{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:01:58Z","timestamp":1791291718022,"version":"4.1.0"},"reference-count":146,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"JADP","award":["2013-1"],"award-info":[{"award-number":["2013-1"]}]},{"DOI":"10.13039\/501100000646","name":"JSPS","doi-asserted-by":"publisher","award":["23591196"],"award-info":[{"award-number":["23591196"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.neuro.2014.06.014","type":"journal-article","created":{"date-parts":[[2014,7,6]],"date-time":"2014-07-06T01:00:15Z","timestamp":1404608415000},"page":"184-193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":122,"special_numbering":"C","title":["Cerebro-renal interactions: Impact of uremic toxins on cognitive function"],"prefix":"10.1016","volume":"44","author":[{"given":"Kimio","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2014.06.014_bib0005","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000329097","article-title":"Relationship between uric acid and subtle cognitive dysfunction in chronic kidney disease","volume":"34","author":"Afsar","year":"2011","journal-title":"Am J Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0010","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2174\/1567205011310040001","article-title":"Asymmetric dimethylarginine: a possible link between vascular disease and dementia","volume":"10","author":"Asif","year":"2013","journal-title":"Curr Alzheimer Res"},{"key":"10.1016\/j.neuro.2014.06.014_bib0015","doi-asserted-by":"crossref","first-page":"C1075","DOI":"10.1152\/ajpcell.00619.2004","article-title":"Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites","volume":"289","author":"Bahn","year":"2005","journal-title":"Am J Physiol: Cell Physiol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0020","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.pbb.2008.05.001","article-title":"Intrastriatal injection of hypoxanthine impairs memory formation of step-down inhibitory avoidance task in rats","volume":"90","author":"Bavaresco","year":"2008","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.neuro.2014.06.014_bib0025","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1047-2797(97)00015-X","article-title":"Risk of Alzheimer's disease among elderly patients with anemia: population-based investigations in Olmsted County, Minnesota","volume":"7","author":"Beard","year":"1997","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0030","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.mad.2011.10.007","article-title":"Serum concentration of an inflammatory glycotoxin, methylglyoxal, is associated with increased cognitive decline in elderly individuals","volume":"132","author":"Beeri","year":"2011","journal-title":"Mech Ageing Dev"},{"key":"10.1016\/j.neuro.2014.06.014_bib0035","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1053\/j.ajkd.2009.05.013","article-title":"Homocysteine lowering and cognition in CKD: the Veterans Affairs homocysteine study","volume":"54","author":"Brady","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.neuro.2014.06.014_bib0040","doi-asserted-by":"crossref","first-page":"10526","DOI":"10.1073\/pnas.97.19.10526","article-title":"Erythropoietin crosses the blood\u2013brain barrier to protect against experimental brain injury","volume":"97","author":"Brines","year":"2000","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.neuro.2014.06.014_bib0045","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1212\/WNL.0b013e3181b72629","article-title":"Kidney function is associated with the rate of cognitive decline in the elderly","volume":"73","author":"Buchman","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.neuro.2014.06.014_bib0050","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1681\/ASN.2012050536","article-title":"Cognitive disorders and dementia in CKD: the neglected kidney-brain axis","volume":"24","author":"Bugnicourt","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0055","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0093-7754(01)90216-7","article-title":"Effects of epoetin alfa on the central nervous system","volume":"28","author":"Cerami","year":"2001","journal-title":"Semin Oncol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0060","first-page":"68","article-title":"A preliminary report of brain edema in patients with uremia at first hemodialysis: evaluation by diffusion-weighted MR imaging","volume":"28","author":"Chen","year":"2007","journal-title":"AJNR, Am J Neuroradiol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0065","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1681\/ASN.2013040432","article-title":"A pegylated leptin antagonist ameliorates CKD-associated cachexia in mice","volume":"25","author":"Cheung","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0070","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.surg.2007.11.019","article-title":"Cognitive changes after parathyroidectomy in patients with secondary hyperparathyroidism","volume":"143","author":"Chou","year":"2008","journal-title":"Surgery"},{"key":"10.1016\/j.neuro.2014.06.014_bib0075","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/0002-9343(78)90748-9","article-title":"Central nervous system manifestations of hyperparathyroidism","volume":"65","author":"Cogan","year":"1978","journal-title":"Am J Med"},{"key":"10.1016\/j.neuro.2014.06.014_bib0080","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.neurobiolaging.2006.05.007","article-title":"Methylglyoxal impairs glucose metabolism and leads to energy depletion in neuronal cells\u2014protection by carbonyl scavengers","volume":"28","author":"de Arriba","year":"2007","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuro.2014.06.014_bib0085","doi-asserted-by":"crossref","first-page":"S77","DOI":"10.1046\/j.1523-1755.2001.59780077.x","article-title":"Endogenous guanidino compounds as uremic neurotoxins","volume":"78","author":"De Deyn","year":"2001","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.neuro.2014.06.014_bib0090","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1111\/j.1460-9568.2005.04083.x","article-title":"Recognition memory impairment and brain oxidative stress induced by postnatal iron administration","volume":"21","author":"de Lima","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.neuro.2014.06.014_bib0095","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1111\/j.1471-4159.2005.03550.x","article-title":"Involvement of organic anion transporters in the efflux of uremic toxins across the blood\u2013brain barrier","volume":"96","author":"Deguchi","year":"2006","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2014.06.014_bib0100","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.biocel.2007.07.019","article-title":"Methylglyoxal causes strong weakening of detoxifying capacity and apoptotic cell death in rat hippocampal neurons","volume":"40","author":"Di Loreto","year":"2008","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0105","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.neurobiolaging.2012.08.003","article-title":"Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid beta","volume":"34","author":"Doherty","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuro.2014.06.014_bib0110","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1056\/NEJMoa062276","article-title":"Normalization of hemoglobin level in patients with chronic kidney disease and anemia","volume":"355","author":"Drueke","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuro.2014.06.014_bib0115","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1681\/ASN.2011121175","article-title":"Normal and pathologic concentrations of uremic toxins","volume":"23","author":"Duranton","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0120","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1159\/000343276","article-title":"Interleukin 6 plasma concentration associates with cognitive decline: the northern Manhattan study","volume":"40","author":"Economos","year":"2013","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.neuro.2014.06.014_bib0125","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/JGP.0b013e31825d08d6","article-title":"Interleukin-6 and memory functions of encoding and recall in healthy and depressed elderly adults","volume":"20","author":"Elderkin-Thompson","year":"2012","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.neuro.2014.06.014_bib0130","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1111\/j.1523-1755.2005.00238.x","article-title":"Kinetic behavior of urea is different from that of other water-soluble compounds: the case of the guanidino compounds","volume":"67","author":"Eloot","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.neuro.2014.06.014_bib0135","doi-asserted-by":"crossref","first-page":"6741","DOI":"10.1073\/pnas.1031753100","article-title":"Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo","volume":"100","author":"Erbayraktar","year":"2003","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.neuro.2014.06.014_bib0140","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/brain\/awn316","article-title":"Serum uric acid and cognitive function and dementia","volume":"132","author":"Euser","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.neuro.2014.06.014_bib0145","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.biopsych.2009.04.002","article-title":"Identification and characterization of spermidine\/spermine N1-acetyltransferase promoter variants in suicide completers","volume":"66","author":"Fiori","year":"2009","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.neuro.2014.06.014_bib0150","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3233\/JAD-2012-111739","article-title":"Effect of homocysteine lowering treatment on cognitive function: a systematic review and meta-analysis of randomized controlled trials","volume":"29","author":"Ford","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuro.2014.06.014_bib0155","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/mp.2011.18","article-title":"Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and cognitive impairment: the health in men study","volume":"17","author":"Ford","year":"2012","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.neuro.2014.06.014_bib0160","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1749-6632.2002.tb02099.x","article-title":"Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E","volume":"959","author":"Fukui","year":"2002","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.neuro.2014.06.014_bib0165","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.etp.2006.12.001","article-title":"Indole-3-acetic acid induces microencephaly in mouse fetuses","volume":"59","author":"Furukawa","year":"2007","journal-title":"Exp Toxicol Pathol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0170","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1093\/ndt\/gfm659","article-title":"Cognitive outcome following kidney transplantation","volume":"23","author":"Gelb","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.neuro.2014.06.014_bib0175","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3233\/JAD-2010-101095","article-title":"Plasma cystatin C and risk of developing Alzheimer's disease in subjects with mild cognitive impairment","volume":"22","author":"Ghidoni","year":"2010","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.neuro.2014.06.014_bib0180","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/ndt\/gfn623","article-title":"Beta2-microglobulin is potentially neurotoxic, but the blood brain barrier is likely to protect the brain from its toxicity","volume":"24","author":"Giorgetti","year":"2009","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.neuro.2014.06.014_bib0185","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1210\/jcem-51-1-130","article-title":"The relationship between the abnormalities in electroencephalogram and blood levels of parathyroid hormone in dialysis patients","volume":"51","author":"Goldstein","year":"1980","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.neuro.2014.06.014_bib0190","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000384956","article-title":"Parathyroid hormone, uremia, and the nervous system","volume":"20","author":"Goldstein","year":"1980","journal-title":"Contrib Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0195","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/ki.2013.133","article-title":"Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway","volume":"84","author":"Gondouin","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.neuro.2014.06.014_bib0200","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1093\/ndt\/gfl385","article-title":"Cognitive functioning pre- to post-kidney transplantation\u2014a prospective study","volume":"21","author":"Griva","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.neuro.2014.06.014_bib0205","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1172\/JCI107984","article-title":"Changes in the electroencephalogram in acute uremia: effects of parathyroid hormone and brain electrolytes","volume":"55","author":"Guisado","year":"1975","journal-title":"J Clin Invest"},{"key":"10.1016\/j.neuro.2014.06.014_bib0210","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuroscience.2009.03.075","article-title":"Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats","volume":"161","author":"Gupta","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuro.2014.06.014_bib0215","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1038\/nn.3512","article-title":"Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner","volume":"16","author":"Gupta","year":"2013","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.neuro.2014.06.014_bib0220","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1681\/ASN.2006101165","article-title":"Moderate chronic kidney disease and cognitive function in adults 20 to 59 years of age: Third National Health and Nutrition Examination Survey (NHANES III)","volume":"18","author":"Hailpern","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0225","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.1161\/STROKEAHA.113.001886","article-title":"Effect of B vitamins and lowering homocysteine on cognitive impairment in patients with previous stroke or transient ischemic attack: a prespecified secondary analysis of a randomized, placebo-controlled trial and meta-analysis","volume":"44","author":"Hankey","year":"2013","journal-title":"Stroke"},{"key":"10.1016\/j.neuro.2014.06.014_bib0230","first-page":"348","article-title":"Dialysis disequilibrium syndrome","volume":"28","author":"Hill","year":"2001","journal-title":"Nephrol Nurs J"},{"key":"10.1016\/j.neuro.2014.06.014_bib0235","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.bbi.2010.10.021","article-title":"Genomic damage in the progression of chronic kidney disease in rats","volume":"25","author":"Hirotsu","year":"2011","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.neuro.2014.06.014_bib0240","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1001\/archpsyc.65.5.508","article-title":"Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults","volume":"65","author":"Hoogendijk","year":"2008","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.neuro.2014.06.014_bib0245","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1365-2796.2011.02484.x","article-title":"Associations between serum homocysteine, holotranscobalamin, folate and cognition in the elderly: a longitudinal study","volume":"271","author":"Hooshmand","year":"2012","journal-title":"J Intern Med"},{"key":"10.1016\/j.neuro.2014.06.014_bib0250","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/SHK.0b013e3182295f91","article-title":"Intestinal ischemia-reperfusion injury leads to inflammatory changes in the brain","volume":"36","author":"Hsieh","year":"2011","journal-title":"Shock"},{"key":"10.1016\/j.neuro.2014.06.014_bib0255","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1161\/CIRCULATIONAHA.108.819912","article-title":"Vascular endothelial-specific dimethylarginine dimethylaminohydrolase-1-deficient mice reveal that vascular endothelium plays an important role in removing asymmetric dimethylarginine","volume":"120","author":"Hu","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.neuro.2014.06.014_bib0260","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.brainres.2012.06.011","article-title":"Possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of methylglyoxal","volume":"1469","author":"Huang","year":"2012","journal-title":"Brain Res"},{"key":"10.1016\/j.neuro.2014.06.014_bib0265","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/ki.2013.353","article-title":"Mendelian randomization analysis associates increased serum urate, due to genetic variation in uric acid transporters, with improved renal function","volume":"85","author":"Hughes","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.neuro.2014.06.014_bib0270","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1007\/s00216-012-5929-3","article-title":"Protein-bound uremic toxins in hemodialysis patients measured by liquid chromatography\/tandem mass spectrometry and their effects on endothelial ROS production","volume":"403","author":"Itoh","year":"2012","journal-title":"Anal Bioanal Chem"},{"key":"10.1016\/j.neuro.2014.06.014_bib0275","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s11095-006-9183-2","article-title":"Involvement of indoxyl sulfate in renal and central nervous system toxicities during cisplatin-induced acute renal failure","volume":"24","author":"Iwata","year":"2007","journal-title":"Pharm Res"},{"key":"10.1016\/j.neuro.2014.06.014_bib0280","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s11255-008-9375-2","article-title":"Differential impairment of psychomotor efficiency and processing speed in patients with chronic kidney disease","volume":"40","author":"Jassal","year":"2008","journal-title":"Int Urol Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0285","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jalz.2011.11.008","article-title":"Homocysteine, progression of ventricular enlargement, and cognitive decline: the Second Manifestations of ARTerial disease\u2014Magnetic Resonance study","volume":"9","author":"Jochemsen","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.neuro.2014.06.014_bib0290","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s00415-005-0027-5","article-title":"Neuropsychological function in relation to serum parathyroid hormone and serum 25-hydroxyvitamin D levels. The Tromso study","volume":"253","author":"Jorde","year":"2006","journal-title":"J Neurol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0295","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1525-139X.2011.00925.x","article-title":"Vascular incompetence in dialysis patients\u2014protein-bound uremic toxins and endothelial dysfunction","volume":"24","author":"Jourde-Chiche","year":"2011","journal-title":"Semin Dial"},{"key":"10.1016\/j.neuro.2014.06.014_bib0300","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1053\/j.ajkd.2010.11.026","article-title":"Cognitive impairment in peritoneal dialysis patients","volume":"57","author":"Kalirao","year":"2011","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.neuro.2014.06.014_bib0305","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1038\/npp.2011.70","article-title":"Hippocampal leptin signaling reduces food intake and modulates food-related memory processing","volume":"36","author":"Kanoski","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuro.2014.06.014_bib0310","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1681\/ASN.2008101090","article-title":"CKD associates with cognitive decline","volume":"20","author":"Khatri","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0315","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1161\/01.STR.0000231640.32543.11","article-title":"ADMA increases arterial stiffness and decreases cerebral blood flow in humans","volume":"37","author":"Kielstein","year":"2006","journal-title":"Stroke"},{"key":"10.1016\/j.neuro.2014.06.014_bib0320","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11065-009-9110-5","article-title":"Adult chronic kidney disease: neurocognition in chronic renal failure","volume":"20","author":"Koushik","year":"2010","journal-title":"Neuropsychol Rev"},{"key":"10.1016\/j.neuro.2014.06.014_bib0325","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1681\/ASN.2005010005","article-title":"Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study","volume":"16","author":"Kurella","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0330","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1053\/j.ajkd.2004.08.044","article-title":"Chronic kidney disease and cognitive impairment in menopausal women","volume":"45","author":"Kurella","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.neuro.2014.06.014_bib0335","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1053\/j.ajkd.2008.05.004","article-title":"Kidney function and cognitive impairment in US adults: the Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study","volume":"52","author":"Kurella Tamura","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.neuro.2014.06.014_bib0340","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1111\/j.1532-5415.2011.03562.x","article-title":"Impaired frontal executive function and predialytic chronic kidney disease","volume":"59","author":"Lee","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.neuro.2014.06.014_bib0345","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0022-3999(03)00528-2","article-title":"Neurocognitive function and quality of life in relation to hematocrit levels in chronic hemodialysis patients","volume":"57","author":"Lee","year":"2004","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.neuro.2014.06.014_bib0350","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/science.1098313","article-title":"Derivatives of erythropoietin that are tissue protective but not erythropoietic","volume":"305","author":"Leist","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.neuro.2014.06.014_bib0355","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.exger.2010.01.005","article-title":"Association of cognitive function with serum uric acid level among Chinese nonagenarians and centenarians","volume":"45","author":"Li","year":"2010","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0360","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.freeradbiomed.2012.10.552","article-title":"Acute carbonyl stress induces occludin glycation and brain microvascular endothelial barrier dysfunction: role for glutathione-dependent metabolism of methylglyoxal","volume":"54","author":"Li","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.neuro.2014.06.014_bib0365","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1073\/pnas.261709299","article-title":"Memory loss in old rats is associated with brain mitochondrial decay and RNA\/DNA oxidation: partial reversal by feeding acetyl-l-carnitine and\/or R-alpha -lipoic acid","volume":"99","author":"Liu","year":"2002","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.neuro.2014.06.014_bib0370","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1681\/ASN.2007080901","article-title":"Acute kidney injury leads to inflammation and functional changes in the brain","volume":"19","author":"Liu","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0375","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neuroscience.2008.06.033","article-title":"Age-related changes in polyamines in memory-associated brain structures in rats","volume":"155","author":"Liu","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuro.2014.06.014_bib0380","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s12035-013-8579-3","article-title":"Attenuation of early brain injury and learning deficits following experimental subarachnoid hemorrhage secondary to cystatin C: possible involvement of the autophagy pathway","volume":"49","author":"Liu","year":"2014","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0385","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuroscience.2013.02.062","article-title":"Leptin and ghrelin prevent hippocampal dysfunction induced by Abeta oligomers","volume":"241","author":"Martins","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuro.2014.06.014_bib0390","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.neuint.2010.06.016","article-title":"Pro-apoptotic effect of methylguanidine on hydrogen peroxide-treated rat glioma cell line","volume":"57","author":"Marzocco","year":"2010","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuro.2014.06.014_bib0395","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s12020-012-9795-8","article-title":"Methylglyoxal, obesity, and diabetes","volume":"43","author":"Matafome","year":"2013","journal-title":"Endocrine"},{"key":"10.1016\/j.neuro.2014.06.014_bib0400","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1056\/NEJMoa054025","article-title":"A controlled trial of homocysteine lowering and cognitive performance","volume":"354","author":"McMahon","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuro.2014.06.014_bib0405","first-page":"471","article-title":"Neuropsychiatric complications of chronic kidney disease. Nature reviews","volume":"6","author":"McQuillan","year":"2010","journal-title":"Nephrology"},{"key":"10.1016\/j.neuro.2014.06.014_bib0410","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.2215\/CJN.02940509","article-title":"p-Cresyl sulfate and indoxyl sulfate in hemodialysis patients","volume":"4","author":"Meijers","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0415","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.brainres.2007.02.004","article-title":"The effect of infusing hypoxanthine or xanthine on hypoxic\u2013ischemic brain injury in rabbits","volume":"1147","author":"Mink","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.neuro.2014.06.014_bib0420","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.bcp.2012.07.033","article-title":"A uremic toxin, 3-carboxy-4-methyl-5-propyl-2-furanpropionate induces cell damage to proximal tubular cells via the generation of a radical intermediate","volume":"84","author":"Miyamoto","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0425","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/joim.12052","article-title":"Circulating interleukin-6 concentration and cognitive decline in old age: the PROSPER study","volume":"274","author":"Mooijaart","year":"2013","journal-title":"J Intern Med"},{"key":"10.1016\/j.neuro.2014.06.014_bib0430","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1021\/cn3001679","article-title":"Restoration of glyoxalase enzyme activity precludes cognitive dysfunction in a mouse model of Alzheimer's disease","volume":"4","author":"More","year":"2013","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.neuro.2014.06.014_bib0435","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/j.ackd.2008.01.010","article-title":"Cognitive impairment in the aging dialysis and chronic kidney disease populations: an occult burden","volume":"15","author":"Murray","year":"2008","journal-title":"Adv Chronic Kidney Dis"},{"key":"10.1016\/j.neuro.2014.06.014_bib0440","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.2337\/dc11-0186","article-title":"Biomarkers of renal function and cognitive impairment in patients with diabetes","volume":"34","author":"Murray","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/j.neuro.2014.06.014_bib0445","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1053\/j.ajkd.2007.05.010","article-title":"Acute variation in cognitive function in hemodialysis patients: a cohort study with repeated measures","volume":"50","author":"Murray","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.neuro.2014.06.014_bib0450","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1212\/01.wnl.0000225182.15532.40","article-title":"Cognitive impairment in hemodialysis patients is common","volume":"67","author":"Murray","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.neuro.2014.06.014_bib0455","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.bbadis.2012.09.006","article-title":"Uremic toxins inhibit renal metabolic capacity through interference with glucuronidation and mitochondrial respiration","volume":"1832","author":"Mutsaers","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.neuro.2014.06.014_bib0460","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/1744-9987.12147","article-title":"Overview of regular dialysis treatment in Japan (as of 31 December 2011)","volume":"17","author":"Nakai","year":"2013","journal-title":"Therapeutic Apheresis and Dialysis"},{"issue":"Suppl 2","key":"10.1016\/j.neuro.2014.06.014_bib0465","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000350843","article-title":"Removal of protein-bound uraemic toxins by haemodialysis","volume":"35","author":"Niwa","year":"2013","journal-title":"Blood Purif"},{"key":"10.1016\/j.neuro.2014.06.014_bib0470","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1471-4159.2002.01108.x","article-title":"Role of blood\u2013brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain","volume":"83","author":"Ohtsuki","year":"2002","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2014.06.014_bib0475","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1525-139X.2008.00474.x","article-title":"Dialysis disequilibrium syndrome: a narrative review","volume":"21","author":"Patel","year":"2008","journal-title":"Semin Dial"},{"key":"10.1016\/j.neuro.2014.06.014_bib0480","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1056\/NEJMoa0907845","article-title":"A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease","volume":"361","author":"Pfeffer","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.neuro.2014.06.014_bib0485","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/S0272-6386(99)70150-2","article-title":"Normalizing hematocrit in dialysis patients improves brain function","volume":"33","author":"Pickett","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.neuro.2014.06.014_bib0490","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1161\/STROKEAHA.109.557116","article-title":"Association of plasma ADMA levels with MRI markers of vascular brain injury: Framingham offspring study","volume":"40","author":"Pikula","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.neuro.2014.06.014_bib0495","doi-asserted-by":"crossref","first-page":"c247","DOI":"10.1159\/000317206","article-title":"Cognitive profile of chronic kidney disease and hemodialysis patients without dementia","volume":"116","author":"Post","year":"2010","journal-title":"Nephron Clin Pract"},{"key":"10.1016\/j.neuro.2014.06.014_bib0500","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1038\/sj.jcbfm.9600478","article-title":"Cerebrovascular effects of hemodialysis in chronic kidney disease","volume":"27","author":"Prohovnik","year":"2007","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.neuro.2014.06.014_bib0505","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1152\/physiol.00016.2008","article-title":"Brain protection by erythropoietin: a manifold task","volume":"23","author":"Rabie","year":"2008","journal-title":"Physiology"},{"key":"10.1016\/j.neuro.2014.06.014_bib0510","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.neurobiolaging.2012.10.022","article-title":"Mapping creatinine- and cystatin C-related white matter brain deficits in the elderly","volume":"34","author":"Rajagopalan","year":"2013","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuro.2014.06.014_bib0515","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.2215\/CJN.00470705","article-title":"Dementia as a predictor of mortality in dialysis patients","volume":"1","author":"Rakowski","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0520","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/SLA.0b013e3181f66720","article-title":"The effects of serum calcium and parathyroid hormone changes on psychological and cognitive function in patients undergoing parathyroidectomy for primary hyperparathyroidism","volume":"253","author":"Roman","year":"2011","journal-title":"Ann Surg"},{"key":"10.1016\/j.neuro.2014.06.014_bib0525","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1021\/bi901786x","article-title":"The uremic toxin 3-indoxyl sulfate is a potent endogenous agonist for the human aryl hydrocarbon receptor","volume":"49","author":"Schroeder","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuro.2014.06.014_bib0530","doi-asserted-by":"crossref","first-page":"3721","DOI":"10.1681\/ASN.2005010006","article-title":"Cystatin C and subclinical brain infarction","volume":"16","author":"Seliger","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0535","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1097\/01.ASN.0000131529.60019.FA","article-title":"Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition Study","volume":"15","author":"Seliger","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0540","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.phrs.2012.03.004","article-title":"Methylglyoxal promotes oxidative stress and endothelial dysfunction","volume":"65","author":"Sena","year":"2012","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.neuro.2014.06.014_bib0545","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000089235","article-title":"Relation of blood pressure to risk of incident Alzheimer's disease and change in global cognitive function in older persons","volume":"26","author":"Shah","year":"2006","journal-title":"Neuroepidemiology"},{"key":"10.1016\/j.neuro.2014.06.014_bib0550","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/jnr.10777","article-title":"An inhibitor of mitochondrial complex I, rotenone, inactivates proteasome by oxidative modification and induces aggregation of oxidized proteins in SH-SY5Y cells","volume":"74","author":"Shamoto-Nagai","year":"2003","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.neuro.2014.06.014_bib0555","doi-asserted-by":"crossref","first-page":"178","DOI":"10.4161\/auto.26918","article-title":"Spermidine-triggered autophagy ameliorates memory during aging","volume":"10","author":"Sigrist","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.neuro.2014.06.014_bib0560","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1056\/NEJMoa065485","article-title":"Correction of anemia with epoetin alfa in chronic kidney disease","volume":"355","author":"Singh","year":"2006","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.neuro.2014.06.014_bib0565","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1681\/ASN.2013060597","article-title":"Prominent accumulation in hemodialysis patients of solutes normally cleared by tubular secretion","volume":"25","author":"Sirich","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0570","doi-asserted-by":"crossref","first-page":"S122","DOI":"10.1053\/ajkd.2001.27419","article-title":"Central nervous dysfunction in uremia","volume":"38","author":"Smogorzewski","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.neuro.2014.06.014_bib0575","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/gerona\/gls100","article-title":"Methylglyoxal, cognitive function and cerebral atrophy in older people","volume":"68","author":"Srikanth","year":"2013","journal-title":"J Gerontol Ser, A: Biol Sci Med Sci"},{"key":"10.1016\/j.neuro.2014.06.014_bib0580","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/ndt\/gfs133","article-title":"p-Cresol sulfate and indoxyl sulfate induce similar cellular inflammatory gene expressions in cultured proximal renal tubular cells","volume":"28","author":"Sun","year":"2013","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.neuro.2014.06.014_bib0585","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1212\/01.wnl.0000326894.40353.93","article-title":"Serum cystatin C and the risk of Alzheimer disease in elderly men","volume":"71","author":"Sundelof","year":"2008","journal-title":"Neurology"},{"key":"10.1016\/j.neuro.2014.06.014_bib0590","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/sj.ki.5002032","article-title":"Frequent Hemodialysis Network (FHN) randomized trials: study design","volume":"71","author":"Suri","year":"2007","journal-title":"Kidney Int"},{"key":"10.1016\/j.neuro.2014.06.014_bib0595","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/2045-8118-8-13","article-title":"Transport characteristics of guanidino compounds at the blood\u2013brain barrier and blood\u2013cerebrospinal fluid barrier: relevance to neural disorders","volume":"8","author":"Tachikawa","year":"2011","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.neuro.2014.06.014_bib0600","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/oxfordjournals.ndt.a092113","article-title":"Recombinant erythropoietin improves cognitive function in chronic haemodialysis patients","volume":"7","author":"Temple","year":"1992","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.neuro.2014.06.014_bib0605","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/hipo.22016","article-title":"Hippocampal polyamine levels and transglutaminase activity are paralleling spatial memory retrieval in the C57BL\/6 J mouse","volume":"22","author":"Tiboldi","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuro.2014.06.014_bib0610","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.physbeh.2004.12.001","article-title":"GSA: behavioral, histological, electrophysiological and neurochemical effects","volume":"84","author":"Torremans","year":"2005","journal-title":"Physiol Behav"},{"key":"10.1016\/j.neuro.2014.06.014_bib0615","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1053\/j.ajkd.2005.02.028","article-title":"Stroke in patients on maintenance hemodialysis: a 22-year single-center study","volume":"45","author":"Toyoda","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.neuro.2014.06.014_bib0620","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.neurobiolaging.2008.09.009","article-title":"Homocysteine and inflammation: predictors of cognitive decline in older persons?","volume":"31","author":"van den Kommer","year":"2010","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.neuro.2014.06.014_bib0625","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1681\/ASN.V1081815","article-title":"Pathophysiologic effects of uremic retention solutes","volume":"10","author":"Vanholder","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0630","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1046\/j.1523-1755.2003.00924.x","article-title":"Review on uremic toxins: classification, concentration, and interindividual variability","volume":"63","author":"Vanholder","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.neuro.2014.06.014_bib0635","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1046\/j.1523-1755.63.s84.43.x","article-title":"New insights in uremic toxins","author":"Vanholder","year":"2003","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.neuro.2014.06.014_bib0640","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00467-008-0762-9","article-title":"What is new in uremic toxicity?","volume":"23","author":"Vanholder","year":"2008","journal-title":"Pediatr Nephrol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0645","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1161\/STROKEAHA.108.521591","article-title":"Cerebral ischemia mediates the effect of serum uric acid on cognitive function","volume":"39","author":"Vannorsdall","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.neuro.2014.06.014_bib0650","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s13105-011-0100-8","article-title":"Age-related changes in xanthine oxidase activity and lipid peroxidation, as well as in the correlation between both parameters, in plasma and several organs from female mice","volume":"67","author":"Vida","year":"2011","journal-title":"J Physiol Biochem"},{"key":"10.1016\/j.neuro.2014.06.014_bib0655","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1093\/ndt\/gfl256","article-title":"Effect of short daily home haemodialysis on quality of life, cognitive functioning and the electroencephalogram","volume":"21","author":"Vos","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.neuro.2014.06.014_bib0660","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1468-1331.2009.02809.x","article-title":"Cystatin C as an index of cerebral small vessel disease: results of a cross-sectional study in community-based Japanese elderly","volume":"17","author":"Wada","year":"2010","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.neuro.2014.06.014_bib0665","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1007\/s00702-013-0989-x","article-title":"Effect of hypoxanthine, antioxidants and allopurinol on cholinesterase activities in rats","volume":"120","author":"Wamser","year":"2013","journal-title":"J Neural Transm"},{"key":"10.1016\/j.neuro.2014.06.014_bib0670","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.lfs.2009.05.003","article-title":"Differential impairment of spatial and nonspatial cognition in a mouse model of brain aging","volume":"85","author":"Wang","year":"2009","journal-title":"Life Sci"},{"key":"10.1016\/j.neuro.2014.06.014_bib0675","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/ki.2012.448","article-title":"p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress by activation of NADPH oxidase","volume":"83","author":"Watanabe","year":"2013","journal-title":"Kidney Int"},{"key":"10.1016\/j.neuro.2014.06.014_bib0680","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1253\/circj.CJ-12-0647","article-title":"Activation of aryl hydrocarbon receptor mediates indoxyl sulfate-induced monocyte chemoattractant protein-1 expression in human umbilical vein endothelial cells","volume":"77","author":"Watanabe","year":"2013","journal-title":"Circ J"},{"key":"10.1016\/j.neuro.2014.06.014_bib0685","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3390\/toxins6010254","article-title":"Methylglyoxal (MG) and cerebro-renal interaction: does long-term orally administered MG cause cognitive impairment in normal Sprague-Dawley rats?","volume":"6","author":"Watanabe","year":"2014","journal-title":"Toxins"},{"key":"10.1016\/j.neuro.2014.06.014_bib0690","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1053\/j.ajkd.2008.08.022","article-title":"Albuminuria, cognitive functioning, and white matter hyperintensities in homebound elders","volume":"53","author":"Weiner","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.neuro.2014.06.014_bib0695","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1093\/ndt\/gfq580","article-title":"p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease","volume":"26","author":"Wu","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.neuro.2014.06.014_bib0700","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/ana.21383","article-title":"Cystatin C as a marker of cognitive function in elders: findings from the health ABC study","volume":"63","author":"Yaffe","year":"2008","journal-title":"Ann Neurol"},{"issue":"Suppl 1","key":"10.1016\/j.neuro.2014.06.014_bib0705","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1016\/j.bone.2009.03.655","article-title":"Recent progress in understanding dialysis-related amyloidosis","volume":"45","author":"Yamamoto","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.neuro.2014.06.014_bib0710","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/jnc.12263","article-title":"IL-1beta and TNF-alpha induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase","volume":"125","author":"Ye","year":"2013","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2014.06.014_bib0715","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/gerona\/gls155","article-title":"Leptin, mild cognitive impairment, and dementia among elderly women","volume":"68","author":"Zeki Al Hazzouri","year":"2013","journal-title":"J Gerontol Ser, A: Biol Sci Med Sci"},{"key":"10.1016\/j.neuro.2014.06.014_bib0720","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.brainres.2009.07.077","article-title":"Therapeutic effects of erythropoietin on histological and functional outcomes following traumatic brain injury in rats are independent of hematocrit","volume":"1294","author":"Zhang","year":"2009","journal-title":"Brain Res"},{"issue":"12","key":"10.1016\/j.neuro.2014.06.014_bib0725","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1021\/pr400939q","article-title":"A novel urinary metabolite signature for diagnosing major depressive disorder","volume":"12","author":"Zheng","year":"2013","journal-title":"J Proteome Res"},{"key":"10.1016\/j.neuro.2014.06.014_bib0730","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.cca.2009.11.003","article-title":"Urinary metabonomic study on biochemical changes in chronic unpredictable mild stress model of depression","volume":"411","author":"Zheng","year":"2010","journal-title":"Clin Chim Acta"}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X14001053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X14001053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T14:57:03Z","timestamp":1649602623000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X14001053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":146,"alternative-id":["S0161813X14001053"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2014.06.014","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cerebro-renal interactions: Impact of uremic toxins on cognitive function","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2014.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}