{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T03:01:24Z","timestamp":1780542084605,"version":"3.54.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"ICMR","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.neuro.2015.03.003","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T03:33:19Z","timestamp":1425871999000},"page":"44-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Nitrous oxide related behavioral and histopathological changes may be related to oxidative stress"],"prefix":"10.1016","volume":"48","author":[{"given":"Sandeep Kumar","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha Kant","family":"Misra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayantee","family":"Kalita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Himangsu K.","family":"Bora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh C.","family":"Murthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neuro.2015.03.003_bib0070","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.apmr.2004.01.019","article-title":"Cobalamin deficiency and subacute combined degeneration after nitrous oxide anesthesia: a case report","volume":"86","author":"Ahn","year":"2005","journal-title":"Arch Phys Med Rehabil"},{"issue":"1","key":"10.1016\/j.neuro.2015.03.003_bib0050","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3109\/00048679709073810","article-title":"Myeloneuropathy from whipped cream bulbs presenting as conversion disorder","volume":"31","author":"Brett","year":"1997","journal-title":"Aust N Z J Psychiatry"},{"key":"10.1016\/j.neuro.2015.03.003_bib0125","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0377-1237(01)80133-7","article-title":"Oxygen toxicity","volume":"57","author":"Chawla","year":"2001","journal-title":"Med J Armed Forces India"},{"key":"10.1016\/j.neuro.2015.03.003_bib0130","first-page":"46","article-title":"Effects of excessive pressures of oxygen, nitrogen, helium, carbon dioxide, and carbon monoxide","volume":"1980","author":"CJ","year":"1901","journal-title":"Med Physiol"},{"key":"10.1016\/j.neuro.2015.03.003_bib0135","first-page":"370","article-title":"Principles of oxygen therapy","author":"DC","year":"1990","journal-title":"Respir Med"},{"issue":"3","key":"10.1016\/j.neuro.2015.03.003_bib0115","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00415-004-0348-9","article-title":"The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy","volume":"251","author":"Gilgun-Sherki","year":"2004","journal-title":"J Neurol"},{"issue":"1","key":"10.1016\/j.neuro.2015.03.003_bib0105","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1352458507080111","article-title":"Oxidative stress and excitotoxicity: a therapeutic issue in multiple sclerosis?","volume":"14","author":"Gonsette","year":"2008","journal-title":"Mult Scler"},{"issue":"1","key":"10.1016\/j.neuro.2015.03.003_bib0120","doi-asserted-by":"crossref","first-page":"33","DOI":"10.17305\/bjbms.2011.2620","article-title":"Serum total antioxidant capacity in patients with multiple sclerosis","volume":"11","author":"Hadzovic-Dzuvo","year":"2011","journal-title":"Bosn J Basic Med Sci"},{"issue":"Pt 7","key":"10.1016\/j.neuro.2015.03.003_bib0110","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1093\/brain\/awr128","article-title":"Oxidative damage in multiple sclerosis lesions","volume":"134","author":"Haider","year":"2011","journal-title":"Brain"},{"issue":"1-2","key":"10.1016\/j.neuro.2015.03.003_bib0095","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jneuroim.2004.02.005","article-title":"Inducible nitric oxide synthase in chronic active multiple sclerosis plaques: distribution, cellular expression and association with myelin damage","volume":"151","author":"Hill","year":"2004","journal-title":"J Neuroimmunol"},{"issue":"3","key":"10.1016\/j.neuro.2015.03.003_bib0040","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.neuroscience.2003.07.012","article-title":"Prolonged exposure to inhalational anesthetic nitrous oxide kills neurons in adult rat brain","volume":"122","author":"Jevtovic-Todorovic","year":"2003","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.neuro.2015.03.003_bib0080","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1093\/bja\/64.2.214","article-title":"Dimethylthiourea, a hydroxyl radical scavenger, impedes the inactivation of methionine synthase by nitrous oxide in mice","volume":"64","author":"Koblin","year":"1990","journal-title":"Br J Anaesth"},{"issue":"5","key":"10.1016\/j.neuro.2015.03.003_bib0035","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1136\/jcp.54.5.356","article-title":"Method for the measurement of antioxidant activity in human fluids","volume":"54","author":"Koracevic","year":"2001","journal-title":"J Clin Pathol"},{"issue":"8102","key":"10.1016\/j.neuro.2015.03.003_bib0005","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/S0140-6736(78)92101-3","article-title":"Myeloneuropathy after prolonged exposure to nitrous oxide","volume":"2","author":"Layzer","year":"1978","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.neuro.2015.03.003_bib0055","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1212\/WNL.28.5.504","article-title":"Neuropathy following abuse of nitrous oxide","volume":"28","author":"Layzer","year":"1978","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.neuro.2015.03.003_bib0085","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/bja\/59.1.3","article-title":"Clinical aspects of the interaction between nitrous oxide and vitamin B12","volume":"59","author":"Nunn","year":"1987","journal-title":"Br J Anaesth"},{"issue":"5","key":"10.1016\/j.neuro.2015.03.003_bib0075","first-page":"894","article-title":"Myelopathy caused by nitrous oxide toxicity","volume":"19","author":"Pema","year":"1998","journal-title":"Am J Neuroradiol"},{"issue":"5","key":"10.1016\/j.neuro.2015.03.003_bib0060","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1212\/WNL.28.5.485","article-title":"Polyneuropathy from inhalation of N2O cartridges through a whipped-cream dispenser","volume":"28","author":"Sahenk","year":"1978","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.neuro.2015.03.003_bib0025","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.expneurol.2004.12.020","article-title":"Cobalamin (vitamin B(12)) in subacute combined degeneration and beyond: traditional interpretations and novel theories","volume":"192","author":"Scalabrino","year":"2005","journal-title":"Exp Neurol"},{"issue":"3","key":"10.1016\/j.neuro.2015.03.003_bib0010","first-page":"297","article-title":"Subacute combined degeneration and induction of ornithine decarboxylase in spinal cords of totally gastrectomized rats","volume":"62","author":"Scalabrino","year":"1990","journal-title":"Lab Invest"},{"key":"10.1016\/j.neuro.2015.03.003_bib0045","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1600-0404.1994.tb05406.x","article-title":"Effects of the disruption of transmethylation in the central nervous system: an animal model","volume":"154","author":"Scott","year":"1994","journal-title":"Acta Neurol Scand Suppl"},{"issue":"5","key":"10.1016\/j.neuro.2015.03.003_bib0100","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1600-0404.1979.tb02980.x","article-title":"Decreased erythrocyte glutathione peroxidase activity in multiple sclerosis","volume":"60","author":"Szeinberg","year":"1979","journal-title":"Acta Neurol Scand"},{"issue":"3","key":"10.1016\/j.neuro.2015.03.003_bib0030","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","article-title":"Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues","volume":"27","author":"Tietze","year":"1969","journal-title":"Anal Biochem"},{"issue":"1","key":"10.1016\/j.neuro.2015.03.003_bib0015","first-page":"165","article-title":"Subacute combined degeneration in totally gastrectomized rats: an ultrastructural study","volume":"30","author":"Tredici","year":"1998","journal-title":"J Submicrosc Cytol Pathol"},{"issue":"3","key":"10.1016\/j.neuro.2015.03.003_bib0020","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1079\/BJN19870116","article-title":"Tissue folates in fruit bats (Rousettus aegyptiacus) with nitrous oxide-induced vitamin B12 deficiency and neurological impairment","volume":"58","author":"van der Westhuyzen","year":"1987","journal-title":"Br J Nutr"},{"issue":"1","key":"10.1016\/j.neuro.2015.03.003_bib0065","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/mus.880140105","article-title":"Reversible myeloneuropathy of nitrous oxide abuse: serial electrophysiological studies","volume":"14","author":"Vishnubhakat","year":"1991","journal-title":"Muscle Nerve"},{"issue":"1","key":"10.1016\/j.neuro.2015.03.003_bib0090","first-page":"3","article-title":"The wide spectrum and unresolved issues of megaloblastic anemia","volume":"36","author":"Wickramasinghe","year":"1999","journal-title":"Semin Hematol"}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X15000303?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X15000303?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T11:31:46Z","timestamp":1537788706000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X15000303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":27,"alternative-id":["S0161813X15000303"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2015.03.003","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitrous oxide related behavioral and histopathological changes may be related to oxidative stress","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2015.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}