{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:01:24Z","timestamp":1783476084600,"version":"3.55.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000125","name":"National Institute of Occupational Safety & Health","doi-asserted-by":"crossref","award":["R01OH010235"],"award-info":[{"award-number":["R01OH010235"]}],"id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.neuro.2016.05.014","type":"journal-article","created":{"date-parts":[[2016,5,25]],"date-time":"2016-05-25T03:34:17Z","timestamp":1464147257000},"page":"65-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Effect of manganese and manganese plus noise on auditory function and cochlear structures"],"prefix":"10.1016","volume":"55","author":[{"given":"Vijaya Prakash Krishnan","family":"Muthaiah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Di","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalian","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Salvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome A.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2016.05.014_bib0005","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.neuro.2008.08.002","article-title":"Manganese exposure alters extracellular GABA, GABA receptor and transporter protein and mRNA levels in the developing rat brain","volume":"29","author":"Anderson","year":"2008","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0010","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/ajim.10194","article-title":"Pulmonary effects of welding fumes: review of worker and experimental animal studies","volume":"43","author":"Antonini","year":"2003","journal-title":"Am. J. Ind. Med."},{"key":"10.1016\/j.neuro.2016.05.014_bib0015","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.neuro.2009.09.006","article-title":"Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure","volume":"30","author":"Antonini","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0020","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.neuro.2008.08.004","article-title":"Involvement of striatal lipid peroxidation and inhibition of calcium influx into brain slices in neurobehavioral alterations in a rat model of short-term oral exposure to manganese","volume":"29","author":"Avila","year":"2008","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0025","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s004200050410","article-title":"Biomonitoring of manganese in blood, urine and axillary hair following low-dose exposure during the manufacture of dry cell batteries","volume":"72","author":"Bader","year":"1999","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.neuro.2016.05.014_bib0030","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00420-003-0491-0","article-title":"Neuropsychological function in manganese alloy plant workers","volume":"77","author":"Bast-Pettersen","year":"2004","journal-title":"Int. Arch. Occup. Environ. Health"},{"key":"10.1016\/j.neuro.2016.05.014_bib0035","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.neuro.2005.10.007","article-title":"Manganese exposure: neuropsychological and neurological symptoms and effects in welders","volume":"27","author":"Bowler","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0040","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/oem.2006.028761","article-title":"Dose-effect relationships between manganese exposure and neurological, neuropsychological and pulmonary function in confined space bridge welders","volume":"64","author":"Bowler","year":"2007","journal-title":"Occup. Environ. Med."},{"key":"10.1016\/j.neuro.2016.05.014_bib0045","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.neuro.2011.06.004","article-title":"Prospective study on neurotoxic effects in manganese-exposed bridge construction welders","volume":"32","author":"Bowler","year":"2011","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0050","first-page":"394","article-title":"Combined effects of noise and neomycin: cochlear changes in the guinea pig","volume":"86","author":"Brown","year":"1978","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.neuro.2016.05.014_bib0055","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/toxsci\/kfp124","article-title":"Effects of chronic manganese exposure on glutamatergic and GABAergic neurotransmitter markers in the nonhuman primate brain","volume":"111","author":"Burton","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.neuro.2016.05.014_bib0060","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.heares.2010.02.010","article-title":"Too much of a good thing: long-term treatment with salicylate strengthens outer hair cell function but impairs auditory neural activity","volume":"265","author":"Chen","year":"2010","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuro.2016.05.014_bib0065","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.heares.2012.11.016","article-title":"Salicylate-induced cochlear impairments, cortical hyperactivity and re-tuning, and tinnitus","volume":"295","author":"Chen","year":"2013","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuro.2016.05.014_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.heares.2014.08.004","article-title":"Prolonged noise exposure-induced auditory threshold shifts in rats","volume":"317","author":"Chen","year":"2014","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuro.2016.05.014_bib0075","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/00043764-200201000-00006","article-title":"Neuro-ototoxicity in andean adults with chronic lead and noise exposure","volume":"44","author":"Counter","year":"2002","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.neuro.2016.05.014_bib0080","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.3174\/ajnr.A0600","article-title":"A preliminary study revealing a new association in patients undergoing maintenance hemodialysis: manganism symptoms and T1 hyperintense changes in the basal ganglia","volume":"28","author":"Da Silva","year":"2007","journal-title":"Am. J. Neuroradiol."},{"key":"10.1016\/j.neuro.2016.05.014_bib0085","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/ajcn\/49.1.170","article-title":"Manganese retention in man: a method for estimating manganese absorption in man","volume":"49","author":"Davidsson","year":"1989","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neuro.2016.05.014_bib0090","first-page":"1","article-title":"Temporary deafness following exposures to loud tones and noise","author":"Davis","year":"1950","journal-title":"Acta Otolaryngol. (Stockholm)"},{"key":"10.1016\/j.neuro.2016.05.014_bib0095","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuro.2010.12.003","article-title":"Manganese is toxic to spiral ganglion neurons and hair cells in vitro","volume":"32","author":"Ding","year":"2011","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0100","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/ar.22577","article-title":"Review: ototoxic characteristics of platinum antitumor drugs","volume":"295","author":"Ding","year":"2012","journal-title":"Anat. Rec."},{"key":"10.1016\/j.neuro.2016.05.014_bib0105","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s10534-014-9765-0","article-title":"Cellular localization and developmental changes of Zip8, Zip14 and transferrin receptor 1 in the inner ear of rats","volume":"27","author":"Ding","year":"2014","journal-title":"Biometals"},{"key":"10.1016\/j.neuro.2016.05.014_bib0110","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0161-813X(02)00012-8","article-title":"Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes","volume":"23","author":"Erikson","year":"2002","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0115","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0197-0186(03)00037-8","article-title":"Manganese neurotoxicity and glutamate-GABA interaction","volume":"43","author":"Erikson","year":"2003","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuro.2016.05.014_bib0120","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.neuro.2007.08.006","article-title":"Modulation of cholinergic systems by manganese","volume":"28","author":"Finkelstein","year":"2007","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0125","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0378-5955(90)90046-R","article-title":"Interaction of cisplatin and noise on the peripheral auditory system","volume":"50","author":"Gratton","year":"1990","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuro.2016.05.014_bib0130","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.neuro.2007.06.005","article-title":"Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects","volume":"28","author":"Guilarte","year":"2007","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0135","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/j.1471-4159.2004.02445.x","article-title":"Parkin attenuates manganese-induced dopaminergic cell death","volume":"89","author":"Higashi","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuro.2016.05.014_bib0140","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.scitotenv.2009.09.016","article-title":"The association between low levels of lead in blood and occupational noise-induced hearing loss in steel workers","volume":"408","author":"Hwang","year":"2009","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.neuro.2016.05.014_bib0145","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jprot.2011.08.007","article-title":"Noise induced changes in the expression of p38\/MAPK signaling proteins in the sensory epithelium of the inner ear","volume":"75","author":"Jamesdaniel","year":"2011","journal-title":"J. Proteom."},{"key":"10.1016\/j.neuro.2016.05.014_bib0150","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/jn\/121.5.711","article-title":"Absorption and biological half-life in humans of intrinsic and extrinsic 54Mn tracers from foods of plant origin","volume":"121","author":"Johnson","year":"1991","journal-title":"J. Nutr."},{"key":"10.1016\/j.neuro.2016.05.014_bib0155","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1212\/01.WNL.0000167411.93483.A1","article-title":"Neurologic manifestations in welders with pallidal MRI T1 hyperintensity","volume":"64","author":"Josephs","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0160","first-page":"72","article-title":"Blood-labyrinth barrier and fluid dynamics of the inner ear","volume":"7","author":"Juhn","year":"2001","journal-title":"Int. Tinnitus J."},{"key":"10.1016\/j.neuro.2016.05.014_bib0165","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.heares.2011.11.007","article-title":"Genetic background effects on age-related hearing loss associated with Cdh23 variants in mice","volume":"283","author":"Kane","year":"2012","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuro.2016.05.014_bib0170","first-page":"134","article-title":"Auditory-vestibular changes in workers in ferrous metallurgy manufacture","volume":"11","author":"Khalkova","year":"1986","journal-title":"Probl. Khig."},{"key":"10.1016\/j.neuro.2016.05.014_bib0175","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1080\/104732200750051175","article-title":"Occupational health concerns in the welding industry","volume":"15","author":"Korczynski","year":"2000","journal-title":"Appl. Occup. Environ. Hyg."},{"key":"10.1016\/j.neuro.2016.05.014_bib0180","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.heares.2004.08.011","article-title":"A physiological place-frequency map of the cochlea in the CBA\/J mouse","volume":"202","author":"M\u00fcller","year":"2005","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuro.2016.05.014_bib0185","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jbt.20241","article-title":"Manganese accumulation in the mouse ear following systemic exposure","volume":"22","author":"Ma","year":"2008","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.neuro.2016.05.014_bib0190","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/enrs.1994.1013","article-title":"Nervous system dysfunction among workers with long-term exposure to manganese","volume":"64","author":"Mergler","year":"1994","journal-title":"Environ. Res."},{"key":"10.1016\/j.neuro.2016.05.014_bib0195","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.anl.2006.07.003","article-title":"Assessment of outer hair cell function and blood antioxidant status of rabbits exposed to noise and metal welding fumes","volume":"34","author":"Mirzaee","year":"2007","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.neuro.2016.05.014_bib0200","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.envres.2007.08.008","article-title":"Biomarkers of manganese exposure in a population living close to a mine and mineral processing plant in Mexico","volume":"106","author":"Montes","year":"2008","journal-title":"Environ. Res."},{"key":"10.1016\/j.neuro.2016.05.014_bib0205","first-page":"15","article-title":"Ototoxic effects of styrene alone or in concert with other agents: a review","volume":"4","author":"Morata","year":"2002","journal-title":"Noise Health"},{"key":"10.1016\/j.neuro.2016.05.014_bib0210","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0378-5955(91)90041-7","article-title":"Frequency representation in the rat cochlea","volume":"51","author":"Muller","year":"1991","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuro.2016.05.014_bib0215","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s10534-015-9885-1","article-title":"Effect of manganese treatment on the accumulation on biologically relevant metals in rat cochlea and brain by inductively coupled plasma mass spectrometry","volume":"28","author":"Mullin","year":"2015","journal-title":"Biometals"},{"key":"10.1016\/j.neuro.2016.05.014_bib0220","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jneumeth.2015.01.009","article-title":"Low-cost blast wave generator for studies of hearing loss and brain injury: blast wave effects in closed spaces","volume":"242","author":"Newman","year":"2015","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neuro.2016.05.014_bib0225","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neuro.2005.10.010","article-title":"Issues in neurological risk assessment for occupational exposures: the Bay Bridge welders","volume":"27","author":"Park","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0230","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.neuroscience.2011.02.017","article-title":"Chronic exposure to manganese decreases striatal dopamine turnover in human alpha-synuclein transgenic mice","volume":"180","author":"Peneder","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuro.2016.05.014_bib0235","doi-asserted-by":"crossref","first-page":"141","DOI":"10.4103\/1463-1741.53358","article-title":"Heavy metals and noise exposure: health effects","volume":"11","author":"Prasher","year":"2009","journal-title":"Noise Health"},{"key":"10.1016\/j.neuro.2016.05.014_bib0240","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuro.2013.09.007","article-title":"Manganism in the 21st century: the Hanninen lecture","volume":"45","author":"Racette","year":"2014","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0245","first-page":"255","article-title":"Prospective study on the reversibility of neurobehavioral effects in workers exposed to manganese dioxide","volume":"20","author":"Roels","year":"1999","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0250","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.neuro.2012.03.009","article-title":"Manganese exposure and cognitive deficits: a growing concern for manganese neurotoxicity","volume":"33","author":"Roels","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0255","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neuint.2012.04.015","article-title":"Effect of glutamate and riluzole on manganese-induced apoptotic cell signaling in neuronally differentiated mouse P19Cells","volume":"61","author":"Roth","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.neuro.2016.05.014_bib0260","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.neuro.2013.01.002","article-title":"The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells","volume":"35","author":"Roth","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.05.014_bib0265","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4067\/S0716-97602006000100006","article-title":"Homeostatic and toxic mechanisms regulating manganese uptake, retention, and elimination","volume":"39","author":"Roth","year":"2006","journal-title":"Biol. Res."},{"key":"10.1016\/j.neuro.2016.05.014_bib0270","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/00003446-198305000-00001","article-title":"Neural correlates of sensorineural hearing loss","volume":"4","author":"Salvi","year":"1983","journal-title":"Ear Hear."},{"key":"10.1016\/j.neuro.2016.05.014_bib0275","first-page":"280","article-title":"An investigation of metal concentrations in blood of industrial workers","volume":"33","author":"Srivastava","year":"1991","journal-title":"Vet. Hum. Toxicol."},{"key":"10.1016\/j.neuro.2016.05.014_bib0280","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0378-5955(01)00397-5","article-title":"Effect of noise exposure on blood-labyrinth barrier in guinea pigs","volume":"164","author":"Suzuki","year":"2002","journal-title":"Hear. Res."},{"key":"10.1016\/j.neuro.2016.05.014_bib0285","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3109\/08958378.2010.548838","article-title":"Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A\/J mice","volume":"23","author":"Zeidler-Erdely","year":"2011","journal-title":"Inhal. Toxicol."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X16300924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X16300924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T20:19:33Z","timestamp":1567973973000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X16300924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":57,"alternative-id":["S0161813X16300924"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2016.05.014","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of manganese and manganese plus noise on auditory function and cochlear structures","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2016.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}