{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:17:41Z","timestamp":1780546661303,"version":"3.54.1"},"reference-count":51,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T00:00:00Z","timestamp":1354320000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1016\/j.neuro.2012.03.001","type":"journal-article","created":{"date-parts":[[2012,3,10]],"date-time":"2012-03-10T13:01:24Z","timestamp":1331384484000},"page":"1454-1472","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Fibromyalgia, mood disorders, and intense creative energy: A1AT polymorphisms are not always silent"],"prefix":"10.1016","volume":"33","author":[{"given":"Donald E.","family":"Schmechel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"September\u2013October (5 Suppl. 56)","key":"10.1016\/j.neuro.2012.03.001_bib0005","first-page":"S33","article-title":"Candidate-gene approach in fibromyalgia syndrome: association analysis of the genes encoding substance P receptor, dopamine transporter and alpha1-antitrypsin","volume":"27","author":"Ablin","year":"2009","journal-title":"Clin Exp Rheumatol"},{"issue":"5","key":"10.1016\/j.neuro.2012.03.001_bib0010","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/j.1440-1819.2004.01294.x","article-title":"White matter hyperintensities in subjects with bipolar disorder","volume":"58","author":"Ahn","year":"2004","journal-title":"Psychiatry Clin Neurosci"},{"issue":"6","key":"10.1016\/j.neuro.2012.03.001_bib0015","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1365-2559.2004.02021.x","article-title":"Polymerized alpha-antitrypsin is present on lung vascular endothelium. New insights into the biological significance of alpha-antitrypsin polymerisation","volume":"45","author":"Aldonyte","year":"2004","journal-title":"Histopathology"},{"issue":"6","key":"10.1016\/j.neuro.2012.03.001_bib0020","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1172\/JCI108906","article-title":"Increased frequency of the MZ phenotype of alpha-1-protease inhibitor in juvenile chronic polyarthritis","volume":"60","author":"Arnaud","year":"1977","journal-title":"J Clin Invest"},{"issue":"November (5)","key":"10.1016\/j.neuro.2012.03.001_bib0025","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1378\/chest.10-0187","article-title":"Accelerated spirometric decline in New York City firefighters with \u03b11-antitrypsin deficiency","volume":"138","author":"Banauch","year":"2010","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.neuro.2012.03.001_bib0030","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.rmed.2008.12.021","article-title":"Lung function in 30-year old alpha-1-antitrypsin deficient individuals","volume":"103","author":"Bernspang","year":"2009","journal-title":"Resp Med"},{"key":"10.1016\/j.neuro.2012.03.001_bib0035","first-page":"343","article-title":"Physical mapping of four serpin genes: alpha 1-antitrypsin, alpha 1-antichymotrypsin, corticosteroidbinding globulin, and protein C inhibitor, within a 280-kb region on chromosome 14q32.1","volume":"2","author":"Billingsley","year":"1993","journal-title":"Am J Hum Genet"},{"issue":"6","key":"10.1016\/j.neuro.2012.03.001_bib0040","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1034\/j.1399-0004.2001.600605.x","article-title":"Distribution of alpha1-antitrypsin PI S and PI Z frequencies in countries outside Europe: a meta-analysis","volume":"60","author":"Blanco","year":"2001","journal-title":"Clin Genet"},{"issue":"October (10)","key":"10.1016\/j.neuro.2012.03.001_bib0045","first-page":"2082","article-title":"Alpha1-antitrypsin replacement therapy controls fibromyalgia symptoms in 2 patients with PI ZZ alpha1-antitrypsin deficiency","volume":"31","author":"Blanco","year":"2004","journal-title":"J Rheumatol"},{"issue":"4","key":"10.1016\/j.neuro.2012.03.001_bib0050","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.mehy.2004.10.005","article-title":"Alpha1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia","volume":"64","author":"Blanco","year":"2005","journal-title":"Med Hypotheses"},{"issue":"May (3)","key":"10.1016\/j.neuro.2012.03.001_bib0055","first-page":"329","article-title":"Protease inhibitor (Pi) locus, fertility and twinning","volume":"89","author":"Boomsma","year":"1992","journal-title":"Hum Genet"},{"issue":"2","key":"10.1016\/j.neuro.2012.03.001_bib0060","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.psc.2005.01.006","article-title":"Magnetic resonance findings in bipolar disorder","volume":"28","author":"Brambilla","year":"2005","journal-title":"Psychiatric Clin N Am"},{"issue":"2","key":"10.1016\/j.neuro.2012.03.001_bib0065","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00004583-199802000-00006","article-title":"Prevalence of PTSD in a community sample of older adolescents","volume":"37","author":"Cuffe","year":"1998","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"issue":"5","key":"10.1016\/j.neuro.2012.03.001_bib0070","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1161\/01.CIR.0000049642.20484.5D","article-title":"Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study","volume":"107","author":"Dahl","year":"2003","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.neuro.2012.03.001_bib0075","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1378\/chest.122.5.1818","article-title":"Worldwide racial and ethnic distribution of alpha1-antitrypsin deficiency: summary of an analysis of published genetic epidemiologic surveys","volume":"122","author":"de Serres","year":"2002","journal-title":"Chest"},{"issue":"16","key":"10.1016\/j.neuro.2012.03.001_bib0080","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1289\/ehp.6511","article-title":"Alpha-1 antitrypsin deficiency is not a rare disease but a disease that is rarely diagnosed","volume":"111","author":"de Serres","year":"2003","journal-title":"Environ Health Perspect"},{"issue":"3","key":"10.1016\/j.neuro.2012.03.001_bib0085","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/01.GIM.0000156533.06057.89","article-title":"Health implications of alpha1-antitrypsin deficiency in Sub-Sahara African countries and their emigrants in Europe and the New World","volume":"7","author":"de Serres","year":"2005","journal-title":"Genet Med"},{"issue":"8","key":"10.1016\/j.neuro.2012.03.001_bib0090","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.rmed.2005.11.017","article-title":"Asthma and allergy in alpha-1 antitrypsin deficiency","volume":"100","author":"Eden","year":"2006","journal-title":"Respir Med"},{"key":"10.1016\/j.neuro.2012.03.001_bib0095","first-page":"27","article-title":"Significance of MTHFR gene mutation with normal homocysteine level in vascular events","author":"Gadiyaram","year":"2009","journal-title":"J Clin Oncol"},{"issue":"November (10)","key":"10.1016\/j.neuro.2012.03.001_bib0100","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1164\/rccm.200610-1467OC","article-title":"A twin study of post-traumatic stress disorder symptoms and asthma","volume":"176","author":"Goodwin","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"issue":"11","key":"10.1016\/j.neuro.2012.03.001_bib0105","first-page":"1053","article-title":"Modulation of iron metabolism in monocytic THP-1 cells and cultured human monocytes by the acute-phase protein alpha1-antitrypsin","volume":"26","author":"Graziadei","year":"1998","journal-title":"Exp Hematol"},{"issue":"4","key":"10.1016\/j.neuro.2012.03.001_bib0110","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S0168-8278(97)80089-X","article-title":"Unidirectional upregulation of the synthesis of the major iron proteins, transferrin-receptor and ferritin, in HepG2 cells by the acute-phase protein alpha1-antitrypsin","volume":"27","author":"Graziadei","year":"1997","journal-title":"J Hepatol"},{"issue":"7","key":"10.1016\/j.neuro.2012.03.001_bib0115","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.biopsych.2005.01.002","article-title":"Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses","volume":"57","author":"Haznedar","year":"2005","journal-title":"Biol Psychiatry"},{"issue":"10","key":"10.1016\/j.neuro.2012.03.001_bib0120","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1136\/thx.2004.022541","article-title":"Chronic obstructive pulmonary disease in alpha1-antitrypsin PI MZ heterozygotes: a meta-analysis","volume":"59","author":"Hersh","year":"2004","journal-title":"Thorax"},{"key":"10.1016\/j.neuro.2012.03.001_bib0125","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1126\/science.1190354","article-title":"An autophagy-enhancing drug promotes degradation of mutant alpha-1-antitrypsin Z and reduces hepatic fibrosis","volume":"329","author":"Hidvegi","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.neuro.2012.03.001_bib0130","series-title":"Touched with fire: manic-depressive illness and the artistic temperament","author":"Jamison K.R.","year":"1993"},{"key":"10.1016\/j.neuro.2012.03.001_bib0135","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1002\/art.21798","article-title":"Importance of genetic influences on chronic widespread pain","volume":"54","author":"Kato","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"8","key":"10.1016\/j.neuro.2012.03.001_bib0140","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/S0002-9149(00)01103-6","article-title":"Effect of common methylenetetrahydrofolate reductase gene mutation on coronary artery disease in familial hypercholesterolemia","volume":"86","author":"Kawashiri","year":"2000","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.neuro.2012.03.001_bib0145","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1212\/WNL.56.9.1143","article-title":"Practice parameter: diagnosis of dementia (an evidencebased review). Report of the Quality Standards Committee of the American Academy of Neurology","volume":"56","author":"Knopman","year":"2001","journal-title":"Neurology"},{"issue":"Pt B","key":"10.1016\/j.neuro.2012.03.001_bib0150","first-page":"45","article-title":"Twinning as a heterozygous advantage for alpha1-antitrypsin deficiency","volume":"24","author":"Lieberman","year":"1978","journal-title":"Prog Clin Biol Res"},{"issue":"5","key":"10.1016\/j.neuro.2012.03.001_bib0155","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/rheumatology\/ken027","article-title":"Exploring the genetic susceptibility of chronic widespread pain: the tender points in genetic association studies","volume":"47","author":"Limer","year":"2008","journal-title":"Rheumatology"},{"issue":"May (10)","key":"10.1016\/j.neuro.2012.03.001_bib0165","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1164\/rccm.200511-1797PP","article-title":"The selective advantage of alpha1-antitrypsin deficiency","volume":"173","author":"Lomas","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"issue":"June","key":"10.1016\/j.neuro.2012.03.001_bib0170","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.2741\/3598","article-title":"Neurobiology of depression, fibromyalgia and neuropathic pain","volume":"14","author":"Maletic","year":"2009","journal-title":"Front Biosci"},{"key":"10.1016\/j.neuro.2012.03.001_bib0175","series-title":"The artistic dividend revisited","author":"Markusen","year":"2004"},{"key":"10.1016\/j.neuro.2012.03.001_bib0180","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/ana.91","article-title":"Primary progressive aphasia","volume":"49","author":"Mesulam","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuro.2012.03.001_bib0185","first-page":"570679","article-title":"Is PiSS alpha-1 antitrypsin deficiency associated with disease?","author":"McGee","year":"2010","journal-title":"Pulm Med"},{"issue":"5","key":"10.1016\/j.neuro.2012.03.001_bib0190","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1378\/chest.125.5.1952","article-title":"Z alpha-1-antitrypsin polymerizes in the lung and serves as a neutrophil chemoattractant","volume":"125","author":"Mulgrew","year":"2004","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.neuro.2012.03.001_bib0195","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S1357-2725(02)00250-9","article-title":"Alpha(1)-antitrypsin deficiency, liver disease and emphysema","volume":"35","author":"Parfrey","year":"2003","journal-title":"Int J Biochem Cell Biol"},{"issue":"11","key":"10.1016\/j.neuro.2012.03.001_bib0200","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1172\/JCI0216787","article-title":"Liver injury in alpha1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury","volume":"110","author":"Perlmutter","year":"2002","journal-title":"J Clin Investig"},{"issue":"October","key":"10.1016\/j.neuro.2012.03.001_bib0205","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/1471-2474-12-224","article-title":"Prevalence of fibromyalgia in France: a multi-step study research combining national screening and clinical confirmation: the DEFI study (Determination of Epidemiology of FIbromyalgia)","volume":"12","author":"Perrot","year":"2011","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.neuro.2012.03.001_bib0210","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1212\/WNL.56.9.1133","article-title":"Practice parameter: early detection of mild dementia: mild cognitive impairment (an evidence-based review). Report of the Quality Standards Committee of the American Academy of Neurology","volume":"56","author":"Petersen","year":"2001","journal-title":"Neurology"},{"issue":"July (Suppl. 1)","key":"10.1016\/j.neuro.2012.03.001_bib0215","first-page":"S30","article-title":"Does the heterozygous state of alpha-1 antitrypsin deficiency have a role in chronic liver diseases? Interim results of a large case-control study","volume":"43","author":"Regev","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"February (2)","key":"10.1016\/j.neuro.2012.03.001_bib0220","first-page":"244","article-title":"Increased frequency of learning disability in patients with primary progressive aphasia and their first-degree relatives","volume":"65","author":"Rogalski","year":"2008","journal-title":"Arch Neurol"},{"key":"10.1016\/j.neuro.2012.03.001_bib0225","doi-asserted-by":"crossref","unstructured":"Russo AJ, Neville L, Wroge C. Low serum alpha-1 antitrypsin (AAT) in family members of individuals with autism correlates with PiMZ genotype Biomarker Insights. 2009;4:45\u201356.","DOI":"10.4137\/BMI.S1115"},{"issue":"September (5)","key":"10.1016\/j.neuro.2012.03.001_bib0230","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.neuro.2006.05.021","article-title":"Strategies for dissecting genetic-environmental interactions in neurodegenerative disorders","volume":"27","author":"Schmechel","year":"2006","journal-title":"Neurotoxicology"},{"issue":"5","key":"10.1016\/j.neuro.2012.03.001_bib0235","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.neuro.2007.05.011","article-title":"Art, alpha-1-antitrypsin polymorphisms and intense creative energy: blessing or curse?","volume":"28","author":"Schmechel","year":"2007","journal-title":"Neurotoxicology"},{"issue":"3","key":"10.1016\/j.neuro.2012.03.001_bib0240","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1155\/2006\/373620","article-title":"A comprehensive candidate gene study on bronchial asthma and juvenile idiopathic arthritis","volume":"22","author":"Schubert","year":"2006","journal-title":"Dis Markers"},{"issue":"5","key":"10.1016\/j.neuro.2012.03.001_bib0245","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/00042737-200605000-00011","article-title":"Does alpha1-antitrypsin phenotype PiMZ increase the risk of fibrosis in liver disease due to hepatitis C virus infection?","volume":"18","author":"Scott","year":"2006","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"November (6)","key":"10.1016\/j.neuro.2012.03.001_bib0250","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/YCO.0b013e32834b56c8","article-title":"Childhood trauma and posttraumatic stress disorder in patients with psychosis: clinical challenges and emerging treatments","volume":"24","author":"Sch\u00e4fer","year":"2011","journal-title":"Curr Opin Psychiatry"},{"issue":"4","key":"10.1016\/j.neuro.2012.03.001_bib0255","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1161\/01.ATV.0000065196.61663.8D","article-title":"Diabetes Atherosclerosis Intervention Study Investigators Progression of atherosclerosis is associated with variation in the alpha1-antitrypsin gene","volume":"23","author":"Talmud","year":"2003","journal-title":"Arteriosc Thromb Vasc Biol"},{"issue":"16","key":"10.1016\/j.neuro.2012.03.001_bib0260","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1001\/jama.288.16.2042","article-title":"Homocysteine and coronary heart disease: how great is the hazard?","volume":"288","author":"Wilson","year":"2002","journal-title":"JAMA"}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X12000642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X12000642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:15:23Z","timestamp":1758982523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X12000642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["S0161813X12000642"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2012.03.001","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibromyalgia, mood disorders, and intense creative energy: A1AT polymorphisms are not always silent","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2012.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}