{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T17:33:53Z","timestamp":1770226433040,"version":"3.49.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["cstc2020jcyj-msxmX0125"],"award-info":[{"award-number":["cstc2020jcyj-msxmX0125"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["cstc2021jcyj- msxmX0105"],"award-info":[{"award-number":["cstc2021jcyj- msxmX0105"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002227"],"award-info":[{"award-number":["82002227"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171522"],"award-info":[{"award-number":["82171522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.neures.2023.02.005","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T11:28:08Z","timestamp":1676633288000},"page":"28-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Anti-LINGO-1 antibody protects neurons and synapses in the medial prefrontal cortex of APP\/PS1 transgenic mice"],"prefix":"10.1016","volume":"193","author":[{"given":"Yu-Ning","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Ni","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Du-Juan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Min","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-Lei","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2023.02.005_bib1","doi-asserted-by":"crossref","unstructured":"2022 Alzheimer\u2019s disease facts and figures, 2022. Alzheimer\u2019s Dement. 18, 700\u2013789. https:\/\/doi.org\/10.1002\/alz.12638.","DOI":"10.1002\/alz.12638"},{"key":"10.1016\/j.neures.2023.02.005_bib2","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.neurobiolaging.2007.03.007","article-title":"Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: Relationship with the progression of Alzheimer\u2019s disease","volume":"29","author":"Akram","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neures.2023.02.005_bib3","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1007\/s12035-017-0798-6","article-title":"Natural dietary supplementation of anthocyanins via PI3K\/Akt\/Nrf2\/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse model of Alzheimer\u2019s disease","volume":"55","author":"Ali","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neures.2023.02.005_bib4","doi-asserted-by":"crossref","first-page":"9956","DOI":"10.1073\/pnas.94.18.9956","article-title":"Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines","volume":"94","author":"Allen","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neures.2023.02.005_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2015.06.009","article-title":"A decade from discovery to therapy: Lingo-1, the dark horse in neurological and psychiatric disorders","author":"Andrews","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neures.2023.02.005_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopsych.2010.07.024","article-title":"From reactive to proactive and selective control: developing a richer model for stopping inappropriate responses","author":"Aron","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neures.2023.02.005_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1074\/mcp.M700077-MCP200","article-title":"The in vivo brain interactome of the amyloid precursor protein","volume":"7","author":"Bai","year":"2008","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.neures.2023.02.005_bib8","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1002\/ana.25049","article-title":"Dendritic spines provide cognitive resilience against Alzheimer\u2019s disease","volume":"82","author":"Boros","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neures.2023.02.005_bib9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S1474-4422(16)30377-5","article-title":"Safety and efficacy of opicinumab in acute optic neuritis (RENEW): a randomised, placebo-controlled, phase 2 trial","volume":"16","author":"Cadavid","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neures.2023.02.005_bib10","first-page":"6","article-title":"Targeting histone K4 trimethylation for treatment of cognitive and synaptic deficits in mouse models of Alzheimer\u2019s disease","author":"Cao","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neures.2023.02.005_bib11","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3233\/JAD-171017","article-title":"Stereological investigation of the effects of treadmill running exercise on the hippocampal neurons in middle-aged APP\/PS1 transgenic mice","volume":"63","author":"Chao","year":"2018","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.neures.2023.02.005_bib12","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/35050103","article-title":"A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease","volume":"408","author":"Chen","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neures.2023.02.005_bib13","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.7150\/thno.47408","article-title":"Inhibition of miR-331-3p and miR-9-5p ameliorates Alzheimer\u2019s disease by enhancing autophagy","volume":"11","author":"Chen","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.neures.2023.02.005_bib14","doi-asserted-by":"crossref","first-page":"11551","DOI":"10.1073\/pnas.0505359102","article-title":"Mass of the postsynaptic density and enumeration of three key molecules","volume":"102","author":"Chen","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neures.2023.02.005_bib15","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1074\/mcp.D500009-MCP200","article-title":"Relative and absolute quantification of postsynaptic density proteome isolated from rat forebrain and cerebellum","volume":"5","author":"Cheng","year":"2006","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/j.neures.2023.02.005_bib16","first-page":"25796","article-title":"LINGO-1 promotes lysosomal degradation of amyloid-\u03b2 protein precursor","volume":"5","author":"de Laat","year":"2015","journal-title":"Pathobiol. Aging Age-Relat. Dis."},{"key":"10.1016\/j.neures.2023.02.005_bib17","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.7150\/thno.52436","article-title":"Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-\u03b2-induced neurotoxicity","volume":"11","author":"Deng","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.neures.2023.02.005_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/nrn.2017.170","article-title":"Mitochondria at the neuronal presynapse in health and disease","author":"Devine","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neures.2023.02.005_bib19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuron.2018.08.030","article-title":"PDGFR\u03b2 cells rapidly relay inflammatory signal from the circulatory system to neurons via chemokine CCL2","volume":"100","author":"Duan","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2023.02.005_bib20","first-page":"22","article-title":"Nlrp2 is overexpressed in spinal astrocytes at the peak of mechanical pain sensitivity during complete freund adjuvant-induced persistent pain","author":"Ducza","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neures.2023.02.005_bib21","first-page":"1","article-title":"The ONDRISeq panel: Custom-designed next-generation sequencing of genes related to neurodegeneration","author":"Farhan","year":"2016","journal-title":"npj Genom. Med."},{"key":"10.1016\/j.neures.2023.02.005_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2021.10.030","article-title":"Economic decision-making in the continuum between healthy aging and Alzheimer\u2019s disease: a systematic review of 20 years of research","author":"Fernandes","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neures.2023.02.005_bib23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.4103\/1673-5374.175048","article-title":"Lingo-1: a novel target in therapy for Alzheimer\u2019s disease?","volume":"11","author":"Fernandez-Enright","year":"2016","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.neures.2023.02.005_bib24","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1162\/jocn_a_00746","article-title":"Past makes future: role of pFC in prediction","volume":"27","author":"Fuster","year":"2015","journal-title":"J. Cogn. Neurosci."},{"key":"10.1016\/j.neures.2023.02.005_bib25","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","article-title":"Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer\u2019s disease","volume":"60","author":"Giannakopoulos","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.neures.2023.02.005_bib26","first-page":"9","article-title":"Genetic analyses of early-onset Alzheimer\u2019s disease using next generation sequencing","author":"Giau","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neures.2023.02.005_bib27","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/s41593-019-0539-4","article-title":"A single-cell atlas of entorhinal cortex from individuals with Alzheimer\u2019s disease reveals cell-type-specific gene expression regulation","volume":"22","author":"Grubman","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neures.2023.02.005_bib28","first-page":"15","article-title":"Human immunodeficiency virus type 1 (HIV-1)-mediated neuroinflammation dysregulates neurogranin and induces synaptodendritic injury","author":"Guha","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.neures.2023.02.005_bib29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1365-2818.1999.00457.x","article-title":"The efficiency of systematic sampling in stereology - reconsidered","volume":"193","author":"Gundersen","year":"1999","journal-title":"J. Microsc."},{"key":"10.1016\/j.neures.2023.02.005_bib30","first-page":"12","article-title":"Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site","author":"Hanf","year":"2020","journal-title":"MAbs"},{"key":"10.1016\/j.neures.2023.02.005_bib31","first-page":"4","article-title":"Amyloid-\u03b21-42 oligomer accelerates senescence in adult hippocampal neural stem\/progenitor cells via formylpeptide receptor 2","author":"He","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neures.2023.02.005_bib32","first-page":"156","article-title":"Anti-LINGO-1 antibody ameliorates cognitive impairment, promotes adult hippocampal neurogenesis, and increases the abundance of CB1R-rich CCK-GABAergic interneurons in AD mice","author":"He","year":"2021","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neures.2023.02.005_bib33","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/35104061","article-title":"Dentritic spines: structure, dynamics and regulation","volume":"2","author":"Hering","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neures.2023.02.005_bib34","first-page":"320","article-title":"LINGO-1 deficiency promotes nerve regeneration through reduction of cell apoptosis, inflammation, and glial scar after spinal cord injury in mice","author":"Huang","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neures.2023.02.005_bib35","doi-asserted-by":"crossref","first-page":"14430","DOI":"10.1073\/pnas.0700901104","article-title":"Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson\u2019s disease models","volume":"104","author":"Inoue","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neures.2023.02.005_bib36","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1212\/WNL.55.4.484","article-title":"Rates of hippocampal atrophy correlate with change in clinical status in aging and AD","volume":"55","author":"Jack","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.neures.2023.02.005_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/alz.12546","article-title":"APP accumulates with presynaptic proteins around amyloid plaques: a role for presynaptic mechanisms in Alzheimer\u2019s disease?","author":"Jord\u00e0-Siquier","year":"2022","journal-title":"Alzheimer\u2019s Dement"},{"key":"10.1016\/j.neures.2023.02.005_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.tins.2010.01.001","article-title":"Structural dynamics of dendritic spines in memory and cognition","author":"Kasai","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neures.2023.02.005_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41386-021-01137-9","article-title":"Development of prefrontal cortex","author":"Kolk","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neures.2023.02.005_bib40","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00401-019-02103-y","article-title":"Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer\u2019s disease","volume":"139","author":"Koper","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neures.2023.02.005_bib41","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4939-8994-2_10","article-title":"The Y-maze for assessment of spatial working and reference memory in mice","author":"Kraeuter","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.neures.2023.02.005_bib42","first-page":"11","article-title":"Amyloid-\u03b242\/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer\u2019s disease","author":"Kwak","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neures.2023.02.005_bib43","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1039\/C9AN02087J","article-title":"The search for a unique Raman signature of amyloid-beta plaques in human brain tissue from Alzheimer\u2019s disease patients","volume":"145","author":"Lochocki","year":"2020","journal-title":"Analyst"},{"key":"10.1016\/j.neures.2023.02.005_bib44","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.neuron.2008.05.025","article-title":"A role for local calcium signaling in rapid synaptic partner selection by dendritic filopodia","volume":"59","author":"Lohmann","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2023.02.005_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2012.11.001","article-title":"Association between prefrontal activity and volume change in prefrontal and medial temporal lobes in aging and dementia: a review","author":"Maillet","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.neures.2023.02.005_bib46","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer\u2019s disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.neures.2023.02.005_bib47","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1212\/WNL.0b013e3181b16431","article-title":"Regional rates of neocortical atrophy from normal aging to early Alzheimer disease","volume":"73","author":"McDonald","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neures.2023.02.005_bib48","doi-asserted-by":"crossref","DOI":"10.1002\/alz.12582","article-title":"Synaptic density and cognitive performance in Alzheimer\u2019s disease: a PET imaging study with [11C]UCB-J","author":"Mecca","year":"2022","journal-title":"Alzheimer\u2019s Dement"},{"key":"10.1016\/j.neures.2023.02.005_bib49","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nn1188","article-title":"LINGO-1 is a component of the Nogo-66 receptor\/p75 signaling complex","volume":"7","author":"Mi","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neures.2023.02.005_bib50","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41591-019-0375-9","article-title":"Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer\u2019s disease","volume":"25","author":"Moreno-Jim\u00e9nez","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.neures.2023.02.005_bib51","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.nbd.2006.12.008","article-title":"BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP\/PS1 transgenic mice","volume":"26","author":"Ohno","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neures.2023.02.005_bib52","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1124\/jpet.111.183483","article-title":"Exposure levels of anti-LINGO-1 Li81 antibody in the central nervous system and dose-efficacy relationships in rat spinal cord remyelination models after systemic administration","volume":"339","author":"Pepinsky","year":"2011","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.neures.2023.02.005_bib53","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40478-016-0285-8","article-title":"A general homeostatic principle following lesion induced dendritic remodeling","volume":"4","author":"Platschek","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.neures.2023.02.005_bib54","first-page":"5","article-title":"Anti-LINGO-1 has no detectable immunomodulatory effects in preclinical and phase 1 studies","author":"Ranger","year":"2018","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.neures.2023.02.005_bib55","article-title":"Spatially regulated adult neurogenesis","author":"Rikani","year":"2013","journal-title":"Ann. Neurosci."},{"key":"10.1016\/j.neures.2023.02.005_bib56","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1001\/archneur.58.9.1403","article-title":"Selective preservation and degeneration within the prefrontal cortex in aging and Alzheimer disease","volume":"58","author":"Salat","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neures.2023.02.005_bib57","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.biopsych.2014.12.029","article-title":"Loss of microtubule-associated protein 2 immunoreactivity linked to dendritic spine loss in schizophrenia","volume":"78","author":"Shelton","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neures.2023.02.005_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2014.05.004","article-title":"The intersection of amyloid beta and tau at synapses in Alzheimer\u2019s disease","author":"Spires-Jones","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2023.02.005_bib59","doi-asserted-by":"crossref","DOI":"10.1080\/102538900410001679310","article-title":"Hemispheric asymmetry in stress processing in rat prefrontal cortex and the role of mesocortical dopamine","author":"Sullivan","year":"2004","journal-title":"Stress"},{"key":"10.1016\/j.neures.2023.02.005_bib60","first-page":"5","article-title":"LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in experimental autoimmune encephalomyelitis mice","author":"Sun","year":"2015","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.neures.2023.02.005_bib61","article-title":"Randomized phase I trials of the safety\/tolerability of anti-LINGO-1 monoclonal antibody BIIB033","volume":"1","author":"Tran","year":"2014","journal-title":"Neurol. (R. ) Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.neures.2023.02.005_bib62","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1471-4159.2012.07671.x","article-title":"Hippocampal expression of myelin-associated inhibitors is induced with age-related cognitive decline and correlates with deficits of spatial learning and memory","volume":"121","author":"Vanguilder","year":"2012","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neures.2023.02.005_bib63","doi-asserted-by":"crossref","first-page":"10298","DOI":"10.1074\/jbc.M112.415141","article-title":"\u03922 adrenergic receptor, protein kinase a (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in alzheimer disease models","volume":"288","author":"Wang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2023.02.005_bib64","first-page":"209","article-title":"Neuronal ApoE4 stimulates C\/EBP\u03b2 activation, promoting Alzheimer\u2019s disease pathology in a mouse model","author":"Wang","year":"2022","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.neures.2023.02.005_bib65","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.neuron.2011.11.029","article-title":"The nogo receptor family restricts synapse number in the developing hippocampus","volume":"73","author":"Wills","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2023.02.005_bib66","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/cns.12809","article-title":"LINGO-1 antibody ameliorates myelin impairment and spatial memory deficits in the early stage of 5XFAD mice","volume":"24","author":"Wu","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neures.2023.02.005_bib67","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1002\/cne.25299","article-title":"Anti-LINGO-1 antibody treatment alleviates cognitive deficits and promotes maturation of oligodendrocytes in the hippocampus of APP\/PS1 mice","volume":"530","author":"Yang","year":"2022","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2023.02.005_bib68","doi-asserted-by":"crossref","DOI":"10.1038\/nrn1956","article-title":"Glial inhibition of CNS axon regeneration","author":"Yiu","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neures.2023.02.005_bib69","doi-asserted-by":"crossref","first-page":"12152","DOI":"10.1074\/jbc.M112.447771","article-title":"LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity","volume":"288","author":"Zhang","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2023.02.005_bib70","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/nature25980","article-title":"A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex","volume":"555","author":"Zhong","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.neures.2023.02.005_bib71","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/cne.25252","article-title":"Running exercise protects spinophilin-immunoreactive puncta and neurons in the medial prefrontal cortex of APP\/PS1 transgenic mice","volume":"530","author":"Zhu","year":"2022","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2023.02.005_bib72","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0896-6273(00)80283-4","article-title":"Evidence for a role of dendritic filopodia in synaptogenesis and spine formation","volume":"17","author":"Ziv","year":"1996","journal-title":"Neuron"}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010223000391?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010223000391?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:33:30Z","timestamp":1759142010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010223000391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":72,"alternative-id":["S0168010223000391"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2023.02.005","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-LINGO-1 antibody protects neurons and synapses in the medial prefrontal cortex of APP\/PS1 transgenic mice","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2023.02.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.","name":"copyright","label":"Copyright"}]}}