{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:25:20Z","timestamp":1792373120931,"version":"4.4.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T00:00:00Z","timestamp":1620518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012576","name":"Major Projects of Guangdong Education Department for Foundation Research and Applied Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012576","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.neures.2021.04.007","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T00:20:36Z","timestamp":1619223636000},"page":"63-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Environmental enrichment modulates HPA axis reprogramming in adult male rats exposed to early adolescent stress"],"prefix":"10.1016","volume":"172","author":[{"given":"Zhixin","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanzhang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiayu","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3335-0520","authenticated-orcid":false,"given":"Hanfang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0680-5099","authenticated-orcid":false,"given":"Can","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2021.04.007_bib0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/npp.2015.215","article-title":"Genetic approaches to hypothalamic-pituitary-adrenal axis regulation","volume":"41","author":"Arnett","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neures.2021.04.007_bib0010","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1146\/annurev.pharmtox.44.101802.121410","article-title":"CRF and CRF receptors: role in stress responsivity and other behaviors","volume":"44","author":"Bale","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.neures.2021.04.007_bib0015","first-page":"191","article-title":"Diagnostic and statistical manual of mental disorders (DSM)","volume":"25","author":"Battle","year":"2013","journal-title":"Codas"},{"key":"10.1016\/j.neures.2021.04.007_bib0020","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.psyneuen.2008.12.018","article-title":"Pre-pubertal stress exposure affects adult behavioral response in association with changes in circulating corticosterone and brain-derived neurotrophic factor","volume":"34","author":"Bazak","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neures.2021.04.007_bib0025","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/mp.2009.141","article-title":"The CRF system, stress, depression and anxiety-insights from human genetic studies","volume":"15","author":"Binder","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neures.2021.04.007_bib0030","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/brb3.182","article-title":"Juvenile stress enhances anxiety and alters corticosteroid receptor expression in adulthood","volume":"4","author":"Brydges","year":"2014","journal-title":"Brain Behav."},{"key":"10.1016\/j.neures.2021.04.007_bib0035","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1677\/joe.0.1440311","article-title":"The influence of ovarian steroids on hypothalamic-pituitary-adrenal regulation in the female rat","volume":"144","author":"Carey","year":"1995","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neures.2021.04.007_bib0040","first-page":"439","article-title":"Paeoniflorin regulates the hypothalamic-pituitary-adrenal axis negative feedback in a rat model of post-traumatic stress disorder","volume":"23","author":"Chen","year":"2020","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.neures.2021.04.007_bib0045","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.chc.2014.01.002","article-title":"The biological effects of childhood trauma","volume":"23","author":"De Bellis","year":"2014","journal-title":"Child Adolesc. Psychiatr. Clin. N. Am."},{"key":"10.1016\/j.neures.2021.04.007_bib0050","first-page":"269","article-title":"Brain corticosteroid receptor balance in health and disease","volume":"19","author":"De Kloet","year":"1998","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.neures.2021.04.007_bib0055","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbr.2005.06.020","article-title":"Glucocorticoid receptor antagonism in the basolateral amygdala and ventral hippocampus interferes with long-term memory of contextual fear","volume":"164","author":"Donley","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neures.2021.04.007_bib0060","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.neuroscience.2012.10.048","article-title":"Stress and the developing adolescent brain","volume":"249","author":"Eiland","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2021.04.007_bib0065","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF03001163","article-title":"Conditioned and unconditional components of post-shock freezing","volume":"15","author":"Fanselow","year":"1980","journal-title":"Pavlov. J. Biol. Sci."},{"key":"10.1016\/j.neures.2021.04.007_bib0070","doi-asserted-by":"crossref","first-page":"13","DOI":"10.5498\/wjp.v2.i1.13","article-title":"Childhood stressful events, HPA axis and anxiety disorders","volume":"2","author":"Faravelli","year":"2012","journal-title":"World J. Psychiatry"},{"key":"10.1016\/j.neures.2021.04.007_bib0075","first-page":"18","article-title":"Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior","author":"Fitzsimons","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neures.2021.04.007_bib0080","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/10253890.2018.1470238","article-title":"Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility","volume":"21","author":"Gjerstad","year":"2018","journal-title":"Stress"},{"key":"10.1016\/j.neures.2021.04.007_bib0085","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jpsychires.2012.01.005","article-title":"The effects of child abuse and neglect on cognitive functioning in adulthood","volume":"46","author":"Gould","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neures.2021.04.007_bib0090","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/dev.20494","article-title":"Neurobiological and psychiatric consequences of child abuse and neglect","volume":"52","author":"Heim","year":"2010","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.neures.2021.04.007_bib0095","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1590\/S0100-879X2012007500041","article-title":"Neural regulation of the stress response: glucocorticoid feedback mechanisms","volume":"45","author":"Herman","year":"2012","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.neures.2021.04.007_bib0100","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0169-328X(01)00050-X","article-title":"Attenuation of fear conditioning by antisense inhibition of brain corticotropin releasing factor-2 receptor","volume":"89","author":"Ho","year":"2001","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.neures.2021.04.007_bib0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000331393","article-title":"Post-weaning to pre-pubertal (\u2019juvenile\u2019) stress: a model of induced predisposition to stress-related disorders","volume":"95","author":"Horovitz","year":"2012","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neures.2021.04.007_bib0110","doi-asserted-by":"crossref","first-page":"e4329","DOI":"10.1371\/journal.pone.0004329","article-title":"Enriched environment experience overcomes learning deficits and depressive-like behavior induced by juvenile stress","volume":"4","author":"Ilin","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.neures.2021.04.007_bib0115","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1196\/annals.1410.012","article-title":"Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stress","volume":"1148","author":"Jankord","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neures.2021.04.007_bib0120","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1210\/me.2013-1187","article-title":"Disrupting hypothalamic glucocorticoid receptors causes HPA axis hyperactivity and excess adiposity","volume":"27","author":"Laryea","year":"2013","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.neures.2021.04.007_bib0125","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbr.2015.04.007","article-title":"Long-term effects of early adolescent stress: dysregulation of hypothalamic-pituitary-adrenal axis and central corticotropin releasing factor receptor 1 expression in adult male rats","volume":"288","author":"Li","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neures.2021.04.007_bib0130","first-page":"3607","article-title":"Effects of environmental enrichment on emotion and behavior, HPA axis activity and corticosteroid receptor expression in rats exposed to chronic stress","volume":"36","author":"Li","year":"2015","journal-title":"Guangdong Med. J."},{"key":"10.1016\/j.neures.2021.04.007_bib0135","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0306-4530(97)00044-9","article-title":"Stress-restress: effects on ACTH and fast feedback","volume":"22","author":"Liberzon","year":"1997","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neures.2021.04.007_bib0140","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1046\/j.1365-2826.1999.00288.x","article-title":"Differential regulation of hippocampal glucocorticoid receptors mRNA and fast feedback: relevance to post-traumatic stress disorder","volume":"11","author":"Liberzon","year":"1999","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.neures.2021.04.007_bib0145","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.pnpbp.2017.05.015","article-title":"Behavioral and cognitive impact of early life stress: insights from an animal model","volume":"78","author":"Liu","year":"2017","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neures.2021.04.007_bib0150","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.semcdb.2017.09.040","article-title":"The impact of adolescent stress experiences on neurobiological development","volume":"77","author":"Lo","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.neures.2021.04.007_bib0155","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1192\/bjp.184.6.482","article-title":"Age of traumatisation as a predictor of post-traumatic stress disorder or major depression in young women","volume":"184","author":"Maercker","year":"2004","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neures.2021.04.007_bib0160","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.tins.2012.01.005","article-title":"Sculpting the hippocampus from within: stress, spines, and CRH","volume":"35","author":"Maras","year":"2012","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neures.2021.04.007_bib0165","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1037\/0278-6133.26.4.447","article-title":"Differentiating the impact of episodic and chronic stressors on hypothalamic-pituitary-adrenocortical axis regulation in young women","volume":"26","author":"Marin","year":"2007","journal-title":"Health Psychol."},{"key":"10.1016\/j.neures.2021.04.007_bib0170","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/j.pnpbp.2009.09.019","article-title":"Adolescent development, hypothalamic-pituitary-adrenal function, and programming of adult learning and memory","volume":"34","author":"McCormick","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neures.2021.04.007_bib0175","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bandc.2009.06.003","article-title":"Investigations of HPA function and the enduring consequences of stressors in adolescence in animal models","volume":"72","author":"McCormick","year":"2010","journal-title":"Brain Cogn."},{"key":"10.1016\/j.neures.2021.04.007_bib0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.yhbeh.2020.104845","article-title":"Adolescent social instability stress leads to immediate and lasting sex-specific changes in the neuroendocrine-immune-gut axis in rats","volume":"126","author":"McCormick","year":"2020","journal-title":"Horm. Behav."},{"key":"10.1016\/j.neures.2021.04.007_bib0185","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1017\/S0033291709992121","article-title":"Childhood adversity, adult stressful life events, and risk of past-year psychiatric disorder: a test of the stress sensitization hypothesis in a population-based sample of adults","volume":"40","author":"McLaughlin","year":"2010","journal-title":"Psychol. Med."},{"key":"10.1016\/j.neures.2021.04.007_bib0190","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1192\/bjp.bp.116.197640","article-title":"Childhood adversities and post-traumatic stress disorder: evidence for stress sensitisation in the World Mental Health Surveys","volume":"211","author":"McLaughlin","year":"2017","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neures.2021.04.007_bib0195","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.yhbeh.2019.03.004","article-title":"Beneficial effects of Spirulina platensis, voluntary exercise and environmental enrichment against adolescent stress induced deficits in cognitive functions, hippocampal BDNF and morphological remolding in adult female rats","volume":"112","author":"Moradi-Kor","year":"2019","journal-title":"Horm. Behav."},{"key":"10.1016\/j.neures.2021.04.007_bib0200","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0014-2999(02)02663-8","article-title":"Effect of chronic administration of a CRF(1) receptor antagonist, CRA1000, on locomotor activity and endocrine responses to stress","volume":"457","author":"Ohata","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neures.2021.04.007_bib0205","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.biopsych.2007.02.008","article-title":"The natural history of neuroendocrine changes in pediatric posttraumatic stress disorder (PTSD) after motor vehicle accidents: progressive divergence of noradrenaline and cortisol concentrations over time","volume":"62","author":"Pervanidou","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neures.2021.04.007_bib0210","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fpsyt.2013.00080","article-title":"Epigenetic risk factors in PTSD and depression","volume":"4","author":"Raabe","year":"2013","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.neures.2021.04.007_bib0215","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/hipo.22823","article-title":"Impact of adolescent stress on the expression of stress-related receptors in the hippocampus of animals exposed to alcohol prenatally","volume":"28","author":"Raineki","year":"2018","journal-title":"Hippocampus"},{"key":"10.1016\/j.neures.2021.04.007_bib0220","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.brainres.2019.05.019","article-title":"Glucocorticoid receptor expression in the stress-limbic circuitry is differentially affected by prenatal alcohol exposure and adolescent stress","volume":"1718","author":"Raineki","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.neures.2021.04.007_bib0225","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/nn1441","article-title":"The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids","volume":"8","author":"Revest","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neures.2021.04.007_bib0230","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/mp.2013.134","article-title":"BDNF-TrkB signaling through Erk1\/2 MAPK phosphorylation mediates the enhancement of fear memory induced by glucocorticoids","volume":"19","author":"Revest","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neures.2021.04.007_bib0235","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3758\/s13415-017-0559-z","article-title":"Childhood maltreatment is associated with increased neural response to ambiguous threatening facial expressions in adulthood: evidence from the late positive potential","volume":"18","author":"Sandre","year":"2018","journal-title":"Cogn. Affect. Behav. Neurosci."},{"key":"10.1016\/j.neures.2021.04.007_bib0240","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nlm.2017.09.008","article-title":"Juvenile stress leads to long-term immunological metaplasticity-like effects on inflammatory responses in adulthood","volume":"154","author":"Shtoots","year":"2018","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.neures.2021.04.007_bib0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2020.172993","article-title":"Differential impact of stress and environmental enrichment on corticolimbic circuits","volume":"197","author":"Smail","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neures.2021.04.007_bib0250","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1080\/10253890.2017.1402883","article-title":"Adolescent environmental enrichment prevents behavioral and physiological sequelae of adolescent chronic stress in female (but not male) rats","volume":"21","author":"Smith","year":"2018","journal-title":"Stress"},{"key":"10.1016\/j.neures.2021.04.007_bib0255","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.psyneuen.2016.04.015","article-title":"Individual differences in early adolescents\u2019 latent trait cortisol (LTC): relation to recent acute and chronic stress","volume":"70","author":"Stroud","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neures.2021.04.007_bib0260","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbr.2014.03.022","article-title":"Female-dependent impaired fear memory of adult rats induced by maternal separation, and screening of possible related genes in the hippocampal CA1","volume":"267","author":"Sun","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neures.2021.04.007_bib0265","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbr.2016.06.016","article-title":"Amelioration of oxidative stress-induced phenotype loss of parvalbumin interneurons might contribute to the beneficial effects of environmental enrichment in a rat model of post-traumatic stress disorder","volume":"312","author":"Sun","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neures.2021.04.007_bib0270","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/nprot.2010.114","article-title":"An environmental enrichment model for mice","volume":"5","author":"Sztainberg","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.neures.2021.04.007_bib0275","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0149-7634(01)00046-X","article-title":"Role of CRF(1) and CRF(2) receptors in fear and anxiety","volume":"25","author":"Takahashi","year":"2001","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neures.2021.04.007_bib0280","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0006-8993(01)02405-2","article-title":"Antagonism of CRF(2) receptors produces anxiolytic behavior in animal models of anxiety","volume":"902","author":"Takahashi","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.neures.2021.04.007_bib0285","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1254\/jphs.11R07CP","article-title":"Preventive effects of an enriched environment on rodent psychiatric disorder models","volume":"117","author":"Takuma","year":"2011","journal-title":"J. Pharmacol. Sci."},{"key":"10.1016\/j.neures.2021.04.007_bib0290","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.neuroscience.2005.08.089","article-title":"Early life trauma decreases glucocorticoid receptors in rat dentate gyrus upon adult re-stress: reversal by escitalopram","volume":"137","author":"Uys","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2021.04.007_bib0295","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/35044558","article-title":"Neural consequences of environmental enrichment","volume":"1","author":"van Praag","year":"2000","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neures.2021.04.007_bib0300","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s11920-019-1032-1","article-title":"PTSD as a public mental health priority","volume":"21","author":"Watson","year":"2019","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.neures.2021.04.007_bib0305","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1037\/a0015752","article-title":"Adolescent male rats exposed to social defeat exhibit altered anxiety behavior and limbic monoamines as adults","volume":"123","author":"Watt","year":"2009","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.neures.2021.04.007_bib0310","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.psyneuen.2015.12.004","article-title":"Adolescent chronic stress causes hypothalamo-pituitary-adrenocortical hypo-responsiveness and depression-like behavior in adult female rats","volume":"65","author":"Wulsin","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neures.2021.04.007_bib0315","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1002\/da.20629","article-title":"Single prolonged stress: toward an animal model of posttraumatic stress disorder","volume":"26","author":"Yamamoto","year":"2009","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.neures.2021.04.007_bib0320","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1749-6632.2009.04979.x","article-title":"Status of glucocorticoid alterations in post-traumatic stress disorder","volume":"1179","author":"Yehuda","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neures.2021.04.007_bib0325","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1267\/ahc.08013","article-title":"Expressions of hippocampal mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) in the single-prolonged stress-rats","volume":"41","author":"Zhe","year":"2008","journal-title":"Acta Histochem. Cytochem."},{"key":"10.1016\/j.neures.2021.04.007_bib0330","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Zhuge","year":"2015"}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016801022100081X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016801022100081X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:29:43Z","timestamp":1759141783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016801022100081X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":66,"alternative-id":["S016801022100081X"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2021.04.007","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmental enrichment modulates HPA axis reprogramming in adult male rats exposed to early adolescent stress","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2021.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}