{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:42:52Z","timestamp":1758123772472},"reference-count":101,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2007,9]]},"DOI":"10.1016\/j.neuro.2007.02.013","type":"journal-article","created":{"date-parts":[[2007,3,13]],"date-time":"2007-03-13T10:02:54Z","timestamp":1173780174000},"page":"979-987","source":"Crossref","is-referenced-by-count":15,"title":["Gene expression profiling of MPP+-treated MN9D cells: A mechanism of toxicity study"],"prefix":"10.1016","volume":"28","author":[{"given":"Jianyong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengjun","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen M.","family":"Duhart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tucker A.","family":"Patterson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed F.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2007.02.013_bib1","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/0140-6736(91)92989-F","article-title":"Parkinson's disease: pathophysiology","volume":"337","author":"Agid","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.neuro.2007.02.013_bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/syn.890180105","article-title":"MPTP-induced oxidative stress and neurotoxicity are age-dependent: evidence from measures of reactive oxygen species and striatal dopamine levels","volume":"18","author":"Ali","year":"1994","journal-title":"Synapse"},{"key":"10.1016\/j.neuro.2007.02.013_bib3","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S0092-8674(00)81694-3","article-title":"IkappaB-NF-kappaB structures: at the interface of inflammation control","volume":"95","author":"Baeuerle","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.neuro.2007.02.013_bib4","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0006-2952(02)01174-7","article-title":"Glutathione, iron and Parkinson's disease","volume":"64","author":"Bharath","year":"2002","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.neuro.2007.02.013_bib5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0301-0082(01)00003-X","article-title":"Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease","volume":"65","author":"Blum","year":"2001","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.neuro.2007.02.013_bib6","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1073\/pnas.80.14.4546","article-title":"A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"80","author":"Burns","year":"1983","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuro.2007.02.013_bib7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF02740692","article-title":"Neurotoxicity, drugs and abuse, and the CuZn-superoxide dismutase transgenic mice","volume":"11","author":"Cadet","year":"1995","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuro.2007.02.013_bib8","first-page":"98","article-title":"Quantitative analysis of phosphoproteins in a Parkinson's disease model using phosphoprotein isotope-coded solid-phase tags","volume":"1","author":"Cawthon","year":"2005","journal-title":"Int J Neuroprotec Neuroregen"},{"key":"10.1016\/j.neuro.2007.02.013_bib9","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/0006-291X(84)91293-2","article-title":"Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase","volume":"120","author":"Chiba","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuro.2007.02.013_bib10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1749-6632.1994.tb21786.x","article-title":"In vivo generation of hydroxyl radicals and MPTP-induced dopaminergic toxicity in the basal ganglia","volume":"738","author":"Chiueh","year":"1994","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.neuro.2007.02.013_bib11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0006-8993(91)90661-E","article-title":"Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cell fusion","volume":"552","author":"Choi","year":"1991","journal-title":"Brain Res"},{"key":"10.1016\/j.neuro.2007.02.013_bib12","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1006\/exnr.1999.7133","article-title":"Characterization of MPP(+)-induced cell death in a dopaminergic neuronal cell line: role of macromolecule synthesis, cytosolic calcium, caspase, and Bcl-2-related proteins","volume":"159","author":"Choi","year":"1999","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuro.2007.02.013_bib13","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1111\/j.1471-4159.2005.03329.x","article-title":"Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells","volume":"94","author":"Chu","year":"2005","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2007.02.013_bib14","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1471-4159.1992.tb09789.x","article-title":"Irreversible inhibition of mitochondrial complex I by 1-methyl-4-phenylpyridinium: evidence for free radical involvement","volume":"58","author":"Cleeter","year":"1992","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2007.02.013_bib15","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson's disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuro.2007.02.013_bib16","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/35104560","article-title":"Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signaling","volume":"414","author":"De Smaele","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.neuro.2007.02.013_bib17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1089\/152308603322110896","article-title":"Peroxynitrite and mitochondrial dysfunction in the pathogenesis of Parkinson's disease","volume":"5","author":"Ebadi","year":"2003","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.neuro.2007.02.013_bib18","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1002\/ana.410320616","article-title":"The oxidant stress hypothesis in Parkinson's disease: evidence supporting it","volume":"32","author":"Fahn","year":"1992","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuro.2007.02.013_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(03)00201-0","article-title":"Parkin: a multipurpose neuroprotective agent?","volume":"38","author":"Feany","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuro.2007.02.013_bib20","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0006-8993(92)91334-B","article-title":"Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study","volume":"593","author":"Good","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.neuro.2007.02.013_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0006-8993(01)02572-0","article-title":"Neuroprotective effects of an adenoviral vector expressing the glucose transporter: a detailed description of the mediating cellular events","volume":"908","author":"Gupta","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.neuro.2007.02.013_bib22","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1523\/JNEUROSCI.23-12-05069.2003","article-title":"Caspase-dependent and -independent cell death pathways in primary cultures of mesencephalic dopaminergic neurons after neurotoxin treatment","volume":"23","author":"Han","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuro.2007.02.013_bib23","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/0006-291X(90)90498-C","article-title":"1-Methyl-4-phenylpyridinium (MPP+) induces NADH-dependent superoxide formation and enhances NADH-dependent lipid peroxidation in bovine heart submitochondrial particles","volume":"170","author":"Hasegawa","year":"1990","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuro.2007.02.013_bib24","first-page":"176","article-title":"Multimerin: a bench-to-bedside chronology of a unique platelet and endothelial cell protein\u2014from discovery to function to abnormalities in disease","volume":"20","author":"Hayward","year":"1997","journal-title":"Clin Invest Med"},{"key":"10.1016\/j.neuro.2007.02.013_bib25","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1126\/science.6610213","article-title":"Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice","volume":"224","author":"Heikkila","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.neuro.2007.02.013_bib26","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.2741\/heizmann","article-title":"S100 proteins: structure, functions and pathology","volume":"7","author":"Heizmann","year":"2002","journal-title":"Front Biosci"},{"key":"10.1016\/j.neuro.2007.02.013_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/jnr.20294","article-title":"Lactate transport and transporters: general principles and functional roles in brain cells","volume":"79","author":"Hertz","year":"2005","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuro.2007.02.013_bib28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1471-4159.1991.tb08170.x","article-title":"Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis","volume":"56","author":"Hirsch","year":"1991","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2007.02.013_bib29","doi-asserted-by":"crossref","first-page":"4515","DOI":"10.1046\/j.1432-1033.2003.03846.x","article-title":"Oxygen tension regulates the expression of a group of procollagen hydroxylases","volume":"270","author":"Hofbauer","year":"2003","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.neuro.2007.02.013_bib30","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0378-4274(98)00231-8","article-title":"Reduced levels of catalase activity potentiate MPP+-induced toxicity: comparison between MN9D cells and CHO cells","volume":"104","author":"Hussain","year":"1999","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.neuro.2007.02.013_bib31","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1016\/S0092-8674(01)00407-X","article-title":"An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin","volume":"105","author":"Imai","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.neuro.2007.02.013_bib32","doi-asserted-by":"crossref","first-page":"35661","DOI":"10.1074\/jbc.C000447200","article-title":"Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity","volume":"275","author":"Imai","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuro.2007.02.013_bib33","doi-asserted-by":"crossref","first-page":"29106","DOI":"10.1074\/jbc.M302763200","article-title":"Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1","volume":"278","author":"Ito","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuro.2007.02.013_bib34","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0028-3908(98)00067-7","article-title":"Effect of melatonin on methamphetamine- and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurotoxicity and methamphetamine-induced behavioral sensitization","volume":"37","author":"Itzhak","year":"1998","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuro.2007.02.013_bib35","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1073\/pnas.82.7.2173","article-title":"Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity","volume":"82","author":"Javitch","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuro.2007.02.013_bib36","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.4049\/jimmunol.164.12.6287","article-title":"Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function","volume":"164","author":"Junn","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.neuro.2007.02.013_bib37","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni0302-221","article-title":"NF-kB at the crossroads of life and death","volume":"3","author":"Karin","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.neuro.2007.02.013_bib38","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1006\/bbrc.2001.5446","article-title":"MPP(+) downregulates mitochondrially encoded gene transcripts and their activities in dopaminergic neuronal cells: protective role of Bcl-2","volume":"286","author":"Kim","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuro.2007.02.013_bib39","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s100489900083","article-title":"Progress in the clinical and molecular genetics of familial parkinsonism","volume":"2","author":"Kitada","year":"2000","journal-title":"Neurogenetics"},{"key":"10.1016\/j.neuro.2007.02.013_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/JNEUROSCI.20-01-00001.2000","article-title":"Mice deficient in cellular glutathione peroxidase show increased vulnerability to malonate, 3-nitropropionic acid, and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine","volume":"20","author":"Klivenyi","year":"2000","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuro.2007.02.013_bib41","doi-asserted-by":"crossref","first-page":"13502","DOI":"10.1073\/pnas.0501902102","article-title":"Cooperative interaction of Angiopoietin-like proteins 1 and 2 in zebrafish vascular development","volume":"102","author":"Kubota","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.neuro.2007.02.013_bib42","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1126\/science.6823561","article-title":"Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis","volume":"219","author":"Langston","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.neuro.2007.02.013_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/s1016-8478(23)12896-2","article-title":"Regulation of BNIP3 in normal and cancer cells","volume":"21","author":"Lee","year":"2006","journal-title":"Mol Cells"},{"key":"10.1016\/j.neuro.2007.02.013_bib44","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ccr.2005.06.015","article-title":"Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer","volume":"8","author":"Lee","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.neuro.2007.02.013_bib45","doi-asserted-by":"crossref","first-page":"15168","DOI":"10.1021\/bi062188q","article-title":"Ankyrin repeat: a unique motif mediating protein-protein interactions","volume":"45","author":"Li","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuro.2007.02.013_bib46","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1523\/JNEUROSCI.19-04-01284.1999","article-title":"Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons","volume":"19","author":"Lotharius","year":"1999","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuro.2007.02.013_bib47","doi-asserted-by":"crossref","first-page":"6708","DOI":"10.1158\/0008-5472.CAN-05-2732","article-title":"Sustained expression of early growth response protein-1 blocks angiogenesis and tumor growth","volume":"66","author":"Lucerna","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.neuro.2007.02.013_bib48","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1006\/nbdi.2001.0387","article-title":"Microarray applications in neuroscience","volume":"8","author":"Luo","year":"2001","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuro.2007.02.013_bib49","doi-asserted-by":"crossref","first-page":"25427","DOI":"10.1074\/jbc.273.39.25427","article-title":"Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB","volume":"273","author":"Malek","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuro.2007.02.013_bib50","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0006-8993(00)02926-7","article-title":"DNA damage in brain mitochondria caused by aging and MPTP treatment","volume":"885","author":"Mandavilli","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.neuro.2007.02.013_bib51","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1046\/j.1471-4159.2000.740443.x","article-title":"Roles of nuclear factor kappaB in neuronal survival and plasticity","volume":"74","author":"Mattson","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2007.02.013_bib52","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neurobiolaging.2005.08.012","article-title":"Protein aggregation in the pathogenesis of familial and sporadic Parkinson's disease","volume":"27","author":"McNaught","year":"2006","journal-title":"Neurobiol Aging"},{"issue":"S5","key":"10.1016\/j.neuro.2007.02.013_bib53","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0893-133X(01)00316-5","article-title":"A commentary on the neurobiology of the hypocretin\/orexin system","volume":"25","author":"Mignot","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuro.2007.02.013_bib54","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/nn1230","article-title":"Progress in the use of microarray technology to study the neurobiology of disease","volume":"7","author":"Mirnics","year":"2004","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuro.2007.02.013_bib55","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1111\/j.1471-4159.1987.tb05737.x","article-title":"Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenylpyridinium ion on activities of the enzymes in the electron transport system in mouse brain","volume":"48","author":"Mizuno","year":"1987","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2007.02.013_bib56","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/ana.20064","article-title":"Pael-R is accumulated in Lewy bodies of Parkinson's disease","volume":"55","author":"Murakami","year":"2004","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuro.2007.02.013_bib57","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/glia.10225","article-title":"Expression of S-100 protein is related to neuronal damage in MPTP-treated mice","volume":"42","author":"Muramatsu","year":"2003","journal-title":"Glia"},{"key":"10.1016\/j.neuro.2007.02.013_bib58","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/0024-3205(85)90146-8","article-title":"Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine","volume":"36","author":"Nicklas","year":"1985","journal-title":"Life Sci"},{"key":"10.1016\/j.neuro.2007.02.013_bib59","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0300-483X(00)00311-5","article-title":"Cell death induced by MPTP, a substrate for monoamine oxidase B","volume":"153","author":"Nicotra","year":"2000","journal-title":"Toxicology"},{"key":"10.1016\/j.neuro.2007.02.013_bib60","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0892-0362(02)00213-1","article-title":"Apoptotic molecules and MPTP-induced cell death","volume":"24","author":"Nicotra","year":"2002","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.neuro.2007.02.013_bib61","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1179\/135100001101536427","article-title":"Regulatory roles of thioredoxin in oxidative stress-induced cellular responses","volume":"6","author":"Nishinaka","year":"2001","journal-title":"Redox Rep"},{"key":"10.1016\/j.neuro.2007.02.013_bib62","doi-asserted-by":"crossref","first-page":"21645","DOI":"10.1074\/jbc.274.31.21645","article-title":"Identification of thioredoxin-binding protein-2\/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression","volume":"274","author":"Nishiyama","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuro.2007.02.013_bib63","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/15216540252774739","article-title":"Redox regulation by thioredoxin and thioredoxin-binding proteins","volume":"52","author":"Nishiyama","year":"2001","journal-title":"IUBMB Life"},{"key":"10.1016\/j.neuro.2007.02.013_bib64","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0304-3940(02)00068-X","article-title":"Sequence conservation between mouse and human synphilin-1","volume":"322","author":"O\u2019Farrell","year":"2002","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuro.2007.02.013_bib65","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/nbdi.1995.0017","article-title":"Overexpression of Bcl-2 attenuates MPP+, but not 6-ODHA, induced cell death in a dopaminergic neuronal cell line","volume":"2","author":"Oh","year":"1995","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuro.2007.02.013_bib66","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.neuro.22.1.123","article-title":"Etiology and pathogenesis of Parkinson's disease","volume":"22","author":"Olanow","year":"1999","journal-title":"Ann Rev Neurosci"},{"key":"10.1016\/j.neuro.2007.02.013_bib67","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neulet.2004.03.072","article-title":"Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease","volume":"363","author":"Park","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuro.2007.02.013_bib68","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0304-3940(98)00343-7","article-title":"Cysteine dioxygenase: regional expression of activity in rat brain","volume":"248","author":"Parsons","year":"1998","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuro.2007.02.013_bib69","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3940(85)90229-0","article-title":"Partial protection from the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by four different antioxidants in the mouse","volume":"60","author":"Perry","year":"1985","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuro.2007.02.013_bib70","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/79690","article-title":"A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains","volume":"6","author":"Peyron","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.neuro.2007.02.013_bib71","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1523\/JNEUROSCI.12-05-01658.1992","article-title":"Transgenic mice with increased Cu\/Zn-superoxide dismutase activity are resistant to N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity","volume":"12","author":"Przedborski","year":"1992","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuro.2007.02.013_bib72","first-page":"135","article-title":"The parkinsonian toxin MPTP: action and mechanism","volume":"16","author":"Przedborski","year":"2000","journal-title":"Restor Neurol Neurosci"},{"key":"10.1016\/j.neuro.2007.02.013_bib73","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1212\/01.WNL.0000142424.65251.DB","article-title":"A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache","volume":"63","author":"Rainero","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neuro.2007.02.013_bib74","first-page":"369","article-title":"The aetiology of idiopathic Parkinson's disease","volume":"54","author":"Ramsden","year":"2001","journal-title":"Mol Pathol"},{"key":"10.1016\/j.neuro.2007.02.013_bib75","doi-asserted-by":"crossref","first-page":"4573","DOI":"10.1016\/0006-2952(88)90674-0","article-title":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and free radicals in vitro","volume":"37","author":"Rossetti","year":"1988","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.neuro.2007.02.013_bib76","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1021\/tx980036t","article-title":"Iron- and manganese-catalyzed autoxidation of dopamine in the presence of l-cysteine: possible insights into iron- and manganese-mediated dopaminergic neurotoxicity","volume":"11","author":"Shen","year":"1998","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.neuro.2007.02.013_bib77","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s007020070045","article-title":"Oxidative metabolites of 5-S-cysteinyldopamine inhibit the alpha-ketoglutarate dehydrogenase complex: possible relevance to the pathogenesis of Parkinson's disease","volume":"107","author":"Shen","year":"2000","journal-title":"J Neural Transm"},{"key":"10.1016\/j.neuro.2007.02.013_bib78","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1021\/tx960145c","article-title":"Oxidation of dopamine in the presence of cysteine: characterization of new toxic products","volume":"10","author":"Shen","year":"1997","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.neuro.2007.02.013_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.1987.tb03384.x","article-title":"Biochemical events in the development of parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"49","author":"Singer","year":"1987","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2007.02.013_bib80","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0892-0362(02)00222-2","article-title":"MPTP: insights into parkinsonian neurodegeneration","volume":"24","author":"Speciale","year":"2002","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.neuro.2007.02.013_bib81","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1007\/s00702-004-0203-2","article-title":"Dopamine transporter: involvement in selective dopaminergic neurotoxicity and degeneration","volume":"111","author":"Storch","year":"2004","journal-title":"J Neural Transm"},{"issue":"S2","key":"10.1016\/j.neuro.2007.02.013_bib82","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1186\/1471-2105-7-S2-S23","article-title":"GOFFA: Gene ontology for functional analysis\u2014a FDA gene ontology tool for analysis of genomic and proteomic data","volume":"7","author":"Sun","year":"2006","journal-title":"BMC Bioinform"},{"key":"10.1016\/j.neuro.2007.02.013_bib83","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1080\/10715760000301361","article-title":"Redox regulation by thioredoxin superfamily; protection against oxidative stress and aging","volume":"33","author":"Tanaka","year":"2000","journal-title":"Free Radic Res"},{"issue":"S3","key":"10.1016\/j.neuro.2007.02.013_bib84","first-page":"25","article-title":"Pael receptor, endoplasmic reticulum stress, and Parkinson's disease","volume":"25","author":"Takahashi","year":"2003","journal-title":"J Neurol"},{"key":"10.1016\/j.neuro.2007.02.013_bib85","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1002\/dvdy.20851","article-title":"Roles of jumonji and jumonji family genes in chromatin regulation and development","volume":"235","author":"Takeuchi","year":"2006","journal-title":"Dev Dyn"},{"key":"10.1016\/j.neuro.2007.02.013_bib86","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.mrfmmm.2003.12.024","article-title":"Development of public toxicogenomics software for microarray data management and analysis","volume":"549","author":"Tong","year":"2004","journal-title":"Mutat Res"},{"key":"10.1016\/j.neuro.2007.02.013_bib87","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/(SICI)1098-1136(199709)21:1<2::AID-GLIA2>3.0.CO;2-C","article-title":"Glucose transporter proteins in brain: delivery of glucose to neurons and glia","volume":"21","author":"Vannucci","year":"1997","journal-title":"Glia"},{"key":"10.1016\/j.neuro.2007.02.013_bib88","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1258\/000456303321016141","article-title":"Brain-specific proteins in cerebrospinal fluid for the diagnosis of neurodegenerative diseases","volume":"40","author":"Verbeek","year":"2003","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/j.neuro.2007.02.013_bib89","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/1531-8249(200004)47:4<521::AID-ANA18>3.0.CO;2-B","article-title":"Synphilin-1 is present in Lewy bodies in Parkinson's disease","volume":"47","author":"Wakabayashi","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuro.2007.02.013_bib90","first-page":"17","article-title":"Mechanisms of MPTP toxicity and their implications for therapy of Parkinson's disease","volume":"11","author":"Watanabe","year":"2005","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.neuro.2007.02.013_bib91","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.yjmcc.2004.11.007","article-title":"BNip3 and signal-specific programmed death in the heart","volume":"38","author":"Webster","year":"2005","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.neuro.2007.02.013_bib92","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1089\/15230860152542916","article-title":"Oxidation of zinc finger transcription factors: physiological consequences","volume":"3","author":"Webster","year":"2001","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.neuro.2007.02.013_bib93","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1021\/tx990170t","article-title":"Oxidative metabolites of 5-S-cysteinylnorepinephrine are irreversible inhibitors of mitochondrial complex I and the alpha-ketoglutarate dehydrogenase and pyruvate dehydrogenase complexes: possible implications for neurodegenerative brain disorders","volume":"13","author":"Xin","year":"2000","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.neuro.2007.02.013_bib94","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.neuro.2004.12.008","article-title":"Selective alterations of transcription factors in MPP+-induced neurotoxicity in PC12 cells","volume":"26","author":"Xu","year":"2005","journal-title":"Neurotoxicology"},{"issue":"S2","key":"10.1016\/j.neuro.2007.02.013_bib95","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1186\/1471-2105-6-S2-S8","article-title":"A microarray study of MPP+-treated PC12 Cells: mechanisms of toxicity (MOT) analysis using bioinformatics tools","volume":"6","author":"Xu","year":"2005","journal-title":"BMC Bioinform"},{"key":"10.1016\/j.neuro.2007.02.013_bib96","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.2741\/1772","article-title":"Basic helix-loop-helix transcription factors, BHLHB2 and BHLHB3; their gene expressions are regulated by multiple extracellular stimuli","volume":"10","author":"Yamada","year":"2005","journal-title":"Front Biosci"},{"key":"10.1016\/j.neuro.2007.02.013_bib97","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0896-6273(03)00143-0","article-title":"Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila","volume":"37","author":"Yang","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.neuro.2007.02.013_bib98","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1093\/nar\/30.4.e15","article-title":"Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation","volume":"30","author":"Yang","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.neuro.2007.02.013_bib99","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1080\/713803493","article-title":"The role of iron in Parkinson disease and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity","volume":"48","author":"Yantiri","year":"1999","journal-title":"IUBMB Life"},{"key":"10.1016\/j.neuro.2007.02.013_bib100","doi-asserted-by":"crossref","unstructured":"Yu J, Baron V, Mercola D, Mustelin T, Adamson ED. A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells. Cell Death Differ 2006 [advance online publication].","DOI":"10.1038\/sj.cdd.4402029"},{"key":"10.1016\/j.neuro.2007.02.013_bib101","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nm1342","article-title":"Angiopoietin-like proteins stimulate ex vivo expansion of hematopoietic stem cells","volume":"12","author":"Zhang","year":"2006","journal-title":"Nat Med"}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X07000484?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X07000484?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T01:30:39Z","timestamp":1707701439000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X07000484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":101,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["S0161813X07000484"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2007.02.013","relation":{},"ISSN":["0161-813X"],"issn-type":[{"type":"print","value":"0161-813X"}],"subject":[],"published":{"date-parts":[[2007,9]]}}}