{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:47:27Z","timestamp":1762145247166},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,8,1]],"date-time":"2017-08-01T00:00:00Z","timestamp":1501545600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2017,8]]},"DOI":"10.1016\/j.neures.2017.03.010","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T23:46:40Z","timestamp":1491522400000},"page":"49-53","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa"],"prefix":"10.1016","volume":"121","author":[{"given":"Yukihisa","family":"Funamizu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruo","family":"Nishijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Mizukami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soroku","family":"Yagihashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Tomiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2017.03.010_bib0005","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pneurobio.2015.07.002","article-title":"Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease","volume":"132","author":"Bastide","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neures.2017.03.010_bib0010","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1093\/brain\/awh290","article-title":"Levodopa-induced changes in synaptic dopamine levels increase with progression of Parkinson's disease: implications for dyskinesias","volume":"127","author":"de la Fuente-Fernandez","year":"2004","journal-title":"Brain: J. Neurol."},{"key":"10.1016\/j.neures.2017.03.010_bib0015","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/01.wco.0000137528.23126.41","article-title":"Dopamine dysregulation syndrome in Parkinson's disease","volume":"17","author":"Evans","year":"2004","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.neures.2017.03.010_bib0020","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/ana.20822","article-title":"Compulsive drug use linked to sensitized ventral striatal dopamine transmission","volume":"59","author":"Evans","year":"2006","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neures.2017.03.010_bib0025","doi-asserted-by":"crossref","first-page":"5316","DOI":"10.1038\/ncomms6316","article-title":"Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia","volume":"5","author":"Fieblinger","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neures.2017.03.010_bib0030","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/jnnp.68.4.423","article-title":"Hedonistic homeostatic dysregulation in patients with Parkinson's disease on dopamine replacement therapies","volume":"68","author":"Giovannoni","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.neures.2017.03.010_bib0035","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nrn2699","article-title":"Experience-dependent structural synaptic plasticity in the mammalian brain","volume":"10","author":"Holtmaat","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neures.2017.03.010_bib0040","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nn1217","article-title":"Differential control over cocaine-seeking behavior by nucleus accumbens core and shell","volume":"7","author":"Ito","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neures.2017.03.010_bib0045","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.tins.2010.01.001","article-title":"Structural dynamics of dendritic spines in memory and cognition","volume":"33","author":"Kasai","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neures.2017.03.010_bib0050","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/WNF.0b013e3181634ea6","article-title":"Dopamine dysregulation syndrome and levodopa-induced dyskinesias in Parkinson disease: common consequences of anomalous forms of neural plasticity","volume":"32","author":"Linazasoro","year":"2009","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.neures.2017.03.010_bib0055","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0006-8993(98)01248-7","article-title":"Loss of regulation by presynaptic dopamine D2 receptors of exogenous L-DOPA-derived dopamine release in the dopaminergic denervated striatum","volume":"817","author":"Maeda","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neures.2017.03.010_bib0060","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0006-8993(98)01248-7","article-title":"Loss of regulation by presynaptic dopamine D2 receptors of exogenous L-DOPA-derived dopamine release in the dopaminergic denervated striatum","volume":"817","author":"Maeda","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.neures.2017.03.010_bib0065","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nature02617","article-title":"Structural basis of long-term potentiation in single dendritic spines","volume":"429","author":"Matsuzaki","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.neures.2017.03.010_bib0070","doi-asserted-by":"crossref","first-page":"3808","DOI":"10.1523\/JNEUROSCI.15-05-03808.1995","article-title":"Effects of dopamine depletion on the morphology of medium spiny neurons in the shell and core of the rat nucleus accumbens","volume":"15","author":"Meredith","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2017.03.010_bib0075","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00429-008-0175-3","article-title":"The structural basis for mapping behavior onto the ventral striatum and its subdivisions","volume":"213","author":"Meredith","year":"2008","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neures.2017.03.010_bib0080","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/mds.25826","article-title":"Morphologic changes of dendritic spines of striatal neurons in the levodopa-induced dyskinesia model","volume":"29","author":"Nishijima","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neures.2017.03.010_bib0085","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/mds.20288","article-title":"Prevalence and clinical features of hedonistic homeostatic dysregulation in Parkinson's disease","volume":"20","author":"Pezzella","year":"2005","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neures.2017.03.010_bib0090","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.tins.2010.02.002","article-title":"The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens","volume":"33","author":"Russo","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neures.2017.03.010_bib0095","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1523\/JNEUROSCI.5638-08.2009","article-title":"Altered dendritic spine plasticity in cocaine-withdrawn rats","volume":"29","author":"Shen","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2017.03.010_bib0100","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/syn.20381","article-title":"Alterations in dendritic morphology of the prefrontal cortical and striatum neurons in the unilateral 6-OHDA-rat model of Parkinson's disease","volume":"61","author":"Solis","year":"2007","journal-title":"Synapse"},{"key":"10.1016\/j.neures.2017.03.010_bib0105","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.neuroscience.2005.01.007","article-title":"Evidence of a breakdown of corticostriatal connections in Parkinson's disease","volume":"132","author":"Stephens","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2017.03.010_bib0110","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.biopsych.2013.05.006","article-title":"L-DOPA treatment selectively restores spine density in dopamine receptor D2Fxpressing projection neurons in dyskinetic mice","volume":"75","author":"Suarez","year":"2014","journal-title":"Biol. Psychiatry"},{"issue":"October 11","key":"10.1016\/j.neures.2017.03.010_bib0115","first-page":"4253","article-title":"L-DOPA Oppositely Regulates Synaptic Strength and Spine Morphology in D1 and D2 Striatal Projection Neurons in Dyskinesia","volume":"26","author":"Suarez","year":"2016","journal-title":"Cereb. Cortex (New York N.Y.: 1991)"},{"key":"10.1016\/j.neures.2017.03.010_bib0120","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.conb.2005.12.001","article-title":"Molecular mechanisms of dendritic spine morphogenesis","volume":"16","author":"Tada","year":"2006","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.neures.2017.03.010_bib0125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fnana.2010.00133","article-title":"Striatal spine plasticity in Parkinson's disease","volume":"4","author":"Villalba","year":"2010","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.neures.2017.03.010_bib0130","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S1474-4422(09)70287-X","article-title":"Chronic dopaminergic stimulation in Parkinson's disease: from dyskinesias to impulse control disorders","volume":"8","author":"Voon","year":"2009","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neures.2017.03.010_bib0135","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1523\/JNEUROSCI.12-11-04372.1992","article-title":"Increases in extracellular dopamine in the nucleus accumbens by cocaine are inversely related to basal levels: effects of acute and repeated administration","volume":"12","author":"Weiss","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2017.03.010_bib0140","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1126\/science.1255514","article-title":"A critical time window for dopamine actions on the structural plasticity of dendritic spines","volume":"345","author":"Yagishita","year":"2014","journal-title":"Science (New York N.Y.)"},{"key":"10.1016\/j.neures.2017.03.010_bib0145","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/0306-4522(92)90202-D","article-title":"On the significance of subterritories in the accumbens part of the rat ventral striatum","volume":"50","author":"Zahm","year":"1992","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2017.03.010_bib0150","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0149-7634(99)00065-2","article-title":"An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens","volume":"24","author":"Zahm","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neures.2017.03.010_bib0155","doi-asserted-by":"crossref","first-page":"11655","DOI":"10.1523\/JNEUROSCI.0288-13.2013","article-title":"Aberrant restoration of spines and their synapses in L-DOPA-induced dyskinesia: involvement of corticostriatal but not thalamostriatal synapses","volume":"33","author":"Zhang","year":"2013","journal-title":"J. Neurosci."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010216302486?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010216302486?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T04:20:13Z","timestamp":1658895613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010216302486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8]]},"references-count":31,"alternative-id":["S0168010216302486"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2017.03.010","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2017,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Morphological dendritic spine changes of medium spiny neurons in the nucleus accumbens in 6-hydroxydopamine-lesioned rats treated with levodopa","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2017.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ireland Ltd and Japan Neuroscience Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}