":"Mitochondrial dynamics and division in budding yeast","volume":"12","author":"Shaw","year":"2002","journal-title":"Trends. Cell Biol."},{"key":"10.1016\/j.neures.2006.02.010_bib32","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1091\/mbc.12.8.2245","article-title":"Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells","volume":"12","author":"Smirnova","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.neures.2006.02.010_bib33","first-page":"1715","article-title":"A comprehensive survey of mutations in the OPA1 gene in patients with autosomal dominant optic atrophy","volume":"43","author":"Thiselton","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neures.2006.02.010_bib34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1083\/jcb.151.2.353","article-title":"Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial division","volume":"151","author":"Tieu","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neures.2006.02.010_bib35","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/hmg\/10.13.1369","article-title":"Spectrum, frequency and penetrance of OPA1 mutations in dominant optic atrophy","volume":"10","author":"Toomes","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neures.2006.02.010_bib36","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1083\/jcb.122.3.553","article-title":"Mutations in human dynamin block an intermediate stage in coated vesicle formation","volume":"122","author":"van der Bliek","year":"1993","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neures.2006.02.010_bib37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1083\/jcb.151.2.341","article-title":"The dynamin-related GTPase, Mgm1p, is an intermembrane space protein required for maintenance of fusion competent mitochondria","volume":"151","author":"Wong","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.neures.2006.02.010_bib38","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1083\/jcb.200209015","article-title":"The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion","volume":"160","author":"Wong","year":"2003","journal-title":"J. Cell Biol."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010206000411?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010206000411?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:18:33Z","timestamp":1759141113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010206000411"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["S0168010206000411"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2006.02.010","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The dynamin-related mouse mitochondrial GTPase OPA1 alters the structure of the mitochondrial inner membrane when exogenously introduced into COS-7 cells","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2006.02.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}