{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:57:53Z","timestamp":1792673873237,"version":"4.5.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.neuro.2014.11.009","type":"journal-article","created":{"date-parts":[[2014,12,12]],"date-time":"2014-12-12T22:55:10Z","timestamp":1418424910000},"page":"60-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Importance of genetics in fetal alcohol effects: Null mutation of the nNOS gene worsens alcohol-induced cerebellar neuronal losses and behavioral deficits"],"prefix":"10.1016","volume":"46","author":[{"suffix":"Jr.","given":"Daniel J.","family":"Bonthius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Winters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahri","family":"Karacay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha Larimer","family":"Bousquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Bonthius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2014.11.009_bib0005","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0892-0362(95)00005-C","article-title":"An update on incidence of FAS: FAS is not an equal opportunity birth defect","volume":"17","author":"Abel","year":"1995","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.neuro.2014.11.009_bib0010","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1212\/WNL.43.8.1536","article-title":"Memory in patients with cerebellar degeneration","volume":"43","author":"Appollonio","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.neuro.2014.11.009_bib0015","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1017\/S0012162201001748","article-title":"MRI findings in children with school problems who had been exposed prenatally to alcohol","volume":"44","author":"Autti-Ramo","year":"2002","journal-title":"Dev Med Child Neurol"},{"key":"10.1016\/j.neuro.2014.11.009_bib0020","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1046\/j.1471-4159.1995.64052087.x","article-title":"Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of beta-amyloid precursor","volume":"64","author":"Barger","year":"1995","journal-title":"J Neurochem"},{"key":"10.1016\/j.neuro.2014.11.009_bib0025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0741-8329(88)90054-7","article-title":"Blood alcohol concentration and severity of microencephaly in neonatal rats depend on the pattern of alcohol administration","volume":"5","author":"Bonthius","year":"1988","journal-title":"Alcohol"},{"key":"10.1016\/j.neuro.2014.11.009_bib0030","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1530-0277.1990.tb00455.x","article-title":"Alcohol-induced neuronal loss in developing rats: Increased brain damage with binge exposure","volume":"14","author":"Bonthius","year":"1990","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0165-3806(02)00458-3","article-title":"Deficiency of neuronal nitric oxide synthase (nNOS) worsens alcohol-induced microencephaly and neuronal loss in developing mice","volume":"138","author":"Bonthius","year":"2002","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0385","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0165-3806(02)00549-7","article-title":"FGF-2, NGF and IGF-1, but not BDNF, utilize a nitric oxide pathway to signal neurotrophic and neuroprotective effects against alcohol toxicity in cerebellar granule cell cultures","volume":"140","author":"Bonthius","year":"2003","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ntt.2003.08.004","article-title":"The NO-cGMP-PKG pathway plays an essential role in the acquisition of ethanol resistance by cerebellar granule neurons","volume":"26","author":"Bonthius","year":"2004","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.neuro.2014.11.009_bib0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.brainresprot.2004.09.003","article-title":"Use of frozen sections to determine neuronal number in the murine hippocampus and neocortex using the optical disector and optical fractionator","volume":"14","author":"Bonthius","year":"2004","journal-title":"Brain Res Protocol"},{"key":"10.1016\/j.neuro.2014.11.009_bib0050","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/cne.21095","article-title":"Severe alcohol-induced neuronal deficits in the hippocampus and neocortex of neonatal mice genetically deficient for neuronal nitric oxide synthase (nNOS)","volume":"499","author":"Bonthius","year":"2006","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.neuro.2014.11.009_bib0055","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.neuro.2008.08.007","article-title":"The protective effect of neuronal nitric oxide synthase (nNOS) against alcohol toxicity depends upon the NO-cGMP-PKG pathway and NF-kappaB","volume":"29","author":"Bonthius","year":"2008","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2014.11.009_bib0060","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.neuropharm.2008.12.006","article-title":"Nitric oxide utilizes NF-kB to signal its neuroprotective effect against alcohol toxicity","volume":"56","author":"Bonthius","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuro.2014.11.009_bib0065","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/ar.b.20114","article-title":"Damage to the human cerebellum from prenatal alcohol exposure: the anatomy of a simple biometrical explanation","volume":"289B","author":"Bookstein","year":"2006","journal-title":"Anat Rec"},{"key":"10.1016\/j.neuro.2014.11.009_bib0070","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.brainresrev.2011.02.001","article-title":"The role of oxidative stress in fetal alcohol spectrum disorders","volume":"67","author":"Brocardo","year":"2011","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.neuro.2014.11.009_bib0075","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0812s15","article-title":"Motor coordination and balance in rodents","author":"Carter","year":"2001","journal-title":"Curr Protoc Neurosci"},{"key":"10.1016\/j.neuro.2014.11.009_bib0080","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/ana.23842","article-title":"Nitric oxide signaling in the brain: a new target for inhaled nitric oxide","volume":"73","author":"Charriaut-Marlangue","year":"2013","journal-title":"Ann Neurol"},{"key":"10.1016\/j.neuro.2014.11.009_bib0085","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/S0022-3476(75)80919-X","article-title":"Fetal alcohol syndrome in dizygotic twins","volume":"87","author":"Christoffel","year":"1975","journal-title":"J Pediatr"},{"key":"10.1016\/j.neuro.2014.11.009_bib0090","first-page":"363","article-title":"Genetic evidence for the neuronal nitric oxide synthase gene (NOS1) as a susceptibility locus for infantile pyloric stenosis","volume":"58","author":"Chung","year":"1996","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.neuro.2014.11.009_bib0095","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0010-9452(08)70275-2","article-title":"Impaired cerebellar learning in children with prenatal alcohol exposure: a comparative study of eyeblink conditioning in children with ADHD and dyslexia","volume":"41","author":"Coffin","year":"2005","journal-title":"Cortex"},{"key":"10.1016\/j.neuro.2014.11.009_bib0100","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.neuropsychologia.2005.07.016","article-title":"Effects of prenatal alcohol exposure on fine motor coordination and balance: a study of two adult samples","volume":"44","author":"Connor","year":"2006","journal-title":"Neuropsychologia"},{"key":"10.1016\/j.neuro.2014.11.009_bib0105","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0891-0618(96)00148-2","article-title":"Nitric oxide neurotoxicity","volume":"10","author":"Dawson","year":"1996","journal-title":"J Chem Neuroanat"},{"key":"10.1016\/j.neuro.2014.11.009_bib0110","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1523\/JNEUROSCI.16-08-02479.1996","article-title":"Resistance to neurotoxicity in cortical cultures from neuronal nitric oxide synthase-deficient mice","volume":"16","author":"Dawson","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuro.2014.11.009_bib0115","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.neuro.2009.01.010","article-title":"A single exposure to alcohol during brain development induces microencephaly and neuronal losses in genetically susceptible mice, but not in wild type mice","volume":"30","author":"de Licona","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2014.11.009_bib0120","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0378-3782(79)90022-7","article-title":"Comparative aspects of the brain growth spurt","volume":"3","author":"Dobbing","year":"1979","journal-title":"Early Hum Dev"},{"key":"10.1016\/j.neuro.2014.11.009_bib0125","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1523\/JNEUROSCI.16-07-02325.1996","article-title":"Nitric oxide delays the death of trophic factor-deprived PC12 cells and sympathetic neurons by a cGMP-mediated mechanism","volume":"16","author":"Farinelli","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuro.2014.11.009_bib0130","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1523\/JNEUROSCI.16-02-00808.1996","article-title":"A positron emission tomography study of the short-term maintenance of verbal information","volume":"16","author":"Fiez","year":"1996","journal-title":"J Neurosci"},{"key":"10.1016\/j.neuro.2014.11.009_bib0135","series-title":"Alcohol: effects on brain and development","first-page":"59","article-title":"Temporal windows of vulnerability within the third trimester equivalent: Why \u201cknowing when\u201d matters","author":"Goodlett","year":"1999"},{"key":"10.1016\/j.neuro.2014.11.009_bib0140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000022861","article-title":"Single tandem repeat polymorphisms in the neuronal nitric oxide synthase gene in different ethnic populations","volume":"49","author":"Grasemann","year":"1999","journal-title":"Hum Hered"},{"key":"10.1016\/j.neuro.2014.11.009_bib0145","doi-asserted-by":"crossref","first-page":"33082","DOI":"10.1016\/S0021-9258(20)30099-5","article-title":"Structural organization of the human neuronal nitric oxide synthase gene (NOS1)","volume":"269","author":"Hall","year":"1994","journal-title":"Biol Chem"},{"key":"10.1016\/j.neuro.2014.11.009_bib0150","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0022-3476(78)80449-1","article-title":"The effects of moderate alcohol consumption during pregnancy on fetal growth and morphogenesis","volume":"92","author":"Hanson","year":"1978","journal-title":"J Pediatr"},{"key":"10.1016\/j.neuro.2014.11.009_bib0155","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/neu.20208","article-title":"Effect of bax deletion on ethanol sensitivity in the neonatal rat cerebellum","volume":"66","author":"Heaton","year":"2006","journal-title":"J Neurobiol"},{"key":"10.1016\/j.neuro.2014.11.009_bib0160","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0006-291X(88)80015-9","article-title":"Nitric oxide: a cytotoxic activated macrophage effector molecule","volume":"157","author":"Hibbs","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.neuro.2014.11.009_bib0165","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1542\/peds.2005-0702","article-title":"A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 Institute of Medicine Criteria","volume":"115","author":"Hoyme","year":"2005","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuro.2014.11.009_bib0170","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/B978-0-12-800254-4.00006-4","article-title":"Hippocampus and nitric oxide","volume":"96","author":"Hu","year":"2014","journal-title":"Vitam Horm"},{"key":"10.1016\/j.neuro.2014.11.009_bib0175","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/0092-8674(93)90615-W","article-title":"Targeted disruption of the neuronal nitric oxide synthase gene","volume":"75","author":"Huang","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.neuro.2014.11.009_bib0180","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1530-0277.1998.tb03659.x","article-title":"Relation of maternal age and pattern of pregnancy drinking to functionally significant cognitive deficit in infancy","volume":"22","author":"Jacobson","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0185","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1097\/01.ALC.0000145691.81233.FA","article-title":"Maternal age, alcohol abuse history, and quality of parenting as moderators of the effects of prenatal alcohol exposure on 7.5 year intellectual function","volume":"28","author":"Jacobson","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0190","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainres.2007.01.059","article-title":"Stimulation of the cAMP pathway protects cultured cerebellar granule neurons against alcohol-induced cell death by activating the neuronal nitric oxide synthase (nNOS) gene","volume":"1143","author":"Karacay","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0195","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.freeradbiomed.2004.08.004","article-title":"The peroxynitrite pathway in development: phenytoin and benzo[a]pyrene embryopathies in inducible nitric oxide synthase knockout mice","volume":"37","author":"Kasapinovic","year":"2004","journal-title":"Free Rad Biol Med"},{"key":"10.1016\/j.neuro.2014.11.009_bib0200","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1530-0277.1987.tb01308.x","article-title":"Developmental changes in alcohol pharmacokinetics in rats","volume":"11","author":"Kelly","year":"1987","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0205","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1111\/j.1530-0277.2002.tb02455.x","article-title":"Drinking during pregnancy: attitudes and knowledge among pregnant Danish women, 1998","volume":"26","author":"Kesmodel","year":"2002","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0210","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/hmg\/ddg009","article-title":"Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case control study","volume":"12","author":"Levecque","year":"2003","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.neuro.2014.11.009_bib0215","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1111\/j.1530-0277.1992.tb01909.x","article-title":"Fetal alcohol syndrome: a case report of neuropsychological, MRI an EEG assessment of two children","volume":"16","author":"Mattson","year":"1992","journal-title":"Alcohol: Clin Exp Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0220","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1242\/dev.094938","article-title":"Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD","volume":"140","author":"McCarthy","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.neuro.2014.11.009_bib0225","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/toxsci\/kft122","article-title":"Embryonic catalase protects against ethanol-initiated DNA oxidation and teratogenesis in acatalasemic and transgenic human catalase-expressing mice","volume":"134","author":"Miller","year":"2013","journal-title":"Toxicol Sci"},{"key":"10.1016\/j.neuro.2014.11.009_bib0230","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.freeradbiomed.2014.09.026","article-title":"Oxidative DNA, damage in the in utero initiation of postnatal neurodevelopmental deficits by normal fetal and ethanol-enhanced oxidative stress in oxoguanine glycosylase 1 knockout mice","volume":"78","author":"Miller-Pinsler","year":"2015","journal-title":"Free Rad Biol Med"},{"key":"10.1016\/j.neuro.2014.11.009_bib0235","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1016\/j.febslet.2005.09.082","article-title":"Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation","volume":"579","author":"Moon","year":"2005","journal-title":"FEBS Lett"},{"key":"10.1016\/j.neuro.2014.11.009_bib0240","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/378383a0","article-title":"Behavioral abnormalities in mice lacking neuronal nitric oxide synthase","volume":"378","author":"Nelson","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.neuro.2014.11.009_bib0245","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ntt.2012.11.003","article-title":"Children with heavy prenatal alcohol exposure have different frequency domain signal characteristics when producing isometric force","volume":"35","author":"Nguyen","year":"2013","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.neuro.2014.11.009_bib0250","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1530-0277.2012.01896.x","article-title":"Children with heavy prenatal alcohol exposure experience reduced control of isotonic force","volume":"37","author":"Nguyen","year":"2013","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0255","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1073\/pnas.1017608108","article-title":"Tissue plasminogen activator is required for the development of fetal alcohol syndrome in mice","volume":"108","author":"Noel","year":"2011","journal-title":"PNAS"},{"key":"10.1016\/j.neuro.2014.11.009_bib0260","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ddrr.72","article-title":"Neuroimaging and fetal alcohol spectrum disorders","volume":"15","author":"Norman","year":"2009","journal-title":"Dev Disabil Res Rev"},{"key":"10.1016\/j.neuro.2014.11.009_bib0265","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0165-3806(98)00107-2","article-title":"Developmental characteristics of neuronal nitric oxide synthase (nNOS) immunoreactive neurons in fetal to adolescent human brains","volume":"110","author":"Ohyu","year":"1998","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0270","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0022-510X(79)90033-9","article-title":"Alcohol embryo- and fetopathy","volume":"41","author":"Peiffer","year":"1979","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.neuro.2014.11.009_bib0275","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1530-0277.1998.tb03646.x","article-title":"Prenatal exposure to alcohol affects the ability to maintain postural balance","volume":"22","author":"Roebuck","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0280","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1111\/j.1530-0277.1998.tb05908.x","article-title":"Neuromuscular responses to disturbance of balance in children with prenatal exoposure to alcohol","volume":"22","author":"Roebuck","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0285","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1530-0277.1998.tb03658.x","article-title":"A review of the neuroanatomical findings in children with fetal alcohol syndrome or prenatal exposure to alcohol","volume":"22","author":"Roebuck","year":"1998","journal-title":"Alcohol: Clin Exp Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0290","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0165-3806(98)00140-0","article-title":"Expression of neuronal nitric oxide synthase during embryonic development of the rat cerebral cortex","volume":"111","author":"Santacana","year":"1998","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0295","first-page":"20","article-title":"Neuronal Nos (Nos 1) polymorphism in patients with epilepsy: a pilot study","volume":"23","author":"Sayitoglu","year":"2006","journal-title":"J Neurol Sci (Turkish)"},{"key":"10.1016\/j.neuro.2014.11.009_bib0300","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/jnnp.64.4.492","article-title":"Functional magnetic resonance imaging of human brain activity in a verbal fluency task","volume":"64","author":"Schlosser","year":"1998","journal-title":"J Neurol Neurosurg Psych"},{"key":"10.1016\/j.neuro.2014.11.009_bib0305","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.neuro.2014.11.009_bib0310","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/hipo.22203","article-title":"Prenatal ethanol exposure has sex-specific effects on hippocampal long-term potentiation","volume":"24","author":"Sickmann","year":"2014","journal-title":"Hippocampus"},{"key":"10.1016\/j.neuro.2014.11.009_bib0315","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1067\/mpd.2002.128112","article-title":"Alcohol dehydrogenase 2 genotypes, maternal alcohol use, and infant outcome","volume":"141","author":"Stoler","year":"2002","journal-title":"J Pediatr"},{"key":"10.1016\/j.neuro.2014.11.009_bib0320","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0376-8716(94)90090-6","article-title":"Prenatal alcohol and offspring development: the first fourteen years","volume":"36","author":"Streissguth","year":"1994","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.neuro.2014.11.009_bib0325","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/ajmg.1320470612","article-title":"Fetal alcohol syndrome in twins of alcoholic mothers: concordance of diagnosis and IQ","volume":"47","author":"Streissguth","year":"1993","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.neuro.2014.11.009_bib0330","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1756-6606-2-19","article-title":"Abnormal social behavior, hyperactivity, impaired remote spatial memory, and increased D1-mediated dopaminergic signaling in neuronal nitric oxide synthase knockout mice","volume":"2","author":"Tanda","year":"2009","journal-title":"Mol Brain"},{"key":"10.1016\/j.neuro.2014.11.009_bib0335","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/S0006-8993(97)81694-0","article-title":"Cyclic guanosine 3\u2032,5\u2032-monophosphate-mediated neuroprotection by nitric oxide in dissociated cultures of rat dorsal root ganglion neurons","volume":"774","author":"Thippeswamy","year":"1997","journal-title":"Brain Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0340","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0165-3806(97)00164-8","article-title":"Alcohol-induced Purkinje cell loss depends on developmental timing of alcohol exposure and correlates with motor performance","volume":"105","author":"Thomas","year":"1998","journal-title":"Brain Res Dev Brain Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0345","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbr.2013.12.016","article-title":"Acute exposure to ethanol on gestational day 15 affects social motivation of female offspring","volume":"261","author":"Varlinskaya","year":"2014","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0350","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1017\/S1355617711000063","article-title":"Neuropsychological comparison of children with heavy prenatal alcohol exposure and an IQ-matched comparison group","volume":"17","author":"Vaurio","year":"2011","journal-title":"J Int Neuropsychol Soc"},{"key":"10.1016\/j.neuro.2014.11.009_bib0355","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1111\/j.1530-0277.2001.tb02180.x","article-title":"Alcohol dehydrogenase-2*2 allele is associated with decreased prevalence of fetal alcohol syndrome in the mixed ancestry population of the Western Cape Province, South Africa","volume":"25","author":"Viljoen","year":"2001","journal-title":"Alcohol Clin Exp Res"},{"key":"10.1016\/j.neuro.2014.11.009_bib0360","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1615\/CritRevNeurobiol.v13.i1.20","article-title":"Neuronal NOS: gene structure, mRNA diversity, and functional relevance","volume":"13","author":"Wang","year":"1999","journal-title":"Crit Rev Neurobiol"},{"key":"10.1016\/j.neuro.2014.11.009_bib0365","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/bdra.20125","article-title":"Genetic polymorphisms: impact on the risk for fetal alcohol spectrum disorders","volume":"73","author":"Warren","year":"2005","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"10.1016\/j.neuro.2014.11.009_bib0370","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.niox.2004.03.007","article-title":"Neuronal nitric oxide synthase knock-out mice show impaired cognitive performance","volume":"10","author":"Weitzdoerfer","year":"2004","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.neuro.2014.11.009_bib0375","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1055\/s-2008-1059578","article-title":"A clinical neuropathological study of the fetal alcohol syndrome","volume":"14","author":"Wisniewski","year":"1983","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.neuro.2014.11.009_bib0380","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/sj.cdd.4401277","article-title":"Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain","volume":"10","author":"Young","year":"2003","journal-title":"Cell Death Different"}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X14002150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X14002150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T10:30:47Z","timestamp":1650796247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X14002150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":77,"alternative-id":["S0161813X14002150"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2014.11.009","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Importance of genetics in fetal alcohol effects: Null mutation of the nNOS gene worsens alcohol-induced cerebellar neuronal losses and behavioral deficits","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2014.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}