{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T17:40:38Z","timestamp":1772559638839,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"vor","delay-in-days":5212,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.neures.2009.06.008","type":"journal-article","created":{"date-parts":[[2009,6,25]],"date-time":"2009-06-25T06:30:56Z","timestamp":1245911456000},"page":"148-155","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["N-Acetylcysteine alters apoptotic gene expression in axotomised primary sensory afferent subpopulations"],"prefix":"10.1016","volume":"65","author":[{"given":"Adam J.","family":"Reid","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan G.","family":"Shawcross","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex E.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Wiberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Terenghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2009.06.008_bib1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.coi.2007.05.004","article-title":"Bcl-2-regulated apoptosis: mechanism and therapeutic potential","volume":"19","author":"Adams","year":"2007","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.neures.2009.06.008_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2003.12.005","article-title":"Cell cycle regulation of neuronal apoptosis in development and disease","volume":"72","author":"Becker","year":"2004","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neures.2009.06.008_bib3","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrn1477","article-title":"Adult neuron survival strategies\u2014slamming on the brakes","volume":"5","author":"Benn","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neures.2009.06.008_bib4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0300-9084(02)01372-X","article-title":"Mitochondrial involvement in the point of no return in neuronal apoptosis","volume":"84","author":"Chang","year":"2002","journal-title":"Biochimie"},{"key":"10.1016\/j.neures.2009.06.008_bib5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/jnr.21846","article-title":"Validation of reference genes for normalization of real-time quantitative RT-PCR data in traumatic brain injury","volume":"87","author":"Cook","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neures.2009.06.008_bib6","doi-asserted-by":"crossref","first-page":"13352","DOI":"10.1073\/pnas.0405479101","article-title":"Real-time imaging of single nerve cell apoptosis in retinal neurodegeneration","volume":"101","author":"Cordeiro","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.neures.2009.06.008_bib7","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1054-3589(08)60985-0","article-title":"N-acetylcysteine: pharmacological considerations and experimental and clinical applications","volume":"38","author":"Cotgreave","year":"1997","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.neures.2009.06.008_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0304-3940(99)00264-5","article-title":"The mouse cpp32 mRNA transcript is early up-regulated in axotomized motoneurons following facial nerve transection","volume":"266","author":"de Bilbao","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neures.2009.06.008_bib9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/BF02740621","article-title":"The cellular and molecular basis of peripheral nerve regeneration","volume":"14","author":"Fu","year":"1997","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neures.2009.06.008_bib10","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1111\/j.1460-9568.1994.tb00555.x","article-title":"Differential expression of bcl-2 and bax mRNA in axotomized dorsal root ganglia of young and adult rats","volume":"6","author":"Gillardon","year":"1994","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neures.2009.06.008_bib11","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0006-8993(96)00829-3","article-title":"Expression pattern of candidate cell death effector proteins Bax, Bcl-2, Bcl-X, and c-Jun in sensory and motor neurons following sciatic nerve transection in the rat","volume":"739","author":"Gillardon","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.neures.2009.06.008_bib12","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1023\/A:1018541726460","article-title":"Axotomy-induced apoptosis in adult rat primary sensory neurons","volume":"26","author":"Groves","year":"1997","journal-title":"J. Neurocytol."},{"key":"10.1016\/j.neures.2009.06.008_bib13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.neuroscience.2003.12.040","article-title":"Sensory neuroprotection, mitochondrial preservation, and therapeutic potential of N-acetyl-cysteine after nerve injury","volume":"125","author":"Hart","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2009.06.008_bib14","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1179\/174313208X362479","article-title":"Neuronal death after peripheral nerve injury and experimental strategies for neuroprotection","volume":"30","author":"Hart","year":"2008","journal-title":"Neurol. Res."},{"key":"10.1016\/j.neures.2009.06.008_bib15","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1002\/jnr.21710","article-title":"N-acetylcysteine prevents beta-amyloid toxicity by a stimulatory effect on p35\/cyclin-dependent kinase 5 activity in cultured cortical neurons","volume":"86","author":"Hsiao","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neures.2009.06.008_bib16","doi-asserted-by":"crossref","first-page":"10559","DOI":"10.1523\/JNEUROSCI.23-33-10559.2003","article-title":"Selective reactions of cutaneous and muscle afferent neurons to peripheral nerve transection in rats","volume":"23","author":"Hu","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2009.06.008_bib17","doi-asserted-by":"crossref","first-page":"9357","DOI":"10.1074\/jbc.273.16.9357","article-title":"Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis","volume":"273","author":"Janicke","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2009.06.008_bib18","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1523\/JNEUROSCI.18-12-04656.1998","article-title":"Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo","volume":"18","author":"Kermer","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2009.06.008_bib19","first-page":"327","article-title":"Bcl-2\/Bax: a rheostat that regulates an anti-oxidant pathway and cell death","volume":"4","author":"Korsmeyer","year":"1993","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.neures.2009.06.008_bib20","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/cne.20400","article-title":"Effects of systemically administered NT-3 on sensory neuron loss and nestin expression following axotomy","volume":"482","author":"Kuo","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2009.06.008_bib21","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/35040009","article-title":"Apoptosis in neurodegenerative disorders","volume":"1","author":"Mattson","year":"2000","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.neures.2009.06.008_bib22","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s00221-001-0929-0","article-title":"Primary sensory neurons and satellite cells after peripheral axotomy in the adult rat: timecourse of cell death and elimination","volume":"142","author":"McKay Hart","year":"2002","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neures.2009.06.008_bib23","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0092-8674(93)90509-O","article-title":"Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death","volume":"74","author":"Oltvai","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.neures.2009.06.008_bib24","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1385-299X(99)00045-8","article-title":"Multiplex semi-quantitative reverse transcriptase-polymerase chain reaction of low abundance neuronal mRNAs","volume":"4","author":"Pernas-Alonso","year":"1999","journal-title":"Brain Res. Brain Res. Protoc."},{"key":"10.1016\/j.neures.2009.06.008_bib25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/sj.cdd.4401352","article-title":"Men are but worms: neuronal cell death in C elegans and vertebrates","volume":"11","author":"Putcha","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.neures.2009.06.008_bib26","first-page":"110","article-title":"Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors","volume":"777","author":"Seaton","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.neures.2009.06.008_bib27","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0014-4886(91)90087-S","article-title":"Sensory neurons of the rat sciatic nerve","volume":"114","author":"Swett","year":"1991","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neures.2009.06.008_bib28","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/(SICI)1096-9861(20000626)422:2<172::AID-CNE2>3.0.CO;2-H","article-title":"Delayed loss of small dorsal root ganglion cells after transection of the rat sciatic nerve","volume":"422","author":"Tandrup","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2009.06.008_bib29","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1046\/j.1460-9568.2000.00241.x","article-title":"Caspase-3 is activated following axotomy of neonatal facial motoneurons and caspase-3 gene deletion delays axotomy-induced cell death in rodents","volume":"12","author":"Vanderluit","year":"2000","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neures.2009.06.008_bib30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/(SICI)1096-9861(19971117)388:2<307::AID-CNE8>3.0.CO;2-5","article-title":"Effect of permanent axotomy on number and volume of dorsal root ganglion cell bodies","volume":"388","author":"Vestergaard","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2009.06.008_bib31","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1021\/cr010379n","article-title":"Mechanisms of pulsed laser ablation of biological tissues","volume":"103","author":"Vogel","year":"2003","journal-title":"Chem. Rev."},{"key":"10.1016\/j.neures.2009.06.008_bib32","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00129492-200205000-00029","article-title":"Apoptosis and expression of BCL-2 in facial motoneurons after facial nerve injury","volume":"23","author":"Wang","year":"2002","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.neures.2009.06.008_bib33","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00221-007-1232-5","article-title":"Survival and regeneration of cutaneous and muscular afferent neurons after peripheral nerve injury in adult rats","volume":"186","author":"Welin","year":"2008","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.neures.2009.06.008_bib34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-3-211-72958-8_6","article-title":"Analysis of the dose-response of N-acetylcysteine in the prevention of sensory neuronal loss after peripheral nerve injury","volume":"100","author":"West","year":"2007","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.neures.2009.06.008_bib35","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1046\/j.1460-9568.1998.00346.x","article-title":"Differential time course of neuronal and glial apoptosis in neonatal rat dorsal root ganglia after sciatic nerve axotomy","volume":"10","author":"Whiteside","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neures.2009.06.008_bib36","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1523\/JNEUROSCI.18-11-04042.1998","article-title":"Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway","volume":"18","author":"Yan","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2009.06.008_bib37","doi-asserted-by":"crossref","first-page":"26827","DOI":"10.1074\/jbc.270.45.26827","article-title":"N-acetylcysteine-promoted survival of PC12 cells is glutathione-independent but transcription-dependent","volume":"270","author":"Yan","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2009.06.008_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nrm2308","article-title":"The BCL-2 protein family: opposing activities that mediate cell death","volume":"9","author":"Youle","year":"2008","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"10.1016\/j.neures.2009.06.008_bib39","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/35037739","article-title":"Apoptosis in the nervous system","volume":"407","author":"Yuan","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neures.2009.06.008_bib40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s000180300001","article-title":"Molecular mechanisms of N-acetylcysteine actions","volume":"60","author":"Zafarullah","year":"2003","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neures.2009.06.008_bib41","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.bjps.2005.04.012","article-title":"Motorneuron protection by N-acetyl-cysteine after ventral root avulsion and ventral rhizotomy","volume":"58","author":"Zhang","year":"2005","journal-title":"Br. J. Plast. Surg."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010209002004?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010209002004?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:21:03Z","timestamp":1759141263000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010209002004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S0168010209002004"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2009.06.008","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N-Acetylcysteine alters apoptotic gene expression in axotomised primary sensory afferent subpopulations","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2009.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}