{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:10:54Z","timestamp":1793293854811,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.neures.2023.01.003","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T11:12:52Z","timestamp":1673867572000},"page":"66-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Tear secretion by Diquafosol suppresses the excitability of trigeminal brainstem nuclear complex neurons by reducing excessive P2Y2 expression in the trigeminal ganglion in dry eye rats"],"prefix":"10.1016","volume":"191","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7381-8557","authenticated-orcid":false,"given":"Ayano","family":"Katagiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8874-7111","authenticated-orcid":false,"given":"Kazuo","family":"Tsubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4547-6718","authenticated-orcid":false,"given":"Lou","family":"Mikuzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9498-3014","authenticated-orcid":false,"given":"Akira","family":"Toyofuku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2452-7328","authenticated-orcid":false,"given":"Takafumi","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Bereiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-9237","authenticated-orcid":false,"given":"Koichi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2023.01.003_bib1","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1124\/pr.58.3.3","article-title":"International union of pharmacology lviii: Update on the p2y g protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy","volume":"58","author":"Abbracchio","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neures.2023.01.003_bib2","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.jtos.2017.05.002","article-title":"Tfos dews ii pain and sensation report","volume":"15","author":"Belmonte","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.neures.2023.01.003_bib3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0304-3959(00)00434-6","article-title":"Trigeminal subnucleus caudalis: beyond homologies with the spinal dorsal horn","volume":"88","author":"Bereiter","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.neures.2023.01.003_bib4","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1167\/iovs.18-24304","article-title":"Trpv1 and trpm8 channels and nocifensive behavior in a rat model for dry eye","volume":"59","author":"Bereiter","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neures.2023.01.003_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fnint.2019.00003","article-title":"Sex differences in estradiol secretion by trigeminal brainstem neurons","volume":"13","author":"Bereiter","year":"2019","journal-title":"Front Integr. Neurosci."},{"key":"10.1016\/j.neures.2023.01.003_bib6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"Tfos dews ii pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.neures.2023.01.003_bib7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1152\/jn.00944.2001","article-title":"Central sensitization of nociceptive neurons in trigeminal subnucleus oralis depends on integrity of subnucleus caudalis","volume":"88","author":"Chiang","year":"2002","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neures.2023.01.003_bib8","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0014-4886(62)90019-5","article-title":"Terminal distribution of primary afferent trigeminal fibers in the rat","volume":"6","author":"Clarke","year":"1962","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neures.2023.01.003_bib9","first-page":"299","article-title":"Fos, nociception and the dorsal horn","volume":"77","author":"Coggeshall","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neures.2023.01.003_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0014-4835(03)00068-X","article-title":"Localization of ocular p2y2 receptor gene expression by in situ hybridization","volume":"77","author":"Cowlen","year":"2003","journal-title":"Exp. eye Res."},{"key":"10.1016\/j.neures.2023.01.003_bib11","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1136\/bjophthalmol-2016-309658","article-title":"Evidence of central sensitisation in those with dry eye symptoms and neuropathic-like ocular pain complaints: incomplete response to topical anaesthesia and generalised heightened sensitivity to evoked pain","volume":"101","author":"Crane","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.neures.2023.01.003_bib12","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/ICL.0b013e31822563be","article-title":"Effects of topical cyclosporine a plus artificial tears versus artificial tears treatment on conjunctival goblet cell density in dysfunctional tear syndrome","volume":"37","author":"Demiryay","year":"2011","journal-title":"Eye Contact Lens"},{"key":"10.1016\/j.neures.2023.01.003_bib13","doi-asserted-by":"crossref","first-page":"6989","DOI":"10.1038\/s41598-021-86433-6","article-title":"Diquafosol tetrasodium elicits total cholesterol release from rabbit meibomian gland cells via p2y2 purinergic receptor signalling","volume":"11","author":"Endo","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neures.2023.01.003_bib14","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1090-3801(99)90186-6","article-title":"Quantification and immunocytochemical characteristics of trigeminal ganglion neurons projecting to the cornea: effect of corneal wounding","volume":"3","author":"Felipe","year":"1999","journal-title":"Eur. J. Pain."},{"key":"10.1016\/j.neures.2023.01.003_bib15","first-page":"96","article-title":"Improvement of corneal barrier function by the p2y(2) agonist ins365 in a rat dry eye model","volume":"42","author":"Fujihara","year":"2001","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neures.2023.01.003_bib16","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/10807680260218524","article-title":"Ins365 suppresses loss of corneal epithelial integrity by secretion of mucin-like glycoprotein in a rabbit short-term dry eye model","volume":"18","author":"Fujihara","year":"2002","journal-title":"J. Ocul. Pharmacol. Ther.: Off. J. Assoc. Ocul. Pharmacol. Ther."},{"key":"10.1016\/j.neures.2023.01.003_bib17","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/bjophthalmol-2014-306057","article-title":"Dry eye symptom severity and persistence are associated with symptoms of neuropathic pain","volume":"99","author":"Galor","year":"2015","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.neures.2023.01.003_bib18","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1001\/jamaophthalmol.2016.3642","article-title":"Assessment of somatosensory function in patients with idiopathic dry eye symptoms","volume":"134","author":"Galor","year":"2016","journal-title":"JAMA Ophthalmol."},{"key":"10.1016\/j.neures.2023.01.003_bib19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S1542-0124(12)70149-0","article-title":"Character of ocular surface mucins and their alteration in dry eye disease","volume":"2","author":"Gipson","year":"2004","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.neures.2023.01.003_bib20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/cne.902400106","article-title":"Morphology of terminations of small and large myelinated trigeminal primary afferent-fibers in the cat","volume":"240","author":"Hayashi","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2023.01.003_bib21","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1152\/jn.2000.84.2.1050","article-title":"Cornea-responsive medullary dorsal horn neurons: modulation by local opioids and projections to thalamus and brain stem","volume":"84","author":"Hirata","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neures.2023.01.003_bib22","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1152\/jn.00544.2003","article-title":"Gaba(a) receptor activation modulates corneal unit activity in rostral and caudal portions of trigeminal subnucleus caudalis","volume":"90","author":"Hirata","year":"2003","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neures.2023.01.003_bib23","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1523\/JNEUROSCI.0381-04.2004","article-title":"A novel class of neurons at the trigeminal subnucleus interpolaris\/caudalis transition region monitors ocular surface fluid status and modulates tear production","volume":"24","author":"Hirata","year":"2004","journal-title":"J. Neurosci.: Off. J. Soc. Neurosci."},{"key":"10.1016\/j.neures.2023.01.003_bib24","doi-asserted-by":"crossref","DOI":"10.1167\/iovs.17-23623","article-title":"Secreted mucins on the ocular surface","volume":"59","author":"Hori","year":"2018","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neures.2023.01.003_bib25","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/ICO.0000000000000213","article-title":"Additive effect of preservative-free sodium hyaluronate 0.1% in treatment of dry eye syndrome with diquafosol 3% eye drops","volume":"33","author":"Hwang","year":"2014","journal-title":"Cornea"},{"key":"10.1016\/j.neures.2023.01.003_bib26","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3109\/08990229009144716","article-title":"Intersubnuclear connections within the rat trigeminal brainstem complex","volume":"7","author":"Jacquin","year":"1990","journal-title":"Somat. Mot. Res"},{"key":"10.1016\/j.neures.2023.01.003_bib27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3109\/08990229009144705","article-title":"Trigeminal projections to contralateral dorsal horn: central extent, peripheral origins, and plasticity","volume":"7","author":"Jacquin","year":"1990","journal-title":"Somat. Mot. Res"},{"key":"10.1016\/j.neures.2023.01.003_bib28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.brainresrev.2008.12.011","article-title":"Map kinase and pain","volume":"60","author":"Ji","year":"2009","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.neures.2023.01.003_bib29","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1006\/exer.1998.0520","article-title":"Regulation of ocular mucin secretion by p2y2 nucleotide receptors in rabbit and human conjunctiva","volume":"67","author":"Jumblatt","year":"1998","journal-title":"Exp. eye Res."},{"key":"10.1016\/j.neures.2023.01.003_bib30","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s12325-018-0685-1","article-title":"Randomized controlled study to investigate the effect of topical diquafosol tetrasodium on corneal sensitivity in short tear break-up time dry eye","volume":"35","author":"Kaido","year":"2018","journal-title":"Adv. Ther."},{"key":"10.1016\/j.neures.2023.01.003_bib31","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.neuroscience.2015.01.046","article-title":"Evidence for trpa1 involvement in central neural mechanisms in a rat model of dry eye","volume":"290","author":"Katagiri","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2023.01.003_bib32","article-title":"Diquafosol sodium reduces neuronal activity in trigeminal subnucleus caudalis in a rat model of chronic dry eye disease","volume":"792","author":"Katagiri","year":"2022","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neures.2023.01.003_bib33","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3109\/02713689508998519","article-title":"Stimulation of goblet cell mucous secretion by activation of nerves in rat conjunctiva","volume":"14","author":"Kessler","year":"1995","journal-title":"Curr. Eye Res"},{"key":"10.1016\/j.neures.2023.01.003_bib34","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1016\/j.ophtha.2012.12.022","article-title":"A randomized, multicenter phase 3 study comparing 2% rebamipide (opc-12759) with 0.1% sodium hyaluronate in the treatment of dry eye","volume":"120","author":"Kinoshita","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.neures.2023.01.003_bib35","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neuroscience.2021.12.002","article-title":"Enhanced ocular surface and intraoral nociception via a transient receptor potential vanilloid 1 mechanism in a rat model of obstructive sleep apnea","volume":"483","author":"Kishimoto","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2023.01.003_bib36","doi-asserted-by":"crossref","first-page":"e671","DOI":"10.1111\/aos.12443","article-title":"Effect of diquafosol ophthalmic solution on the optical quality of the eyes in patients with aqueous-deficient dry eye","volume":"92","author":"Koh","year":"2014","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.neures.2023.01.003_bib37","doi-asserted-by":"crossref","DOI":"10.1186\/1744-8069-10-21","article-title":"Inhibition of g protein-coupled p2y2 receptor induced analgesia in a rat model of trigeminal neuropathic pain","volume":"10","author":"Li","year":"2014","journal-title":"Mol. Pain."},{"key":"10.1016\/j.neures.2023.01.003_bib38","doi-asserted-by":"crossref","first-page":"C595","DOI":"10.1152\/ajpcell.2001.281.2.C595","article-title":"Rabbit conjunctival epithelium transports fluid, and p2y2(2) receptor agonists stimulate cl(-) and fluid secretion","volume":"281","author":"Li","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.neures.2023.01.003_bib39","article-title":"Unilateral corneal insult also alters sensory nerve activity in the contralateral eye","volume":"8","author":"Luna","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.neures.2023.01.003_bib40","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/jnc.15537","article-title":"Extracellular atp and camp signaling promote piezo2-dependent mechanical allodynia after trigeminal nerve compression injury","volume":"160","author":"Luo","year":"2022","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neures.2023.01.003_bib41","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/glia.22819","article-title":"P2y2 receptor antagonists as anti-allodynic agents in acute and sub-chronic trigeminal sensitization: Role of satellite glial cells","volume":"63","author":"Magni","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.neures.2023.01.003_bib42","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.pain.2008.01.026","article-title":"Thermal nociception and trpv1 function are attenuated in mice lacking the nucleotide receptor p2y2","volume":"138","author":"Malin","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.neures.2023.01.003_bib43","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1002\/cne.902610309","article-title":"Corneal sensory pathway in the rat: a horseradish peroxidase tracing study","volume":"261","author":"Marfurt","year":"1987","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2023.01.003_bib44","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0306-4522(95)00541-2","article-title":"Differential distribution of fos-like immunoreactivity in the spinal trigeminal nucleus after noxious and innocuous thermal and chemical stimulation of rat cornea","volume":"72","author":"Meng","year":"1996","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2023.01.003_bib45","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1152\/jn.1997.77.1.43","volume":"77","author":"Meng","year":"1997","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neures.2023.01.003_bib46","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1046\/j.1460-9568.2002.02253.x","article-title":"Atp and utp excite sensory neurons and induce creb phosphorylation through the metabotropic receptor, p2y2","volume":"16","author":"Molliver","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neures.2023.01.003_bib47","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.ne.14.030191.002225","article-title":"Stimulus-transcription coupling in the nervous system: involvement of the inducible proto-oncogenes fos and jun","volume":"14","author":"Morgan","year":"1991","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neures.2023.01.003_bib48","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1159\/000076887","article-title":"Diquafosol elicits increases in net cl- transport through p2y2 receptor stimulation in rabbit conjunctiva","volume":"36","author":"Murakami","year":"2004","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.neures.2023.01.003_bib49","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/cne.901300406","article-title":"Somatotopic organization in the spinal trigeminal nucleus, the dorsal column nuclei and related structures in the rat","volume":"130","author":"Nord","year":"1967","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2023.01.003_bib50","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1124\/jpet.102.036079","article-title":"Analgesic effects of intrathecal administration of p2y nucleotide receptor agonists utp and udp in normal and neuropathic pain model rats","volume":"303","author":"Okada","year":"2002","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.neures.2023.01.003_bib51","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.exer.2009.11.018","article-title":"Distinct central representations for sensory fibers innervating either the conjunctiva or cornea of the rat","volume":"90","author":"Panneton","year":"2010","journal-title":"Exp. eye Res."},{"key":"10.1016\/j.neures.2023.01.003_bib52","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/nm.2264","article-title":"Ocular surface wetness is regulated by trpm8-dependent cold thermoreceptors of the cornea","volume":"16","author":"Parra","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.neures.2023.01.003_bib53","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/cne.902110105","article-title":"Immunocytochemical localization of substance p in the spinal trigeminal nucleus of the rat: a light and electron microscopic study","volume":"211","author":"Priestley","year":"1982","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2023.01.003_bib54","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1097\/j.pain.0000000000000135","article-title":"Sensitization of trigeminal brainstem pathways in a model for tear deficient dry eye","volume":"156","author":"Rahman","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.neures.2023.01.003_bib55","doi-asserted-by":"crossref","first-page":"7034","DOI":"10.1167\/iovs.12-10025","article-title":"Menthol activation of corneal cool cells induces trpm8-mediated lacrimation but not nociceptive responses in rodents","volume":"53","author":"Robbins","year":"2012","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neures.2023.01.003_bib56","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1177\/10454411000110010401","article-title":"Acute and chronic craniofacial pain: Brainstem mechanisms of nociceptive transmission and neuroplasticity, and their clinical correlates","volume":"11","author":"Sessle","year":"2000","journal-title":"Crit. Rev. Oral. Biol. Med.: Off. Publ. Am. Assoc. Oral. Biol."},{"key":"10.1016\/j.neures.2023.01.003_bib57","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s10384-015-0408-y","article-title":"Diquafosol sodium ophthalmic solution for the treatment of dry eye: clinical evaluation and biochemical analysis of tear composition","volume":"59","author":"Shigeyasu","year":"2015","journal-title":"Jpn. J. Ophthalmol."},{"issue":"Suppl 1","key":"10.1016\/j.neures.2023.01.003_bib58","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1097\/ICO.0000000000000996","article-title":"Influence of ophthalmic solutions on tear components","volume":"35","author":"Shigeyasu","year":"2016","journal-title":"Cornea"},{"key":"10.1016\/j.neures.2023.01.003_bib59","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1167\/iovs.15-18133","article-title":"Corneal mechanical thresholds negatively associate with dry eye and ocular pain symptoms","volume":"57","author":"Spierer","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.neures.2023.01.003_bib60","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pain.2004.01.007","article-title":"The p2y agonist utp activates cutaneous afferent fibers","volume":"109","author":"Stucky","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.neures.2023.01.003_bib61","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/aos.12012","article-title":"Correlations between commonly used objective signs and symptoms for the diagnosis of dry eye disease: clinical implications","volume":"92","author":"Sullivan","year":"2014","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.neures.2023.01.003_bib62","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s10384-014-0342-4","article-title":"Expression of the p2y(2) receptor on the rat ocular surface during a 1-year rearing period","volume":"58","author":"Tanioka","year":"2014","journal-title":"Jpn J. Ophthalmol."},{"key":"10.1016\/j.neures.2023.01.003_bib63","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jtos.2016.09.003","article-title":"New perspectives on dry eye definition and diagnosis: a consensus report by the asia dry eye society","volume":"15","author":"Tsubota","year":"2017","journal-title":"Ocul. Surf."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010223000032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010223000032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:34:03Z","timestamp":1759142043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010223000032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":63,"alternative-id":["S0168010223000032"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2023.01.003","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tear secretion by Diquafosol suppresses the excitability of trigeminal brainstem nuclear complex neurons by reducing excessive P2Y2 expression in the trigeminal ganglion in dry eye rats","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2023.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}