{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:20:49Z","timestamp":1771482049671,"version":"3.50.1"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.neures.2007.11.011","type":"journal-article","created":{"date-parts":[[2007,12,10]],"date-time":"2007-12-10T20:06:02Z","timestamp":1197317162000},"page":"314-318","source":"Crossref","is-referenced-by-count":17,"title":["Myocardial nerve fibers are preserved in MPTP-treated mice, despite cardiac sympathetic dysfunction"],"prefix":"10.1016","volume":"60","author":[{"given":"Takeshi","family":"Amino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Uchihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Tsunekawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazue","family":"Takahata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichiro","family":"Shimazu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiro","family":"Mizusawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Orimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2007.11.011_bib1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1750-3639.2005.tb00097.x","article-title":"Profound cardiac sympathetic denervation occurs in Parkinson disease","volume":"15","author":"Amino","year":"2005","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neures.2007.11.011_bib2","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1073\/pnas.80.14.4546","article-title":"A primate model of Parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"80","author":"Burns","year":"1983","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neures.2007.11.011_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nucmedbio.2005.07.010","article-title":"Reduced 125I-meta-iodobenzylguanidine uptake and norepinephrine transporter density in the hearts of mice with MPTP-induced Parkinsonism","volume":"33","author":"Fukumitsu","year":"2006","journal-title":"Nucl. Med. Biol."},{"issue":"Suppl.","key":"10.1016\/j.neures.2007.11.011_bib4","doi-asserted-by":"crossref","first-page":"299S","DOI":"10.1016\/0197-0186(92)90256-Q","article-title":"The MPTP-treated mouse as a model of Parkinsonism: how good is it?","volume":"20","author":"Heikkila","year":"1992","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neures.2007.11.011_bib5","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1073\/pnas.82.7.2173","article-title":"Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity","volume":"82","author":"Javitch","year":"1985","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neures.2007.11.011_bib6","doi-asserted-by":"crossref","first-page":"23326","DOI":"10.1074\/jbc.M601156200","article-title":"Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization","volume":"281","author":"Jayanthi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2007.11.011_bib7","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.neures.2007.11.011_bib8","doi-asserted-by":"crossref","first-page":"H2229","DOI":"10.1152\/ajpheart.00768.2003","article-title":"Infarction alters both the distribution and noradrenergic properties of cardiac sympathetic neurons","volume":"286","author":"Li","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.neures.2007.11.011_bib9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2169\/internalmedicine.42.127","article-title":"[123I]meta-iodobenzylguanidine myocardial scintigraphy differentiates corticobasal degeneration from Parkinson's disease","volume":"42","author":"Orimo","year":"2003","journal-title":"Intern. Med."},{"key":"10.1016\/j.neures.2007.11.011_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/jnnp.67.2.189","article-title":"(123)I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson's disease","volume":"67","author":"Orimo","year":"1999","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neures.2007.11.011_bib11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1002\/(SICI)1096-9861(20000501)420:2<211::AID-CNE5>3.0.CO;2-3","article-title":"Immunolocalization of the cocaine- and antidepressant-sensitive l-norepinephrine transporter","volume":"420","author":"Schroeter","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2007.11.011_bib12","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s00702-003-0002-1","article-title":"Recovery of motor function and dopaminergic parameters in a mouse model of Parkinson's disease induced by co-administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and diethyldithiocarbamate","volume":"110","author":"Shimazu","year":"2003","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neures.2007.11.011_bib13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0014-2999(86)90444-9","article-title":"The influence of dose and dosing interval on MPTP-induced dopaminergic neurotoxicity in mice","volume":"129","author":"Sonsalla","year":"1986","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neures.2007.11.011_bib14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0006-8993(87)90986-3","article-title":"Studies on the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on central catecholamine neurons in C57BL\/6 mice. Comparison with three other strains of mice","volume":"405","author":"Sundstr\u00f6m","year":"1987","journal-title":"Brain Res."},{"issue":"Suppl.","key":"10.1016\/j.neures.2007.11.011_bib15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000116720","article-title":"Autonomic nervous system disorders in Parkinson's disease","volume":"31","author":"Takahashi","year":"1991","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.neures.2007.11.011_bib16","first-page":"71","article-title":"Cardiac sympathetic denervation from the early stage of Parkinson's disease: clinical and experimental studies with radiolabeled MIBG","volume":"41","author":"Takatsu","year":"2000","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.neures.2007.11.011_bib17","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00006231-200202000-00008","article-title":"Significant reduction of 125 I-meta-iodobenzylguanidine accumulation directly caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine, a toxic agent for inducing experimental Parkinson's disease","volume":"23","author":"Takatsu","year":"2002","journal-title":"Nucl. Med. Commun."},{"key":"10.1016\/j.neures.2007.11.011_bib18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0022-510X(97)00278-5","article-title":"Differentiation of idiopathic Parkinson's disease from striatonigral degeneration and progressive supranuclear palsy using iodine-123 meta-iodobenzylguanidine myocardial scintigraphy","volume":"155","author":"Yoshita","year":"1998","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neures.2007.11.011_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0074-7742(08)60277-9","article-title":"Animal models of Parkinsonism using selective neurotoxins: clinical and basic implications","volume":"31","author":"Zigmond","year":"1989","journal-title":"Int. Rev. Neurobiol."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010207018524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010207018524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T04:59:04Z","timestamp":1546405144000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010207018524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0168010207018524"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2007.11.011","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}