{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:27:00Z","timestamp":1793734020055,"version":"4.6.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.neures.2023.07.004","type":"journal-article","created":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T02:10:36Z","timestamp":1689041436000},"page":"21-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["A novel hydrogen sulfide donor reduces neuroinflammation and seizures by activating ATP-sensitive potassium channels"],"prefix":"10.1016","volume":"199","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7605-3251","authenticated-orcid":false,"given":"Qiyun","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongrui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xutao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuisheng","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2801-1217","authenticated-orcid":false,"given":"Zishu","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.neures.2023.07.004_bib1","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1172\/JCI25495","article-title":"ATP-sensitive potassium channelopathies: focus on insulin secretion","volume":"115","author":"Ashcroft","year":"2005","journal-title":"J. Clin Investig."},{"issue":"1","key":"10.1016\/j.neures.2023.07.004_bib2","doi-asserted-by":"crossref","first-page":"H262","DOI":"10.1152\/ajpheart.00857.2010","article-title":"Endosomal KATP channels as a reservoir after myocardial ischemia: a role for SUR2 subunits","volume":"300","author":"Bao","year":"2011","journal-title":"Am J. Physiol-Heart C."},{"key":"10.1016\/j.neures.2023.07.004_bib3","first-page":"12","article-title":"Hydrogen sulfide attenuated sepsis-induced myocardial dysfunction through TLR4 pathway and endoplasmic reticulum stress","author":"Chen","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neures.2023.07.004_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41419-018-0437-9","article-title":"Kir6.1\/K-ATP channel modulates microglia phenotypes: implication in Parkinson\u2019s disease","volume":"9","author":"Du","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neures.2023.07.004_bib5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.lfs.2016.11.006","article-title":"Levosimendan exerts anticonvulsant properties against PTZ-induced seizures in mice through activation of nNOS\/NO pathway: Role for KATP channel","volume":"168","author":"Gooshe","year":"2017","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.neures.2023.07.004_bib6","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.neures.2005.07.002","article-title":"Modulating effect of hydrogen sulfide on gamma-aminobutyric acid B receptor in recurrent febrile seizures in rats","volume":"53","author":"Han","year":"2005","journal-title":"Neurosci. Res."},{"issue":"2","key":"10.1016\/j.neures.2023.07.004_bib7","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bbrc.2004.12.028","article-title":"Hydrogen sulfide may improve the hippocampal damage induced by recurrent febrile seizures in rats","volume":"327","author":"Han","year":"2005","journal-title":"Biochem. Biophys. Res. Co"},{"issue":"2","key":"10.1016\/j.neures.2023.07.004_bib8","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/WNL.55.2.250","article-title":"Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy","volume":"55","author":"Henshall","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.neures.2023.07.004_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105187","article-title":"AMPK S-sulfuration contributes to H2S donors-induced AMPK phosphorylation and autophagy activation in dopaminergic cells","volume":"150","author":"Hou","year":"2021","journal-title":"Neurochem. Int."},{"issue":"1","key":"10.1016\/j.neures.2023.07.004_bib10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nrneurol.2014.207","article-title":"Microglial and macrophage polarization-new prospects for brain repair","volume":"11","author":"Hu","year":"2015","journal-title":"Nat. Rev. Neurol."},{"issue":"13","key":"10.1016\/j.neures.2023.07.004_bib11","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1001\/jama.2022.3880","article-title":"Antiseizure medications for adults with epilepsy: a review","volume":"327","author":"Kanner","year":"2022","journal-title":"JAMA-J. Am. Med. Assoc."},{"key":"10.1016\/j.neures.2023.07.004_bib12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.nbd.2018.02.002","article-title":"Seizure progression and inflammatory mediators promote pericytosis and pericyte-microglia clustering at the cerebrovasculature","volume":"113","author":"Klement","year":"2018","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.neures.2023.07.004_bib13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/iovs.62.2.3","article-title":"KATP opener attenuates diabetic-induced muller gliosis and inflammation by modulating Kir6.1 in Microglia","volume":"62","author":"Li","year":"2021","journal-title":"Investig. Ophth. Vis. Sci."},{"issue":"1","key":"10.1016\/j.neures.2023.07.004_bib14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.freeradbiomed.2009.04.014","article-title":"GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat","volume":"47","author":"Li","year":"2009","journal-title":"FREE Radic. Bio Med."},{"key":"10.1016\/j.neures.2023.07.004_bib15","first-page":"11","article-title":"Exogenous hydrogen sulfide ameliorates diabetic myocardial fibrosis by inhibiting cell aging through SIRT6\/AMPK autophagy","author":"Li","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neures.2023.07.004_bib16","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jss.2019.07.092","article-title":"Effect of hydrogen sulfide on the mitogen-activated protein kinase signaling pathway in cultured skin macrophages of burned rats","volume":"245","author":"Li","year":"2020","journal-title":"J. Surg. Res."},{"issue":"2","key":"10.1016\/j.neures.2023.07.004_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.neulet.2005.10.018","article-title":"The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells","volume":"394","author":"Liu","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neures.2023.07.004_bib18","first-page":"15","article-title":"A novel hydrogen sulfide donor reduces pilocarpine-induced status epilepticus and regulates microglial inflammatory profile","author":"Liu","year":"2021","journal-title":"Front. Cell Neurosci."},{"issue":"4","key":"10.1016\/j.neures.2023.07.004_bib19","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1007\/s11064-019-02734-3","article-title":"2-Deoxy-d-Glucose exhibits anti-seizure effects by mediating the netrin-G1-KATP signaling pathway in epilepsy","volume":"44","author":"Long","year":"2019","journal-title":"Neurochem. Res."},{"issue":"5","key":"10.1016\/j.neures.2023.07.004_bib20","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/cns.12228","article-title":"Aggravation of seizure-like events by hydrogen sulfide: involvement of multiple targets that control neuronal excitability","volume":"20","author":"Luo","year":"2014","journal-title":"CNS Neurosci. Ther."},{"issue":"3","key":"10.1016\/j.neures.2023.07.004_bib21","first-page":"283","article-title":"Expression of KATP in pulmonary artery smooth muscle cells under hypoxia-hypercapnia condition and the relationship with p38 MAPK pathway","volume":"66","author":"Ma","year":"2014","journal-title":"Sheng Li Xue Bao"},{"issue":"2","key":"10.1016\/j.neures.2023.07.004_bib22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2174\/1871527320666210119095626","article-title":"ATP-sensitive potassium channel subunits in neuroinflammation: novel drug targets in neurodegenerative disorders","volume":"21","author":"Maqoud","year":"2022","journal-title":"CNS Neurol. Disord-DR"},{"issue":"1","key":"10.1016\/j.neures.2023.07.004_bib23","first-page":"14","article-title":"Cromakalim, a potassium channel opener, ameliorates the organophosphate and carbamate-induced seizure in mice","volume":"56","author":"Ostadhadi","year":"2018","journal-title":"Acta Med. Iran."},{"issue":"12","key":"10.1016\/j.neures.2023.07.004_bib24","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1111\/cns.13265","article-title":"Rosiglitazone polarizes microglia and protects against pilocarpine\u2010induced status epilepticus","volume":"25","author":"Peng","year":"2019","journal-title":"CNS Neurosci Ther."},{"issue":"2","key":"10.1016\/j.neures.2023.07.004_bib25","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.cell.2019.08.053","article-title":"Microglia biology: one century of evolving concepts","volume":"179","author":"Prinz","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.neures.2023.07.004_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxlet.2021.05.008","article-title":"Inhibition of NLRP3 inflammasome by glibenclamide attenuated dopaminergic neurodegeneration and motor deficits in paraquat and maneb-induced mouse Parkinson\u2019s disease model","volume":"349","author":"Qiu","year":"2021","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.neures.2023.07.004_bib27","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/194546","article-title":"Targeting microglial K(ATP) channels to treat neurodegenerative diseases: a mitochondrial issue","volume":"2013","author":"Rodriguez","year":"2013","journal-title":"Oxid. Med. Cell Longev"},{"key":"10.1016\/j.neures.2023.07.004_bib28","first-page":"1","article-title":"A comprehensive review of treatments for hydrogen sulfide poisoning: past, present, and future","author":"Santana","year":"2022","journal-title":"Toxicol. Mech. Method"},{"key":"10.1016\/j.neures.2023.07.004_bib29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.eplepsyres.2016.01.003","article-title":"A role for ATP-sensitive potassium channels in the anticonvulsant effects of triamterene in mice","volume":"121","author":"Shafaroodi","year":"2016","journal-title":"Epilepsy Res."},{"issue":"3","key":"10.1016\/j.neures.2023.07.004_bib30","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1006\/bbrc.1997.7891","article-title":"Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria","volume":"241","author":"Suzuki","year":"1997","journal-title":"Biochem. Biophys. Res. Co"},{"issue":"2","key":"10.1016\/j.neures.2023.07.004_bib31","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/epi.16788","article-title":"Inflammation, ictogenesis, and epileptogenesis: an exploration through human disease","volume":"62","author":"Tan","year":"2021","journal-title":"EPILEPSIA"},{"key":"10.1016\/j.neures.2023.07.004_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107742","article-title":"Inflammation and reactive oxygen species as disease modifiers in epilepsy","volume":"167","author":"Terrone","year":"2020","journal-title":"Neuropharmacology"},{"issue":"10172","key":"10.1016\/j.neures.2023.07.004_bib33","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S0140-6736(18)32596-0","article-title":"Epilepsy in adults","volume":"393","author":"Thijs","year":"2019","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.neures.2023.07.004_bib34","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1471-4159.2010.06785.x","article-title":"KATP channel blockade protects midbrain dopamine neurons by repressing a glia-to-neuron signaling cascade that ultimately disrupts mitochondrial calcium homeostasis","volume":"114","author":"Toulorge","year":"2010","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neures.2023.07.004_bib35","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-4757-6376-8_10","article-title":"Functional role of proinhammatory and anti-inflammatory cytokines in seizures","volume":"548","author":"Vezzani","year":"2004","journal-title":"Adv. Exp. Med. Biol."},{"issue":"3","key":"10.1016\/j.neures.2023.07.004_bib36","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1177\/1535370220904342","article-title":"Hydrogen sulfide alleviates cigarette smoke-induced COPD through inhibition of the TGF-b1\/smad pathway","volume":"245","author":"Wang","year":"2020","journal-title":"EXP BIOL MED"},{"key":"10.1016\/j.neures.2023.07.004_bib37","doi-asserted-by":"crossref","first-page":"341","DOI":"10.3389\/fnmol.2018.00341","article-title":"Inflammation: a network in the pathogenesis of status epilepticus","volume":"11","author":"Wang","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.neures.2023.07.004_bib38","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1152\/physrev.00017.2011","article-title":"Physiological implications of hydrogen sulfide: a whiff exploration that blossomed","volume":"92","author":"Wang","year":"2012","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.neures.2023.07.004_bib39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12974-016-0786-1","article-title":"Inflammation in epileptogenesis after traumatic brain injury","volume":"14","author":"Webster","year":"2017","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.neures.2023.07.004_bib40","first-page":"11","article-title":"Hydrogen sulfide attenuates high-fat diet-induced non-alcoholic fatty liver disease by inhibiting apoptosis and promoting autophagy via reactive oxygen species\/phosphatidylinositol 3-Kinase\/AKT\/Mammalian target of rapamycin signaling pathway","author":"Wu","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.neures.2023.07.004_bib41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1177\/1535759719890336","article-title":"Emerging roles for microglial phagocytic signaling in epilepsy","volume":"20","author":"Wyatt-Johnson","year":"2020","journal-title":"Epilepsy Curr."},{"issue":"4","key":"10.1016\/j.neures.2023.07.004_bib42","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s11064-012-0958-z","article-title":"The antiepileptic effect of the glycolytic inhibitor 2-Deoxy-d-Glucose is mediated by upregulation of KATP channel subunits Kir6.1 and Kir6.2","volume":"38","author":"Yang","year":"2013","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neures.2023.07.004_bib43","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.bbi.2017.03.003","article-title":"Resveratrol regulates microglia M1\/M2 polarization via PGC-1\u03b1 in conditions of neuroinflammatory injury","volume":"64","author":"Yang","year":"2017","journal-title":"Brain, Behav. Immun."},{"issue":"2","key":"10.1016\/j.neures.2023.07.004_bib44","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4103\/2045-9912.208517","article-title":"Hydrogen sulfide therapy in brain diseases: from bench to bedside","volume":"7","author":"Zhang","year":"2017","journal-title":"Med. Gas Res."},{"issue":"5a","key":"10.1016\/j.neures.2023.07.004_bib45","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1111\/j.1582-4934.2007.00144.x","article-title":"Opening of microglial KATP channels inhibits rotenone-induced neuroinflammation","volume":"12","author":"Zhou","year":"2008","journal-title":"J. Cell Mol. Med."},{"issue":"5A","key":"10.1016\/j.neures.2023.07.004_bib46","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1111\/j.1582-4934.2007.00144.x","article-title":"Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation","volume":"12","author":"Zhou","year":"2008","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.neures.2023.07.004_bib47","article-title":"A novel carbazole-based hydrogen-sulfide donor suppresses seizures and upregulates ATP-sensitive potassium channels","volume":"19","author":"Zhu","year":"2020","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.neures.2023.07.004_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173959","article-title":"A hydrogen sulfide donor suppresses pentylenetetrazol-induced seizures in rats via PKC signaling","volume":"898","author":"Zhu","year":"2021","journal-title":"Eur. J. Pharmacol."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010223001396?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010223001396?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:34:39Z","timestamp":1759142079000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010223001396"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":48,"alternative-id":["S0168010223001396"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2023.07.004","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel hydrogen sulfide donor reduces neuroinflammation and seizures by activating ATP-sensitive potassium channels","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2023.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}