{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T23:07:01Z","timestamp":1794438421758,"version":"4.9.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","award":["tsqnz20230634"],"award-info":[{"award-number":["tsqnz20230634"]}],"id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012620","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31971060"],"award-info":[{"award-number":["31971060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200939"],"award-info":[{"award-number":["32200939"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.neures.2025.105008","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T16:06:09Z","timestamp":1765641969000},"page":"105008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Inhibition of calcium-sensing receptors improves intestinal motility in obese mice through enteric neurons and vagal center"],"prefix":"10.1016","volume":"223","author":[{"given":"Zigan","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrong","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neures.2025.105008_bib1","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s12038-014-9474-4","article-title":"Effects of nitric oxide modulating activities on development of enteric nervous system mediated gut motility in chick embryo model","volume":"39","author":"Arab","year":"2014","journal-title":"J. Biosci."},{"key":"10.1016\/j.neures.2025.105008_bib2","doi-asserted-by":"crossref","unstructured":"Auteri, M., Zizzo, M.G., Amato, A., Serio, R., 2016. Dopamine induces inhibitory effects on the circular muscle contractility of mouse distal colon via D1- and D2-like receptors. 73: pp. 395-404.","DOI":"10.1007\/s13105-017-0566-0"},{"key":"10.1016\/j.neures.2025.105008_bib3","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1523\/JNEUROSCI.0419-22.2022","article-title":"Interactions between brainstem neurons that regulate the motility to the stomach","volume":"42","author":"Bellusci","year":"2022","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.neures.2025.105008_bib4","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1023\/A:1012750723644","article-title":"Control of irritable bowel syndrome with polyamine analogs: a structure-activity study","volume":"46","author":"Bergeron","year":"2001","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.neures.2025.105008_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1566-0702(00)00215-0","article-title":"Functional and chemical anatomy of the afferent vagal system","volume":"85","author":"Berthoud","year":"2000","journal-title":"Aut. Neurosci. Basic Clin."},{"key":"10.1016\/j.neures.2025.105008_bib6","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2174\/138920109787847484","article-title":"Regulation of cellular signal transduction pathways by the extracellular calcium-sensing receptor","volume":"10","author":"Brennan","year":"2009","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.neures.2025.105008_bib7","doi-asserted-by":"crossref","first-page":"G60","DOI":"10.1152\/ajpgi.00425.2011","article-title":"Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system","volume":"303","author":"Cheng","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.neures.2025.105008_bib8","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1016\/j.febslet.2014.05.007","article-title":"Epithelial CaSR deficiency alters intestinal integrity and promotes proinflammatory immune responses","volume":"588","author":"Cheng","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.neures.2025.105008_bib9","doi-asserted-by":"crossref","first-page":"11247","DOI":"10.1096\/fj.201900858R","article-title":"Slowed gastric emptying and improved oral glucose tolerance produced by a nanomolar-potency inhibitor of calcium-activated chloride channel TMEM16A","volume":"33","author":"Cil","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.neures.2025.105008_bib10","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.beem.2013.05.010","article-title":"Calcium-sensing receptor (CaSR): pharmacological properties and signaling pathways","volume":"27","author":"Conigrave","year":"2013","journal-title":"Best. Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.neures.2025.105008_bib11","doi-asserted-by":"crossref","first-page":"G1084","DOI":"10.1152\/ajpgi.00571.2004","article-title":"The calcium-sensing receptor acts as a modulator of gastric acid secretion in freshly isolated human gastric glands","volume":"289","author":"Dufner","year":"2005","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.neures.2025.105008_bib12","article-title":"L-phenylalanine increased gut hormone secretion through calcium-sensing receptor in the porcine duodenum","volume":"9","author":"Feng","year":"2019","journal-title":"Anim. Open Access J. MDPI"},{"key":"10.1016\/j.neures.2025.105008_bib13","doi-asserted-by":"crossref","first-page":"17791","DOI":"10.1073\/pnas.1009078107","article-title":"Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion","volume":"107","author":"Feng","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neures.2025.105008_bib14","doi-asserted-by":"crossref","first-page":"721","DOI":"10.17235\/reed.2016.4058\/2015","article-title":"Mechanisms responsible for neuromuscular relaxation in the gastrointestinal tract","volume":"108","author":"Gallego","year":"2016","journal-title":"Rev. Esp. De. Enferm. Dig."},{"key":"10.1016\/j.neures.2025.105008_bib15","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1053\/j.gastro.2006.11.002","article-title":"The serotonin signaling system: from basic understanding to drug development for functional GI disorders","volume":"132","author":"Gershon","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neures.2025.105008_bib16","doi-asserted-by":"crossref","first-page":"F1047","DOI":"10.1152\/ajprenal.00230.2016","article-title":"A model of calcium homeostasis in the rat","volume":"311","author":"Granjon","year":"2016","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.neures.2025.105008_bib17","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.ejphar.2016.10.008","article-title":"The calcilytics Calhex-231 and NPS 2143 and the calcimimetic Calindol reduce vascular reactivity via inhibition of voltage-gated Ca(2+) channels","volume":"791","author":"Greenberg","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neures.2025.105008_bib18","doi-asserted-by":"crossref","first-page":"11926","DOI":"10.1039\/D1FO01988K","article-title":"Calcium-sensing receptor (CaSR) agonist R568 inhibits small intestinal motility of mice through neural and non-neural mechanisms","volume":"12","author":"Guo","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.neures.2025.105008_bib19","article-title":"Regulation of the central amygdala on intestinal motility and behavior via the lateral hypothalamus in irritable bowel syndrome model mice","volume":"35","author":"He","year":"2023","journal-title":"Neurogastroenterol. Motil. Off. J. Eur. Gastrointest. Motil. Soc."},{"key":"10.1016\/j.neures.2025.105008_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202200245","article-title":"Activation of calcium-sensing receptor in the area postrema inhibits food intake via glutamatergic and GABAergic signaling pathways","volume":"66","author":"Huang","year":"2022","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.neures.2025.105008_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1159\/000526455","article-title":"Effect of calcium-sensitive receptor agonist R568 on gastric motility and the underlying mechanism","volume":"113","author":"Jin","year":"2023","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neures.2025.105008_bib22","article-title":"Inhibition of calcium-sensing receptor by its antagonist promotes gastrointestinal motility in a Parkinson's disease mouse model","volume":"174","author":"Li","year":"2024","journal-title":"Biomed. Pharmacother. = Biomedecine Pharmacother."},{"key":"10.1016\/j.neures.2025.105008_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.521","article-title":"The calcium-sensing receptor: a novel target for treatment and prophylaxis of neratinib-induced diarrhea","volume":"7","author":"Lysyy","year":"2019","journal-title":"Pharmacol. Res. Perspect."},{"key":"10.1016\/j.neures.2025.105008_bib24","doi-asserted-by":"crossref","first-page":"10437","DOI":"10.1021\/acs.jafc.5b03812","article-title":"Anti-inflammatory effects of poly-L-lysine in intestinal mucosal system mediated by calcium-sensing receptor activation","volume":"63","author":"Mine","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.neures.2025.105008_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810984","article-title":"Unhealthy diets induce distinct and regional effects on intestinal inflammatory signalling pathways and long-lasting metabolic dysfunction in rats","volume":"23","author":"Nogueira","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neures.2025.105008_bib26","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1172\/JCI119413","article-title":"Expression of the calcium-sensing receptor on human antral gastrin cells in culture","volume":"99","author":"Ray","year":"1997","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.neures.2025.105008_bib27","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.pharep.2017.01.034","article-title":"Activity of the calcium-sensing receptor influences blood glucose and insulin levels in rats","volume":"69","author":"Rybczy\u0144ska","year":"2017","journal-title":"Pharmacol. Rep. PR"},{"key":"10.1016\/j.neures.2025.105008_bib28","first-page":"245","article-title":"The extracellular calcium-sensing receptor in the intestine: evidence for regulation of colonic absorption, secretion, motility, and immunity","volume":"7","author":"Tang","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neures.2025.105008_bib29","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrgastro.2016.76","article-title":"Vagal neurocircuitry and its influence on gastric motility","volume":"13","author":"Travagli","year":"2016","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.neures.2025.105008_bib30","article-title":"Calcium sensing receptor protects high glucose-induced energy metabolism disorder via blocking gp78-ubiquitin proteasome pathway","volume":"8","author":"Wang","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.neures.2025.105008_bib31","doi-asserted-by":"crossref","first-page":"643","DOI":"10.3389\/fphys.2020.00643","article-title":"Dissecting the role of subtypes of gastrointestinal vagal afferents","volume":"11","author":"Wang","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.neures.2025.105008_bib32","first-page":"407","article-title":"Dopamine receptor D1 mediates the inhibition of dopamine on the distal colonic motility","volume":"159","author":"Zhang","year":"2012","journal-title":"Transl. Res. J. Lab. Clin. Med."},{"key":"10.1016\/j.neures.2025.105008_bib33","article-title":"Increased colonic motility in a rat model of irritable bowel syndrome is associated with up-regulation of L-type calcium channels in colonic smooth muscle cells","volume":"22","author":"Zhang","year":"2010","journal-title":"Neurogastroenterol. Motil. Off. J. Eur. Gastrointest. Motil. Soc."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010225001919?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010225001919?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:44:49Z","timestamp":1773924289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010225001919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":33,"alternative-id":["S0168010225001919"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2025.105008","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of calcium-sensing receptors improves intestinal motility in obese mice through enteric neurons and vagal center","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2025.105008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105008"}}