{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:37:51Z","timestamp":1791200271564,"version":"4.2.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.neures.2007.01.008","type":"journal-article","created":{"date-parts":[[2007,1,21]],"date-time":"2007-01-21T12:08:20Z","timestamp":1169381300000},"page":"32-39","source":"Crossref","is-referenced-by-count":198,"title":["Depressive behaviors and decreased expression of serotonin reuptake transporter in rats that experienced neonatal maternal separation"],"prefix":"10.1016","volume":"58","author":[{"given":"Jong-Ho","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Goo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bom-Taeck","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Won","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Won","family":"Jahng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2007.01.008_bib1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.mp.4000473","article-title":"Environment and vulnerability to major psychiatric illness: a case control study of early parental loss in major depression, bipolar disorder and schizophrenia","volume":"4","author":"Agid","year":"1999","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.neures.2007.01.008_bib2","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s00213-004-1883-x","article-title":"Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation","volume":"176","author":"Arborelius","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neures.2007.01.008_bib3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1192\/bjp.180.1.24","article-title":"State and trait abnormalities in serotonin function in major depression","volume":"180","author":"Bhagwagar","year":"2002","journal-title":"Br. J. Psychiatr."},{"key":"10.1016\/j.neures.2007.01.008_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-0115(03)00126-5","article-title":"Systemic 5-hydroxy-l-tryptophan down-regulates the arcuate CART mRNA level in rats","volume":"115","author":"Choi","year":"2003","journal-title":"Regul. Pept."},{"key":"10.1016\/j.neures.2007.01.008_bib5","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0169-328X(00)00167-4","article-title":"Decreased 5-HT transporter mRNA in neurons of the dorsal raphe nucleus and behavioral depression in the obese leptin-deficient ob\/ob mouse","volume":"81","author":"Collin","year":"2000","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.neures.2007.01.008_bib6","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1749-6632.1990.tb16907.x","article-title":"Serotonin and appetite","volume":"600","author":"Curzon","year":"1990","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.neures.2007.01.008_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1023\/B:MEBR.0000027412.19664.b3","article-title":"Maternal separation in rats lead to anxiety-like behavior and a blunted ACTH response and altered neurotransmitter levels in response to a subsequent stressor","volume":"19","author":"Daniels","year":"2004","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.neures.2007.01.008_bib8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0969-8051(00)00119-0","article-title":"Serotonin type-1 A receptor imaging in depression","volume":"27","author":"Drevets","year":"2000","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.neures.2007.01.008_bib9","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1071\/RD05043","article-title":"Glucocorticoids and serotonin alter glucocorticoid receptor mRNA levels in fetal guinea-pig hippocampal neurons, in vitro","volume":"17","author":"Erdeljan","year":"2005","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.neures.2007.01.008_bib10","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study","volume":"14","author":"Felitti","year":"1998","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.neures.2007.01.008_bib11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0165-0327(98)00054-8","article-title":"Early parental separation experiences among patients with bipolar and major depression: a case\u2013control study","volume":"52","author":"Furukawa","year":"1999","journal-title":"J. Affect. Dis."},{"key":"10.1016\/j.neures.2007.01.008_bib12","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1046\/j.1460-9568.2003.02668.x","article-title":"Early life adversity programs changes in central 5-HT neuronal function in adulthood","volume":"17","author":"Gartside","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neures.2007.01.008_bib13","first-page":"33","article-title":"SSRIs and SMRIs: broad spectrum of efficacy beyond major depression","volume":"60","author":"Gorman","year":"1999","journal-title":"J. Clin. Psychiatr."},{"key":"10.1016\/j.neures.2007.01.008_bib14","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0193-953X(05)70342-7","article-title":"Serotonergic systems","volume":"20","author":"Graeff","year":"1997","journal-title":"Psychiatr. Clin. N. Am."},{"key":"10.1016\/j.neures.2007.01.008_bib15","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0006-3223(01)01157-X","article-title":"The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies","volume":"49","author":"Heim","year":"2001","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neures.2007.01.008_bib16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/jama.284.5.592","article-title":"Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood","volume":"284","author":"Heim","year":"2000","journal-title":"JAMA"},{"key":"10.1016\/j.neures.2007.01.008_bib17","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1176\/appi.ajp.158.4.575","article-title":"Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse","volume":"158","author":"Heim","year":"2001","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.neures.2007.01.008_bib18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1210\/edrv-17-2-187","article-title":"Antidepressants and hypothalamic-pituitary-adrenocortical regulation","volume":"17","author":"Holsboer","year":"1996","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.neures.2007.01.008_bib19","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0031-9384(00)00305-X","article-title":"Effect of maternal separation on feeding behavior of rats in later life","volume":"70","author":"Iwasaki","year":"2000","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neures.2007.01.008_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0165-3806(98)00013-3","article-title":"Differential expression of monoamine oxidase A, serotonin transporter, tyrosine hydroxylase and norepinephrine transporter mRNA by anorexia mutation and food deprivation","volume":"107","author":"Jahng","year":"1998","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.neures.2007.01.008_bib21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0091-3057(02)00781-5","article-title":"Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long-Evans rats","volume":"73","author":"Kalinichev","year":"2002","journal-title":"Pharm. Biochem. Behav."},{"key":"10.1016\/j.neures.2007.01.008_bib22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/archpsyc.1992.01820020029004","article-title":"Childhood parental loss and adult psychopathology in women. A twin study perspective","volume":"49","author":"Kendler","year":"1992","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.neures.2007.01.008_bib23","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.pnpbp.2005.11.011","article-title":"Adult life behavioral consequences of early maternal separation are alleviated by escitalopram treatment in a rat model of depression","volume":"30","author":"Khoury","year":"2006","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatr."},{"key":"10.1016\/j.neures.2007.01.008_bib24","unstructured":"Kim, H.J., Yoo, S.B., Ryu, V., Kim, G.T., Jahng, J.W., 2005a. The hypothalamic expression of corticotropin-releasing hormone by stress is blunted in the rat experienced maternal separation during neonatal period. Soc. Neurosci. Abs."},{"key":"10.1016\/j.neures.2007.01.008_bib25","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.npep.2005.09.003","article-title":"Fasting-induced increases of arcuate NPY mRNA and plasma corticosterone are blunted in the rat experienced neonatal maternal separation","volume":"39","author":"Kim","year":"2005","journal-title":"Neuropeptides"},{"key":"10.1016\/j.neures.2007.01.008_bib26","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1210\/en.137.4.1212","article-title":"Persistent changes in corticotropin-releasing factor neuronal systems induced by maternal deprivation","volume":"137","author":"Ladd","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.neures.2007.01.008_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0079-6123(08)62132-9","article-title":"Long-term behavioral and neuroendocrine adaptations to adverse early experience","volume":"122","author":"Ladd","year":"2000","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.neures.2007.01.008_bib28","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0006-3223(98)00186-3","article-title":"Hypothalamic serotonin in control of eating behavior, meal size, and body weight","volume":"44","author":"Leibowitz","year":"1998","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neures.2007.01.008_bib29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1210\/jcem-65-1-141","article-title":"24-hour profiles of adrenocorticotropin, cortisol, and growth hormone in major depressive illness: effect of antidepressant treatment","volume":"65","author":"Linkowski","year":"1987","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neures.2007.01.008_bib30","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0006-8993(95)00906-7","article-title":"Serotonin depletion decreases serotonin transporter mRNA levels in rat brain","volume":"697","author":"Linnet","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.neures.2007.01.008_bib31","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/S0006-3223(03)00696-6","article-title":"Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice","volume":"54","author":"Lira","year":"2003","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neures.2007.01.008_bib32","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/S0006-3223(98)00272-8","article-title":"Reduced brain serotonin transporter availability in major depression as measured by [123I]-2beta-carbomethoxy-3beta-(4-iodophenyl)tropane and single photon emission computed tomography","volume":"44","author":"Malison","year":"1998","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.neures.2007.01.008_bib33","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0893-133X(95)00016-7","article-title":"Blunted serotonergic responsivity in depressed inpatients","volume":"13","author":"Mann","year":"1995","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neures.2007.01.008_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/1098-2396(200104)40:1<1::AID-SYN1020>3.0.CO;2-E","article-title":"Periodic maternal separation of neonatal rats produces region- and gender-specific effects on biogenic amine content in postmortem adult brain","volume":"40","author":"Matthews","year":"2001","journal-title":"Synapse"},{"key":"10.1016\/j.neures.2007.01.008_bib35","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0145-2134(95)00112-3","article-title":"The long-term impact of the physical, emotional, and sexual abuse of children: a community study","volume":"20","author":"Mullen","year":"1996","journal-title":"Child Abuse Negl."},{"key":"10.1016\/j.neures.2007.01.008_bib36","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1176\/appi.ajp.159.8.1265","article-title":"Parental depression: animal models of an adverse life event","volume":"159","author":"Newport","year":"2002","journal-title":"Am. J. Psychiatr."},{"issue":"Suppl. 11","key":"10.1016\/j.neures.2007.01.008_bib37","first-page":"22","article-title":"Neurobiological mechanisms in generalized anxiety disorder","volume":"62","author":"Nutt","year":"2001","journal-title":"J. Clin. Psychiatr."},{"key":"10.1016\/j.neures.2007.01.008_bib38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF01250331","article-title":"Reevaluation of the indoleamine hypothesis of depression, evidence for a reduction of functional activity of central 5-HT system by antidepressant drugs","volume":"46","author":"Ogren","year":"1979","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.neures.2007.01.008_bib39","series-title":"The Rat Brain in Stereotaxic Coordinate","author":"Paxions","year":"1986"},{"key":"10.1016\/j.neures.2007.01.008_bib40","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.neures.2007.01.008_bib41","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.eatbeh.2005.11.004","article-title":"Psychosocial variables, eating behavior, depression, and binge eating in morbidly obese subjects","volume":"7","author":"Riener","year":"2006","journal-title":"Eat. Behav."},{"key":"10.1016\/j.neures.2007.01.008_bib42","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1176\/ajp.153.2.275","article-title":"Childhood physical and sexual abuse in patients with anxiety disorders in a community sample","volume":"153","author":"Stein","year":"1996","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.neures.2007.01.008_bib43","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0165-3806(98)00143-6","article-title":"Early vs. late maternal deprivation differentially alters the endocrine and hypothalamic responses to stress","volume":"111","author":"Van Oers","year":"1998","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.neures.2007.01.008_bib44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/syn.20033","article-title":"Effect of early life stress on serotonin responses in the hippocampus of young adult rats","volume":"53","author":"Van Riel","year":"2004","journal-title":"Synapse"},{"key":"10.1016\/j.neures.2007.01.008_bib45","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0006-8993(99)02307-0","article-title":"Maternal deprivation regulates serotonin 1A and 2A receptors in the infant rat","volume":"855","author":"Vazquez","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.neures.2007.01.008_bib46","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1111\/j.1471-4159.1982.tb07897.x","volume":"38","author":"Wagner","year":"1982","journal-title":"J. Neurochem."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010207000338?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010207000338?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T20:50:43Z","timestamp":1547067043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010207000338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0168010207000338"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2007.01.008","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}