{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:16:31Z","timestamp":1790460991581,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100010053","name":"Oxford Brookes University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000275","name":"Leverhulme Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.neuro.2016.06.007","type":"journal-article","created":{"date-parts":[[2016,6,11]],"date-time":"2016-06-11T12:07:04Z","timestamp":1465646824000},"page":"207-213","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Cloning and functional expression of intracellular loop variants of the honey bee (Apis mellifera) RDL GABA receptor"],"prefix":"10.1016","volume":"60","author":[{"given":"Jennina","family":"Taylor-Wells","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Hawkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Bermudez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew K.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2016.06.007_bib0005","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/ps.937","article-title":"Identification of the Rdl mutation in laboratory and field strains of the cat flea, Ctenocephalides felis (Siphonaptera: pulicidae)","volume":"60","author":"Bass","year":"2004","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1385\/JMN:30:1:97","article-title":"Phosphorylation and function of alpha4beta2 receptor","volume":"30","author":"Bermudez","year":"2006","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0015","doi-asserted-by":"crossref","first-page":"4895","DOI":"10.1523\/JNEUROSCI.5039-09.2010","article-title":"The short splice variant of the gamma 2 subunit acts as an external modulator of GABA(A) receptor function","volume":"30","author":"Boileau","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0020","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1124\/mol.105.015313","article-title":"Insect GABA receptors: splicing, editing, and targeting by antiparasitics and insecticides","volume":"68","author":"Buckingham","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.neuro.2016.06.007_bib0025","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1111\/j.1460-9568.2012.08090.x","article-title":"gamma-Aminobutyric acid receptor A-mediated inhibition in the honeybee's antennal lobe is necessary for the formation of configural olfactory percepts","volume":"35","author":"Choudhary","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0030","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuro.2013.05.001","article-title":"A memorial to Toshio Narahashi, PhD: an international leader of neurotoxicology and the Father of Cellular Neuropharmacology","volume":"37","author":"Cranmer","year":"2013","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2016.06.007_bib0035","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0304-3940(01)02400-4","article-title":"The insecticide imidacloprid is a partial agonist of the nicotinic receptor of honeybee Kenyon cells","volume":"321","author":"Deglise","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuro.2016.06.007_bib0040","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.vetpar.2013.08.023","article-title":"Discovery of the Rdl mutation in association with a cyclodiene resistant population of horn flies, Haematobia irritans (Diptera: muscidae)","volume":"198","author":"Domingues","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.neuro.2016.06.007_bib0045","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2583.2005.00544.x","article-title":"Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabiensis","volume":"14","author":"Du","year":"2005","journal-title":"Insect Mol. Biol."},{"key":"10.1016\/j.neuro.2016.06.007_bib0050","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1152\/jn.00798.2009","article-title":"Homomeric RDL and heteromeric RDL\/LCCH3 GABA receptors in the honeybee antennal lobes: two candidates for inhibitory transmission in olfactory processing","volume":"103","author":"Dupuis","year":"2010","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.neuro.2016.06.007_bib0055","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/etc.2527","article-title":"Risks of neonicotinoid insecticides to honeybees","volume":"33","author":"Fairbrother","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.neuro.2016.06.007_bib0060","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.pestbp.2015.01.004","article-title":"Genotype to phenotype, the molecular and physiological dimensions of resistance in arthropods","volume":"121","author":"Feyereisen","year":"2015","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.neuro.2016.06.007_bib0065","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1111\/j.1471-4159.1993.tb03523.x","article-title":"Drosophila gamma-aminobutyric acid receptor gene Rdl shows extensive alternative splicing","volume":"60","author":"Ffrench-Constant","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuro.2016.06.007_bib0070","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/363449a0","article-title":"A point mutation in a Drosophila GABA receptor confers insecticide resistance","volume":"363","author":"Ffrench-Constant","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.neuro.2016.06.007_bib0075","doi-asserted-by":"crossref","first-page":"7168","DOI":"10.1523\/JNEUROSCI.14-11-07168.1994","article-title":"Immunocytochemical localization of gamma 2 short and gamma 2 long subunits of the GABAA receptor in the rat brain","volume":"14","author":"Gutierrez","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0080","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nature05260","article-title":"Insights into social insects from the genome of the honeybee Apis mellifera","volume":"443","author":"Honeybee Genome Sequencing Consortium","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.neuro.2016.06.007_bib0085","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.1476-5381.1995.tb15896.x","article-title":"Actions of the insecticide fipronil, on dieldrin-sensitive and- resistant GABA receptors of Drosophila melanogaster","volume":"115","author":"Hosie","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuro.2016.06.007_bib0090","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pestbp.2015.02.011","article-title":"Probing new components (loop G and the alpha\u2013alpha interface) of neonicotinoid binding sites on nicotinic acetylcholine receptors","volume":"121","author":"Ihara","year":"2015","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.neuro.2016.06.007_bib0095","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.pestbp.2014.10.010","article-title":"Identification of polymorphisms in Cyrtorhinus lividipennis RDL subunit contributing to fipronil sensitivity","volume":"117","author":"Jiang","year":"2015","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.neuro.2016.06.007_bib0100","doi-asserted-by":"crossref","first-page":"29420","DOI":"10.1074\/jbc.M114.603068","article-title":"Ring finger protein 34 (RNF34) interacts with and promotes gamma-aminobutyric acid type-A receptor degradation via ubiquitination of the gamma2 subunit","volume":"289","author":"Jin","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuro.2016.06.007_bib0105","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s10158-006-0026-y","article-title":"The Cys-loop ligand-gated ion channel superfamily of the honeybee, Apis mellifera","volume":"6","author":"Jones","year":"2006","journal-title":"Invert. Neurosci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0110","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1101\/gr.4549206","article-title":"The nicotinic acetylcholine receptor gene family of the honey bee, Apis mellifera","volume":"16","author":"Jones","year":"2006","journal-title":"Genome Res."},{"key":"10.1016\/j.neuro.2016.06.007_bib0115","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1523\/JNEUROSCI.5251-08.2009","article-title":"Splice-variant- and stage-specific RNA editing of the Drosophila GABA receptor modulates agonist potency","volume":"29","author":"Jones","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0120","doi-asserted-by":"crossref","first-page":"11780","DOI":"10.1523\/JNEUROSCI.0969-12.2012","article-title":"Molecular and functional interaction between protocadherin-gammaC5 and GABAA receptors","volume":"32","author":"Li","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0125","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neuron.2014.01.040","article-title":"WIDE AWAKE mediates the circadian timing of sleep onset","volume":"82","author":"Liu","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuro.2016.06.007_bib0130","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.tibtech.2015.10.006","article-title":"New technologies forinsect-resistant and herbicide-tolerant plants","volume":"34","author":"Lombardo","year":"2016","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.neuro.2016.06.007_bib0135","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0165-6147(00)01820-4","article-title":"Neonicotinoids: insecticides acting on insect nicotinic acetylcholine receptors","volume":"22","author":"Matsuda","year":"2001","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0140","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1113\/jphysiol.2004.066233","article-title":"Preferential accumulation of GABAA receptor gamma 2L, not gamma 2S, cytoplasmic loops at rat spinal cord inhibitory synapses","volume":"559","author":"Meier","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.neuro.2016.06.007_bib0145","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10158-006-0040-0","article-title":"Nicotinic acetylcholine receptors: targets for commercially important insecticides","volume":"7","author":"Millar","year":"2007","journal-title":"Invert. Neurosci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0150","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1603\/EC10391","article-title":"The A2'N mutation of the RDL gamma-aminobutyric acid receptor conferring fipronil resistance in Laodelphax striatellus (Hemiptera: delphacidae)","volume":"104","author":"Nakao","year":"2011","journal-title":"J. Econ. Entomol."},{"key":"10.1016\/j.neuro.2016.06.007_bib0155","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.bcp.2013.07.001","article-title":"Structural insights into Cys-loop receptor function and ligand recognition","volume":"86","author":"Nys","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.neuro.2016.06.007_bib0160","doi-asserted-by":"crossref","unstructured":"Official Journal of the European Union, (2013) L 219, 15 August.","DOI":"10.30875\/ed5e8679-en"},{"key":"10.1016\/j.neuro.2016.06.007_bib0165","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuro.2016.06.007_bib0170","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s10158-005-0004-9","article-title":"Ion channels: molecular targets of neuroactive insecticides","volume":"5","author":"Raymond-Delpech","year":"2005","journal-title":"Invert. Neurosci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0175","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.mcn.2008.02.006","article-title":"Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex","volume":"38","author":"Rosenberg","year":"2008","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2016.04.057","article-title":"Towards understanding pre-mRNA splicing mechanisms and the role of SR proteins","author":"Sahebi","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.neuro.2016.06.007_bib0185","doi-asserted-by":"crossref","first-page":"D344","DOI":"10.1093\/nar\/gks1067","article-title":"New and continuing developments at PROSITE","volume":"41","author":"Sigrist","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuro.2016.06.007_bib0190","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.tips.2015.05.002","article-title":"Looking below the surface of nicotinic acetylcholine receptors","volume":"36","author":"Stokes","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0195","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.biocel.2014.05.028","article-title":"Phosphorylation mediated structural and functional changes in pentameric ligand-gated ion channels: implications for drug discovery","volume":"53","author":"Talwar","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.neuro.2016.06.007_bib0200","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/jnc.13290","article-title":"The neonicotinoid imidacloprid, and the pyrethroid deltamethrin, are antagonists of the insect Rdl GABA receptor","volume":"135","author":"Taylor-Wells","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuro.2016.06.007_bib0205","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.tips.2006.11.006","article-title":"Exploring the pharmacological properties of insect nicotinic acetylcholine receptors","volume":"28","author":"Thany","year":"2007","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0210","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1093\/nar\/25.24.4876","article-title":"The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools","volume":"25","author":"Thompson","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuro.2016.06.007_bib0215","doi-asserted-by":"crossref","first-page":"9966","DOI":"10.1073\/pnas.87.24.9966","article-title":"Another mechanism for creating diversity in gamma-aminobutyrate type A receptors: RNA splicing directs expression of two forms of gamma 2 phosphorylation site","volume":"87","author":"Whiting","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuro.2016.06.007_bib0220","doi-asserted-by":"crossref","first-page":"27417","DOI":"10.1074\/jbc.M112.360461","article-title":"gamma-Aminobutyric acid type A (GABAA) receptor alpha subunits play a direct role in synaptic versus extrasynaptic targeting","volume":"287","author":"Wu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuro.2016.06.007_bib0225","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nn.3581","article-title":"Female contact modulates male aggression via a sexually dimorphic GABAergic circuit in Drosophila","volume":"17","author":"Yuan","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuro.2016.06.007_bib0230","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1124\/jpet.103.051839","article-title":"Differential actions of fipronil and dieldrin insecticides on GABA-gated chloride channels in cockroach neurons","volume":"306","author":"Zhao","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X16301085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X16301085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T15:37:11Z","timestamp":1656689831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X16301085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":46,"alternative-id":["S0161813X16301085"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2016.06.007","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cloning and functional expression of intracellular loop variants of the honey bee (Apis mellifera) RDL GABA receptor","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2016.06.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}