{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T01:13:20Z","timestamp":1777338800856,"version":"3.51.4"},"reference-count":69,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"University Grants Commission, Government of India","award":["F.4-5\/151-FRP\/2014\/BSR"],"award-info":[{"award-number":["F.4-5\/151-FRP\/2014\/BSR"]}]},{"name":"University Research Grant Scheme, Savitribai Phule Pune University"},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["EMR\/2017\/000621"],"award-info":[{"award-number":["EMR\/2017\/000621"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research","doi-asserted-by":"publisher","award":["37[1718]\/18\/EMR-II"],"award-info":[{"award-number":["37[1718]\/18\/EMR-II"]}],"id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Department Research and Development Program of the Department of Biotechnology, SPPU"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.neures.2019.06.003","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T12:26:41Z","timestamp":1561724801000},"page":"34-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Repeated mild traumatic brain injury induces persistent variations in mitochondrial DNA copy number in mesocorticolimbic neurocircuitry of the rat"],"prefix":"10.1016","volume":"155","author":[{"given":"Nagalakshmi","family":"Balasubramanian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinav","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namrata","family":"Pawar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sneha","family":"Sagarkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7382-0945","authenticated-orcid":false,"given":"Amul J.","family":"Sakharkar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2019.06.003_bib0005","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1007\/s12035-014-8752-3","article-title":"Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury","volume":"51","author":"Abdul-Muneer","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neures.2019.06.003_bib0010","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s11102-007-0052-8","article-title":"Traumatic brain injury induced hypothalamic-pituitary dysfunction: a paediatric perspective","volume":"10","author":"Acerini","year":"2007","journal-title":"Pituitary"},{"key":"10.1016\/j.neures.2019.06.003_bib0015","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.expneurol.2015.07.028","article-title":"GABAergic interneuronal loss and reduced inhibitory synaptic transmission in the hippocampal CA1 region after mild traumatic brain injury","volume":"273","author":"Almeida-Suhett","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neures.2019.06.003_bib0020","first-page":"723060","article-title":"Perspectives on molecular biomarkers of oxidative stress and antioxidant strategies in traumatic brain injury","author":"Andr\u00e9 Mendes","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.neures.2019.06.003_bib0025","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/ajmg.b.32086","article-title":"The mitochondrial genome and psychiatric illness","volume":"159","author":"Anglin","year":"2012","journal-title":"Am. J. Med. Genet. B: Neuropsychiatr. Genet."},{"issue":"2","key":"10.1016\/j.neures.2019.06.003_bib0030","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1017\/S1355617709991287","article-title":"Neuropsychological performance following a history of multiple self- reported concussions: a meta-analysis","volume":"16","author":"Belanger","year":"2010","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"10.1016\/j.neures.2019.06.003_bib0035","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.neuron.2012.11.021","article-title":"The neuropathology and neurobiology of traumatic brain injury","volume":"76","author":"Blennow","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2019.06.003_bib0040","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.bbagrm.2012.03.002","article-title":"Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number","volume":"1819","author":"Campbell","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neures.2019.06.003_bib0045","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","article-title":"Mitochondrial dynamics-fusion, fission, movement, and mitophagy in neurodegenerative diseases","volume":"18","author":"Chen","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.neures.2019.06.003_bib0050","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1177\/0963689717714105","article-title":"Impact of traumatic brain injury on dopaminergic transmission","volume":"26","author":"Chen","year":"2017","journal-title":"Cell Transplant."},{"key":"10.1016\/j.neures.2019.06.003_bib0055","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S1673-8527(08)60099-5","article-title":"Number matters: control of mammalian mitochondrial DNA copy number","volume":"36","author":"Clay Montier","year":"2009","journal-title":"J. Genet. Genomics"},{"key":"10.1016\/j.neures.2019.06.003_bib0060","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/npp.2012.189","article-title":"Involvement of the ventral tegmental area in a rodent model of post-traumatic stress disorder","volume":"38","author":"Corral-Frias","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.neures.2019.06.003_bib0065","doi-asserted-by":"crossref","DOI":"10.3171\/2012.10.FOCUS12284","article-title":"An overview of the basic science of concussion and subconcussion: where we are and where we are going","volume":"33","author":"Dashnaw","year":"2012","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.neures.2019.06.003_bib0070","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.expneurol.2009.05.020","article-title":"Heterogeneity of nervous system mitochondria: location, location, location!","volume":"218","author":"Dubinsky","year":"2009","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neures.2019.06.003_bib0075","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11102-008-0130-6","article-title":"Pathophysiology of hypopituitarism in the setting of brain injury","volume":"15","author":"Dusick","year":"2012","journal-title":"Pituitary"},{"issue":"7","key":"10.1016\/j.neures.2019.06.003_bib0080","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1177\/0963689717714092","article-title":"Repeated mild traumatic brain injury: potential mechanisms of damage","volume":"26","author":"Fehily","year":"2017","journal-title":"Cell Transplant."},{"key":"10.1016\/j.neures.2019.06.003_bib0085","doi-asserted-by":"crossref","first-page":"e103653","DOI":"10.1371\/journal.pone.0103653","article-title":"Reduced amygdala and ventral striatal activity to happy faces in PTSD is associated with emotional numbing","volume":"9","author":"Felmingham","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neures.2019.06.003_bib0090","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fnsys.2016.00029","article-title":"Altered mitochondrial dynamics and TBI pathophysiology","volume":"10","author":"Fischer","year":"2016","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.neures.2019.06.003_bib0095","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.bbabio.2010.11.016","article-title":"Regional variation in mitochondrial DNA copy number in mouse brain","volume":"1807","author":"Fuke","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.neures.2019.06.003_bib0100","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.dnarep.2012.06.002","article-title":"Oxidants and not alkylating agents induce rapid mtDNA loss and mitochondrial dysfunction","volume":"11","author":"Furda","year":"2012","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.neures.2019.06.003_bib0105","series-title":"Neuronal Growth Cones","first-page":"260","author":"Gordon-Weeks","year":"2000"},{"key":"10.1016\/j.neures.2019.06.003_bib0110","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1089\/neu.2015.4395","article-title":"Striatal mitochondrial disruption following severe traumatic brain injury","volume":"34","author":"Harmon","year":"2017","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neures.2019.06.003_bib0115","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/MAJ.0000000000000506","article-title":"Traumatic brain injury and mitochondrial dysfunction","volume":"350","author":"Hiebert","year":"2015","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.neures.2019.06.003_bib0120","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1089\/neu.2015.4339","article-title":"Early and persistent dendritic hypertrophy in the basolateral amygdala following experimental diffuse traumatic brain injury","volume":"34","author":"Hoffman","year":"2017","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neures.2019.06.003_bib0125","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1089\/neu.2010.1723","article-title":"Traumatic brain injury in adult rats causes progressive nigrostriatal dopaminergic cell loss and enhanced vulnerability to the pesticide paraquat","volume":"28","author":"Hutson","year":"2011","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neures.2019.06.003_bib0130","doi-asserted-by":"crossref","first-page":"753","DOI":"10.4103\/2230-8210.167561","article-title":"Pituitary and\/or hypothalamic dysfunction following moderate to severe traumatic brain injury: current perspectives","volume":"19","author":"Javed","year":"2015","journal-title":"Indian J. Endocrinol. Metab."},{"key":"10.1016\/j.neures.2019.06.003_bib0135","doi-asserted-by":"crossref","first-page":"170","DOI":"10.3389\/fnsys.2015.00170","article-title":"Prefrontal-hippocampal interactions in memory and emotion","volume":"9","author":"Jin","year":"2015","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.neures.2019.06.003_bib0140","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/B978-0-444-52892-6.00009-X","article-title":"Mild traumatic brain injury","volume":"127","author":"Katz","year":"2015","journal-title":"Handb. Clin. Neurol."},{"key":"10.1016\/j.neures.2019.06.003_bib0145","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nn.2321","article-title":"Motivation and cognitive control in the human prefrontal cortex","volume":"12","author":"Kouneiher","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neures.2019.06.003_bib0150","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00001199-200609000-00001","article-title":"The epidemiology and impact of traumatic brain injury","volume":"21","author":"Langlois","year":"2006","journal-title":"J. Head Trauma Rehabil."},{"key":"10.1016\/j.neures.2019.06.003_bib0155","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.4172\/2327-5146.1000275","article-title":"Epidemiology of traumatic brain injury over the world: a systematic review","volume":"4","author":"Li","year":"2016","journal-title":"Gen. Med."},{"key":"10.1016\/j.neures.2019.06.003_bib0160","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.mito.2004.07.021","article-title":"Mitochondrial damage and dysfunction in traumatic brain injury","volume":"4","author":"Lifshitz","year":"2004","journal-title":"Mitochondrion"},{"key":"10.1016\/j.neures.2019.06.003_bib0165","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.neures.2019.06.003_bib0170","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1177\/1073858406287661","article-title":"Mitochondria at the synapse","volume":"12","author":"Ly","year":"2006","journal-title":"Neuroscientist"},{"key":"10.1016\/j.neures.2019.06.003_bib0175","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1023\/A:1009068804787","article-title":"Traumatic brain injury as a risk factor for Alzheimer\u2019s disease: a review","volume":"10","author":"Lye","year":"2000","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.neures.2019.06.003_bib0180","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mito.2016.05.003","article-title":"Accurate quantification of mouse mitochondrial DNA without co-amplification of nuclear mitochondrial insertion sequences","volume":"29","author":"Malik","year":"2016","journal-title":"Mitochondrion"},{"key":"10.1016\/j.neures.2019.06.003_bib0185","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrn3229","article-title":"Impaired mitochondrial function in psychiatric disorders","volume":"13","author":"Manji","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neures.2019.06.003_bib0190","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.neuron.2008.10.010","article-title":"Mitochondria in neuroplasticity and neurological disorders","volume":"60","author":"Mattson","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2019.06.003_bib0195","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/NEN.0b013e3181a9d503","article-title":"Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury","volume":"68","author":"McKee","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neures.2019.06.003_bib0200","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.mito.2010.05.011","article-title":"Depressive behaviour in children diagnosed with a mitochondrial disorder","volume":"10","author":"Morava","year":"2010","journal-title":"Mitochondrion"},{"key":"10.1016\/j.neures.2019.06.003_bib0205","first-page":"e51820","article-title":"A novel model of mild traumatic brain injury for juvenile rats","volume":"94","author":"Mychasiuk","year":"2014","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.neures.2019.06.003_bib0210","doi-asserted-by":"crossref","first-page":"e4047","DOI":"10.7717\/peerj.4047","article-title":"Evaluation of potential reference genes for real-time qPCR analysis in a biparental beetle, Lethrus apterus (Coleoptera: Geotrupidae)","volume":"5","author":"Nagy","year":"2017","journal-title":"PeerJ"},{"key":"10.1016\/j.neures.2019.06.003_bib0215","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neubiorev.2015.01.019","article-title":"Reward functioning in PTSD: a systematic review exploring the mechanisms underlying anhedonia","volume":"51","author":"Nawijn","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neures.2019.06.003_bib0220","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1111\/j.1476-5381.2010.01163.x","article-title":"Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here?","volume":"164","author":"Niklas","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neures.2019.06.003_bib0225","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3389\/fnbeh.2014.00213","article-title":"Neurobehavioral, neuropathological and biochemical profiles in a novel mouse model of co-morbid post-traumatic stress disorder and mild traumatic brain injury","volume":"8","author":"Ojo","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neures.2019.06.003_bib0230","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fpsyt.2016.00030","article-title":"Ventral tegmental area afferents and drug-dependent behaviors","volume":"7","author":"Oliva","year":"2016","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.neures.2019.06.003_bib0235","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.exger.2014.01.021","article-title":"Mitochondrial homeostasis: the interplay between mitophagy and mitochondrial biogenesis","volume":"56","author":"Palikaras","year":"2014","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.neures.2019.06.003_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2010.04.061","article-title":"VTA neurons show a potentially protective transcriptional response to MPTP","volume":"1343","author":"Phani","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.neures.2019.06.003_bib0245","doi-asserted-by":"crossref","first-page":"E6614","DOI":"10.1073\/pnas.1515733112","article-title":"Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress","volume":"112","author":"Picard","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neures.2019.06.003_bib0250","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ymeth.2010.03.006","article-title":"Alterations in bioenergetics due to changes in mitochondrial DNA copy number","volume":"51","author":"Qian","year":"2014","journal-title":"Methods"},{"key":"10.1016\/j.neures.2019.06.003_bib0255","first-page":"621","article-title":"Dopamine and reward seeking: the role of ventral tegmental area","volume":"25","author":"Ranaldi","year":"2014","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.neures.2019.06.003_bib0260","doi-asserted-by":"crossref","first-page":"e100054","DOI":"10.1371\/journal.pone.0100054","article-title":"Assessment of cytochrome C oxidase dysfunction in the substantia nigra\/ventral tegmental area in schizophrenia","volume":"9","author":"Rice","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.neures.2019.06.003_bib0265","doi-asserted-by":"crossref","first-page":"37116","DOI":"10.1038\/srep37116","article-title":"Assessment of brain reference genes for RT-qPCR studies in neurodegenerative diseases","volume":"6","author":"Rydbirk","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neures.2019.06.003_bib0270","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1007\/s12035-016-0153-3","article-title":"The alterations in mitochondrial DNA copy number and nuclear-encoded mitochondrial genes in rat brain structures after cocaine self-administration","volume":"54","author":"Sadakierska-Chudy","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neures.2019.06.003_bib0275","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.nbd.2017.06.016","article-title":"Minimal traumatic brain injury causes persistent changes in DNA methylation at BDNF gene promoters in the amygdala of rat: a possible role in anxiety-like behaviors","volume":"106","author":"Sagarkar","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neures.2019.06.003_bib0280","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.brainres.2019.01.022","article-title":"Repeated mild traumatic brain injury causes persistent changes in histone deacetylase function in hippocampus: implications in learning and memory deficits in rats","volume":"1711","author":"Sagarkar","year":"2019","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.neures.2019.06.003_bib0285","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1186\/s12864-017-4356-4","article-title":"A tissue-based approach to selection of reference genes for quantitative real-time PCR in a sheep osteoporosis model","volume":"18","author":"Schulze","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.neures.2019.06.003_bib0290","doi-asserted-by":"crossref","first-page":"22331","DOI":"10.1074\/jbc.M111.250092","article-title":"Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication","volume":"286","author":"Shapovalov","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2019.06.003_bib0295","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1471-4159.2011.07581.x","article-title":"Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer\u2019s disease","volume":"120","author":"Sheng","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neures.2019.06.003_bib0300","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrn3156","article-title":"Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration","volume":"13","author":"Sheng","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neures.2019.06.003_bib0305","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1751-9004.2007.00064.x","article-title":"Prefrontal cortex, emotion, and approach\/withdrawal motivation","volume":"2","author":"Spielberg","year":"2008","journal-title":"Soc. Personal. Psychol. Compass"},{"key":"10.1016\/j.neures.2019.06.003_bib0310","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1590\/1516-4446-2013-1224","article-title":"Mitochondria and the central nervous system: searching for a pathophysiological basis of psychiatric disorders","volume":"36","author":"Streck","year":"2014","journal-title":"Braz. J. Psychiatr."},{"key":"10.1016\/j.neures.2019.06.003_bib0315","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.biopsych.2014.12.025","article-title":"Alterations of mitochondrial DNA copy number and telomere length with early adversity and psychopathology","volume":"79","author":"Tyrka","year":"2016","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neures.2019.06.003_bib0320","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1016\/j.apmr.2012.05.024","article-title":"Health outcomes associated with military deployment: mild traumatic brain injury, blast, trauma, and combat associations in the Florida National Guard","volume":"93","author":"Vanderploeg","year":"2012","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.neures.2019.06.003_bib0325","doi-asserted-by":"crossref","first-page":"6810","DOI":"10.1523\/JNEUROSCI.22-15-06810.2002","article-title":"Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons","volume":"22","author":"Vyas","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2019.06.003_bib0330","first-page":"12","article-title":"Impaired cortical mitochondrial function following TBI precedes behavioral changes","volume":"5","author":"Watson","year":"2014","journal-title":"Front. Neuroenerg."},{"key":"10.1016\/j.neures.2019.06.003_bib0335","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.nbd.2014.06.016","article-title":"Injury timing alters metabolic, inflammatory and functional outcomes following repeated mild traumatic brain injury","volume":"70","author":"Weil","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neures.2019.06.003_bib0340","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.brainres.2015.11.016","article-title":"Mitochondrial division inhibitor 1 (Mdivi-1) offers neuroprotection through diminishing cell death and improving functional outcome in a mouse model of traumatic brain injury","volume":"1630","author":"Wu","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.neures.2019.06.003_bib0345","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/nrn3407","article-title":"Animal models of traumatic brain injury","volume":"14","author":"Xiong","year":"2013","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010218306989?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010218306989?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:27:47Z","timestamp":1759141667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010218306989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":69,"alternative-id":["S0168010218306989"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2019.06.003","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Repeated mild traumatic brain injury induces persistent variations in mitochondrial DNA copy number in mesocorticolimbic neurocircuitry of the rat","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2019.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}