{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:11:18Z","timestamp":1790791878825,"version":"4.1.0"},"reference-count":115,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23wm0625001"],"award-info":[{"award-number":["JP23wm0625001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP15dm0207001"],"award-info":[{"award-number":["JP15dm0207001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP20dm0207065"],"award-info":[{"award-number":["JP20dm0207065"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["25wm0625102h0002 E.S."],"award-info":[{"award-number":["25wm0625102h0002 E.S."]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.neures.2025.104984","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T15:53:24Z","timestamp":1762617204000},"page":"104984","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Advances in non-human primate models for Alzheimer's disease research"],"prefix":"10.1016","volume":"221","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5623-0266","authenticated-orcid":false,"given":"Daisuke","family":"Joho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenya","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wakako","family":"Kumita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi C.","family":"Saido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Sasaguri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2025.104984_bib1","first-page":"339","article-title":"Aspects of common marmoset basic biology and life history important for biomedical research","volume":"53","author":"Abbott","year":"2003","journal-title":"Comp. Med."},{"key":"10.1016\/j.neures.2025.104984_bib2","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1001\/jama.2019.4782","article-title":"Diagnosis and management of dementia: review","volume":"322","author":"Arvanitakis","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.neures.2025.104984_bib3","doi-asserted-by":"crossref","first-page":"10970","DOI":"10.3390\/ijms231810970","article-title":"Genetics, functions, and clinical impact of presenilin-1 (PSEN1) gene","volume":"23","author":"Bagaria","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neures.2025.104984_bib4","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1038\/s41467-021-22624-z","article-title":"Generation of a humanized A\u03b2 expressing mouse demonstrating aspects of Alzheimer\u2019s disease-like pathology","volume":"12","author":"Baglietto-Vargas","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neures.2025.104984_bib5","first-page":"441","article-title":"Evidence for the experimental transmission of cerebral beta-amyloidosis to primates","volume":"74","author":"Baker","year":"1993","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.neures.2025.104984_bib6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1750-3639.1991.tb00661.x","article-title":"Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections","volume":"1","author":"Braak","year":"1991","journal-title":"Brain Pathol."},{"key":"10.1016\/j.neures.2025.104984_bib7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neubiorev.2008.09.002","article-title":"Default-mode brain dysfunction in mental disorders: a systematic review","volume":"33","author":"Broyd","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neures.2025.104984_bib8","doi-asserted-by":"crossref","first-page":"19762","DOI":"10.1073\/pnas.0710310104","article-title":"Other-regarding preferences in a non-human primate: Common marmosets provision food altruistically","volume":"104","author":"Burkart","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neures.2025.104984_bib9","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.1038\/ncomms5747","article-title":"The evolutionary origin of human hyper-cooperation","volume":"5","author":"Burkart","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neures.2025.104984_bib10","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jalz.2016.01.012","article-title":"Molecular genetics of early-onset Alzheimer's disease revisited","volume":"12","author":"Cacace","year":"2016","journal-title":"Alzheimer's. Dement."},{"key":"10.1016\/j.neures.2025.104984_bib11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature20412","article-title":"The road to restoring neural circuits for the treatment of Alzheimer's disease","volume":"539","author":"Canter","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.neures.2025.104984_bib12","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1212\/WNL.0b013e3182a1aafe","article-title":"Impaired default network functional connectivity in autosomal dominant Alzheimer disease","volume":"81","author":"Chhatwal","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.neures.2025.104984_bib13","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1534\/genetics.110.120717","article-title":"Targeting DNA double-strand breaks with TAL effector nucleases","volume":"186","author":"Christian","year":"2010","journal-title":"Genetics"},{"key":"10.1016\/j.neures.2025.104984_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2025.1598245","article-title":"Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders","volume":"17","author":"Colwell","year":"2025","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neures.2025.104984_bib15","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1016\/S1388-2457(01)00699-X","article-title":"Investigation of the sleep electrocorticogram of the common marmoset (Callithrix jacchus) using radiotelemetry","volume":"112","author":"Crofts","year":"2001","journal-title":"Clin. Neurophysiol."},{"key":"10.1016\/j.neures.2025.104984_bib16","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/s41593-018-0236-8","article-title":"Animal models of neurodegenerative diseases","volume":"21","author":"Dawson","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neures.2025.104984_bib17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/34910","article-title":"Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein","volume":"391","author":"De Strooper","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.neures.2025.104984_bib18","doi-asserted-by":"crossref","first-page":"0069","DOI":"10.1038\/s41559-016-0069","article-title":"The evolution and population diversity of human-specific segmental duplications","volume":"1","author":"Dennis","year":"2017","journal-title":"Nat. Ecol. Evol."},{"key":"10.1016\/j.neures.2025.104984_bib19","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","article-title":"The neuropathological diagnosis of Alzheimer\u2019s disease","volume":"14","author":"DeTure","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.neures.2025.104984_bib20","doi-asserted-by":"crossref","first-page":"W117","DOI":"10.1093\/nar\/gks608","article-title":"TAL Effector-Nucleotide Targeter (TALE-NT) 2.0: tools for TAL effector design and target prediction","volume":"40","author":"Doyle","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neures.2025.104984_bib21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3389\/fnagi.2019.00277","article-title":"Aging reduces the functional brain networks strength-a resting state fMRI study of healthy mouse brain","volume":"11","author":"Egimendia","year":"2019","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.neures.2025.104984_bib22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/imr.12896","article-title":"The role of innate immunity in Alzheimer's disease","volume":"297","author":"Ennerfelt","year":"2020","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.neures.2025.104984_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fnimg.2025.1558759","article-title":"Modeling functional connectivity with learning and memory in a mouse model of Alzheimer's disease","volume":"4","author":"Fadel","year":"2025","journal-title":"Front. Neuroimaging"},{"key":"10.1016\/j.neures.2025.104984_bib24","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1093\/ilar.52.1.78","article-title":"The development of small primate models for aging research","volume":"52","author":"Fischer","year":"2011","journal-title":"ILAR J."},{"key":"10.1016\/j.neures.2025.104984_bib25","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1126\/science.aaa1975","article-title":"Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion","volume":"347","author":"Florio","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.neures.2025.104984_bib26","series-title":"The common marmoset in captivity and biomedical research","first-page":"43","article-title":"Neuroanatomy of the marmoset","author":"Fukushima","year":"2019"},{"key":"10.1016\/j.neures.2025.104984_bib27","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/cne.25490","article-title":"Expression of tau and phosphorylated tau in the brain of normal and hemiparkinsonian rhesus macaques","volume":"531","author":"Gambardella","year":"2023","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.neures.2025.104984_bib28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s004010100429","article-title":"Amyloid-\u03b2 deposits in the cerebral cortex of the aged common marmoset (Callithrix jacchus): incidence and chemical composition","volume":"103","author":"Geula","year":"2002","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.neures.2025.104984_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/archpsyc.57.1.65","article-title":"Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia","volume":"57","author":"Glantz","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neures.2025.104984_bib30","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease","volume":"349","author":"Goate","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.neures.2025.104984_bib31","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.1132814","article-title":"A century of Alzheimer's disease","volume":"314","author":"Goedert","year":"2006","journal-title":"science"},{"key":"10.1016\/j.neures.2025.104984_bib32","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41583-018-0054-8","article-title":"Rodent models for Alzheimer disease","volume":"19","author":"G\u00f6tz","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neures.2025.104984_bib33","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nm0798-827","article-title":"Aging renders the brain vulnerable to amyloid \u03b2-protein neurotoxicity","volume":"4","author":"Guela","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.neures.2025.104984_bib34","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/ilar\/ilx033","article-title":"Nonhuman primates and translational research: progress, opportunities, and challenges","volume":"58","author":"Harding","year":"2017","journal-title":"ILAR J."},{"key":"10.1016\/j.neures.2025.104984_bib35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41597-023-02121-2","article-title":"Multi-modal brain magnetic resonance imaging database covering marmosets with a wide age range","volume":"10","author":"Hata","year":"2023","journal-title":"Sci. Data"},{"key":"10.1016\/j.neures.2025.104984_bib36","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1126\/science.abb2401","article-title":"Human-specific ARHGAP11B increases size and folding of primate neocortex in the fetal marmoset","volume":"369","author":"Heide","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.neures.2025.104984_bib37","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neures.2025.104984_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/alz.14366","article-title":"Marmosets as model systems for the study of Alzheimer's disease and related dementias: Substantiation of physiological tau 3R and 4R isoform expression and phosphorylation","volume":"21","author":"Huhe","year":"2025","journal-title":"Alzheimer's. Dement."},{"key":"10.1016\/j.neures.2025.104984_bib39","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1097\/00001756-199602290-00029","article-title":"Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease","volume":"7","author":"Hutton","year":"1996","journal-title":"Neuroreport"},{"key":"10.1016\/j.neures.2025.104984_bib40","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuron.2015.03.021","article-title":"Brains, genes, and primates","volume":"86","author":"Izpisua Belmonte","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2025.104984_bib41","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13195-024-01392-0","article-title":"A nonhuman primate model with Alzheimer\u2019s disease-like pathology induced by hippocampal overexpression of human tau","volume":"16","author":"Jiang","year":"2024","journal-title":"Alzheimer's. Res. Ther."},{"key":"10.1016\/j.neures.2025.104984_bib42","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nm.3935","article-title":"Modeling psychiatric disorders for developing effective treatments","volume":"21","author":"Kaiser","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.neures.2025.104984_bib43","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1471-4159.2007.05038.x","article-title":"Variable phenotype of Alzheimer\u2019s disease with spastic paraparesis","volume":"104","author":"Karlstrom","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neures.2025.104984_bib44","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S1474-4422(20)30231-3","article-title":"Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches","volume":"19","author":"Kellar","year":"2020","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neures.2025.104984_bib45","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/dgd.12109","article-title":"Common marmoset as a new model animal for neuroscience research and genome editing technology","volume":"56","author":"Kishi","year":"2014","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.neures.2025.104984_bib46","doi-asserted-by":"crossref","DOI":"10.3791\/58980","article-title":"Chronic implantation of whole-cortical electrocorticographic array in the common marmoset","author":"Komatsu","year":"2019","journal-title":"J. Vis. Exp. (JoVE)"},{"key":"10.1016\/j.neures.2025.104984_bib47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer's disease","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.neures.2025.104984_bib48","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3233\/JAD-130746","article-title":"Presenilin-1 mutations in Alzheimer's disease: an update on genotype-phenotype relationships","volume":"37","author":"Larner","year":"2013","journal-title":"J. Alzheimer\u2019S. Dis."},{"key":"10.1016\/j.neures.2025.104984_bib49","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.nbd.2017.04.020","article-title":"Deletion of exons 9 and 10 of the Presenilin 1 gene in a patient with Early-onset Alzheimer Disease generates longer amyloid seeds","volume":"104","author":"Le Guennec","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.neures.2025.104984_bib50","doi-asserted-by":"crossref","first-page":"17169","DOI":"10.1073\/pnas.0708228104","article-title":"Diminished adult neurogenesis in the marmoset brain precedes old age","volume":"104","author":"Leuner","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neures.2025.104984_bib51","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer's disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.neures.2025.104984_bib52","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1038\/s41467-019-09813-7","article-title":"Anatomical and functional investigation of the marmoset default mode network","volume":"10","author":"Liu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neures.2025.104984_bib53","first-page":"369","article-title":"Clinical care and diseases of the common marmoset (Callithrix jacchus)","volume":"53","author":"Ludlage","year":"2003","journal-title":"Comp. Med."},{"key":"10.1016\/j.neures.2025.104984_bib54","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/s007020070060","article-title":"Naturally occurring and experimentally induced \u03b2-amyloid deposits in the brains of marmosets (Callithrix jacchus)","volume":"107","author":"Maclean","year":"2000","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neures.2025.104984_bib55","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1038\/s41380-024-02779-z","article-title":"Aging-dependent loss of functional connectivity in a mouse model of Alzheimer's disease and reversal by mGluR5 modulator","volume":"30","author":"Mandino","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neures.2025.104984_bib56","first-page":"383","article-title":"Marmoset models commonly used in biomedical research","volume":"53","author":"Mansfield","year":"2003","journal-title":"Comp. Med."},{"key":"10.1016\/j.neures.2025.104984_bib57","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neuron.2016.03.018","article-title":"Marmosets: a neuroscientific model of human social behavior","volume":"90","author":"Miller","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2025.104984_bib58","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s10522-012-9388-1","article-title":"Life span of common marmoset (Callithrix jacchus) at CLEA Japan breeding colony","volume":"13","author":"Nishijima","year":"2012","journal-title":"Biogerontology"},{"key":"10.1016\/j.neures.2025.104984_bib59","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-neuro-030520-101844","article-title":"Current status of and perspectives on the application of marmosets in neurobiology","volume":"44","author":"Okano","year":"2021","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neures.2025.104984_bib60","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1146\/annurev-neuro-030520-101844","article-title":"Current status of and perspectives on the application of marmosets in neurobiology","volume":"44","author":"Okano","year":"2021","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.neures.2025.104984_bib61","first-page":"336","article-title":"The common marmoset as a novel animal model system for biomedical and neuroscience research applications","volume":"17","author":"Okano","year":"2012"},{"key":"10.1016\/j.neures.2025.104984_bib62","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.neuron.2016.10.018","article-title":"Brain\/MINDS: a Japanese national brain project for marmoset neuroscience","volume":"92","author":"Okano","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2025.104984_bib63","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s42003-024-05873-8","article-title":"Longitudinal monitoring of the mouse brain reveals heterogenous network trajectories during aging","volume":"7","author":"Ozalay","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.neures.2025.104984_bib64","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/ilar\/ilab002","article-title":"Assisted reproductive techniques and genetic manipulation in the common marmoset","volume":"61","author":"Park","year":"2020","journal-title":"ILAR J."},{"key":"10.1016\/j.neures.2025.104984_bib65","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.tins.2023.02.002","article-title":"The common marmoset as a model of neurodegeneration","volume":"46","author":"Perez-Cruz","year":"2023","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neures.2025.104984_bib66","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00001756-199512000-00071","article-title":"A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene","volume":"7","author":"Perez-Tur","year":"1995","journal-title":"Neuroreport"},{"key":"10.1016\/j.neures.2025.104984_bib67","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/JAD-160673","article-title":"Acceleration of amyloidosis by inflammation in the amyloid-beta marmoset monkey model of Alzheimer\u2019s disease","volume":"55","author":"Philippens","year":"2016","journal-title":"J. Alzheimer\u2019S. Dis."},{"key":"10.1016\/j.neures.2025.104984_bib68","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1121\/1.2225899","article-title":"Acoustic analysis of vocal development in a New World primate, the common marmoset (Callithrix jacchus)","volume":"120","author":"Pistorio","year":"2006","journal-title":"J. Acoust. Soc. Am."},{"key":"10.1016\/j.neures.2025.104984_bib69","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/13383","article-title":"Alzheimer disease PS-1 exon 9 deletion defined","volume":"5","author":"Prihar","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.neures.2025.104984_bib70","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1073\/pnas.98.2.676","article-title":"A default mode of brain function","volume":"98","author":"Raichle","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neures.2025.104984_bib71","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s00702-005-0385-2","article-title":"Very long term studies of the seeding of \u03b2-amyloidosis in primates","volume":"113","author":"Ridley","year":"2006","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neures.2025.104984_bib72","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3389\/fnagi.2016.00315","article-title":"Evidence of tau hyperphosphorylation and dystrophic microglia in the common marmoset","volume":"8","author":"Rodriguez-Callejas","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neures.2025.104984_bib73","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3389\/fnins.2020.00716","article-title":"Systems biology approaches to understand the host\u2013microbiome interactions in neurodegenerative diseases","volume":"14","author":"Rosario","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neures.2025.104984_bib74","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3233\/NHA-180046","article-title":"Aging research using the common marmoset: Focus on aging interventions","volume":"5","author":"Ross","year":"2019","journal-title":"Nutr. Healthy Aging"},{"key":"10.1016\/j.neures.2025.104984_bib75","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/35014735","article-title":"Presenilin-1 mutations in Alzheimer's disease","volume":"405","author":"Russo","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.neures.2025.104984_bib76","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nn.3697","article-title":"Single App knock-in mouse models of Alzheimer's disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neures.2025.104984_bib77","first-page":"32758","article-title":"Moving toward \u2018common\u2019use of the marmoset as a non-human primate aging model","volume":"6","author":"Salmon","year":"2016","journal-title":"Pathobiol. Aging AgeRelat. Dis."},{"key":"10.1016\/j.neures.2025.104984_bib78","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s00018-023-05031-z","article-title":"Mistranslation-associated perturbations of proteostasis do not promote accumulation of amyloid beta and plaque deposition in aged mouse brain","volume":"80","author":"Santhosh Kumar","year":"2023","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neures.2025.104984_bib79","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.15252\/embj.201797397","article-title":"APP mouse models for Alzheimer's disease preclinical studies","volume":"36","author":"Sasaguri","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.neures.2025.104984_bib80","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.15252\/embj.201797397","article-title":"APP mouse models for Alzheimer's disease preclinical studies","volume":"36","author":"Sasaguri","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.neures.2025.104984_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.807473","article-title":"Recent advances in the modeling of Alzheimer\u2019s disease","volume":"16","author":"Sasaguri","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neures.2025.104984_bib82","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature08090","article-title":"Generation of transgenic non-human primates with germline transmission","volume":"459","author":"Sasaki","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.neures.2025.104984_bib83","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature08090","article-title":"Generation of transgenic non-human primates with germline transmission","volume":"459","author":"Sasaki","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.neures.2025.104984_bib84","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.stem.2016.06.003","article-title":"Generation of a nonhuman primate model of severe combined immunodeficiency using highly efficient genome editing","volume":"19","author":"Sato","year":"2016","journal-title":"Cell stem Cell"},{"key":"10.1016\/j.neures.2025.104984_bib85","first-page":"1","article-title":"Production of a heterozygous exon skipping model of common marmosets using gene-editing technology","author":"Sato","year":"2024","journal-title":"Lab Anim."},{"key":"10.1016\/j.neures.2025.104984_bib86","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","article-title":"Alzheimer's disease","volume":"388","author":"Scheltens","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.neures.2025.104984_bib87","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/S0140-6736(20)32205-4","article-title":"Alzheimer's disease","volume":"397","author":"Scheltens","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.neures.2025.104984_bib88","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3233\/JAD-191081","article-title":"Generation of transgenic cynomolgus monkeys overexpressing the gene for amyloid-beta precursor protein","volume":"75","author":"Seita","year":"2020","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neures.2025.104984_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2025.110390","article-title":"Development of a non-invasive novel individual marmoset holder for evaluation by awake functional magnetic resonance brain imaging","volume":"417","author":"Seki","year":"2025","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neures.2025.104984_bib90","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1126\/science.275.5300.630","article-title":"Alzheimer's disease: genotypes, phenotypes, and treatments","volume":"275","author":"Selkoe","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.neures.2025.104984_bib91","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1152\/physrev.2001.81.2.741","article-title":"Alzheimer's disease: genes, proteins, and therapy","volume":"81","author":"Selkoe","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neures.2025.104984_bib92","doi-asserted-by":"crossref","first-page":"11433","DOI":"10.1074\/jbc.RA119.008415","article-title":"Tau isoform expression and phosphorylation in marmoset brains","volume":"294","author":"Sharma","year":"2019","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neures.2025.104984_bib93","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neures.2025.104984_bib94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2017.10.009","article-title":"Digital gene atlas of neonate common marmoset brain","volume":"128","author":"Shimogori","year":"2018","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.neures.2025.104984_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2021.113320","article-title":"Alzheimer\u2019s disease and its treatment by different approaches: a review","volume":"216","author":"Srivastava","year":"2021","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.neures.2025.104984_bib96","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/NEN.0b013e31819f1d24","article-title":"Clinical, pathological, and immunologic aspects of the multiple sclerosis model in common marmosets (Callithrix jacchus)","volume":"68","author":"'t Hart","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neures.2025.104984_bib97","first-page":"364","article-title":"Reproduction in captive common marmosets (Callithrix jacchus)","volume":"53","author":"Tardif","year":"2003","journal-title":"Comp. Med."},{"key":"10.1016\/j.neures.2025.104984_bib98","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/ilar.52.1.54","article-title":"The marmoset as a model of aging and age-related diseases","volume":"52","author":"Tardif","year":"2011","journal-title":"ILAR J."},{"key":"10.1016\/j.neures.2025.104984_bib99","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.5665\/SLEEP.1174","article-title":"REM sleep behavior disorder in the marmoset MPTP model of early Parkinson disease","volume":"34","author":"Verhave","year":"2011","journal-title":"Sleep"},{"key":"10.1016\/j.neures.2025.104984_bib100","doi-asserted-by":"crossref","first-page":"17763","DOI":"10.1073\/pnas.1010461107","article-title":"Spatial correlation between brain aerobic glycolysis and amyloid-\u03b2 (A\u03b2) deposition","volume":"107","author":"Vlassenko","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neures.2025.104984_bib101","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1016\/j.neuron.2023.04.028","article-title":"Local and long-distance organization of prefrontal cortex circuits in the marmoset brain","volume":"111","author":"Watakabe","year":"2023","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2025.104984_bib102","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1474-4422(16)00062-4","article-title":"Defeating Alzheimer's disease and other dementias: a priority for European science and society","volume":"15","author":"Winblad","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neures.2025.104984_bib103","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/19077","article-title":"Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and \u03b3-secretase activity","volume":"398","author":"Wolfe","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.neures.2025.104984_bib104","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00429-020-02073-y","article-title":"The NanoZoomer artificial intelligence connectomics pipeline for tracer injection studies of the marmoset brain","volume":"225","author":"Woodward","year":"2020","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.neures.2025.104984_bib105","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.coph.2021.06.004","article-title":"Functional visualization and manipulation in the marmoset brain using viral vectors","volume":"60","author":"Yamamori","year":"2021","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.neures.2025.104984_bib106","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1468-5884.2009.00398.x","article-title":"Marmosets as a next-generation model of comparative cognition","volume":"51","author":"Yamazaki","year":"2009","journal-title":"Jpn. Psychol. Res."},{"key":"10.1016\/j.neures.2025.104984_bib107","doi-asserted-by":"crossref","first-page":"8417","DOI":"10.3390\/ijms24098417","article-title":"Presenilin-1 (PSEN1) mutations: clinical phenotypes beyond Alzheimer\u2019s disease","volume":"24","author":"Yang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neures.2025.104984_bib108","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.912995","article-title":"Mouse models of Alzheimer\u2019s disease","volume":"15","author":"Yokoyama","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neures.2025.104984_bib109","article-title":"Development of a noninvasive olfactory stimulation fMRI system in marmosets","volume":"14","author":"Yurimoto","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neures.2025.104984_bib110","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s42003-024-05864-9","article-title":"Development of a 3D tracking system for multiple marmosets under free-moving conditions","volume":"7","author":"Yurimoto","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.neures.2025.104984_bib111","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1212\/WNL.0000000000003391","article-title":"Gram-negative bacterial molecules associate with Alzheimer disease pathology","volume":"87","author":"Zhan","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.neures.2025.104984_bib112","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3389\/fnagi.2018.00042","article-title":"Lipopolysaccharide associates with amyloid plaques, neurons and oligodendrocytes in Alzheimer\u2019s disease brain: a review","volume":"10","author":"Zhan","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.neures.2025.104984_bib113","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.ymthe.2019.01.014","article-title":"Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9","volume":"27","author":"Zhang","year":"2019","journal-title":"Mol. Ther."},{"key":"10.1016\/j.neures.2025.104984_bib114","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jneuroim.2008.09.017","article-title":"Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)","volume":"206","author":"Zhang","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neures.2025.104984_bib115","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3389\/fcimb.2017.00318","article-title":"Secretory products of the human GI tract microbiome and their potential impact on Alzheimer's disease (AD): detection of lipopolysaccharide (LPS) in AD hippocampus","volume":"7","author":"Zhao","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010225001671?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010225001671?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T00:14:50Z","timestamp":1777508090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010225001671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":115,"alternative-id":["S0168010225001671"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2025.104984","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances in non-human primate models for Alzheimer's disease research","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2025.104984","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104984"}}