{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T17:49:56Z","timestamp":1788544196165,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T00:00:00Z","timestamp":1730160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2021R1F1A1051450"],"award-info":[{"award-number":["NRF-2021R1F1A1051450"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.neures.2024.10.006","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T22:23:26Z","timestamp":1730327006000},"page":"97-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Neurexin1 level in Huntington\u2019s Disease and decreased Neurexin1 in disease progression"],"prefix":"10.1016","volume":"212","author":[{"given":"Kyoungjoo","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyung Whan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2024.10.006_bib1","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1093\/brain\/awae063","article-title":"A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease","volume":"147","author":"Aldous","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.neures.2024.10.006_bib2","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12868-021-00661-0","article-title":"NRXN1alpha(+\/-) is associated with increased excitability in ASD iPSC-derived neurons","volume":"22","author":"Avazzadeh","year":"2021","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.neures.2024.10.006_bib3","doi-asserted-by":"crossref","unstructured":"Berg, M.J., Veeranna, Rosa\u00a0C.M., Kumar, A., Mohan, P.S., Stavrides, P., Marchionini, D.M., Yang, D.S., Nixon, R.A., 2024.\u00a0Pathobiology of the autophagy-lysosomal pathway in the Huntington's disease brain. bioRxiv.","DOI":"10.1101\/2024.05.29.596470"},{"key":"10.1016\/j.neures.2024.10.006_bib4","doi-asserted-by":"crossref","DOI":"10.1113\/JP286401","article-title":"Membrane trafficking of synaptic adhesion molecules","author":"Bogaciu","year":"2024","journal-title":"J. Physiol."},{"key":"10.1016\/j.neures.2024.10.006_bib5","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1016\/j.cell.2021.03.048","article-title":"Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome","volume":"184","author":"Bourdenx","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.neures.2024.10.006_bib6","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1038\/d41586-018-05173-2","article-title":"Huntington's disease","volume":"557","author":"Brody","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.neures.2024.10.006_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105582","article-title":"Regulation of neuronal autophagy and the implications in neurodegenerative diseases","volume":"162","author":"Cai","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neures.2024.10.006_bib8","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1021\/acs.biochem.1c00330","article-title":"Redefining the scope of targeted protein degradation: translational opportunities in hijacking the autophagy-lysosome pathway","volume":"62","author":"Cassidy","year":"2023","journal-title":"Biochemistry"},{"key":"10.1016\/j.neures.2024.10.006_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/cge.13537","article-title":"Phenotypic spectrum of NRXN1 mono- and bi-allelic deficiency: a systematic review","volume":"97","author":"Castronovo","year":"2020","journal-title":"Clin. Genet."},{"key":"10.1016\/j.neures.2024.10.006_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbrc.2021.04.089","article-title":"Suppressor of cytokine signaling 2 is induced in Huntington's disease and involved in autophagy","volume":"559","author":"Cho","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neures.2024.10.006_bib11","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1212\/WNL.0000000000012969","article-title":"Synaptic damage and its clinical correlates in people with early Huntington disease: a PET study","volume":"98","author":"Delva","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.neures.2024.10.006_bib12","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.neuron.2017.06.009","article-title":"Molecular mechanism of MDGA1: regulation of neuroligin 2:neurexin trans-synaptic bridges","volume":"94","author":"Gangwar","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2024.10.006_bib13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/jnr.21484","article-title":"Transsynaptic modulation of the synaptic vesicle cycle by cell-adhesion molecules","volume":"86","author":"Gottmann","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neures.2024.10.006_bib14","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.1523\/JNEUROSCI.1253-05.2006","article-title":"Structure function and splice site analysis of the synaptogenic activity of the neurexin-1 beta LNS domain","volume":"26","author":"Graf","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2024.10.006_bib15","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1056\/NEJM199405193302011","article-title":"Huntington's disease and repeating trinucleotides","volume":"330","author":"Gusella","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neures.2024.10.006_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2020.524258","article-title":"Multiple rare risk coding variants in postsynaptic density-related genes associated with schizophrenia susceptibility","volume":"11","author":"Hu","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.neures.2024.10.006_bib17","doi-asserted-by":"crossref","first-page":"29350","DOI":"10.1074\/jbc.M114.549279","article-title":"A combined transgenic proteomic analysis and regulated trafficking of neuroligin-2","volume":"289","author":"Kang","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2024.10.006_bib18","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pnpbp.2012.11.004","article-title":"Organotypic hippocampal slice culture from the adult mouse brain: a versatile tool for translational neuropsychopharmacology","volume":"41","author":"Kim","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.neures.2024.10.006_bib19","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1007\/s12035-018-1334-z","article-title":"Cellular proteostasis in neurodegeneration","volume":"56","author":"Kurtishi","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neures.2024.10.006_bib20","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1007\/s00018-006-6061-3","article-title":"The neuroligin and neurexin families: from structure to function at the synapse","volume":"63","author":"Lise","year":"2006","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neures.2024.10.006_bib21","volume":"24","author":"Loers","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neures.2024.10.006_bib22","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.tins.2016.02.002","article-title":"The autophagy-lysosomal pathway in neurodegeneration: a TFEB perspective","volume":"39","author":"Martini-Stoica","year":"2016","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neures.2024.10.006_bib23","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1523\/JNEUROSCI.0169-23.2023","article-title":"Role of neurexins in Alzheimer's disease","volume":"43","author":"Medina-Samame","year":"2023","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2024.10.006_bib24","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tins.2010.08.002","article-title":"Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease","volume":"33","author":"Milnerwood","year":"2010","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neures.2024.10.006_bib25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2014.05.032","article-title":"Impaired TrkB receptor signaling underlies corticostriatal dysfunction in Huntington's disease","volume":"83","author":"Plotkin","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2024.10.006_bib26","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1080\/15548627.2023.2235196","article-title":"LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles","volume":"19","author":"Qiao","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.neures.2024.10.006_bib27","doi-asserted-by":"crossref","first-page":"27585","DOI":"10.1074\/jbc.M114.595413","article-title":"Dystroglycan binding to alpha-neurexin competes with neurexophilin-1 and neuroligin in the brain","volume":"289","author":"Reissner","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2024.10.006_bib28","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/bpa.12426","article-title":"Huntington's disease (HD): the neuropathology of a multisystem neurodegenerative disorder of the human brain","volume":"26","author":"Rub","year":"2016","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neures.2024.10.006_bib29","doi-asserted-by":"crossref","first-page":"5345","DOI":"10.1523\/JNEUROSCI.1875-16.2017","article-title":"APLP1 is a synaptic cell adhesion molecule, supporting maintenance of dendritic spines and basal synaptic transmission","volume":"37","author":"Schilling","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neures.2024.10.006_bib30","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.neurobiolaging.2013.09.032","article-title":"Role for the neurexin-neuroligin complex in Alzheimer's disease","volume":"35","author":"Sindi","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neures.2024.10.006_bib31","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/jnc.14723","article-title":"Alterations in synaptic function and plasticity in Huntington disease","volume":"150","author":"Smith-Dijak","year":"2019","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neures.2024.10.006_bib32","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cell.2017.10.024","article-title":"Synaptic neurexin complexes: a molecular code for the logic of neural circuits","volume":"171","author":"Sudhof","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.neures.2024.10.006_bib33","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1016\/j.jmb.2019.11.012","article-title":"Lowering mutant huntingtin levels and toxicity: autophagy-endolysosome pathways in Huntington's disease","volume":"432","author":"Valionyte","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.neures.2024.10.006_bib34","doi-asserted-by":"crossref","first-page":"7436","DOI":"10.1038\/s41380-021-01190-2","article-title":"Neurexin 1 variants as risk factors for suicide death","volume":"26","author":"William","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neures.2024.10.006_bib35","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-024-04230-4","article-title":"Chaperone-mediated autophagy in brain injury: a double-edged sword with therapeutic potentials","author":"Zhang","year":"2024","journal-title":"Mol. Neurobiol."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010224001330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010224001330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T11:16:51Z","timestamp":1741087011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010224001330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":35,"alternative-id":["S0168010224001330"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2024.10.006","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurexin1 level in Huntington\u2019s Disease and decreased Neurexin1 in disease progression","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2024.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}