{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:59:12Z","timestamp":1791467952760,"version":"4.3.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004484","name":"Tehran University of Medical Sciences and Health Services","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004484","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004887","name":"Tehran University of Medical Sciences The Institute of Pharmaceutical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004887","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neuroscience Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.neures.2026.105117","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:03:54Z","timestamp":1789023834000},"page":"105117","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Psilocybin restores spatial memory but not fronto-hippocampal synchrony in a rat model of Alzheimer's disease"],"prefix":"10.1016","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-2586-1937","authenticated-orcid":false,"given":"Mersedeh","family":"Shamsedin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.neures.2026.105117_bib1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.neuron.2012.03.023","article-title":"Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment","volume":"74","author":"Bakker","year":"2012","journal-title":"Neuron"},{"issue":"5896","key":"10.1016\/j.neures.2026.105117_bib2","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1126\/science.1162844","article-title":"Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease","volume":"321","author":"Busche","year":"2008","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.neures.2026.105117_bib3","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1073\/pnas.1119598109","article-title":"Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin","volume":"109","author":"Carhart-Harris","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"8011","key":"10.1016\/j.neures.2026.105117_bib4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/s41586-024-07309-z","article-title":"Control of working memory by phase-amplitude coupling of human hippocampal neurons","volume":"629","author":"Daume","year":"2024","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.neures.2026.105117_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data","volume":"31","author":"Ennaceur","year":"1988","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.neures.2026.105117_bib6","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3233\/JAD-220508","article-title":"Systematic review of EEG coherence in Alzheimer\u2019s disease","volume":"91","author":"Fischer","year":"2023","journal-title":"J. Alzheimer\u2019S. Dis."},{"issue":"3","key":"10.1016\/j.neures.2026.105117_bib7","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1007\/s12035-015-9132-3","article-title":"Intracerebroventricular Streptozotocin Injections as a Model of Alzheimer\u2019s Disease: in Search of a Relevant Mechanism","volume":"53","author":"Grieb","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"5580","key":"10.1016\/j.neures.2026.105117_bib8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"issue":"1-2","key":"10.1016\/j.neures.2026.105117_bib9","first-page":"59","article-title":"Effects of active constituents of Crocus sativus L., crocin on streptozocin-induced model of sporadic Alzheimer's disease in male rats","volume":"14","author":"Khalili","year":"2010","journal-title":"Iran. Biomed. J."},{"issue":"7","key":"10.1016\/j.neures.2026.105117_bib10","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1007\/s00213-024-06644-3","article-title":"Unraveling psilocybin\u2019s therapeutic potential: behavioral and neuroplasticity insights in Wistar-Kyoto and Wistar male rat models of treatment-resistant depression","volume":"242","author":"Kolasa","year":"2025","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neures.2026.105117_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.neuroscience.2014.12.032","article-title":"Local N-methyl-d-aspartate receptor antagonism in the prefrontal cortex attenuates spatial cognitive deficits induced by gonadectomy in adult male rats","volume":"288","author":"Locklear","year":"2015","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.neures.2026.105117_bib12","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/j.celrep.2018.05.022","article-title":"Psychedelics Promote Structural and Functional Neural Plasticity","volume":"23","author":"Ly","year":"2018","journal-title":"Cell. Rep."},{"key":"10.1016\/j.neures.2026.105117_bib13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neuroscience.2015.06.050","article-title":"Cognitive impairment and morphological changes in the dorsal hippocampus of very old female rats","volume":"303","author":"Morel","year":"2015","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.neures.2026.105117_bib14","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","article-title":"Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease","volume":"55","author":"Palop","year":"2007","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.neures.2026.105117_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","article-title":"Forced swimming test in mice: a review of antidepressant activity","volume":"177","author":"Petit-Demouliere","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.neures.2026.105117_bib16","article-title":"Type-2 diabetes alters hippocampal neural oscillations and disrupts synchrony between hippocampus and cortex","author":"Rabiller","year":"2023","journal-title":"bioRxiv"},{"issue":"42","key":"10.1016\/j.neures.2026.105117_bib17","doi-asserted-by":"crossref","first-page":"E2895","DOI":"10.1073\/pnas.1121081109","article-title":"Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer\u2019s disease model","volume":"109","author":"Sanchez","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.neures.2026.105117_bib18","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1136\/jnnp.20.1.11","article-title":"Loss of recent memory after bilateral hippocampal lesions","volume":"20","author":"Scoville","year":"1957","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"8087","key":"10.1016\/j.neures.2026.105117_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-025-09671-y","article-title":"Publisher Correction: Psilocybin's lasting action requires pyramidal cell types and 5-HT2A receptors","volume":"646","author":"Shao","year":"2025","journal-title":"Nature"},{"issue":"8023","key":"10.1016\/j.neures.2026.105117_bib20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-024-07624-5","article-title":"Psilocybin desynchronizes the human brain","volume":"632","author":"Siegel","year":"2024","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.neures.2026.105117_bib21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41398-025-03308-4","article-title":"Intravenous psilocybin induces dose-dependent changes in functional network organization in rat cortex","volume":"15","author":"Silverstein","year":"2025","journal-title":"Transl. Psychiatry"},{"issue":"7","key":"10.1016\/j.neures.2026.105117_bib22","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1177\/02698811221092508","article-title":"Neural mechanisms underlying psilocybin's therapeutic potential - the need for preclinical in vivo electrophysiology","volume":"36","author":"Smausz","year":"2022","journal-title":"J. Psychopharmacol."},{"issue":"12","key":"10.1016\/j.neures.2026.105117_bib23","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1212\/WNL.58.12.1791","article-title":"Phases of A beta-deposition in the human brain and its relevance for the development of AD","volume":"58","author":"Thal","year":"2002","journal-title":"Neurology"},{"issue":"6633","key":"10.1016\/j.neures.2026.105117_bib24","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1126\/science.adf0435","article-title":"Psychedelics promote neuroplasticity through the activation of intracellular 5-HT2A receptors","volume":"379","author":"Vargas","year":"2023","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.neures.2026.105117_bib25","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s00702-018-1928-7","article-title":"Intracerebroventricular streptozotocin induces impaired Barnes maze spatial memory and reduces astrocyte branching in the CA1 and CA3 hippocampal regions","volume":"125","author":"Zappa Villar","year":"2018","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neures.2026.105117_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1420601","article-title":"Psilocybin for the treatment of Alzheimer\u2019s disease","volume":"18","author":"Zheng","year":"2024","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.neures.2026.105117_bib27","doi-asserted-by":"crossref","first-page":"5380","DOI":"10.1038\/s41598-019-41851-5","article-title":"Impaired hippocampal-cortical coupling but preserved local synchrony during sleep in APP\/PS1 mice modeling Alzheimer\u2019s disease","volume":"9","author":"Zhurakovskaya","year":"2019","journal-title":"Sci. Rep."}],"container-title":["Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010226001045?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0168010226001045?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:17:03Z","timestamp":1791465423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0168010226001045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":27,"alternative-id":["S0168010226001045"],"URL":"https:\/\/doi.org\/10.1016\/j.neures.2026.105117","relation":{},"ISSN":["0168-0102"],"issn-type":[{"value":"0168-0102","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Psilocybin restores spatial memory but not fronto-hippocampal synchrony in a rat model of Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Neuroscience Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neures.2026.105117","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105117"}}