{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:24:30Z","timestamp":1793193870851,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.neuro.2009.08.001","type":"journal-article","created":{"date-parts":[[2009,8,9]],"date-time":"2009-08-09T08:09:57Z","timestamp":1249805397000},"page":"1000-1007","source":"Crossref","is-referenced-by-count":104,"title":["Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain"],"prefix":"10.1016","volume":"30","author":[{"given":"Masatake","family":"Fujimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusako","family":"Usuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masumi","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2009.08.001_bib1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1600-0773.1989.tb00650.x","article-title":"Methyl mercury uptake across bovine brain capillary endothelial cells in vitro: the role of amino acids","volume":"64","author":"Ashner","year":"1989","journal-title":"Pharmacol Toxicol"},{"key":"10.1016\/j.neuro.2009.08.001_bib2","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1096\/fasebj.8.9.7516300","article-title":"Mechanisms of methylmercury-induced neurotoxicity","volume":"8","author":"Atchison","year":"1994","journal-title":"FASEB J"},{"key":"10.1016\/j.neuro.2009.08.001_bib3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1126\/science.181.4096.230","article-title":"Methylmercury poisoning in Iraq","volume":"181","author":"Bakir","year":"1973","journal-title":"Science"},{"key":"10.1016\/j.neuro.2009.08.001_bib4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1515\/REVEH.2003.18.1.19","article-title":"Neurotoxic and molecular effects of methylmercury in humans","volume":"18","author":"Castoldi","year":"2003","journal-title":"Rev Environ Health"},{"key":"10.1016\/j.neuro.2009.08.001_bib5","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/ana.410350608","article-title":"Methylmercury poisoning: long-term clinical, radiological, toxicological, and pathological studies of an affected family","volume":"35","author":"Davis","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuro.2009.08.001_bib6","first-page":"373","article-title":"Methylmercury neurotoxicity and antioxidant defenses","volume":"128","author":"do Nascimento","year":"2008","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.neuro.2009.08.001_bib7","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1177\/019262339902700608","article-title":"Differential diagnosis between organic and inorganic mercury poisoning in human cases\u2014the pathologic point of view","volume":"27","author":"Eto","year":"1999","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.neuro.2009.08.001_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jneuroim.2005.09.007","article-title":"Methylmercury causes oxidative stress and cytotoxicity in microglia: attenuation by 15-deoxy-delta 12,14-prostaglandin J2","volume":"171","author":"Garg","year":"2006","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.neuro.2009.08.001_bib9","doi-asserted-by":"crossref","first-page":"15376","DOI":"10.1021\/bi026813c","article-title":"The environmental toxin arsenite induces Tau hyperphosphorylation","volume":"41","author":"Giasson","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuro.2009.08.001_bib10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0892-0362(97)00097-4","article-title":"Cognitive deficit in 7-year-old children with prenatal exposure to methylmercury","volume":"19","author":"Grandjean","year":"1997","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.neuro.2009.08.001_bib11","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0304-3940(91)90676-K","article-title":"Human neuroblastoma cells treated with aluminium express an epitope associated with Alzheimer's disease neurofibrillary tangles","volume":"121","author":"Guy","year":"1991","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuro.2009.08.001_bib12","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1046\/j.1471-4159.1998.71062465.x","article-title":"New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry","volume":"71","author":"Hanger","year":"1998","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2009.08.001_bib13","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0014-5793(96)00271-2","article-title":"Characterization of mAb AP422, a novel phosphorylation-dependent monoclonal antibody against tau protein","volume":"384","author":"Hasegawa","year":"1996","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neuro.2009.08.001_bib14","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/0041-008X(80)90093-9","article-title":"Effect of amino acids on brain uptake of methyl mercury","volume":"55","author":"Hirayama","year":"1980","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.neuro.2009.08.001_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s007020050038","article-title":"Increased blood mercury levels in patients with Alzheimer's disease","volume":"105","author":"Hock","year":"1998","journal-title":"J Neural Transm"},{"key":"10.1016\/j.neuro.2009.08.001_bib16","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.toxlet.2007.11.004","article-title":"Neurotoxicological mechanism of methylmercury induced by low-dose and long-term exposure in mice: oxidative stress and down-regulated Na+\/K+-ATPase involved","volume":"176","author":"Huang","year":"2008","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.neuro.2009.08.001_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00401-004-0951-y","article-title":"Metabolic\/signal transduction hypothesis of Alzheimer's disease and other tauopathies","volume":"109","author":"Iqbal","year":"2005","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.neuro.2009.08.001_bib18","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0006-8993(00)02717-7","article-title":"Intrauterine methylmercury intoxication. Consequence of the inherent brain lesions and cognitive dysfunction in maturity","volume":"877","author":"Kakita","year":"2000","journal-title":"Brain Res"},{"key":"10.1016\/j.neuro.2009.08.001_bib19","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1021\/bi051634r","article-title":"Glycogen synthase kinase 3beta phosphorylates Alzheimer's disease-specific Ser396 of microtubule-associated protein tau by a sequential mechanism","volume":"45","author":"Li","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuro.2009.08.001_bib20","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0006-8993(01)02281-8","article-title":"Involvement of enhanced sensitivity of N-methyl-d-aspartate receptors in vulnerability of developing cortical neurons to methylmercury neurotoxicity","volume":"901","author":"Miyamoto","year":"2001","journal-title":"Brain Res"},{"key":"10.1016\/j.neuro.2009.08.001_bib21","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1074\/jbc.270.2.823","article-title":"Proline-directed and non-proline-directed phosphorylation of PHF-tau","volume":"270","author":"Morishima-Kawashima","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.neuro.2009.08.001_bib22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1046\/j.1471-4159.2000.0740231.x","article-title":"Mercury induces cell cytotoxicity and oxidative stress and increases b-amyloid secretion and Tau phosphorylation in SHSY5Y neuroblastoma cells","volume":"74","author":"Olivieri","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2009.08.001_bib23","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1046\/j.1471-4159.2000.0741587.x","article-title":"Phosphorylation sites on tau identified by nanoelectrospray mass spectrometry: differences in vitro between the mitogen-activated protein kinases ERK2, c-Jun N-terminal kinase and P38, and glycogen synthase kinase-3beta","volume":"74","author":"Reynolds","year":"2000","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2009.08.001_bib24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0165-0270(98)00147-2","article-title":"Annexin V binding assay as a tool measure apoptosis in differential neuronal cells","volume":"86","author":"Schutte","year":"1998","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.neuro.2009.08.001_bib25","doi-asserted-by":"crossref","first-page":"7221","DOI":"10.1523\/JNEUROSCI.14-11-07221.1994","article-title":"Aluminium modified the properties of Alzheimer's disease PHF\u03c4 proteins in vivo and in vitro","volume":"14","author":"Shin","year":"1994","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuro.2009.08.001_bib26","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/S0166-2236(98)01337-X","article-title":"Tau protein pathology in neurodegenerative diseases","volume":"21","author":"Spillantini","year":"1998","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.neuro.2009.08.001_bib27","first-page":"73","article-title":"Pathology of Minamata disease. With special reference to its pathogenesis","volume":"32","author":"Takeuchi","year":"1982","journal-title":"Acta Pathol Jpn"},{"key":"10.1016\/j.neuro.2009.08.001_bib28","first-page":"193","article-title":"Studies on the cause of the Niigata episode of Minamata disease outbreak","volume":"19","author":"Takizawa","year":"1972","journal-title":"Acta Med Biol (Niigata)"},{"key":"10.1016\/j.neuro.2009.08.001_bib29","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1212\/01.WNL.0000129697.01779.0A","article-title":"The importance of neuritic plaques and tangles to the development and evolution of AD","volume":"62","author":"Tiraboschi","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.neuro.2009.08.001_bib30","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1749-6632.2000.tb05561.x","article-title":"\u201cFatal attractions\u201d of proteins. A comprehensive hypothetical mechanism underlying Alzheimer's disease and other neurodegenerative disorders","volume":"924","author":"Trojanowski","year":"2000","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.neuro.2009.08.001_bib31","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1080\/03601239509372961","article-title":"Neurologic features of chronic Minamata disease (organic mercury poisoning) and incidence of complications with aging","volume":"B30","author":"Uchino","year":"1995","journal-title":"J Environ Sci Health"},{"key":"10.1016\/j.neuro.2009.08.001_bib32","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0304-3940(01)01764-5","article-title":"In vivo protection of a water-soluble derivative of vitamin E, Trolox, against methylmercury-intoxication","volume":"304","author":"Usuki","year":"2001","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.neuro.2009.08.001_bib33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0006-8993(95)01208-7","article-title":"Variability of brain lesions in rats administered methylmercury at various postnatal development phases","volume":"705","author":"Wakabayashi","year":"1995","journal-title":"Brain Res"},{"key":"10.1016\/j.neuro.2009.08.001_bib34","first-page":"813","article-title":"The toxicology of aluminium in the brain: a review","volume":"21","author":"Yokel","year":"2000","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2009.08.001_bib35","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1476-069X-2-8","article-title":"Low level methylmercury exposure affects neuropsychological function in adults","volume":"2","author":"Yokoo","year":"2003","journal-title":"Environ Health"},{"key":"10.1016\/j.neuro.2009.08.001_bib36","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1471-4159.2004.02479.x","article-title":"Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK)","volume":"90","author":"Yoshida","year":"2004","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2009.08.001_bib37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1006\/taap.1993.1104","article-title":"Disruption by methylmercury of membrane excitability and synaptic transmission of CA1 neurons in hippocampal slices of the rat","volume":"120","author":"Yuan","year":"1993","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.neuro.2009.08.001_bib38","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1046\/j.1471-4159.2001.00046.x","article-title":"Activation and redistribution of c-jun N-terminal kinase\/stress activated protein kinase in degenerating neurons In Alzheimer's disease","volume":"76","author":"Zhu","year":"2001","journal-title":"J Neurochem"}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X09001739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X09001739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T22:45:09Z","timestamp":1558478709000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X09001739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0161813X09001739"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2009.08.001","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}