{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T20:29:46Z","timestamp":1747168186642,"version":"3.40.5"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T00:00:00Z","timestamp":1703030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.neures.2023.12.006","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T07:02:07Z","timestamp":1703574127000},"page":"42-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The therapeutic role of SSEA3(+) human umbilical cord blood mononuclear cells in ischemic stroke model"],"prefix":"10.1016","volume":"203","author":[{"given":"Dongjie","family":"Xiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guojun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunshan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8591-9205","authenticated-orcid":false,"given":"Hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2023.12.006_bib1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1161\/STROKEAHA.119.026589","article-title":"Intravenously transplanted human multilineage-differentiating stress-enduring cells afford brain repair in a mouse lacunar stroke model","volume":"51","author":"Abe","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.neures.2023.12.006_bib2","doi-asserted-by":"crossref","first-page":"19328","DOI":"10.18632\/oncotarget.25039","article-title":"Stress and stem cells: adult Muse cells tolerate extensive genotoxic stimuli better than mesenchymal stromal cells","volume":"9","author":"Alessio","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.neures.2023.12.006_bib3","first-page":"17","article-title":"Update on inflammatory biomarkers and treatments in ischemic stroke","author":"Bonaventura","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neures.2023.12.006_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-3-030-31206-0_3","article-title":"Hematopoietic stem and progenitor cells (HSPCs)","volume":"1201","author":"Bujko","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.neures.2023.12.006_bib5","first-page":"19","article-title":"Translational regenerative therapies for chronic spinal cord injury","author":"Dalamagkas","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neures.2023.12.006_bib6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.5966\/sctm.2013-0066","article-title":"Intravenous administration of human umbilical cord blood-derived AC133+ endothelial progenitor cells in rat stroke model reduces infarct volume: magnetic resonance imaging and histological findings","volume":"2","author":"Iskander","year":"2013","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.neures.2023.12.006_bib7","doi-asserted-by":"crossref","first-page":"250","DOI":"10.2174\/1574888X15666200124115444","article-title":"A review of evaluating hematopoietic stem cells derived from umbilical cord blood's expansion and homing","volume":"15","author":"Islami","year":"2020","journal-title":"Curr. stem Cell Res. Ther."},{"key":"10.1016\/j.neures.2023.12.006_bib8","doi-asserted-by":"crossref","first-page":"460","DOI":"10.2174\/1574888X14666190214162453","article-title":"Therapeutic potential of endothelial colony forming cells derived from human umbilical cord blood","volume":"14","author":"Jia","year":"2019","journal-title":"Curr. stem Cell Res. Ther."},{"key":"10.1016\/j.neures.2023.12.006_bib9","doi-asserted-by":"crossref","first-page":"7380","DOI":"10.3390\/ijms21197380","article-title":"Clinical trials of stem cell therapy for cerebral ischemic stroke","volume":"21","author":"Kawabori","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neures.2023.12.006_bib10","doi-asserted-by":"crossref","first-page":"8639","DOI":"10.1073\/pnas.0911647107","article-title":"Unique multipotent cells in adult human mesenchymal cell populations","volume":"107","author":"Kuroda","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neures.2023.12.006_bib11","doi-asserted-by":"crossref","first-page":"1027961","DOI":"10.3389\/fphar.2022.1027961","article-title":"Endogenous reparative pluripotent muse cells with a unique immune privilege system: hint at a new strategy for controlling acute and chronic inflammation","volume":"13","author":"Kuroda","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neures.2023.12.006_bib12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/sctm.18-0008","article-title":"Allogeneic umbilical cord blood infusion for adults with ischemic stroke: clinical outcomes from a phase I safety study","volume":"7","author":"Laskowitz","year":"2018","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.neures.2023.12.006_bib13","doi-asserted-by":"crossref","DOI":"10.1177\/09636897211067447","article-title":"Complete restoration of motor function in acute cerebral stroke treated with allogeneic human umbilical cord blood monocytes: preliminary results of a phase I clinical trial","author":"Lee","year":"2021","journal-title":"Cell Transplant."},{"key":"10.1016\/j.neures.2023.12.006_bib14","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.18632\/aging.202399","article-title":"Adipose-derived stromal cells improve functional recovery after spinal cord injury through TGF-\u03b21\/Smad3\/PLOD2 pathway activation","volume":"13","author":"Li","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.neures.2023.12.006_bib15","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1007\/s00221-023-06600-1","article-title":"Human umbilical cord blood mononuclear cells ameliorate ischemic brain injury via promoting microglia\/macrophages M2 polarization in MCAO Rats","volume":"241","author":"Li","year":"2023","journal-title":"Exp. brain Res."},{"key":"10.1016\/j.neures.2023.12.006_bib16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral Artery cclusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.neures.2023.12.006_bib17","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1002\/stem.1681","article-title":"Concise review: the surface markers and identity of human mesenchymal stem cells","volume":"32","author":"Lv","year":"2014","journal-title":"Stem Cells (Dayt., Ohio)"},{"key":"10.1016\/j.neures.2023.12.006_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13287-021-02694-y","article-title":"Optimization of human umbilical cord blood-derived mesenchymal stem cell isolation and culture methods in serum- and xeno-free conditions","volume":"13","author":"Nguyen","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.neures.2023.12.006_bib19","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3233\/JAD-190150","article-title":"Effects of transplanted umbilical cord blood mononuclear cells overexpressing GDNF on spatial memory and hippocampal synaptic proteins in a mouse model of alzheimer's disease","volume":"69","author":"Petukhova","year":"2019","journal-title":"J. Alzheimer'S. Dis. JAD"},{"key":"10.1016\/j.neures.2023.12.006_bib20","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s12264-020-00534-2","article-title":"Guidelines for acute ischemic stroke treatment","volume":"36","author":"Qiu","year":"2020","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.neures.2023.12.006_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12975-020-00841-w","article-title":"Neurogenesis after stroke: a therapeutic perspective","volume":"12","author":"Rahman","year":"2021","journal-title":"Transl. Stroke Res."},{"key":"10.1016\/j.neures.2023.12.006_bib22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.46582\/jsrm.1402011","article-title":"Intra-arterial transplantation of human umbilical cord blood mononuclear cells in sub-acute ischemic stroke increases VEGF expression in rats","volume":"14","author":"Ramli","year":"2018","journal-title":"J. stem Cells Regen. Med."},{"key":"10.1016\/j.neures.2023.12.006_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/stcltm\/szac086","article-title":"Umbilical cord blood transplantation: connecting its origin to its future","volume":"12","author":"Sanchez-Petitto","year":"2023","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.neures.2023.12.006_bib24","doi-asserted-by":"crossref","DOI":"10.1177\/0963689720923574","article-title":"A novel type of stem cells double-positive for SSEA-3 and CD45 in human peripheral blood","author":"Sato","year":"2020","journal-title":"Cell Transplant."},{"key":"10.1016\/j.neures.2023.12.006_bib25","doi-asserted-by":"crossref","first-page":"e319","DOI":"10.1016\/j.wneu.2022.02.004","article-title":"Systemic administration of allogeneic cord blood mononuclear cells in adults with severe acute contusion spinal cord injury: phase 1\/2a pilot clinical study-safety and primary efficacy evaluation","volume":"161","author":"Smirnov","year":"2022","journal-title":"World Neurosurg."},{"key":"10.1016\/j.neures.2023.12.006_bib26","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1177\/0271678X20972656","article-title":"Intravenously delivered multilineage-differentiating stress enduring cells dampen excessive glutamate metabolism and microglial activation in experimental perinatal hypoxic ischemic encephalopathy","volume":"41","author":"Suzuki","year":"2021","journal-title":"J. Cereb. Blood Flow. Metab. Off. J. Int. Soc. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.neures.2023.12.006_bib27","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neuroscience.2014.01.018","article-title":"Effects of intravenous administration of umbilical cord blood CD34(+) cells in a mouse model of neonatal stroke","volume":"263","author":"Tsuji","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.neures.2023.12.006_bib28","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/STROKEAHA.116.014950","article-title":"Human muse cells reconstruct neuronal circuitry in subacute lacunar stroke model","volume":"48","author":"Uchida","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.neures.2023.12.006_bib29","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10495-019-01556-6","article-title":"Apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins","volume":"24","author":"Uzdensky","year":"2019","journal-title":"Apoptosis: Int. J. Program. Cell death"},{"key":"10.1016\/j.neures.2023.12.006_bib30","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1089\/scd.2005.14.722","article-title":"Transplantation of a novel cell line population of umbilical cord blood stem cells ameliorates neurological deficits associated with ischemic brain injury","volume":"14","author":"Xiao","year":"2005","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.neures.2023.12.006_bib31","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1161\/CIRCRESAHA.117.311648","article-title":"S1P-S1PR2 axis mediates homing of muse cells into damaged heart for long-lasting tissue repair and functional recovery after acute myocardial infarction","volume":"122","author":"Yamada","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.neures.2023.12.006_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116009","article-title":"Therapeutic effects of human multilineage-differentiating stress enduring (MUSE) cell transplantation into infarct brain of mice","volume":"10","author":"Yamauchi","year":"2015","journal-title":"Plos One"},{"key":"10.1016\/j.neures.2023.12.006_bib33","doi-asserted-by":"crossref","first-page":"1040686","DOI":"10.3389\/fimmu.2022.1040686","article-title":"Bibliometric analysis of tumor necrosis factor in post-stroke neuroinflammation from 2003 to 2021","volume":"13","author":"Zhao","year":"2022","journal-title":"Front. Immunol."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010223002237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010223002237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T20:48:44Z","timestamp":1728938924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010223002237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":33,"alternative-id":["S0168010223002237"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2023.12.006","relation":{},"ISSN":["0168-0102"],"issn-type":[{"type":"print","value":"0168-0102"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The therapeutic role of SSEA3(+) human umbilical cord blood mononuclear cells in ischemic stroke model","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2023.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}