{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:16:03Z","timestamp":1790507763847,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.neures.2006.03.007","type":"journal-article","created":{"date-parts":[[2006,5,5]],"date-time":"2006-05-05T02:20:11Z","timestamp":1146795611000},"page":"264-270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Glutamate transporters GLAST and EAAT4 regulate postischemic Purkinje cell death: An in vivo study using a cardiac arrest model in mice lacking GLAST or EAAT4"],"prefix":"10.1016","volume":"55","author":[{"given":"Akihide","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koshi","family":"Makita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Kuroiwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohichi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2006.03.007_bib1","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1073\/pnas.94.8.4155","article-title":"Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance","volume":"94","author":"Arriza","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neures.2006.03.007_bib2","doi-asserted-by":"crossref","first-page":"14821","DOI":"10.1073\/pnas.94.26.14821","article-title":"Glutamate transporter currents in Bergmann glial cells follow the time course of extrasynaptic glutamate","volume":"94","author":"Bergles","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neures.2006.03.007_bib3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0306-4522(90)90091-H","article-title":"Calbindin D-28k and parvalbumin in the rat nervous system","volume":"35","author":"Celio","year":"1990","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2006.03.007_bib4","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/0896-6273(95)90158-2","article-title":"Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry","volume":"15","author":"Chaudhry","year":"1995","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2006.03.007_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"Danbolt","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neures.2006.03.007_bib6","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1523\/JNEUROSCI.18-10-03606.1998","article-title":"The glutamate transporter EAAT4 in rat cerebellar Purkinje cells: a glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia","volume":"18","author":"Dehnes","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2006.03.007_bib7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1523\/JNEUROSCI.4473-03.2004","article-title":"Climbing fiber activation of EAAT4 transporters and kainate receptors in cerebellar Purkinje cells","volume":"24","author":"Huang","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2006.03.007_bib8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0304-3940(02)00101-5","article-title":"Cardiac arrest cerebral ischemia model in mice failed to cause delayed neuronal death in the hippocampus","volume":"322","author":"Kawahara","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neures.2006.03.007_bib9","doi-asserted-by":"crossref","first-page":"8751","DOI":"10.1523\/JNEUROSCI.18-21-08751.1998","article-title":"The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain","volume":"18","author":"Lehre","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2006.03.007_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/72101","article-title":"Polyglutamine expansion down-regulates specific neuronal genes before pathologic changes in SCA1","volume":"3","author":"Lin","year":"2000","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neures.2006.03.007_bib11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0891-0618(97)00051-3","article-title":"Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites","volume":"13","author":"Lujan","year":"1997","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.neures.2006.03.007_bib12","doi-asserted-by":"crossref","first-page":"7176","DOI":"10.1523\/JNEUROSCI.23-18-07176.2003","article-title":"Functional changes of glial glutamate transporter GLT-1 during ischemia: an in vivo study in the hippocampal CA1 of normal mice and mutant mice lacking GLT-1","volume":"23","author":"Mitani","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2006.03.007_bib13","first-page":"929","article-title":"EAAT4, a glutamate transporter with properties of a chloride channel, is predominantly localized in Purkinje cell dendrites, and forms parasagittal compartments in rat cerebellum","volume":"78","author":"Nagao","year":"1997","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2006.03.007_bib14","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/0306-4522(93)90485-X","article-title":"Distribution of the mRNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system o the rat","volume":"53","author":"Ohishi","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2006.03.007_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0079-6123(08)63360-9","article-title":"Molecular organization of cerebellar glutamate synapses","volume":"114","author":"Ottersen","year":"1997","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neures.2006.03.007_bib16","doi-asserted-by":"crossref","first-page":"3822","DOI":"10.1093\/emboj\/16.13.3822","article-title":"Glutamate transporter EAAC-1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration","volume":"16","author":"Peghini","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.neures.2006.03.007_bib17","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0301-0082(03)00114-X","article-title":"Patterned Purkinje cell death in the cerebellum","volume":"70","author":"Sarna","year":"2003","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neures.2006.03.007_bib18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0079-6123(04)48029-7","article-title":"Don\u2019t get too excited: mechanims of glutamate-mediated Purkinje cell death","volume":"148","author":"Slemmer","year":"2005","journal-title":"Prog. Brain Re."},{"key":"10.1016\/j.neures.2006.03.007_bib19","doi-asserted-by":"crossref","first-page":"8771","DOI":"10.1523\/JNEUROSCI.1961-04.2004","article-title":"Molecular, topographic, and functional organization of the cerebellar cortex: a study with combined aldolase C and olivocerebellar labeling","volume":"24","author":"Sugihara","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2006.03.007_bib20","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1523\/JNEUROSCI.1020-05.2005","article-title":"Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses","volume":"25","author":"Takayasu","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2006.03.007_bib21","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1097\/00001756-199707280-00010","article-title":"Extra-junctional localization of glutamate transporter EAAT4 at excitatory Purkinje cell synapses","volume":"8","author":"Tanaka","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.neures.2006.03.007_bib22","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1126\/science.276.5319.1699","article-title":"Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1","volume":"276","author":"Tanaka","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neures.2006.03.007_bib23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0168-0102(00)00104-8","article-title":"Functions of glutamate transporters in the brain","volume":"37","author":"Tanaka","year":"2000","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neures.2006.03.007_bib24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.molmed.2005.04.002","article-title":"Antibiotics rescue neurons from glutamate attack","volume":"11","author":"Tanaka","year":"2005","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neures.2006.03.007_bib25","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1046\/j.1460-9568.1998.00108.x","article-title":"Motor discoordination and increased susceptibility to cerebellar injury in GLAST mutant mice","volume":"10","author":"Watase","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neures.2006.03.007_bib26","first-page":"331","article-title":"Why do Purkinje cells die so easily after global brain ischemia? Aldolase C EAAT4, and the cerebellar contribution to posthypoxic myoclonus","volume":"89","author":"Welsh","year":"2002","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.neures.2006.03.007_bib27","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/(SICI)1096-9861(20000228)418:1<106::AID-CNE8>3.0.CO;2-N","article-title":"Dynamic transfromation of Bergmann glial fibers proceeds in correlation with dendritic outgrowth of cerebellar Purkinje cells","volume":"418","author":"Yamada","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2006.03.007_bib28","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1097\/00001756-199608120-00032","article-title":"EAAT4 is a post-synaptic glutamate transporter at Purkinje cell synapses","volume":"7","author":"Yamada","year":"1996","journal-title":"Neuroreport"}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016801020600071X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016801020600071X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:18:42Z","timestamp":1759141122000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016801020600071X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S016801020600071X"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2006.03.007","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glutamate transporters GLAST and EAAT4 regulate postischemic Purkinje cell death: An in vivo study using a cardiac arrest model in mice lacking GLAST or EAAT4","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2006.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}