{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:39:42Z","timestamp":1791686382906,"version":"4.3.4"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005286","name":"Canon Foundation in Europe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24bm1123047"],"award-info":[{"award-number":["JP24bm1123047"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23bm1223013"],"award-info":[{"award-number":["JP23bm1223013"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JPMH24FC1008"],"award-info":[{"award-number":["JPMH24FC1008"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24fm0208101"],"award-info":[{"award-number":["JP24fm0208101"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24wm0625501"],"award-info":[{"award-number":["JP24wm0625501"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24wm0625501 \\u3000 JP23bm1423012"],"award-info":[{"award-number":["JP24wm0625501 \\u3000 JP23bm1423012"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23dk0207066"],"award-info":[{"award-number":["JP23dk0207066"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23bm1423014"],"award-info":[{"award-number":["JP23bm1423014"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24wm0625201"],"award-info":[{"award-number":["JP24wm0625201"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23bm1323001"],"award-info":[{"award-number":["JP23bm1323001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23bm1423012"],"award-info":[{"award-number":["JP23bm1423012"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.neures.2025.104985","type":"journal-article","created":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T10:26:11Z","timestamp":1762597571000},"page":"104985","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Drug discovery research with iPSC models of neurodegenerative diseases"],"prefix":"10.1016","volume":"222","author":[{"given":"Masahiro","family":"Adachi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Banno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhisa","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2025.104985_bib1","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1038\/s41467-020-14815-x","article-title":"Optogenetic modulation of TDP-43 oligomerization accelerates ALS-related pathologies in the spinal motor neurons","volume":"11","author":"Asakawa","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neures.2025.104985_bib2","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.3390\/cells13141207","article-title":"APOE4 increases energy metabolism in APOE-Isogenic iPSC-derived neurons","volume":"13","author":"Budny","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.neures.2025.104985_bib3","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1093\/brain\/awae168","article-title":"Failure of C9orf72 sense repeat-targeting antisense oligonucleotides: lessons learned and the path forward","volume":"147","author":"Cammack","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.neures.2025.104985_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuron.2011.09.011","article-title":"Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS","volume":"72","author":"DeJesus-Hernandez","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2025.104985_bib5","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S1474-4422(24)00216-3","article-title":"Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study","volume":"23","author":"van den Berg","year":"2024","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neures.2025.104985_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3004052","article-title":"Drug screening for ALS using patient-specific induced pluripotent stem cells","volume":"4","author":"Egawa","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neures.2025.104985_bib7","doi-asserted-by":"crossref","first-page":"7988","DOI":"10.1038\/s41598-022-12133-4","article-title":"TDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2","volume":"12","author":"Egawa","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neures.2025.104985_bib8","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/s41591-018-0140-5","article-title":"Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent","volume":"24","author":"Fujimori","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.neures.2025.104985_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adq6077","article-title":"Loss of intracellular ATP affects axoplasmic viscosity and pathological protein aggregation in mammalian neurons","volume":"11","author":"Guillaud","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neures.2025.104985_bib10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.neures.2025.104985_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.patter.2020.100140","article-title":"Prediction of compound bioactivities using heat-diffusion equation","volume":"1","author":"Hidaka","year":"2020","journal-title":"Patterns"},{"key":"10.1016\/j.neures.2025.104985_bib12","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1093\/brain\/aww237","article-title":"Exosome secretion is a key pathway for clearance of pathological TDP-43","volume":"139","author":"Iguchi","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.neures.2025.104985_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf3962","article-title":"The Src\/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis","volume":"9","author":"Imamura","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.neures.2025.104985_bib14","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/ana.26047","article-title":"Prediction model of amyotrophic lateral sclerosis by deep learning with patient induced pluripotent stem cells","volume":"89","author":"Imamura","year":"2021","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neures.2025.104985_bib15","article-title":"Safety and tolerability of bosutinib in patients with amyotrophic lateral sclerosis (iDReAM study): a multicentre, open-label, dose-escalation phase 1 trial","volume":"25","author":"Imamura","year":"2022","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.neures.2025.104985_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-082142","article-title":"Protocol for a phase 2 study of bosutinib for amyotrophic lateral sclerosis using real-world data: induced pluripotent stem cell-based drug repurposing for amyotrophic lateral sclerosis medicine (iDReAM) study","volume":"14","author":"Imamura","year":"2024","journal-title":"BMJ Open"},{"key":"10.1016\/j.neures.2025.104985_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejcb.2025.151484","article-title":"iPSC screening identifies CACNA2D2 as a potential therapeutic target for FTLD-Tau","volume":"104","author":"Imamura","year":"2025","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.neures.2025.104985_bib18","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/embj.201387098","article-title":"iPS cells: a game changer for future medicine","volume":"33","author":"Inoue","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.neures.2025.104985_bib19","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.celrep.2017.01.013","article-title":"Altered tau isoform ratio caused by loss of FUS and SFPQ function leads to FTLD-like phenotypes","volume":"18","author":"Ishigaki","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.neures.2025.104985_bib20","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41582-024-00988-2","article-title":"Multifaceted roles of APOE in Alzheimer disease","volume":"20","author":"Jackson","year":"2024","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neures.2025.104985_bib21","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202301254R","article-title":"The ketone body \u03b2-hydroxybutyrate shifts microglial metabolism and suppresses amyloid-\u03b2 oligomer-induced inflammation in human microglia","volume":"37","author":"Jin","year":"2023","journal-title":"FASEB J."},{"key":"10.1016\/j.neures.2025.104985_bib22","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer's disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neures.2025.104985_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.70046","article-title":"Alzheimer's disease and frontotemporal dementia: a review of pathophysiology and therapeutic approaches","volume":"103","author":"Kelliny","year":"2025","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.neures.2025.104985_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.neulet.2009.06.014","article-title":"SORL1 is genetically associated with Alzheimer disease in a Japanese population","volume":"461","author":"Kimura","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neures.2025.104985_bib25","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1016\/j.celrep.2017.10.109","article-title":"iPSC-Based Compound Screening and In Vitro Trials Identify a Synergistic Anti-amyloid \u03b2 Combination for Alzheimer's Disease","volume":"21","author":"Kondo","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.neures.2025.104985_bib26","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-051343","volume":"11","author":"Kondo","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.neures.2025.104985_bib27","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1038\/s41598-022-06513-z","article-title":"Metabolites of soil microorganisms modulate amyloid \u03b2 production in Alzheimer's neurons","volume":"12","author":"Kondo","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neures.2025.104985_bib28","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/s43587-021-00158-9","article-title":"Dissection of the polygenic architecture of neuronal A\u03b2 production using a large sample of individual iPSC lines derived from Alzheimer's disease patients","volume":"2","author":"Kondo","year":"2022","journal-title":"Nat. Aging"},{"key":"10.1016\/j.neures.2025.104985_bib29","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1001\/jamaneurol.2022.1113","article-title":"TDP-43 accumulation within intramuscular nerve bundles of patients with amyotrophic lateral sclerosis","volume":"79","author":"Kurashige","year":"2022","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neures.2025.104985_bib30","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1126\/science.1166066","article-title":"Mutations in the FUS\/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis","volume":"323","author":"Kwiatkowski","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neures.2025.104985_bib31","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.neuron.2024.12.016","article-title":"CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions","volume":"113","author":"Li","year":"2025","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2025.104985_bib32","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.omtn.2022.04.007","article-title":"Preclinical evaluation of WVE-004, aninvestigational stereopure oligonucleotide forthe treatment of C9orf72-associated ALS or FTD","volume":"20","author":"Liu","year":"2022","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.neures.2025.104985_bib33","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkaf253","article-title":"High-throughput screen of 100 000 small molecules in C9ORF72 ALS neurons identifies spliceosome modulators that mobilize G4C2 repeat RNA into nuclear export and repeat associated non-canonical translation","volume":"53","author":"Luteijn","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neures.2025.104985_bib34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature08971","article-title":"Mutations of optineurin in amyotrophic lateral sclerosis","volume":"465","author":"Maruyama","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.neures.2025.104985_bib35","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcae101","article-title":"Morphological profiling in human neural progenitor cells classifies hits in a pilot drug screen for Alzheimer's disease","volume":"6","author":"McDiarmid","year":"2024","journal-title":"Brain Commun."},{"key":"10.1016\/j.neures.2025.104985_bib36","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.stem.2023.04.017","article-title":"Phase 1\/2a clinical trial in ALS with ropinirole, a drug candidate identified by iPSC drug discovery","volume":"30","author":"Morimoto","year":"2023","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.neures.2025.104985_bib37","doi-asserted-by":"crossref","first-page":"7575","DOI":"10.1038\/s41467-023-43293-0","article-title":"Small molecule regulators of microRNAs identified by high-throughput screen coupled with high-throughput sequencing","volume":"14","author":"Nguyen","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neures.2025.104985_bib38","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18214","article-title":"Induced pluripotent stem cell-based assays recapture multiple properties of human astrocytes","volume":"28","author":"Nonaka","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.neures.2025.104985_bib39","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13041-020-0561-1","article-title":"Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs","volume":"13","author":"Onodera","year":"2020","journal-title":"Mol. Brain"},{"key":"10.1016\/j.neures.2025.104985_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aat5847","article-title":"Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons","volume":"4","author":"Osaki","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.neures.2025.104985_bib41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.neures.2025.104985_bib42","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.neures.2025.104985_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-16871-3","article-title":"Cellular analysis of SOD1 protein-aggregation propensity and toxicity: a case of ALS with slow progression harboring homozygous SOD1-D92G mutation","volume":"12","author":"Sawamura","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neures.2025.104985_bib44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrd.2016.245","article-title":"Induced pluripotent stem cell technology: a decade of progress","volume":"16","author":"Shi","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.neures.2025.104985_bib45","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/gtc.13010","article-title":"Alterations of ATG4A and LC3B in neurons derived from Alzheimer's disease patients","volume":"28","author":"Shirotani","year":"2023","journal-title":"Genes Cells"},{"key":"10.1016\/j.neures.2025.104985_bib46","doi-asserted-by":"crossref","DOI":"10.1172\/JCI165523","article-title":"Galectin-3 aggravates microglial activation and tau transmission in tauopathy","volume":"134","author":"Siew","year":"2024","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.neures.2025.104985_bib47","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13041-024-01086-6","article-title":"Mutant \u03b1-synuclein causes death of human cortical neurons via ERK1\/2 and JNK activation","volume":"17","author":"Suzuki","year":"2024","journal-title":"Mol. Brain"},{"issue":"126","key":"10.1016\/j.neures.2025.104985_bib48","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"2006","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.neures.2025.104985_bib49","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.3390\/cimb45060290","article-title":"Neural differentiation of induced pluripotent stem cells for a xenogeneic material-free 3D neurological disease model neurulation from pluripotent cells using a human hydrogel","volume":"45","author":"Valerio","year":"2023","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.neures.2025.104985_bib50","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1165942","article-title":"Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6","volume":"323","author":"Vance","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.neures.2025.104985_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2014.03.019","article-title":"Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons","volume":"7","author":"Wainger","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.neures.2025.104985_bib52","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1001\/jamaneurol.2020.4300","article-title":"Effect of ezogabine on cortical and spinal motor neuron excitability in amyotrophic lateral sclerosis: a randomized clinical trial","volume":"78","author":"Wainger","year":"2021","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neures.2025.104985_bib53","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3233\/JAD-240625","article-title":"Degradation of amyloid-\u03b2 species by multi-copper oxidases","volume":"101","author":"Yang","year":"2024","journal-title":"J. Alzheimers Dis."},{"issue":"147","key":"10.1016\/j.neures.2025.104985_bib54","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1093\/brain\/awad361","article-title":"Extracellular vesicle proteome unveils cathepsin B connection to Alzheimer's disease pathogenesis","volume":"1","author":"Yuyama","year":"2024","journal-title":"Brain"},{"key":"10.1016\/j.neures.2025.104985_bib55","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.immuni.2025.02.024","article-title":"Single-cell transcriptomic and functional studies identify glial state changes and a role for inflammatory RIPK1 signaling in ALS pathogenesis","volume":"58","author":"Zelic","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.neures.2025.104985_bib56","doi-asserted-by":"crossref","first-page":"3644","DOI":"10.1038\/s41380-024-02629-y","article-title":"iPSC-derived hindbrain organoids to evaluate escitalopram oxalate treatment responses targeting neuropsychiatric symptoms in Alzheimer's disease","volume":"29","author":"Zivko","year":"2024","journal-title":"Mol. Psychiatry"}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010225001683?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010225001683?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T14:31:13Z","timestamp":1773844273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010225001683"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":56,"alternative-id":["S0168010225001683"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2025.104985","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Drug discovery research with iPSC models of neurodegenerative diseases","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2025.104985","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104985"}}