{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T09:53:59Z","timestamp":1770630839596,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.neures.2015.10.002","type":"journal-article","created":{"date-parts":[[2015,10,24]],"date-time":"2015-10-24T18:42:35Z","timestamp":1445712155000},"page":"28-34","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome"],"prefix":"10.1016","volume":"105","author":[{"given":"Alessio","family":"Cortelazzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"De Felice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Guerranti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Signorini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Leoncini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Pecorelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Scalabr\u00ec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Madonna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Filosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinzia","family":"Della Giovampaola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonietta","family":"Capone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Durand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiana","family":"Mirasole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lello","family":"Zolla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Valacchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Ciccoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacky","family":"Guy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"D\u2019Esposito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joussef","family":"Hayek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2015.10.002_bib0005","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/S0304-4165(99)00165-8","article-title":"On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database","volume":"1473","author":"Apweiler","year":"1999","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neures.2015.10.002_bib0010","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.2337\/diabetes.54.10.3021","article-title":"The K121Q polymorphism of the ENPP1\/PC-1 gene is associated with insulin resistance\/atherogenic phenotypes, including earlier onset of type 2 diabetes and myocardial infarction","volume":"54","author":"Bacci","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.neures.2015.10.002_bib0015","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s00125-004-1660-8","article-title":"Potential involvement of adipocyte insulin resistance in obesity-associated up-regulation of adipocyte lysophospholipase D\/autotaxin expression","volume":"48","author":"Boucher","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.neures.2015.10.002_bib0020","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1152\/physrev.00043.2006","article-title":"Physiology and pathophysiology of purinergic neurotransmission","volume":"87","author":"Burnstock","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neures.2015.10.002_bib0025","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: from clinic to neurobiology","volume":"56","author":"Chahrour","year":"2007","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2015.10.002_bib0030","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ijdevneu.2008.05.001","article-title":"Expression mapping of ectonucleotide pyrophosphatase\/phosphodiesterase 1-3 (E-NPP1-3) in different brain structures during rat development","volume":"26","author":"Cognato","year":"2008","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.neures.2015.10.002_bib0035","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nbd.2014.04.006","article-title":"Oxidative brain damage in Mecp2-mutant murine models of Rett syndrome","volume":"68","author":"De Felice","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neures.2015.10.002_bib0040","doi-asserted-by":"crossref","first-page":"38528","DOI":"10.1074\/jbc.M305437200","article-title":"Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family","volume":"278","author":"Duan","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2015.10.002_bib0045","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ajhg.2013.08.007","article-title":"Cole disease results from mutations in ENPP1","volume":"93","author":"Eytan","year":"2013","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.neures.2015.10.002_bib0050","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1474-4422(12)70040-6","article-title":"Neurology of inherited glycosylation disorders","volume":"11","author":"Freeze","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neures.2015.10.002_bib0055","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0925-4439(03)00058-9","article-title":"Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase\/phosphodiesterase family","volume":"1638","author":"Goding","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neures.2015.10.002_bib0060","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/(SICI)1522-2683(20000401)21:6<1037::AID-ELPS1037>3.0.CO;2-V","article-title":"The current state of two-dimensional electrophoresis with immobilized pH gradients","volume":"21","author":"G\u00f6rg","year":"2000","journal-title":"Electrophoresis"},{"key":"10.1016\/j.neures.2015.10.002_bib0065","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1146\/annurev-cellbio-092910-154121","article-title":"The role of MeCP2 in the brain","volume":"27","author":"Guy","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.neures.2015.10.002_bib0070","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1138389","article-title":"Reversal of neurological defects in a mouse model of Rett syndrome","volume":"315","author":"Guy","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.neures.2015.10.002_bib0075","doi-asserted-by":"crossref","first-page":"82","DOI":"10.2174\/187152711794488656","article-title":"Sweet and sour \u2013 oxidative and carbonyl stress in neurological disorders","volume":"10","author":"Harris","year":"2011","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.neures.2015.10.002_bib0080","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1126\/science.291.5512.2364","article-title":"Intracellular functions of N-linked glycans","volume":"291","author":"Helenius","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.neures.2015.10.002_bib0085","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1073\/pnas.91.2.728","article-title":"Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates","volume":"91","author":"Ioffe","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neures.2015.10.002_bib0090","doi-asserted-by":"crossref","first-page":"11253","DOI":"10.1074\/jbc.M114.554311","article-title":"Epigenetic regulation of a brain-specific glycosyltransferase N-acetylglucosaminyltransferase-IX (GnT-IX) by specific chromatin modifiers","volume":"289","author":"Kizuka","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2015.10.002_bib0095","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.nbd.2005.05.021","article-title":"Proteomic analysis of glial fibrillary acidic protein in Alzheimer's disease and aging brain","volume":"20","author":"Korolainen","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neures.2015.10.002_bib0100","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"10.1016\/j.neures.2015.10.002_bib0105","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1203\/01.pdr.0000246802.57692.ea","article-title":"Congenital disorders of N-glycosylation including diseases associated with O- as well as N-glycosylation defects","volume":"60","author":"Leroy","year":"2006","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.neures.2015.10.002_bib0110","doi-asserted-by":"crossref","first-page":"421624","DOI":"10.1155\/2015\/421624","article-title":"Cytokine dysregulation in MECP2- and CDKL5-related Rett syndrome: relationships with aberrant redox homeostasis, inflammation, and \u03c9-3 PUFAs","volume":"2015","author":"Leoncini","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.neures.2015.10.002_bib0115","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev.pathmechdis.3.121806.151434","article-title":"Endoplasmic reticulum stress in disease pathogenesis","volume":"3","author":"Lin","year":"2008","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.neures.2015.10.002_bib0120","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1089\/ars.2007.1782","article-title":"Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?","volume":"9","author":"Malhotra","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.neures.2015.10.002_bib0125","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/toxsci\/kfq206","article-title":"Glycosylation protects proteins against free radicals generated from toxic xenobiotics","volume":"117","author":"Mart\u00ednek","year":"2010","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.neures.2015.10.002_bib0130","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1002\/j.1460-2075.1994.tb06480.x","article-title":"Complex asparagine-linked oligosaccharides are required for morphogenic events during post-implantation development","volume":"13","author":"Metzler","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.neures.2015.10.002_bib0135","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4161\/epi.1.4.3514","article-title":"Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation","volume":"1","author":"Nagarajan","year":"2006","journal-title":"Epigenetics"},{"key":"10.1016\/j.neures.2015.10.002_bib0140","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s004390050993","article-title":"Association of the human NPPS gene with ossification of the posterior longitudinal ligament of the spine (OPLL)","volume":"104","author":"Nakamura","year":"1999","journal-title":"Hum. Genet."},{"key":"10.1016\/j.neures.2015.10.002_bib0145","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0006-291X(03)01454-2","article-title":"Characterization of nucleotide pyrophosphatase-5 as an oligomannosidic glycoprotein in rat brain","volume":"308","author":"Ohe","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neures.2015.10.002_bib0150","doi-asserted-by":"crossref","first-page":"260973","DOI":"10.1155\/2014\/260973","article-title":"Immune dysfunction in Rett syndrome patients revealed by high levels of serum anti-N(Glc) IgM antibody fraction","volume":"2014","author":"Papini","year":"2014","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.neures.2015.10.002_bib0155","first-page":"22677","article-title":"Antibody recognition in multiple sclerosis and Rett syndrome using a collection of linear and cyclic N-glucosylated antigenic probes","volume":"2015","author":"Real Fern\u00e1ndez","year":"2015","journal-title":"Biopolymers"},{"key":"10.1016\/j.neures.2015.10.002_bib0160","doi-asserted-by":"crossref","first-page":"23084","DOI":"10.1074\/jbc.M413438200","article-title":"Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase\/phosphodiesterase family","volume":"280","author":"Sakagami","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2015.10.002_bib0165","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/glycob\/cwu015","article-title":"The role of protein N-glycosylation in neural transmission","volume":"24","author":"Scott","year":"2014","journal-title":"Glycobiology"},{"key":"10.1016\/j.neures.2015.10.002_bib0170","doi-asserted-by":"crossref","first-page":"10766","DOI":"10.1016\/S0021-9258(18)33889-4","article-title":"A one-step purification of membrane proteins using a high efficiency immunomatrix","volume":"257","author":"Schneider","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2015.10.002_bib0175","doi-asserted-by":"crossref","first-page":"195935","DOI":"10.1155\/2014\/195935","article-title":"Redox imbalance and morphological changes in skin fibroblasts in typical Rett syndrome","volume":"2014","author":"Signorini","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.neures.2015.10.002_bib0180","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/pmic.201200333","article-title":"Characterization of disease-associated N-linked glycoproteins","volume":"13","author":"Tian","year":"2013","journal-title":"Proteomics"},{"key":"10.1016\/j.neures.2015.10.002_bib0185","first-page":"484","article-title":"Control of glycosylation-related genes by DNA methylation: the intriguing case of the B3GALT5 gene and its distinct promoters","volume":"3","author":"Trinchera","year":"2014","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.neures.2015.10.002_bib0190","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.canlet.2003.11.002","article-title":"Expression and localization of ecto-nucleotide pyrophosphatase\/phosphodiesterase I-1 (E-NPP1\/PC-1) and -3 (E-NPP3\/CD203c\/PD-Ibeta\/B10\/gp130(RB13-6)) in inflammatory and neoplastic bile duct diseases","volume":"207","author":"Yano","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.neures.2015.10.002_bib0195","doi-asserted-by":"crossref","first-page":"e349","DOI":"10.1038\/tp.2013.123","article-title":"Increased binding of MeCP2 to the GAD1 and RELN promoters may be mediated by an enrichment of 5-hmC in autism spectrum disorder (ASD) cerebellum","volume":"4","author":"Zhubi","year":"2014","journal-title":"Transl. Psychiatry"}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010215002345?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010215002345?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,24]],"date-time":"2022-05-24T02:43:18Z","timestamp":1653360198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010215002345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":39,"alternative-id":["S0168010215002345"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2015.10.002","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abnormal N-glycosylation pattern for brain nucleotide pyrophosphatase-5 (NPP-5) in Mecp2-mutant murine models of Rett syndrome","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2015.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2015 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}