{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:06:52Z","timestamp":1790996812387,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Ministry of Education","award":["2014R1A1A4A01007348"],"award-info":[{"award-number":["2014R1A1A4A01007348"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.neures.2016.09.007","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T20:02:07Z","timestamp":1474574527000},"page":"62-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Lipopolysaccharide-induced functional and structural injury of the mitochondria in the nigrostriatal pathway"],"prefix":"10.1016","volume":"114","author":[{"given":"Randy","family":"Hunter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttam","family":"Ojha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Bhurtel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoying","family":"Bing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2016.09.007_bib0005","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.parkreldis.2009.09.010","article-title":"Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson\u2019s disease","volume":"15","author":"Ahlskog","year":"2009","journal-title":"Parkinsonism Relat. Disord."},{"key":"10.1016\/j.neures.2016.09.007_bib0010","first-page":"133","article-title":"Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease","volume":"59","author":"Albers","year":"2000","journal-title":"J. Neural Transm. Suppl."},{"key":"10.1016\/j.neures.2016.09.007_bib0015","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbi.2009.09.001","article-title":"Minimal penetration of lipopolysaccharide across the murine blood\u2013brain barrier","volume":"24","author":"Banks","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neures.2016.09.007_bib0020","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0166-2236(00)01584-8","article-title":"Energetics in the pathogenesis of neurodegenerative diseases","volume":"23","author":"Beal","year":"2000","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neures.2016.09.007_bib0025","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1056\/NEJM199601113340202","article-title":"Prevalence of parkinsonian signs and associated mortality in a community population of older people","volume":"334","author":"Bennett","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neures.2016.09.007_bib0030","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00441-004-0976-5","article-title":"Redox imbalance","volume":"318","author":"Berg","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.neures.2016.09.007_bib0035","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1046\/j.1432-1327.1999.00725.x","article-title":"Mitochondria and cell death. Mechanistic aspects and methodological issues","volume":"264","author":"Bernardi","year":"1999","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.neures.2016.09.007_bib0040","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fnana.2015.00091","article-title":"Oxidative stress and Parkinson\u2019s disease","volume":"9","author":"Blesa","year":"2015","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.neures.2016.09.007_bib0045","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0304-3940(94)90684-X","article-title":"Immunocytochemical analysis of tumor necrosis factor and its receptors in Parkinson\u2019s disease","volume":"172","author":"Boka","year":"1994","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neures.2016.09.007_bib0050","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1126\/science.1077209","article-title":"Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism","volume":"299","author":"Bonifati","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neures.2016.09.007_bib0055","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1042\/bj1340707","article-title":"The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen","volume":"134","author":"Boveris","year":"1973","journal-title":"Biochem. J."},{"key":"10.1016\/j.neures.2016.09.007_bib0060","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00441-004-0956-9","article-title":"Stages in the development of Parkinson\u2019s disease-related pathology","volume":"318","author":"Braak","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.neures.2016.09.007_bib0065","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jneumeth.2004.02.028","article-title":"Nitrogen disruption of synaptoneurosomes: an alternative method to isolate brain mitochondria","volume":"137","author":"Brown","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neures.2016.09.007_bib0070","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1111\/bph.12433","article-title":"Unravelling mitochondrial pathways to Parkinson\u2019s disease","volume":"171","author":"Celardo","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neures.2016.09.007_bib0075","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/archneur.60.8.1059","article-title":"Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease","volume":"60","author":"Chen","year":"2003","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neures.2016.09.007_bib0080","doi-asserted-by":"crossref","first-page":"e5482","DOI":"10.1371\/journal.pone.0005482","article-title":"Striatal neuroinflammation promotes Parkinsonism in rats","volume":"4","author":"Choi","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.neures.2016.09.007_bib0085","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1023\/A:1022642114734","article-title":"Mitochondrial dysfunction in neurodegeneration","volume":"29","author":"Cooper","year":"1997","journal-title":"J. Bioenergy Biomembr."},{"key":"10.1016\/j.neures.2016.09.007_bib0090","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1126\/science.1087753","article-title":"Molecular pathways of neurodegeneration in Parkinson\u2019s disease","volume":"302","author":"Dawson","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.neures.2016.09.007_bib0095","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1042\/bss0660085","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease","volume":"66","author":"Greenamyre","year":"1999","journal-title":"Biochem. Soc. Symp."},{"key":"10.1016\/j.neures.2016.09.007_bib0100","doi-asserted-by":"crossref","first-page":"6315","DOI":"10.1073\/pnas.90.13.6315","article-title":"Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo","volume":"90","author":"Hagg","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neures.2016.09.007_bib0105","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/ana.410300409","article-title":"Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson\u2019s disease","volume":"30","author":"Hattori","year":"1991","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neures.2016.09.007_bib0110","first-page":"140","article-title":"Parkinson\u2019s disease and the adaptive capacity of the nigrostriatal dopamine system: possible neurochemical mechanisms","volume":"60","author":"Hornykiewicz","year":"1993","journal-title":"Adv. Neurol."},{"key":"10.1016\/j.neures.2016.09.007_bib0115","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0306-4522(95)00578-1","article-title":"Nitric oxide synthase and neuronal vulnerability in Parkinson\u2019s disease","volume":"72","author":"Hunot","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2016.09.007_bib0120","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/jnr.22012","article-title":"Intrastriatal lipopolysaccharide injection induces parkinsonism in C57\/B6 mice","volume":"87","author":"Hunter","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neures.2016.09.007_bib0125","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1111\/j.1471-4159.2006.04327.x","article-title":"Inflammation induces mitochondrial dysfunction and dopaminergic neurodegeneration in the nigrostriatal system","volume":"100","author":"Hunter","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neures.2016.09.007_bib0130","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/febs.13127","article-title":"PINK1 and Parkin\u2014mitochondrial interplay between phosphorylation and ubiquitylation in Parkinson\u2019s disease","volume":"282","author":"Kazlauskaite","year":"2015","journal-title":"FEBS J."},{"key":"10.1016\/j.neures.2016.09.007_bib0135","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuropharm.2004.03.019","article-title":"A new anti-inflammatory agent KL-1037 represses proinflammatory cytokine and inducible nitric oxide synthase (iNOS) gene expression in activated microglia","volume":"47","author":"Kim","year":"2004","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neures.2016.09.007_bib0140","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1056\/NEJM199810083391506","article-title":"Parkinson\u2019s disease. First of two parts","volume":"339","author":"Lang","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neures.2016.09.007_bib0145","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0306-4522(00)00033-6","article-title":"Naloxone prevents microglia-induced degeneration of dopaminergic substantia nigra neurons in adult rats","volume":"97","author":"Lu","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2016.09.007_bib0150","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1750-3639.2000.tb00278.x","article-title":"The role of mitochondria in the pathogenesis of neurodegenerative diseases","volume":"10","author":"Manfredi","year":"2000","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neures.2016.09.007_bib0155","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1212\/WNL.38.8.1285","article-title":"Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson\u2019s and Alzheimer\u2019s disease brains","volume":"38","author":"McGeer","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.neures.2016.09.007_bib0160","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/BF00973287","article-title":"Immunocytochemical investigations on the presence of neuron-specific antibodies in the CSF of Parkinson\u2019s disease cases","volume":"13","author":"McRae-Degueurce","year":"1988","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neures.2016.09.007_bib0165","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/191144a0","article-title":"Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism","volume":"191","author":"Mitchell","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.neures.2016.09.007_bib0170","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0304-3940(96)12706-3","article-title":"Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson\u2019s disease","volume":"211","author":"Mogi","year":"1996","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neures.2016.09.007_bib0175","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/S1357-2725(02)00077-8","article-title":"Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease","volume":"34","author":"Nicholls","year":"2002","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.neures.2016.09.007_bib0180","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuint.2014.02.008","article-title":"Systemic injection of LPS induces region-specific neuroinflammation and mitochondrial dysfunction in normal mouse brain","volume":"69","author":"Noh","year":"2014","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neures.2016.09.007_bib0185","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.neures.2016.09.007_bib0190","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF01249445","article-title":"Time course of nigrostriatal degeneration in Parkinson\u2019s disease. A detailed study of influential factors in human brain amine analysis","volume":"38","author":"Riederer","year":"1976","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neures.2016.09.007_bib0195","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1172\/JCI200317741","article-title":"Neuronal degeneration and mitochondrial dysfunction","volume":"111","author":"Schon","year":"2003","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neures.2016.09.007_bib0200","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/jemt.1140","article-title":"Nervous system-derived chondroitin sulfate proteoglycans regulate growth cone morphology and inhibit neurite outgrowth: a light, epifluorescence, and electron microscopy study","volume":"54","author":"Snow","year":"2001","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.neures.2016.09.007_bib0205","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/ana.10543","article-title":"Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death","volume":"53","author":"Sullivan","year":"2003","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neures.2016.09.007_bib0210","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/1531-8249(200011)48:5<723::AID-ANA5>3.0.CO;2-W","article-title":"Dietary supplement creatine protects against traumatic brain injury","volume":"48","author":"Sullivan","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neures.2016.09.007_bib0215","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/1098-2396(200102)39:2<167::AID-SYN8>3.0.CO;2-U","article-title":"Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson\u2019s disease","volume":"39","author":"Teismann","year":"2001","journal-title":"Synapse"},{"key":"10.1016\/j.neures.2016.09.007_bib0220","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1186\/1742-2094-3-6","article-title":"Cyclooxygenase-2 mediates microglial activation and secondrary dopaminergic cell death in the mouse MPTP model of Parkinson\u2019s disease","volume":"3","author":"Vijitruth","year":"2006","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.neures.2016.09.007_bib0225","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0197-4580(93)90112-O","article-title":"New stereological methods for counting neurons","volume":"14","author":"West","year":"1993","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neures.2016.09.007_bib0230","doi-asserted-by":"crossref","first-page":"300","DOI":"10.15252\/embr.201541486","article-title":"The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation","volume":"17","author":"Yamano","year":"2016","journal-title":"EMBO Rep."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016801021630164X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016801021630164X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T06:22:30Z","timestamp":1536387750000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016801021630164X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":46,"alternative-id":["S016801021630164X"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2016.09.007","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipopolysaccharide-induced functional and structural injury of the mitochondria in the nigrostriatal pathway","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2016.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}