{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:43:03Z","timestamp":1790142183520,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Research on Risk of Chemical Substances, Ministry of Health, Labor and Welfare, Japan"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.neuro.2016.07.003","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T18:12:23Z","timestamp":1467915143000},"page":"64-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Neonatal exposure to SERMs disrupts neuroendocrine development and postnatal reproductive function through alteration of hypothalamic kisspeptin neurons in female rats"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0644-7041","authenticated-orcid":false,"given":"Ryohei","family":"Ichimura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miwa","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Kuwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kento","family":"Usuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Yokosuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Midori","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2016.07.003_bib0005","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1095\/biolreprod.109.078261","article-title":"Neonatal bisphenol-a exposure alters rat reproductive development and ovarian morphology without impairing activation of gonadotropin-releasing hormone neurons","volume":"81","author":"Adewale","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.neuro.2016.07.003_bib0010","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0006-8993(78)90977-0","article-title":"Independent masculinization of neuroendocrine systems by intracerebral implants of testosterone or estradiol in the neonatal female rat","volume":"146","author":"Christensen","year":"1978","journal-title":"Brain. Res."},{"key":"10.1016\/j.neuro.2016.07.003_bib0015","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1210\/en.2010-1103","article-title":"Endocrine disruption of brain sexual differentiation by developmental PCB exposure","volume":"152","author":"Dickerson","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuro.2016.07.003_bib0020","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1293\/tox.27.1S","article-title":"Nonproliferative and proliferative lesions of the rat and mouse female reproductive system","volume":"27","author":"Dixon","year":"2014","journal-title":"J. Toxicol. Pathol."},{"key":"10.1016\/j.neuro.2016.07.003_bib0025","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1210\/en.2005-1282","article-title":"Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion","volume":"147","author":"Dungan","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuro.2016.07.003_bib0030","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1210\/me.2011-1210","article-title":"Early life exposure to endocrine-disrupting chemicals causes lifelong molecular reprogramming of the hypothalamus and premature reproductive aging","volume":"25","author":"Gore","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.neuro.2016.07.003_bib0035","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1095\/biolreprod.109.078311","article-title":"Significance of neonatal testicular sex steroids to defeminize anteroventral periventricular kisspeptin neurons and the GnRH\/LH surge system in male rats","volume":"81","author":"Homma","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.neuro.2016.07.003_bib0040","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.reprotox.2015.01.004","article-title":"Prior attenuation of KiSS1\/GPR54 signaling in the anteroventral periventricular nucleus is a trigger for the delayed effect induced by neonatal exposure to 17alpha-ethynylestradiol in female rats","volume":"51","author":"Ichimura","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.neuro.2016.07.003_bib0045","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1095\/biolreprod.115.129650","article-title":"The critical hormone-sensitive window for the development of delayed effects extends to 10 days after birth in female rats postnatally exposed to 17alpha-ethynylestradiol","volume":"93","author":"Ichimura","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.neuro.2016.07.003_bib0050","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1289\/ehp.01109785","article-title":"The OECD program to validate the rat uterotrophic bioassay to screen compounds for in vivo estrogenic responses: phase 1","volume":"109","author":"Kanno","year":"2001","journal-title":"Environ. Health. Perspect."},{"key":"10.1016\/j.neuro.2016.07.003_bib0055","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/taap.2000.8940","article-title":"Irreversible effects of neonatal exposure to p-tert-octylphenol on the reproductive tract in female rats","volume":"165","author":"Katsuda","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.neuro.2016.07.003_bib0060","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.tins.2007.08.001","article-title":"Emerging ideas about kisspeptin- GPR54 signaling in the neuroendocrine regulation of reproduction","volume":"30","author":"Kauffman","year":"2007","journal-title":"Trends. Neurosci."},{"key":"10.1016\/j.neuro.2016.07.003_bib0065","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.reprotox.2010.10.002","article-title":"Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat","volume":"31","author":"Losa","year":"2011","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.neuro.2016.07.003_bib0070","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1210\/endo.138.4.5083","article-title":"Characterization of the ovariectomized rat model for the evaluation of estrogen effects on plasma cholesterol levels","volume":"138","author":"Lundeen","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuro.2016.07.003_bib0075","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11154-007-9032-6","article-title":"Metastin\/kisspeptin and control of estrous cycle in rats","volume":"8","author":"Maeda","year":"2007","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.neuro.2016.07.003_bib0080","first-page":"1437","article-title":"Selective estrogen receptor modulators: tissue specificity and clinical utility","volume":"9","author":"Martinkovich","year":"2014","journal-title":"Clin. Interv. Aging."},{"key":"10.1016\/j.neuro.2016.07.003_bib0085","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0015-0282(16)46520-9","article-title":"Reduced fertility in female mice exposed transplacentally to diethylstilbestrol (DES)","volume":"38","author":"McLachlan","year":"1982","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.neuro.2016.07.003_bib0090","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2174\/092986707780598023","article-title":"Medicinal chemistry and emerging strategies applied to the development of selective estrogen receptor modulators (SERMs)","volume":"14","author":"Musa","year":"2007","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.neuro.2016.07.003_bib0095","first-page":"1","article-title":"Toxicology and carcinogenesis study of ethinyl estradiol (CAS No. 57-63-6) in Sprague-Dawley rats (feed study)","volume":"548","author":"National Toxicology Program","year":"2010","journal-title":"Natl. Toxicol. Program. Technol. Rep. Ser."},{"key":"10.1016\/j.neuro.2016.07.003_bib0100","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1210\/en.2008-0580","article-title":"Persistent impairment of hypothalamic KiSS-1 system after exposures to estrogenic compounds at critical periods of brain sex differentiation","volume":"150","author":"Navarro","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuro.2016.07.003_bib0105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.reprotox.2012.04.014","article-title":"Delayed reproductive dysfunction in female rats induced by early life exposure to low-dose diethylstilbestrol","volume":"34","author":"Ohta","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.neuro.2016.07.003_bib0110","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1530\/rep.0.1210915","article-title":"Oestrogenic effects of neonatal administration of raloxifene on hypothalamic-pituitary-gonadal axis in male and female rats","volume":"121","author":"Pinilla","year":"2001","journal-title":"Reproduction"},{"key":"10.1016\/j.neuro.2016.07.003_bib0115","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3940(01)02104-8","article-title":"Evidence for an estrogen-like action of raloxifene upon the hypothalamic-pituitary unit: raloxifene inhibits luteinizing hormone secretion and stimulates prolactin secretion in ovariectomized female rats","volume":"311","author":"Pinilla","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuro.2016.07.003_bib0120","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1677\/joe.0.1720441","article-title":"Comparative effects of testosterone propionate, oestradiol benzoate, ICI 182,780, tamoxifen and raloxifene on hypothalamic differentiation in the female rat","volume":"172","author":"Pinilla","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.neuro.2016.07.003_bib0125","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jsbmb.2013.12.011","article-title":"Use of SERMs for treatment in postmenopausal women","volume":"142","author":"Pinkerton","year":"2014","journal-title":"J. Steroid. Biochem. Mol. Biol."},{"key":"10.1016\/j.neuro.2016.07.003_bib0130","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1210\/endo.141.2.7342","article-title":"Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats","volume":"141","author":"Qu","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuro.2016.07.003_bib0135","doi-asserted-by":"crossref","first-page":"4289","DOI":"10.1210\/en.2003-0146","article-title":"Prepubertal administration of estradiol valerate disrupts cyclicity and leads to cystic ovarian morphology during adult life in the rat: role of sympathetic innervation","volume":"144","author":"Rosa-E-Silva","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.neuro.2016.07.003_bib0140","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1159\/000065952","article-title":"Tamoxifen but not other selective estrogen receptor modulators antagonizes estrogen actions on luteinizing hormone secretion while inducing gonadotropin-releasing hormone self-priming in the rat","volume":"76","author":"S\u00e1nchez-Criado","year":"2002","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.neuro.2016.07.003_bib0145","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1289\/ehp.961041296","article-title":"Assessing environmental chemicals for estrogenicity using a combination of in vitro and in vivo assays","volume":"104","author":"Shelby","year":"1996","journal-title":"Environ. Health. Perspect."},{"key":"10.1016\/j.neuro.2016.07.003_bib0150","doi-asserted-by":"crossref","first-page":"681","DOI":"10.2131\/jts.37.681","article-title":"Delayed effects of single neonatal subcutaneous exposure of low-dose 17\u03b1-ethynylestradiol on reproductive function in female rats","volume":"37","author":"Shirota","year":"2012","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.neuro.2016.07.003_bib0155","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1095\/biolreprod.107.063974","article-title":"Neonatal exposure to estradiol valerate programs ovarian sympathetic innervation and follicular development in the adult rat","volume":"78","author":"Sotomayor-Z\u00e1rate","year":"2008","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.neuro.2016.07.003_bib0160","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.reprotox.2013.05.005","article-title":"Delayed effects of neonatal exposure to 17alpha-ethynylestradiol on the estrous cycle and uterine carcinogenesis in Wistar Hannover GALAS rats","volume":"40","author":"Takahashi","year":"2013","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.neuro.2016.07.003_bib0165","doi-asserted-by":"crossref","first-page":"775","DOI":"10.2131\/jts.39.775","article-title":"Early indicators of delayed adverse effects in female reproductive organs in rats receiving neonatal exposure to 17alpha-ethynylestradiol","volume":"39","author":"Takahashi","year":"2014","journal-title":"J. Toxicol. Sci."},{"key":"10.1016\/j.neuro.2016.07.003_bib0170","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1530\/jrf.0.0690265","article-title":"Induction of superovulation in prepubertal female rats by anterior pituitary transplants","volume":"69","author":"Taya","year":"1983","journal-title":"J. Reprod. Fertil."},{"key":"10.1016\/j.neuro.2016.07.003_bib0175","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1530\/eje.0.1500397","article-title":"Mechanisms for altered reproductive function in female rats following neonatal administration of raloxifene","volume":"150","author":"Tena-Sempere","year":"2004","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.neuro.2016.07.003_bib0180","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1292\/jvms.14-0148","article-title":"Neonatal exposure to 17\u03b1-ethinyl estradiol affects kisspeptin expression and LH-surge level in female rats","volume":"76","author":"Usuda","year":"2014","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.neuro.2016.07.003_bib0185","first-page":"3867","article-title":"A potent specific pure antiestrogen with clinical potential","volume":"51","author":"Wakeling","year":"1991","journal-title":"Cancer. Res."},{"key":"10.1016\/j.neuro.2016.07.003_bib0190","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1385\/ENDO:22:3:305","article-title":"Tamoxifen is an estrogen antagonist on gonadotropin secretion and responsiveness of the hypothalamic-pituitary- adrenal axis in female monkeys","volume":"22","author":"Wilson","year":"2003","journal-title":"Endocrine"},{"key":"10.1016\/j.neuro.2016.07.003_bib0195","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/carcin\/23.10.1745","article-title":"Induction of different types of uterine adenocarcinomas in Donryu rats due to neonatal exposure to high-dose p-t-octylphenol for different periods","volume":"23","author":"Yoshida","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.neuro.2016.07.003_bib0200","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1177\/0192623311413785","article-title":"Delayed adverse effects of neonatal exposure to diethylstilbestrol and their dose dependency in female rats","volume":"39","author":"Yoshida","year":"2011","journal-title":"Toxicol. Pathol."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X16301218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X16301218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T13:52:17Z","timestamp":1536587537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X16301218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":40,"alternative-id":["S0161813X16301218"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2016.07.003","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neonatal exposure to SERMs disrupts neuroendocrine development and postnatal reproductive function through alteration of hypothalamic kisspeptin neurons in female rats","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2016.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}