{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:32Z","timestamp":1792787252629,"version":"4.5.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","award":["JSPS KAKENHI 15K21745"],"award-info":[{"award-number":["JSPS KAKENHI 15K21745"]}],"id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japan Society for the Promotion of Science Postdoctoral Fellowships","id":[{"id":"https:\/\/ror.org\/00hhkn466","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.neures.2018.05.001","type":"journal-article","created":{"date-parts":[[2018,5,8]],"date-time":"2018-05-08T12:45:23Z","timestamp":1525783523000},"page":"6-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Role of C1 neurons in anti-inflammatory reflex: Mediation between afferents and efferents"],"prefix":"10.1016","volume":"136","author":[{"given":"Chikara","family":"Abe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2018.05.001_bib0005","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/ejn.12421","article-title":"Vesicular glutamate transporter 2 is required for the respiratory and parasympathetic activation produced by optogenetic stimulation of catecholaminergic neurons in the rostral ventrolateral medulla of mice in vivo","volume":"39","author":"Abbott","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0010","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nn.4526","article-title":"C1 neurons mediate a stress-induced anti-inflammatory reflex in mice","volume":"20","author":"Abe","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0015","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.neures.2018.05.001_bib0020","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1006\/brbi.1993.1021","article-title":"Acetylcholinesterase staining and choline acetyltransferase activity in the young adult rat spleen: lack of evidence for cholinergic innervation","volume":"7","author":"Bellinger","year":"1993","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neures.2018.05.001_bib0025","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/S0025-6196(12)62272-1","article-title":"The central autonomic network: functional organization dysfunction, and perspective","volume":"68","author":"Benarroch","year":"1993","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.neures.2018.05.001_bib0030","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1084\/jem.20011714","article-title":"Pharmacological stimulation of the cholinergic antiinflammatory pathway","volume":"195","author":"Bernik","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neures.2018.05.001_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1566-0702(00)00215-0","article-title":"Functional and chemical anatomy of the afferent vagal system","volume":"85","author":"Berthoud","year":"2000","journal-title":"Autonom. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0040","doi-asserted-by":"crossref","first-page":"14062","DOI":"10.1523\/JNEUROSCI.3795-08.2008","article-title":"Nociceptors are interleukin-1beta sensors","volume":"28","author":"Binshtok","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0045","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1566-0702(00)00233-2","article-title":"Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation","volume":"85","author":"Borovikova","year":"2000","journal-title":"Autonom. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0050","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neures.2018.05.001_bib0055","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1113\/expphysiol.2011.061531","article-title":"Neural regulation of inflammation: no neural connection from the vagus to splenic sympathetic neurons","volume":"97","author":"Bratton","year":"2012","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.neures.2018.05.001_bib0060","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1046\/j.1440-1681.2001.03490.x","article-title":"Role of circumventricular organs in pro-inflammatory cytokine-induced activation of the hypothalamic-pituitary-adrenal axis","volume":"28","author":"Buller","year":"2001","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.neures.2018.05.001_bib0065","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1164\/rccm.201407-1262OC","article-title":"Optogenetic stimulation of adrenergic C1 neurons causes sleep state-dependent cardiorespiratory stimulation and arousal with sighs in rats","volume":"190","author":"Burke","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.neures.2018.05.001_bib0070","doi-asserted-by":"crossref","first-page":"13035","DOI":"10.1038\/ncomms13035","article-title":"A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication","volume":"7","author":"Carnevale","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neures.2018.05.001_bib0075","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.immuni.2017.06.008","article-title":"Mechanisms and therapeutic relevance of neuro-immune communication","volume":"46","author":"Chavan","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.neures.2018.05.001_bib0080","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/nn.3144","article-title":"Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology","volume":"15","author":"Chiu","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0085","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1046\/j.0953-816x.2001.01733.x","article-title":"Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups","volume":"14","author":"Dayas","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0090","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1523\/JNEUROSCI.4269-12.2013","article-title":"Glutamatergic neurotransmission between the C1 neurons and the parasympathetic preganglionic neurons of the dorsal motor nucleus of the vagus","volume":"33","author":"DePuy","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0095","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12026-014-8517-0","article-title":"Effects of stress on immune function: the good, the bad, and the beautiful","volume":"58","author":"Dhabhar","year":"2014","journal-title":"Immunol. Res."},{"key":"10.1016\/j.neures.2018.05.001_bib0100","doi-asserted-by":"crossref","first-page":"9471","DOI":"10.1523\/JNEUROSCI.18-22-09471.1998","article-title":"Activation of vagal afferents after intravenous injection of interleukin-1beta: role of endogenous prostaglandins","volume":"18","author":"Ek","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0105","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/ni1229","article-title":"Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway","volume":"6","author":"de Jonge","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.neures.2018.05.001_bib0110","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0031-6997(24)01470-4","article-title":"The sympathetic nerve \u2013 an integrative interface between two supersystems: the brain and the immune system","volume":"52","author":"Elenkov","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neures.2018.05.001_bib0115","doi-asserted-by":"crossref","first-page":"5442","DOI":"10.1210\/en.2007-0732","volume":"148","author":"Fuzesi","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.neures.2018.05.001_bib0120","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000026343","article-title":"Bacterial endotoxin induces fos immunoreactivity in primary afferent neurons of the vagus nerve","volume":"5","author":"Gaykema","year":"1998","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.neures.2018.05.001_bib0125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0304-3940(95)11251-Q","article-title":"Blockade of cytokine induced conditioned taste aversion by subdiaphragmatic vagotomy: further evidence for vagal mediation of immune-brain communication","volume":"185","author":"Goehler","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neures.2018.05.001_bib0130","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/S0006-8993(98)00685-4","article-title":"Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve","volume":"804","author":"Goehler","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.neures.2018.05.001_bib0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1566-0702(00)00219-8","article-title":"Vagal immune-to-brain communication: a visceral chemosensory pathway","volume":"85","author":"Goehler","year":"2000","journal-title":"Autonom. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0140","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.1113\/JP271537","article-title":"The intestinal cholinergic anti-inflammatory pathway","volume":"594","author":"Goverse","year":"2016","journal-title":"J. Physiol."},{"key":"10.1016\/j.neures.2018.05.001_bib0145","doi-asserted-by":"crossref","first-page":"R187","DOI":"10.1152\/ajpregu.00054.2013","article-title":"C1 neurons: the body's EMTs","volume":"305","author":"Guyenet","year":"2013","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neures.2018.05.001_bib0150","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.yfrne.2003.07.001","article-title":"Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness","volume":"24","author":"Herman","year":"2003","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neures.2018.05.001_bib0155","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1748-1716.1973.tb05522.x","article-title":"Evidence for adrenaline neurons in the rat brain","volume":"89","author":"Hokfelt","year":"1973","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.neures.2018.05.001_bib0160","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.autneu.2004.11.012","article-title":"Novel pathway for LPS-induced afferent vagus nerve activation: possible role of nodose ganglion","volume":"120","author":"Hosoi","year":"2005","journal-title":"Autonom. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0165","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1084\/jem.20052362","article-title":"Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis","volume":"203","author":"Huston","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.neures.2018.05.001_bib0170","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1210\/en.2003-0258","article-title":"Immunotoxic destruction of distinct catecholaminergic neuron populations disrupts the reproductive response to glucoprivation in female rats","volume":"144","author":"I\u2019Anson","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.neures.2018.05.001_bib0175","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1172\/JCI83658","article-title":"Vagus nerve stimulation mediates protection from kidney ischemia-reperfusion injury through alpha7nAChR+ splenocytes","volume":"126","author":"Inoue","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neures.2018.05.001_bib0180","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1164\/rccm.201001-0047OC","article-title":"Photostimulation of Phox2b medullary neurons activates cardiorespiratory function in conscious rats","volume":"182","author":"Kanbar","year":"2010","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.neures.2018.05.001_bib0185","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jneuroim.2003.09.011","article-title":"Via beta-adrenoceptors, stimulation of extrasplenic sympathetic nerve fibers inhibits lipopolysaccharide-induced TNF secretion in perfused rat spleen","volume":"145","author":"Kees","year":"2003","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neures.2018.05.001_bib0190","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/joim.12591","article-title":"Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence","volume":"282","author":"Lai","year":"2017","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.neures.2018.05.001_bib0195","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1073\/pnas.93.6.2359","article-title":"Distinct mechanisms underlie activation of hypothalamic neurosecretory neurons and their medullary catecholaminergic afferents in categorically different stress paradigms","volume":"93","author":"Li","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neures.2018.05.001_bib0200","doi-asserted-by":"crossref","first-page":"R358","DOI":"10.1152\/ajpregu.00065.2015","article-title":"Orexin-A enhances feeding in male rats by activating hindbrain catecholamine neurons","volume":"309","author":"Li","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neures.2018.05.001_bib0205","doi-asserted-by":"crossref","first-page":"H2734","DOI":"10.1152\/ajpheart.00155.2003","article-title":"Cardiovascular regulation after destruction of the C1 cell group of the rostral ventrolateral medulla in rats","volume":"285","author":"Madden","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.neures.2018.05.001_bib0210","doi-asserted-by":"crossref","first-page":"R751","DOI":"10.1152\/ajpregu.00800.2005","article-title":"Attenuation of homeostatic responses to hypotension and glucoprivation after destruction of catecholaminergic rostral ventrolateral medulla neurons","volume":"291","author":"Madden","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.neures.2018.05.001_bib0215","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1523\/JNEUROSCI.4701-12.2013","article-title":"alpha2 Adrenergic receptor-mediated inhibition of thermogenesis","volume":"33","author":"Madden","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0220","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1113\/jphysiol.2013.268573","article-title":"Reflex control of inflammation by sympathetic nerves, not the vagus","volume":"592","author":"Martelli","year":"2014","journal-title":"J. Physiol."},{"key":"10.1016\/j.neures.2018.05.001_bib0225","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1152\/physrev.00039.2015","article-title":"Vagal afferent innervation of the airways in health and disease","volume":"96","author":"Mazzone","year":"2016","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neures.2018.05.001_bib0230","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13075-015-0597-2","article-title":"The interface between cholinergic pathways and the immune system and its relevance to arthritis","volume":"17","author":"McAllen","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.neures.2018.05.001_bib0235","series-title":"Application of Control Theory to Physiological Systems","author":"Milhorn","year":"1966"},{"key":"10.1016\/j.neures.2018.05.001_bib0240","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3109\/10253890.2011.630436","article-title":"The effect of acute stress exposure on ischemia and reperfusion injury in rat heart: role of oxytocin","volume":"15","author":"Moghimian","year":"2012","journal-title":"Stress"},{"key":"10.1016\/j.neures.2018.05.001_bib0245","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bbi.2007.03.008","article-title":"Autonomic innervation and regulation of the immune system (1987\u20132007)","volume":"21","author":"Nance","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neures.2018.05.001_bib0250","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1523\/JNEUROSCI.17-03-00975.1997","article-title":"Tumor necrosis factor enhances the capsaicin sensitivity of rat sensory neurons","volume":"17","author":"Nicol","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0255","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0165-1838(96)00098-7","article-title":"The afferent discharges from sensors for interleukin 1 beta in the hepatoportal system in the anesthetized rat","volume":"61","author":"Niijima","year":"1996","journal-title":"J. Auton. Nerv. Syst."},{"key":"10.1016\/j.neures.2018.05.001_bib0260","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.it.2015.08.007","article-title":"The regulation of immunological processes by peripheral neurons in homeostasis and disease","volume":"36","author":"Ordovas-Montanes","year":"2015","journal-title":"Trends Immunol."},{"key":"10.1016\/j.neures.2018.05.001_bib0265","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nn.4477","article-title":"Neural regulation of immunity: molecular mechanisms and clinical translation","volume":"20","author":"Pavlov","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0270","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/0006-8993(93)91472-5","article-title":"Activation of brainstem catecholaminergic neurons by conditioned and unconditioned aversive stimuli as revealed by c-Fos immunoreactivity","volume":"608","author":"Pezzone","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.neures.2018.05.001_bib0275","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.it.2016.10.001","article-title":"Nociceptor sensory neuron-immune interactions in pain and inflammation","volume":"38","author":"Pinho-Ribeiro","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.neures.2018.05.001_bib0280","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0006-8993(98)00655-6","article-title":"Subgroups of hindbrain catecholamine neurons are selectively activated by 2-deoxy-D-glucose induced metabolic challenge","volume":"805","author":"Ritter","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.neures.2018.05.001_bib0285","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/cne.1097","article-title":"Immunotoxic destruction of distinct catecholamine subgroups produces selective impairment of glucoregulatory responses and neuronal activation","volume":"432","author":"Ritter","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2018.05.001_bib0290","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1126\/science.1209985","article-title":"Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit","volume":"334","author":"Rosas-Ballina","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.neures.2018.05.001_bib0295","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/s13075-014-0470-8","article-title":"Nociceptive neurons detect cytokines in arthritis","volume":"16","author":"Schaible","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.neures.2018.05.001_bib0300","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/cne.21329","article-title":"Specificity and generality of the involvement of catecholaminergic afferents in hypothalamic responses to immune insults","volume":"502","author":"Schiltz","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2018.05.001_bib0305","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0361-9230(82)90040-5","article-title":"Insular cortex projection to the nucleus of the solitary tract and brainstem visceromotor regions in the mouse","volume":"8","author":"Shipley","year":"1982","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.neures.2018.05.001_bib0310","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/ALN.0b013e3182426ebd","article-title":"Electroacupuncture improves survival in rats with lethal endotoxemia via the autonomic nervous system","volume":"116","author":"Song","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.neures.2018.05.001_bib0315","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/(SICI)1096-9861(19991227)415:4<482::AID-CNE5>3.0.CO;2-4","article-title":"Location and electrophysiological characterization of rostral medullary adrenergic neurons that contain neuropeptide Y mRNA in rat medulla","volume":"415","author":"Stornetta","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2018.05.001_bib0320","doi-asserted-by":"crossref","first-page":"4027","DOI":"10.1007\/s00429-015-1143-3","article-title":"Afferent and efferent connections of C1 cells with spinal cord or hypothalamic projections in mice","volume":"221","author":"Stornetta","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neures.2018.05.001_bib0325","doi-asserted-by":"crossref","first-page":"14629","DOI":"10.1073\/pnas.96.25.14629","article-title":"Repeated, but not acute, stress suppresses inflammatory plasma extravasation","volume":"96","author":"Strausbaugh","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neures.2018.05.001_bib0330","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nature01321","article-title":"The inflammatory reflex","volume":"420","author":"Tracey","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.neures.2018.05.001_bib0335","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1172\/JCI30555","article-title":"Physiology and immunology of the cholinergic antiinflammatory pathway","volume":"117","author":"Tracey","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neures.2018.05.001_bib0340","doi-asserted-by":"crossref","first-page":"E802","DOI":"10.1152\/ajpendo.00466.2010","article-title":"Rostroventrolateral medullary neurons modulate glucose homeostasis in the rat","volume":"299","author":"Verberne","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"Pt. 2","key":"10.1016\/j.neures.2018.05.001_bib0345","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1111\/j.1469-7793.1999.0477t.x","article-title":"Properties of C1 and other ventrolateral medullary neurones with hypothalamic projections in the rat","volume":"517","author":"Verberne","year":"1999","journal-title":"J. Physiol."},{"key":"10.1016\/j.neures.2018.05.001_bib0350","doi-asserted-by":"crossref","first-page":"4340","DOI":"10.4049\/jimmunol.1003722","article-title":"alpha7-cholinergic receptor mediates vagal induction of splenic norepinephrine","volume":"186","author":"Vida","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.neures.2018.05.001_bib0355","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1096\/fj.11-191007","article-title":"beta2-Adrenoreceptors of regulatory lymphocytes are essential for vagal neuromodulation of the innate immune system","volume":"25","author":"Vida","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.neures.2018.05.001_bib0360","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1053\/j.gastro.2006.02.022","article-title":"The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice","volume":"130","author":"van Westerloo","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neures.2018.05.001_bib0365","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature01339","article-title":"Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation","volume":"421","author":"Wang","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.neures.2018.05.001_bib0370","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1038\/nm1124","article-title":"Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis","volume":"10","author":"Wang","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.neures.2018.05.001_bib0375","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.4049\/jimmunol.181.5.3441","article-title":"Enhanced resistance of restraint-stressed mice to sepsis","volume":"181","author":"Wang","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.neures.2018.05.001_bib0380","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nm.3527","article-title":"Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex","volume":"20","author":"Wang","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.neures.2018.05.001_bib0385","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0304-3940(94)11105-R","article-title":"Blockade of interleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication","volume":"183","author":"Watkins","year":"1995","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neures.2018.05.001_bib0390","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1146\/annurev.immunol.20.082401.104914","article-title":"Neuroendocrine regulation of immunity","volume":"20","author":"Webster","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.neures.2018.05.001_bib0395","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1523\/JNEUROSCI.3922-16.2017","article-title":"Blood pressure regulation by the rostral ventrolateral medulla in conscious rats: effects of hypoxia, hypercapnia, baroreceptor denervation, and anesthesia","volume":"37","author":"Wenker","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2018.05.001_bib0400","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/sj.bjp.0701148","article-title":"Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor alpha","volume":"121","author":"Woolf","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neures.2018.05.001_bib0405","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuron.2017.05.031","article-title":"A central catecholaminergic circuit controls blood glucose levels during stress","volume":"95","author":"Zhao","year":"2017","journal-title":"Neuron"}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010218301664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010218301664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T06:54:49Z","timestamp":1751612089000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010218301664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":81,"alternative-id":["S0168010218301664"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2018.05.001","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of C1 neurons in anti-inflammatory reflex: Mediation between afferents and efferents","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2018.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}