{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T14:23:38Z","timestamp":1792938218826,"version":"4.5.0"},"reference-count":114,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,1,3]],"date-time":"2014-01-03T00:00:00Z","timestamp":1388707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Jim Himelic Foundation (ME)"},{"name":"Southern Arizona Foundation (ME)"},{"name":"Keatings Institute (ME)"},{"DOI":"10.13039\/100000066","name":"National Institutes of Environmental Health Sciences","doi-asserted-by":"crossref","award":["R21-ES012305"],"award-info":[{"award-number":["R21-ES012305"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Office of Research and Development, Department of Veterans Affairs"},{"name":"NIH National Center for Research Resources (NCRR)"},{"name":"International C. elegans Gene Knockout Consortium"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.neuro.2013.12.012","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T18:46:13Z","timestamp":1389033973000},"page":"28-43","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["The neurodegenerative effects of selenium are inhibited by FOXO and PINK1\/PTEN regulation of insulin\/insulin-like growth factor signaling in Caenorhabditis elegans"],"prefix":"10.1016","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8840-1340","authenticated-orcid":false,"given":"Annette O.","family":"Estevez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen L.","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel J.","family":"Szewczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Gems","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Estevez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.neuro.2013.12.012_bib0005","doi-asserted-by":"crossref","first-page":"e1002498","DOI":"10.1371\/journal.pgen.1002498","article-title":"Insulin\/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans","volume":"8","author":"Ackerman","year":"2012","journal-title":"PLoS Genet"},{"issue":"1","key":"10.1016\/j.neuro.2013.12.012_bib0010","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.nbd.2011.08.034","article-title":"PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis","volume":"45","author":"Akundi","year":"2012","journal-title":"Neurobiol Dis"},{"issue":"23","key":"10.1016\/j.neuro.2013.12.012_bib0015","doi-asserted-by":"crossref","first-page":"6541","DOI":"10.1002\/j.1460-2075.1996.tb01045.x","article-title":"Mechanism of activation of protein kinase B by insulin and IGF-1","volume":"15","author":"Alessi","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.neuro.2013.12.012_bib0020","series-title":"WormAtlas","article-title":"Nervous system, general description","author":"Altun","year":"2011"},{"issue":"4","key":"10.1016\/j.neuro.2013.12.012_bib0025","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/1531-8249(200004)47:4<447::AID-ANA7>3.0.CO;2-R","article-title":"Partial deficiency of manganese superoxide dismutase exacerbates a transgenic mouse model of amyotrophic lateral sclerosis","volume":"47","author":"Andreassen","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuro.2013.12.012_bib0030","doi-asserted-by":"crossref","first-page":"608478","DOI":"10.1155\/2012\/608478","article-title":"ROS in aging Caenorhabditis elegans: damage or signaling?","volume":"2012","author":"Back","year":"2012","journal-title":"Oxid Med Cell Longev"},{"issue":"4","key":"10.1016\/j.neuro.2013.12.012_bib0035","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.tem.2005.03.010","article-title":"FoxO proteins in insulin action and metabolism","volume":"16","author":"Barthel","year":"2005","journal-title":"Trends Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.neuro.2013.12.012_bib0040","doi-asserted-by":"crossref","first-page":"e33494","DOI":"10.1371\/journal.pone.0033494","article-title":"Daf-2 signaling modifies mutant SOD1 toxicity in C. elegans","volume":"7","author":"Boccitto","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.neuro.2013.12.012_bib0045","doi-asserted-by":"crossref","first-page":"e71525","DOI":"10.1371\/journal.pone.0071525","article-title":"Deletion of thioredoxin reductase and effects of selenite and selenate toxicity in Caenorhabditis elegans","volume":"8","author":"Boehler","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.neuro.2013.12.012_bib0050","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.cell.2008.05.044","article-title":"An elt-3\/elt-5\/elt-6 GATA transcription circuit guides aging in C. elegans","volume":"134","author":"Budovskaya","year":"2008","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.neuro.2013.12.012_bib0055","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.freeradbiomed.2011.07.020","article-title":"Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage","volume":"51","author":"Cabreiro","year":"2011","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuro.2013.12.012_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2011.04.046","article-title":"Progression of neurodegeneration and morphologic changes in the brains of juvenile mice with selenoprotein P deleted","volume":"1398","author":"Caito","year":"2011","journal-title":"Brain Res"},{"issue":"12","key":"10.1016\/j.neuro.2013.12.012_bib0065","doi-asserted-by":"crossref","first-page":"e1003141","DOI":"10.1371\/journal.pgen.1003141","article-title":"Diapause formation and downregulation of insulin-like signaling via DAF-16\/FOXO delays axonal degeneration and neuronal loss","volume":"8","author":"Calixto","year":"2012","journal-title":"PLoS Genet"},{"issue":"10","key":"10.1016\/j.neuro.2013.12.012_bib0070","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/nn1316","article-title":"Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans","volume":"7","author":"Chase","year":"2004","journal-title":"Nat Neurosci"},{"issue":"1\u20132","key":"10.1016\/j.neuro.2013.12.012_bib0075","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jns.2008.11.012","article-title":"Protection against paraquat and A53T alpha-synuclein toxicity by cabergoline is partially mediated by dopamine receptors","volume":"278","author":"Chau","year":"2009","journal-title":"J Neurol Sci"},{"issue":"23","key":"10.1016\/j.neuro.2013.12.012_bib0080","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1242\/dev.069062","article-title":"A conserved PTEN\/FOXO pathway regulates neuronal morphology during C. elegans development","volume":"138","author":"Christensen","year":"2011","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.neuro.2013.12.012_bib0085","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1177\/1040638711435407","article-title":"Toxicokinetics and pathology of plant-associated acute selenium toxicosis in steers","volume":"24","author":"Davis","year":"2012","journal-title":"J Vet Diagn Invest"},{"issue":"1","key":"10.1016\/j.neuro.2013.12.012_bib0090","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.nbd.2010.05.012","article-title":"Neurodegenerative disorders: insights from the nematode Caenorhabditis elegans","volume":"40","author":"Dimitriadi","year":"2010","journal-title":"Neurobiol Dis"},{"issue":"9","key":"10.1016\/j.neuro.2013.12.012_bib0095","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1096\/fj.11-181958","article-title":"PTEN ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models","volume":"25","author":"Domanskyi","year":"2011","journal-title":"FASEB J"},{"issue":"23","key":"10.1016\/j.neuro.2013.12.012_bib0100","doi-asserted-by":"crossref","first-page":"3236","DOI":"10.1101\/gad.504808","article-title":"Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans","volume":"22","author":"Doonan","year":"2008","journal-title":"Genes Dev"},{"issue":"8","key":"10.1016\/j.neuro.2013.12.012_bib0105","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1056\/NEJMoa070174","article-title":"Whole-genome analysis of sporadic amyotrophic lateral sclerosis","volume":"357","author":"Dunckley","year":"2007","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.neuro.2013.12.012_bib0110","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nrm3507","article-title":"FOXOs: signalling integrators for homeostasis maintenance","volume":"14","author":"Eijkelenboom","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.neuro.2013.12.012_bib0115","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1046\/j.1471-4159.2003.02140.x","article-title":"The voltage-gated calcium channel UNC-2 is involved in stress-mediated regulation of tryptophan hydroxylase","volume":"88","author":"Estevez","year":"2004","journal-title":"J Neurochem"},{"issue":"5","key":"10.1016\/j.neuro.2013.12.012_bib0120","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.neuro.2012.04.019","article-title":"Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans","volume":"33","author":"Estevez","year":"2012","journal-title":"Neurotoxicology"},{"issue":"7","key":"10.1016\/j.neuro.2013.12.012_bib0125","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1089\/ars.2010.3275","article-title":"Selenium in human health and disease","volume":"14","author":"Fairweather-Tait","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"10.1016\/j.neuro.2013.12.012_bib0130","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.freeradbiomed.2013.05.027","article-title":"SOD2 in mitochondrial dysfunction and neurodegeneration","volume":"62","author":"Flynn","year":"2013","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"10.1016\/j.neuro.2013.12.012_bib0135","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/genetics\/150.1.129","article-title":"Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans","volume":"150","author":"Gems","year":"1998","journal-title":"Genetics"},{"issue":"2","key":"10.1016\/j.neuro.2013.12.012_bib0140","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1006\/bbrc.1999.0765","article-title":"Selenocysteine-containing thioredoxin reductase in C. elegans","volume":"259","author":"Gladyshev","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.neuro.2013.12.012_bib0145","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1073\/pnas.81.3.819","article-title":"A pheromone-induced developmental switch in Caenorhabditis elegans: temperature-sensitive mutants reveal a wild-type temperature-dependent process","volume":"81","author":"Golden","year":"1984","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.neuro.2013.12.012_bib0150","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.expneurol.2009.05.027","article-title":"Differential effects of PINK1 nonsense and missense mutations on mitochondrial function and morphology","volume":"219","author":"Gr\u00fcnewald","year":"2009","journal-title":"Exp Neurol"},{"key":"10.1016\/j.neuro.2013.12.012_bib0155","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3389\/fphys.2013.00147","article-title":"Mitochondria and FOXO3: breath or die","volume":"4","author":"Hagenbuchner","year":"2013","journal-title":"Front Physiol"},{"issue":"24","key":"10.1016\/j.neuro.2013.12.012_bib0160","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/S0960-9822(01)00594-2","article-title":"daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans","volume":"11","author":"Henderson","year":"2001","journal-title":"Curr Biol"},{"issue":"2","key":"10.1016\/j.neuro.2013.12.012_bib0165","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.nbd.2006.10.007","article-title":"Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6","volume":"25","author":"Hoepken","year":"2007","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.neuro.2013.12.012_bib0170","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1749-6632.2002.tb02117.x","article-title":"Oxidative stress and life span determination in the nematode Caenorhabditis elegans","volume":"959","author":"Honda","year":"2002","journal-title":"Ann N Y Acad Sci"},{"issue":"Suppl. 1","key":"10.1016\/j.neuro.2013.12.012_bib0175","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1111\/j.1447-0594.2010.00591.x","article-title":"Redox regulation, gene expression and longevity","volume":"10","author":"Honda","year":"2010","journal-title":"Geriatr Gerontol Int"},{"issue":"Pt 15","key":"10.1016\/j.neuro.2013.12.012_bib0180","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1242\/jcs.001222","article-title":"Dynamic FoxO transcription factors","volume":"120","author":"Huang","year":"2007","journal-title":"J Cell Sci"},{"issue":"45","key":"10.1016\/j.neuro.2013.12.012_bib0185","doi-asserted-by":"crossref","first-page":"28652","DOI":"10.1074\/jbc.272.45.28652","article-title":"Cloning, expression, and characterization of two manganese superoxide dismutases from Caenorhabditis elegans","volume":"272","author":"Hunter","year":"1997","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.neuro.2013.12.012_bib0190","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.ydbio.2006.04.467","article-title":"Insulin signaling in Caenorhabditis elegans regulates both endocrine-like and cell-autonomous outputs","volume":"303","author":"Iser","year":"2007","journal-title":"Dev Biol"},{"issue":"11","key":"10.1016\/j.neuro.2013.12.012_bib0195","doi-asserted-by":"crossref","first-page":"e27401","DOI":"10.1371\/journal.pone.0027401","article-title":"Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes","volume":"6","author":"Iwakami","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.neuro.2013.12.012_bib0200","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1534\/genetics.107.076703","article-title":"Caenorhabditis elegans SDF-9 enhances insulin\/insulin-like signaling through interaction with DAF-2","volume":"177","author":"Jensen","year":"2007","journal-title":"Genetics"},{"issue":"8878","key":"10.1016\/j.neuro.2013.12.012_bib0205","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/0140-6736(93)92905-9","article-title":"Cu\/Zn superoxide dismutase (SOD1) mutations and sporadic amyotrophic lateral sclerosis","volume":"342","author":"Jones","year":"1993","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.neuro.2013.12.012_bib0210","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/ng.132","article-title":"TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis","volume":"40","author":"Kabashi","year":"2008","journal-title":"Nat Genet"},{"issue":"13","key":"10.1016\/j.neuro.2013.12.012_bib0215","doi-asserted-by":"crossref","first-page":"6314","DOI":"10.1158\/0008-5472.CAN-06-4217","article-title":"Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells","volume":"67","author":"Kim","year":"2007","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.neuro.2013.12.012_bib0220","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.bbrc.2011.02.133","article-title":"Redox regulation of the tumor suppressor PTEN by glutaredoxin 5 and Ycp4","volume":"407","author":"Kim","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"issue":"5328","key":"10.1016\/j.neuro.2013.12.012_bib0225","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1126\/science.277.5328.942","article-title":"daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans","volume":"277","author":"Kimura","year":"1997","journal-title":"Science"},{"issue":"Pt 2","key":"10.1016\/j.neuro.2013.12.012_bib0230","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1093\/brain\/awq345","article-title":"Phosphatase and tensin homologue\/protein kinase B pathway linked to motor neuron survival in human superoxide dismutase 1-related amyotrophic lateral sclerosis","volume":"134","author":"Kirby","year":"2011","journal-title":"Brain"},{"issue":"12","key":"10.1016\/j.neuro.2013.12.012_bib0235","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1089\/ars.2010.3526","article-title":"Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice","volume":"14","author":"Labunskyy","year":"2011","journal-title":"Antioxid Redox Signal"},{"issue":"5","key":"10.1016\/j.neuro.2013.12.012_bib0240","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/dvdy.22244","article-title":"Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16\/FOXO","volume":"239","author":"Landis","year":"2010","journal-title":"Dev Dyn"},{"issue":"18","key":"10.1016\/j.neuro.2013.12.012_bib0245","doi-asserted-by":"crossref","first-page":"9782","DOI":"10.1073\/pnas.93.18.9782","article-title":"Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice","volume":"93","author":"Lebovitz","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"10.1016\/j.neuro.2013.12.012_bib0250","first-page":"299","article-title":"Bimodal actions of selenium essential for antioxidant and toxic pro-oxidant activities: the selenium paradox (Review)","volume":"5","author":"Lee","year":"2012","journal-title":"Mol Med Rep"},{"issue":"4","key":"10.1016\/j.neuro.2013.12.012_bib0255","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S0092-8674(03)00889-4","article-title":"Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan","volume":"115","author":"Libina","year":"2003","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.neuro.2013.12.012_bib0260","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/88850","article-title":"Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin\/IGF-1 and germline signaling","volume":"28","author":"Lin","year":"2001","journal-title":"Nat Genet"},{"issue":"5341","key":"10.1016\/j.neuro.2013.12.012_bib0265","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1126\/science.278.5341.1319","article-title":"daf-16: an HNF-3\/forkhead family member that can function to double the life-span of Caenorhabditis elegans","volume":"278","author":"Lin","year":"1997","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.neuro.2013.12.012_bib0270","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.cmet.2009.08.009","article-title":"Reactive oxygen species enhance insulin sensitivity","volume":"10","author":"Loh","year":"2009","journal-title":"Cell Metab"},{"key":"10.1016\/j.neuro.2013.12.012_bib0275","doi-asserted-by":"crossref","first-page":"e481","DOI":"10.1038\/cddis.2013.3","article-title":"PTEN-regulated AKT\/FoxO3a\/Bim signaling contributes to reactive oxygen species-mediated apoptosis in selenite-treated colorectal cancer cells","volume":"4","author":"Luo","year":"2013","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.neuro.2013.12.012_bib0280","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.canlet.2011.10.014","article-title":"Selenite induces apoptosis in colorectal cancer cells via AKT-mediated inhibition of \u00df-catenin survival axis","volume":"315","author":"Luo","year":"2012","journal-title":"Cancer Lett"},{"issue":"4","key":"10.1016\/j.neuro.2013.12.012_bib0285","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1177\/107385840200800408","article-title":"Role of superoxide dismutases in oxidative damage and neurodegenerative disorders","volume":"8","author":"Maier","year":"2002","journal-title":"Neuroscientist"},{"issue":"4","key":"10.1016\/j.neuro.2013.12.012_bib0290","doi-asserted-by":"crossref","first-page":"295","DOI":"10.2174\/156720207782446306","article-title":"\u201cSly as a FOXO\u201d: new paths with Forkhead signaling in the brain","volume":"4","author":"Maiese","year":"2007","journal-title":"Curr Neurovasc Res"},{"issue":"3","key":"10.1016\/j.neuro.2013.12.012_bib0295","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbrc.2010.07.033","article-title":"Oxidative stress alters the regulatory control of p66Shc and Akt in PINK1 deficient cells","volume":"399","author":"Maj","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"10.1016\/j.neuro.2013.12.012_bib0300","doi-asserted-by":"crossref","first-page":"e3354","DOI":"10.1371\/journal.pone.0003354","article-title":"A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans","volume":"3","author":"Masse","year":"2008","journal-title":"PLoS One"},{"issue":"24","key":"10.1016\/j.neuro.2013.12.012_bib0305","doi-asserted-by":"crossref","first-page":"8852","DOI":"10.1073\/pnas.0308096101","article-title":"Development of insulin resistance and obesity in mice overexpressing cellular glutathione peroxidase","volume":"101","author":"McClung","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"13","key":"10.1016\/j.neuro.2013.12.012_bib0310","doi-asserted-by":"crossref","first-page":"5153","DOI":"10.1073\/pnas.0901104106","article-title":"FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation","volume":"106","author":"Mei","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"10.1016\/j.neuro.2013.12.012_bib0315","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/j.1460-2075.1991.tb04966.x","article-title":"Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences","volume":"10","author":"Mello","year":"1991","journal-title":"EMBO J"},{"issue":"4","key":"10.1016\/j.neuro.2013.12.012_bib0320","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.freeradbiomed.2009.05.018","article-title":"Regulation of superoxide dismutase genes: implications in disease","volume":"47","author":"Miao","year":"2009","journal-title":"Free Radic Biol Med"},{"issue":"25","key":"10.1016\/j.neuro.2013.12.012_bib0325","doi-asserted-by":"crossref","first-page":"8236","DOI":"10.1523\/JNEUROSCI.1805-09.2009","article-title":"FOXO3a is broadly neuroprotective in vitro and in vivo against insults implicated in motor neuron diseases","volume":"29","author":"Mojsilovic-Petrovic","year":"2009","journal-title":"J Neurosci"},{"issue":"2","key":"10.1016\/j.neuro.2013.12.012_bib0330","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/toxsci\/kfq273","article-title":"The glutaredoxin GLRX-21 functions to prevent selenium-induced oxidative stress in Caenorhabditis elegans","volume":"118","author":"Morgan","year":"2010","journal-title":"Toxicol Sci"},{"issue":"8","key":"10.1016\/j.neuro.2013.12.012_bib0335","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1002\/jnr.22341","article-title":"Induction of parkinsonism-related proteins in the spinal motor neurons of transgenic mouse carrying a mutant SOD1 gene","volume":"88","author":"Morimoto","year":"2010","journal-title":"J Neurosci Res"},{"issue":"16","key":"10.1016\/j.neuro.2013.12.012_bib0340","doi-asserted-by":"crossref","first-page":"10417","DOI":"10.1073\/pnas.152161099","article-title":"The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans","volume":"99","author":"Morley","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6591","key":"10.1016\/j.neuro.2013.12.012_bib0345","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/382536a0","article-title":"A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans","volume":"382","author":"Morris","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.neuro.2013.12.012_bib0350","article-title":"Protective role of DNJ-27\/ERdj5 in Caenorhabditis elegans models of human neurodegenerative diseases","author":"Mu\u00f1oz-Lobato","year":"2013","journal-title":"Antioxid Redox Signal"},{"issue":"9","key":"10.1016\/j.neuro.2013.12.012_bib0355","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1074\/jbc.M110.179390","article-title":"A new cytosolic pathway from a Parkinson disease-associated kinase, BRPK\/PINK1: activation of AKT via mTORC2","volume":"286","author":"Murata","year":"2011","journal-title":"J Biol Chem"},{"issue":"6654","key":"10.1016\/j.neuro.2013.12.012_bib0360","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1038\/40194","article-title":"The fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans","volume":"389","author":"Ogg","year":"1997","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.neuro.2013.12.012_bib0365","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/ng1723","article-title":"Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation","volume":"38","author":"Oh","year":"2006","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.neuro.2013.12.012_bib0370","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/faat.1996.0124","article-title":"Comparative toxicity of selenium from seleno-dl-methionine, sodium selenate, and Astragalus bisulcatus in pigs","volume":"32","author":"Panter","year":"1996","journal-title":"Fundam Appl Toxicol"},{"issue":"16","key":"10.1016\/j.neuro.2013.12.012_bib0375","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1101\/gad.12.16.2488","article-title":"Caenorhabditis elegans Akt\/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor","volume":"12","author":"Paradis","year":"1998","journal-title":"Genes Dev"},{"issue":"11","key":"10.1016\/j.neuro.2013.12.012_bib0570","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1101\/gad.13.11.1438","article-title":"A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans","volume":"13","author":"Paradis","year":"1999","journal-title":"Genes Dev"},{"issue":"36","key":"10.1016\/j.neuro.2013.12.012_bib0380","doi-asserted-by":"crossref","first-page":"12630","DOI":"10.1523\/JNEUROSCI.0277-12.2012","article-title":"Integration of \u00df-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity","volume":"32","author":"Parker","year":"2012","journal-title":"J Neurosci"},{"issue":"6","key":"10.1016\/j.neuro.2013.12.012_bib0385","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.jinorgbio.2011.03.010","article-title":"Delaying of insulin signal transduction in skeletal muscle cells by selenium compounds","volume":"105","author":"Pinto","year":"2011","journal-title":"J Inorg Biochem"},{"key":"10.1016\/j.neuro.2013.12.012_bib0390","doi-asserted-by":"crossref","first-page":"939751","DOI":"10.1155\/2012\/939751","article-title":"Role of forkhead transcription factors in diabetes-induced oxidative stress","volume":"2012","author":"Ponugoti","year":"2012","journal-title":"Exp Diabetes Res"},{"issue":"8","key":"10.1016\/j.neuro.2013.12.012_bib0395","doi-asserted-by":"crossref","first-page":"e1002836","DOI":"10.1371\/journal.pgen.1002836","article-title":"Cell-nonautonomous signaling of FOXO\/DAF-16 to the stem cells of Caenorhabditis elegans","volume":"8","author":"Qi","year":"2012","journal-title":"PLoS Genet"},{"key":"10.1016\/j.neuro.2013.12.012_bib0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.freeradbiomed.2013.04.003","article-title":"Epidemiology of selenium and type 2 diabetes: can we make sense of it?","author":"Rayman","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuro.2013.12.012_bib0405","first-page":"101","article-title":"A genetic pathway for dauer larva formation in Caenorhabditis elegans","volume":"9","author":"Riddle","year":"1977","journal-title":"Stadler Genet Symp"},{"key":"10.1016\/j.neuro.2013.12.012_bib0410","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/290668a0","article-title":"Interacting genes in nematode dauer larva formation","volume":"290","author":"Riddle","year":"1981","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.neuro.2013.12.012_bib0415","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3390\/nu5041349","article-title":"Selenium supranutrition: are the potential benefits of chemoprevention outweighed by the promotion of diabetes and insulin resistance?","volume":"5","author":"Rocourt","year":"2013","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.neuro.2013.12.012_bib0420","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.etap.2009.07.006","article-title":"A cadmium toxicity assay using stress responsive Caenorhabditis elegans mutant strains","volume":"28","author":"Roh","year":"2009","journal-title":"Environ Toxicol Pharmacol"},{"issue":"6415","key":"10.1016\/j.neuro.2013.12.012_bib0425","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/362059a0","article-title":"Mutations in Cu\/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis","volume":"362","author":"Rosen","year":"1993","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.neuro.2013.12.012_bib0430","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/s12031-011-9687-z","article-title":"PINK1 overexpression protects against C2-ceramide-induced CAD cell death through the PI3K\/AKT pathway","volume":"47","author":"S\u00e1nchez-Mora","year":"2012","journal-title":"J Mol Neurosci"},{"issue":"8","key":"10.1016\/j.neuro.2013.12.012_bib0435","doi-asserted-by":"crossref","first-page":"9649","DOI":"10.3390\/ijms13089649","article-title":"Selenium compounds, apoptosis and other types of cell death: an overview for cancer therapy","volume":"13","author":"Sanmart\u00edn","year":"2012","journal-title":"Int J Mol Sci"},{"issue":"5577","key":"10.1016\/j.neuro.2013.12.012_bib0440","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1126\/science.1072302","article-title":"Regulation of hypoxic death in C. elegans by the insulin\/IGF receptor homolog DAF-2","volume":"296","author":"Scott","year":"2002","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.neuro.2013.12.012_bib0445","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.tcb.2013.04.007","article-title":"A cytoprotective perspective on longevity regulation","volume":"23","author":"Shore","year":"2013","journal-title":"Trends Cell Biol"},{"issue":"1","key":"10.1016\/j.neuro.2013.12.012_bib0450","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neulet.2009.12.078","article-title":"Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles","volume":"471","author":"Sonoda","year":"2010","journal-title":"Neurosci Lett"},{"issue":"1","key":"10.1016\/j.neuro.2013.12.012_bib0455","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.forsciint.2006.06.077","article-title":"Two fatal cases of selenium toxicity","volume":"171","author":"Spiller","year":"2007","journal-title":"Forensic Sci Int"},{"issue":"5870","key":"10.1016\/j.neuro.2013.12.012_bib0460","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1126\/science.1154584","article-title":"TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis","volume":"319","author":"Sreedharan","year":"2008","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.neuro.2013.12.012_bib0465","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0092-8674(00)81780-8","article-title":"Negative regulation of PKB\/Akt-dependent cell survival by the tumor suppressor PTEN","volume":"95","author":"Stambolic","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.neuro.2013.12.012_bib0470","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.freeradbiomed.2013.07.016","article-title":"Interference of selenium and selenoproteins with the insulin-regulated carbohydrate and lipid metabolism","volume":"65","author":"Steinbrenner","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuro.2013.12.012_bib0475","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.fct.2012.10.038","article-title":"High-dose sodium selenite toxicity cannot be prevented by the co-administration of pharmacological levels of epigallocatechin-3-gallate which in turn aggravates the toxicity","volume":"52","author":"Sun","year":"2013","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"10.1016\/j.neuro.2013.12.012_bib0480","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0012-1606(81)90367-5","article-title":"Critical periods in the development of the Caenorhabditis elegans dauer larva","volume":"84","author":"Swanson","year":"1981","journal-title":"Dev Biol"},{"issue":"Pt 11","key":"10.1016\/j.neuro.2013.12.012_bib0485","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1242\/jcs.113.11.2003","article-title":"Genetic defects in acetylcholine signalling promote protein degradation in muscle cells of Caenorhabditis elegans","volume":"113","author":"Szewczyk","year":"2000","journal-title":"J Cell Sci"},{"issue":"1","key":"10.1016\/j.neuro.2013.12.012_bib0490","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1177\/104063870601800108","article-title":"Comparative toxicosis of sodium selenite and selenomethionine in lambs","volume":"18","author":"Tiwary","year":"2006","journal-title":"J Vet Diagn Invest"},{"issue":"8","key":"10.1016\/j.neuro.2013.12.012_bib0495","doi-asserted-by":"crossref","first-page":"15286","DOI":"10.3390\/ijms140815286","article-title":"Exposure to environmental toxicants and pathogenesis of amyotrophic lateral sclerosis: state of the art and research perspectives","volume":"14","author":"Trojsi","year":"2013","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.neuro.2013.12.012_bib0500","doi-asserted-by":"crossref","first-page":"e1002806","DOI":"10.1371\/journal.pgen.1002806","article-title":"TDP-1\/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans","volume":"8","author":"Vaccaro","year":"2012","journal-title":"PLoS Genet"},{"issue":"5674","key":"10.1016\/j.neuro.2013.12.012_bib0505","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1126\/science.1096284","article-title":"Hereditary early-onset Parkinson's disease caused by mutations in PINK1","volume":"304","author":"Valente","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.neuro.2013.12.012_bib0510","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neuro.2013.05.016","article-title":"Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite","volume":"38","author":"Vinceti","year":"2013","journal-title":"Neurotoxicology"},{"issue":"3","key":"10.1016\/j.neuro.2013.12.012_bib0515","first-page":"279","article-title":"Possible involvement of overexposure to environmental selenium in the etiology of amyotrophic lateral sclerosis: a short review","volume":"46","author":"Vinceti","year":"2010","journal-title":"Ann Ist Super Sanita"},{"issue":"2","key":"10.1016\/j.neuro.2013.12.012_bib0520","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.bbrc.2007.10.171","article-title":"Stimulation of selenoprotein P promoter activity in hepatoma cells by FoxO1a transcription factor","volume":"365","author":"Walter","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"10.1016\/j.neuro.2013.12.012_bib0525","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.freeradbiomed.2010.11.033","article-title":"Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions","volume":"50","author":"Wilhelmus","year":"2011","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"10.1016\/j.neuro.2013.12.012_bib0530","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1096\/fj.09-143974","article-title":"Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration","volume":"24","author":"Wirth","year":"2010","journal-title":"FASEB J"},{"issue":"3","key":"10.1016\/j.neuro.2013.12.012_bib0535","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/jcp.21269","article-title":"The MAP kinase JNK-1 of Caenorhabditis elegans: location, activation, and influences over temperature-dependent insulin-like signaling, stress responses, and fitness","volume":"214","author":"Wolf","year":"2008","journal-title":"J Cell Physiol"},{"issue":"15","key":"10.1016\/j.neuro.2013.12.012_bib0540","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1093\/hmg\/ddt164","article-title":"De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease","volume":"22","author":"Wong","year":"2013","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1016\/j.neuro.2013.12.012_bib0545","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1158\/1535-7163.MCT-05-0376","article-title":"Delineating the mechanism by which selenium deactivates Akt in prostate cancer cells","volume":"5","author":"Wu","year":"2006","journal-title":"Mol Cancer Ther"},{"issue":"8","key":"10.1016\/j.neuro.2013.12.012_bib0550","doi-asserted-by":"crossref","first-page":"E1325","DOI":"10.1210\/jc.2011-0620","article-title":"Serum selenoprotein P levels in patients with type 2 diabetes and prediabetes: implications for insulin resistance, inflammation, and atherosclerosis","volume":"96","author":"Yang","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.neuro.2013.12.012_bib0555","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.toxlet.2007.12.002","article-title":"Further insight into the impact of sodium selenite on selenoenzymes: high-dose selenite enhances hepatic thioredoxin reductase 1 activity as a consequence of liver injury","volume":"176","author":"Zhang","year":"2008","journal-title":"Toxicol Lett"},{"issue":"4","key":"10.1016\/j.neuro.2013.12.012_bib0560","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.mad.2010.02.006","article-title":"Selenoproteins and the aging brain","volume":"131","author":"Zhang","year":"2010","journal-title":"Mech Ageing Dev"},{"issue":"10","key":"10.1016\/j.neuro.2013.12.012_bib0565","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1093\/hmg\/ddr076","article-title":"TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin\/IGF-1 signaling","volume":"20","author":"Zhang","year":"2011","journal-title":"Hum Mol Genet"}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X13001939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X13001939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T16:06:34Z","timestamp":1716393994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X13001939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":114,"alternative-id":["S0161813X13001939"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2013.12.012","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The neurodegenerative effects of selenium are inhibited by FOXO and PINK1\/PTEN regulation of insulin\/insulin-like growth factor signaling in Caenorhabditis elegans","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2013.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}