{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:42:56Z","timestamp":1791286976492,"version":"4.1.0"},"reference-count":121,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010801","name":"Xunta de Galicia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.neuro.2019.08.006","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T11:13:25Z","timestamp":1566299605000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":111,"special_numbering":"C","title":["Gut microbiota and neurological effects of glyphosate"],"prefix":"10.1016","volume":"75","author":[{"given":"Lola","family":"Rueda-Ruzafa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5966-0498","authenticated-orcid":false,"given":"Pablo","family":"Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6761-3598","authenticated-orcid":false,"given":"Diana","family":"Cardona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2019.08.006_bib0005","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1007\/s00284-014-0732-3","article-title":"The influence of glyphosate on the microbiota and production of botulinum neurotoxin during ruminal fermentation","volume":"70","author":"Ackermann","year":"2015","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0010","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ntt.2018.04.002","article-title":"Glyphosate based- herbicide exposure affects gut microbiota, anxiety and depression-like behaviors in mice","volume":"67","author":"Aitbali","year":"2018","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0015","first-page":"167","article-title":"Bacterial lipopolysaccharides and innate immunity","volume":"7","author":"Alexander","year":"2001","journal-title":"J. Endotoxin Res."},{"key":"10.1016\/j.neuro.2019.08.006_bib0020","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3109\/1354750X.2010.548010","article-title":"Urinary p-cresol is elevated in small children with severe autism spectrum disorder","volume":"16","author":"Altieri","year":"2011","journal-title":"Biomarkers"},{"key":"10.1016\/j.neuro.2019.08.006_bib0025","first-page":"29","article-title":"Clostridium Bacteria and autism Spectrum conditions: a systematic review and hypothetical contribution of environmental glyphosate levels","volume":"6","author":"Argou-Cardozo","year":"2018","journal-title":"Med. Sci."},{"key":"10.1016\/j.neuro.2019.08.006_bib0030","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1139\/apnm-2017-0648","article-title":"Lactobacilli and bifidobacteria ameliorate memory and learning deficits and oxidative stress in \u03b2-amyloid (1-42) injected rats","volume":"43","author":"Athari Nik Azm","year":"2018","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.neuro.2019.08.006_bib0035","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbi.2009.09.001","article-title":"Minimal penetration of lipopolysaccharide across the murine blood-brain barrier","volume":"24","author":"Banks","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuro.2019.08.006_bib0040","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/mds.1105","article-title":"Parkinsonism after glycine-derivate exposure","volume":"16","author":"Barbosa","year":"2001","journal-title":"Mov. Disord."},{"key":"10.1016\/j.neuro.2019.08.006_bib0045","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1053\/j.gastro.2010.06.063","article-title":"Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice","volume":"139","author":"Bercik","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neuro.2019.08.006_bib0050","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF00409776","article-title":"Mode of action of glyphosate in Candida maltosa","volume":"140","author":"Bode","year":"1984","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0055","first-page":"241","article-title":"Inflammatory bowel diseases: a dysfunction of brain-gut interactions?","volume":"59","author":"Bonaz","year":"2013","journal-title":"Minerva Gastroenterol. Dietol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0060","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0272-0590(91)90237-X","article-title":"Metabolism of glyphosate in Sprague-Dawley rats: tissue distribution, identification, and quantitation of glyphosate-derived materials following a single oral dose","volume":"17","author":"Brewster","year":"1991","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0065","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tox.2017.10.007","article-title":"Glyphosate and Roundup\u00ae alter morphology and behavior in zebrafish","volume":"392","author":"Bridi","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.neuro.2019.08.006_bib0070","article-title":"A novel 5-Enolpyruvylshikimate-3-Phosphate synthase shows high glyphosate tolerance in Escherichia coli and tobacco plants","volume":"7","author":"Cao","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.neuro.2019.08.006_bib0075","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.3390\/ijms19061689","article-title":"Microbiome-gut-Brain Axis and toll-like receptors in Parkinson\u2019s disease","volume":"19","author":"Caputi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuro.2019.08.006_bib0080","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neurobiolaging.2016.08.019","article-title":"Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly","volume":"49","author":"Cattaneo","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.neuro.2019.08.006_bib0085","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tox.2017.06.001","article-title":"Developmental exposure to glyphosate-based herbicide and depressive-like behavior in adult offspring: implication of glutamate excitotoxicity and oxidative stress","volume":"387","author":"Cattani","year":"2017","journal-title":"Toxicology"},{"key":"10.1016\/j.neuro.2019.08.006_bib0090","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.tox.2014.03.001","article-title":"Mechanisms underlying the neurotoxicity induced by glyphosate-based herbicide in immature rat hippocampus: involvement of glutamate excitotoxicity","volume":"320","author":"Cattani","year":"2014","journal-title":"Toxicology"},{"key":"10.1016\/j.neuro.2019.08.006_bib0095","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4103\/0971-6580.139813","article-title":"Demographics, clinical characteristics and management of herbicide poisoning in tertiary care hospital","volume":"21","author":"Cherukuri","year":"2014","journal-title":"Toxicol. Int."},{"key":"10.1016\/j.neuro.2019.08.006_bib0100","series-title":"Glyphosate in Beer and Wine","author":"Cook","year":"2019"},{"key":"10.1016\/j.neuro.2019.08.006_bib0105","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/enrs.2000.4229","article-title":"Effect of the herbicide glyphosate on enzymatic activity in pregnant rats and their fetuses","volume":"85","author":"Daruich","year":"2001","journal-title":"Environ. Res."},{"key":"10.1016\/j.neuro.2019.08.006_bib0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076993","article-title":"Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified","volume":"8","author":"De Angelis","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuro.2019.08.006_bib0115","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.freeradbiomed.2013.06.043","article-title":"Roundup disrupts male reproductive functions by triggering calcium-mediated cell death in rat testis and Sertoli cells","volume":"65","author":"de Liz Oliveira Cavalli","year":"2013","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuro.2019.08.006_bib0120","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1289\/ehp.7340","article-title":"Cancer incidence among glyphosate-exposed pesticide applicators in the Agricultural Health Study","volume":"113","author":"De Roos","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.neuro.2019.08.006_bib0125","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.toxrep.2017.12.025","article-title":"Toxicity of formulants and heavy metals in glyphosate-based herbicides and other pesticides","volume":"5","author":"Defarge","year":"2018","journal-title":"Toxicol. reports"},{"key":"10.1016\/j.neuro.2019.08.006_bib0130","doi-asserted-by":"crossref","first-page":"9093","DOI":"10.1021\/bi00426a005","article-title":"Inactivation of dopamine beta-hydroxylase by p-cresol: isolation and characterization of covalently modified active site peptides","volume":"27","author":"DeWolf","year":"1988","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuro.2019.08.006_bib0135","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1046\/j.1432-1327.2000.00994.x","article-title":"Characterization of Streptococcus pneumoniae 5-enolpyruvylshikimate 3-phosphate synthase and its activation by univalent cations","volume":"267","author":"Du","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.neuro.2019.08.006_bib0140","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.etap.2009.06.001","article-title":"Oxidative stress responses of rats exposed to Roundup and its active ingredient glyphosate","volume":"28","author":"El-Shenawy","year":"2009","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0145","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1002\/ijc.23589","article-title":"Pesticide exposure as risk factor for non-Hodgkin lymphoma including histopathological subgroup analysis","volume":"123","author":"Eriksson","year":"2008","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.neuro.2019.08.006_bib0150","series-title":"Health and Food Safety Directorate-general. Summary Report of the Appeal Committe - Phytopharmaceuticals - Plan Protection Products - Legislation","author":"European Commision","year":"2017"},{"key":"10.1016\/j.neuro.2019.08.006_bib0155","article-title":"Peer review of the pesticide risk assessment of the potential endocrine disrupting properties of glyphosate","volume":"15","author":"European Food Safety Authority","year":"2017","journal-title":"EFSA J."},{"key":"10.1016\/j.neuro.2019.08.006_bib0160","series-title":"Summary Report for Diazinon, Glyphosate, Malathion","author":"FAO\/WHO Joint Meeting on Pesticide Residues","year":"2016"},{"key":"10.1016\/j.neuro.2019.08.006_bib0165","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13293-018-0166-x","article-title":"Effects of gut-derived endotoxin on anxiety-like and repetitive behaviors in male and female mice","volume":"9","author":"Fields","year":"2018","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.neuro.2019.08.006_bib0170","series-title":"Advances in Experimental Medicine and Biology","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-4939-0897-4_5","article-title":"Vagal pathways for microbiome-brain-gut axis communication","author":"Forsythe","year":"2014"},{"key":"10.1016\/j.neuro.2019.08.006_bib0175","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1007\/s00244-011-9661-3","article-title":"Effects of glyphosate and polyoxyethylenamine on growth and energetic reserves in the freshwater crayfish Cherax quadricarinatus (Decapoda, Parastacidae)","volume":"61","author":"Frontera","year":"2011","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0180","series-title":"Advances in Experimental Medicine and Biology","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/978-1-4939-0897-4_3","article-title":"The enteric nervous system and gastrointestinal innervation: integrated local and central control","author":"Furness","year":"2014"},{"key":"10.1016\/j.neuro.2019.08.006_bib0185","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/aur.1571","article-title":"Slow intestinal transit contributes to elevate urinary p -cresol level in Italian autistic children","volume":"9","author":"Gabriele","year":"2016","journal-title":"Autism Res."},{"key":"10.1016\/j.neuro.2019.08.006_bib0190","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s12640-018-9894-2","article-title":"Perinatal glyphosate-based herbicide exposure in rats alters brain antioxidant status, glutamate and acetylcholine metabolism and affects recognition memory","volume":"34","author":"Gallegos","year":"2018","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neuro.2019.08.006_bib0195","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.tox.2009.06.006","article-title":"Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines","volume":"262","author":"Gasnier","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.neuro.2019.08.006_bib0200","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.bbi.2007.08.009","article-title":"Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: possible anatomical substrates for viscerosensory modulation of exploratory behavior","volume":"22","author":"Goehler","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuro.2019.08.006_bib0205","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1021\/bi00383a025","article-title":"Mechanism-based inactivation of dopamine beta-hydroxylase by p-cresol and related alkylphenols","volume":"26","author":"Goodhart","year":"1987","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuro.2019.08.006_bib0210","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S1470-2045(15)70134-8","article-title":"Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate","volume":"16","author":"Guyton","year":"2015","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0215","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1566-0702(00)00230-7","article-title":"Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in rats","volume":"85","author":"Hansen","year":"2000","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.neuro.2019.08.006_bib0220","doi-asserted-by":"crossref","first-page":"41802","DOI":"10.1038\/srep41802","article-title":"Reduction of Abeta amyloid pathology in APPPS1 transgenic mice in the absence of gut microbiota","volume":"7","author":"Harach","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuro.2019.08.006_bib0225","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.scitotenv.2018.05.377","article-title":"Glyphosate decreases mycorrhizal colonization and affects plant-soil feedback","volume":"642","author":"Helander","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.neuro.2019.08.006_bib0230","doi-asserted-by":"crossref","first-page":"907","DOI":"10.2307\/3870046","article-title":"The shikimate pathway: early steps in the biosynthesis of aromatic compounds","volume":"7","author":"Herrmann","year":"1995","journal-title":"Plant Cell"},{"key":"10.1016\/j.neuro.2019.08.006_bib0235","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1146\/annurev.arplant.50.1.473","article-title":"The shikimate pathway","volume":"50","author":"Herrmann","year":"1999","journal-title":"Annu. Rev. Plant Physiol. Plant Mol. Biol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0240","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.2147\/NDT.S188340","article-title":"Possible association of Firmicutes in the gut microbiota of patients with major depressive disorder","volume":"14","author":"Huang","year":"2018","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.neuro.2019.08.006_bib0245","first-page":"240","article-title":"[Gut microbiota in health and disease]","volume":"78","author":"Icaza-Ch\u00e1vez","year":"2013","journal-title":"Rev. Gastroenterol. Mex."},{"key":"10.1016\/j.neuro.2019.08.006_bib0250","series-title":"IARC Monographs Volume 112: Evaluation of Five Organophosphate Insecticides and Herbicides","author":"International Agency for Research on Cancer","year":"2015"},{"key":"10.1016\/j.neuro.2019.08.006_bib0255","doi-asserted-by":"crossref","first-page":"819","DOI":"10.3390\/nu11040819","article-title":"The preventive and curative effects of Lactobacillus reuteri NK33 and Bifidobacterium adolescentis NK98 on immobilization stress-induced anxiety\/depression and colitis in mice","volume":"11","author":"Jang","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.neuro.2019.08.006_bib0260","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1159\/000494677","article-title":"Efficacy of probiotics supplementation on chronic kidney disease: a systematic review and meta-analysis","volume":"43","author":"Jia","year":"2018","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.neuro.2019.08.006_bib0265","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2015.03.016","article-title":"Altered fecal microbiota composition in patients with major depressive disorder","volume":"48","author":"Jiang","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuro.2019.08.006_bib0270","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/FBP.0000000000000013","article-title":"Obsessive-compulsive-like behaviors in house mice are attenuated by a probiotic (Lactobacillus rhamnosus GG)","volume":"25","author":"Kantak","year":"2014","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0275","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/j.gastro.2007.04.005","article-title":"The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects","volume":"133","author":"Kassinen","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neuro.2019.08.006_bib0280","doi-asserted-by":"crossref","first-page":"19267","DOI":"10.1007\/s11356-017-9438-y","article-title":"Effects of low doses of glyphosate on DNA damage, cell proliferation and oxidative stress in the HepG2 cell line","volume":"24","author":"Ka\u0161uba","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.neuro.2019.08.006_bib0285","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jpsychires.2016.07.019","article-title":"Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat","volume":"82","author":"Kelly","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.neuro.2019.08.006_bib0290","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrneurol.2014.187","article-title":"Maternal immune activation and abnormal brain development across CNS disorders","volume":"10","author":"Knuesel","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0295","doi-asserted-by":"crossref","first-page":"13510","DOI":"10.1038\/s41598-017-13368-2","article-title":"Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer\u2019s disease","volume":"7","author":"Kobayashi","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuro.2019.08.006_bib0300","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1104\/pp.114.241901","article-title":"Herbicides as weed control agents: state of the art: I. Weed control research and safener technology: the path to modern agriculture","volume":"166","author":"Kraehmer","year":"2014","journal-title":"Plant Physiol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0305","first-page":"1","article-title":"Detection of glyphosate residues in animals and humans","volume":"4","author":"Kr\u00fcger","year":"2014","journal-title":"Environ. Anal. Toxicol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0310","doi-asserted-by":"crossref","DOI":"10.4172\/2161-0525.1000230","article-title":"Detection of glyphosate in malformed piglets","volume":"4","author":"Kr\u00fcger","year":"2014","journal-title":"J. Environ. Anal. Toxicol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0315","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.anaerobe.2013.01.005","article-title":"Glyphosate suppresses the antagonistic effect of Enterococcus spp. on Clostridium botulinum","volume":"20","author":"Kr\u00fcger","year":"2013","journal-title":"Anaerobe"},{"key":"10.1016\/j.neuro.2019.08.006_bib0320","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jbiotec.2009.09.014","article-title":"A novel RPMXR motif among class II 5-enolpyruvylshikimate-3-phosphate synthases is required for enzymatic activity and glyphosate resistance","volume":"144","author":"Li","year":"2009","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0325","doi-asserted-by":"crossref","first-page":"14762","DOI":"10.1007\/s11356-018-1676-0","article-title":"Glyphosate application increased catabolic activity of gram-negative bacteria but impaired soil fungal community","volume":"25","author":"Liu","year":"2018","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.neuro.2019.08.006_bib0330","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.toxrep.2017.12.005","article-title":"Sex-dependent impact of Roundup on the rat gut microbiome","volume":"5","author":"Lozano","year":"2018","journal-title":"Toxicol. Reports"},{"key":"10.1016\/j.neuro.2019.08.006_bib0335","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.physbeh.2006.06.019","article-title":"Induction of anxiety-like behavior in mice during the initial stages of infection with the agent of murine colonic hyperplasia Citrobacter rodentium","volume":"89","author":"Lyte","year":"2006","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuro.2019.08.006_bib0340","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbr.2006.07.025","article-title":"Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders","volume":"176","author":"MacFabe","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuro.2019.08.006_bib0345","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1146\/annurev-arplant-042811-105439","article-title":"The shikimate pathway and aromatic amino acid biosynthesis in plants","volume":"63","author":"Maeda","year":"2012","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0350","first-page":"53","article-title":"Evaluation of genotoxicity of the herbicide glyphosate quantitatively measures by the comet assay and micronucleius formation in treated mice","volume":"15","author":"Ma\u00f1as","year":"2006","journal-title":"Theoria"},{"key":"10.1016\/j.neuro.2019.08.006_bib0355","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1210\/er.2009-0030","article-title":"Gut microbiota, lipopolysaccharides, and innate immunity in the pathogenesis of obesity and cardiovascular risk","volume":"31","author":"Manco","year":"2010","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.neuro.2019.08.006_bib0360","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3748\/wjg.v22.i1.361","article-title":"Gut microbiota in autism and mood disorders","volume":"22","author":"Mangiola","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0365","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12940-019-0453-y","article-title":"The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system","volume":"18","author":"Manservisi","year":"2019","journal-title":"Environ. Heal."},{"key":"10.1016\/j.neuro.2019.08.006_bib0370","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12940-018-0394-x","article-title":"The Ramazzini Institute 13-week pilot study on glyphosate and Roundup administered at human-equivalent dose to Sprague Dawley rats: effects on the microbiome","volume":"17","author":"Mao","year":"2018","journal-title":"Environ. Health"},{"key":"10.1016\/j.neuro.2019.08.006_bib0375","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.envres.2017.10.051","article-title":"Neurotransmitter changes in rat brain regions following glyphosate exposure","volume":"161","author":"Mart\u00ednez","year":"2018","journal-title":"Environ. Res."},{"key":"10.1016\/j.neuro.2019.08.006_bib0380","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4161\/gmic.2.4.16108","article-title":"Beneficial psychological effects of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in healthy human volunteers","volume":"2","author":"Messaoudi","year":"2011","journal-title":"Gut Microbes"},{"key":"10.1016\/j.neuro.2019.08.006_bib0385","doi-asserted-by":"crossref","first-page":"10305","DOI":"10.1073\/pnas.1803880115","article-title":"Glyphosate perturbs the gut microbiota of honey bees","volume":"115","author":"Motta","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuro.2019.08.006_bib0390","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/nmo.12378","article-title":"Correlation between the human fecal microbiota and depression","volume":"26","author":"Naseribafrouei","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.neuro.2019.08.006_bib0395","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2982.2010.01620.x","article-title":"Reduced anxiety-like behavior and central neurochemical change in germ-free mice","volume":"23","author":"Neufeld","year":"2011","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.neuro.2019.08.006_bib0400","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.biopsych.2008.06.026","article-title":"Early life stress alters behavior, immunity, and microbiota in rats: implications for irritable bowel syndrome and psychiatric illnesses","volume":"65","author":"O\u2019Mahony","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuro.2019.08.006_bib0405","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1021\/tx1001749","article-title":"Glyphosate-based herbicides produce teratogenic effects on vertebrates by impairing retinoic acid signaling","volume":"23","author":"Paganelli","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0410","doi-asserted-by":"crossref","first-page":"799","DOI":"10.3920\/BM2017.0202","article-title":"Gut bacterial composition in a mouse model of Parkinson\u2019s disease","volume":"9","author":"Perez-Pardo","year":"2018","journal-title":"Benef. Microbes"},{"key":"10.1016\/j.neuro.2019.08.006_bib0415","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.envpol.2008.01.015","article-title":"Levels of glyphosate in surface waters, sediments and soils associated with direct sowing soybean cultivation in north pampasic region of Argentina","volume":"156","author":"Peruzzo","year":"2008","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.neuro.2019.08.006_bib0420","article-title":"Gastrointestinal dysfunctions in Parkinson\u2019s disease: symptoms and treatments","volume":"2016","author":"Poirier","year":"2016","journal-title":"Parkinsons Dis."},{"key":"10.1016\/j.neuro.2019.08.006_bib0425","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1053\/j.gastro.2011.07.043","article-title":"Global and deep molecular analysis of microbiota signatures in fecal samples from patients with irritable bowel syndrome","volume":"141","author":"Rajili\u0107-Stojanovi\u0107","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.neuro.2019.08.006_bib0430","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2174\/138945007780058951","article-title":"The inhibition of 5-enolpyruvylshikimate-3-phosphate synthase as a model for development of novel antimicrobials","volume":"8","author":"Ribeiro Marques","year":"2007","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.neuro.2019.08.006_bib0435","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1289\/ehp.7728","article-title":"Differential effects of glyphosate and roundup on human placental cells and aromatase","volume":"113","author":"Richard","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.neuro.2019.08.006_bib0440","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/jam.13190","article-title":"Investigations on the possible impact of a glyphosate-containing herbicide on ruminal metabolism and bacteria in vitro by means of the \u2018Rumen Simulation Technique\u2019","volume":"121","author":"Riede","year":"2016","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0445","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/FBP.0000000000000428","article-title":"Gut\u2013brain axis in the executive function of austism spectrum disorder","volume":"29","author":"Roman","year":"2018","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0450","article-title":"Survey of glyphosate residues in honey, corn and soy products","volume":"5","author":"Rubio","year":"2014","journal-title":"J. Environ. Anal. Toxicol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0455","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4103\/2152-7806.153876","article-title":"Glyphosate, pathways to modern diseases III: manganese, neurological diseases, and associated pathologies","volume":"6","author":"Samsel","year":"2015","journal-title":"Surg. Neurol. Int."},{"key":"10.1016\/j.neuro.2019.08.006_bib0460","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2478\/intox-2013-0026","article-title":"Glyphosate, pathways to modern diseases II: celiac sprue and gluten intolerance","volume":"6","author":"Samsel","year":"2013","journal-title":"Interdiscip. Toxicol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0465","first-page":"1","article-title":"In vitro evaluation of genomic damage induced by glyphosate on human lymphocytes","author":"Santovito","year":"2018","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.neuro.2019.08.006_bib0470","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1073\/pnas.98.4.1376","article-title":"Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail","volume":"98","author":"Schonbrunn","year":"2001","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.neuro.2019.08.006_bib0475","first-page":"50","article-title":"Elevated urinary glyphosate and Clostridia metabolites with altered dopamine metabolism in triplets with autistic Spectrum disorder or suspected seizure disorder: a case study","volume":"16","author":"Shaw","year":"2017","journal-title":"Integr. Med. (Encinitas)"},{"key":"10.1016\/j.neuro.2019.08.006_bib0480","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1179\/147683010X12611460763968","article-title":"Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. In the gastrointestinal tract, in urine samples from patients with autism and schizophrenia","volume":"13","author":"Shaw","year":"2010","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.neuro.2019.08.006_bib0485","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s00284-012-0277-2","article-title":"The effect of glyphosate on potential pathogens and beneficial members of poultry microbiota in vitro","volume":"66","author":"Shehata","year":"2013","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0490","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/MOG.0000000000000139","article-title":"The gut microbiome in health and in disease","volume":"31","author":"Shreiner","year":"2015","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0495","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/protein\/5.5.461","article-title":"Over-production of 5-enolpyruvylshikimate-3-phosphate synthase in Escherichia coli: use of the T7 promoter","volume":"5","author":"Shuttleworth","year":"1992","journal-title":"Protein Eng."},{"key":"10.1016\/j.neuro.2019.08.006_bib0500","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.aquatox.2017.09.021","article-title":"Phytoplankton growth and PSII efficiency sensitivity to a glyphosate-based herbicide (Factor 540\u00ae)","volume":"192","author":"Smedbol","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0505","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0021-9258(18)65371-2","article-title":"The biosynthesis of shikimic acid from D-glucose","volume":"220","author":"Srinivasan","year":"1956","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuro.2019.08.006_bib0510","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbi.2018.02.005","article-title":"Neuroprotective effects of fecal microbiota transplantation on MPTP-induced Parkinson\u2019s disease mice: gut microbiota, glial reaction and TLR4\/TNF-\u03b1 signaling pathway","volume":"70","author":"Sun","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuro.2019.08.006_bib0515","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbi.2016.10.023","article-title":"Sex-specific modulation of the gut microbiome and behavior in Siberian hamsters","volume":"60","author":"Sylvia","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuro.2019.08.006_bib0520","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.fct.2013.05.057","article-title":"Glyphosate induces human breast cancer cells growth via estrogen receptors","volume":"59","author":"Thongprakaisang","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0525","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuro.2019.08.006_bib0530","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.scitotenv.2017.10.309","article-title":"Environmental and health effects of the herbicide glyphosate","volume":"616\u2013617","author":"Van Bruggen","year":"2018","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.neuro.2019.08.006_bib0535","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1002\/ps.4218","article-title":"Glyphosate residues in rural groundwater, Nottawasaga River Watershed, Ontario, Canada","volume":"72","author":"Van Stempvoort","year":"2016","journal-title":"Pest Manag. Sci."},{"key":"10.1016\/j.neuro.2019.08.006_bib0540","first-page":"1","article-title":"Experiences with fecal microbiota transplantation in Clostridium difficile infections via upper gastrointestinal tract","author":"Vigv\u00e1ri","year":"2018","journal-title":"Acta Microbiol. Immunol. Hung."},{"key":"10.1016\/j.neuro.2019.08.006_bib0545","doi-asserted-by":"crossref","first-page":"13537","DOI":"10.1038\/s41598-017-13601-y","article-title":"Gut microbiome alterations in Alzheimer\u2019s disease","volume":"7","author":"Vogt","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuro.2019.08.006_bib0550","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.chom.2013.09.012","article-title":"Microbial modulation of energy availability in the Colon Regulates intestinal transit","volume":"14","author":"Wichmann","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.neuro.2019.08.006_bib0555","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/rtph.1999.1371","article-title":"Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans","volume":"31","author":"Williams","year":"2000","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0560","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1093\/aje\/kwq303","article-title":"Metal emissions and urban incident Parkinson disease: a community health study of Medicare beneficiaries by using geographic information systems","volume":"172","author":"Willis","year":"2010","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0565","first-page":"1","article-title":"Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic acid, 3-Hydroxyphenylacetic acid, and 3-Hydroxyhippuric acid are elevated in children with autism Spectrum disorders","volume":"2016","author":"Xiong","year":"2016","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.neuro.2019.08.006_bib0570","doi-asserted-by":"crossref","first-page":"4","DOI":"10.12659\/AJCR.891287","article-title":"Clostridium tertium bacteremia in a patient with glyphosate ingestion","volume":"16","author":"You","year":"2015","journal-title":"Am. J. Case Rep."},{"key":"10.1016\/j.neuro.2019.08.006_bib0575","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.bbrc.2018.04.200","article-title":"Circular RNA expression profiles in hippocampus from mice with perinatal glyphosate exposure","volume":"501","author":"Yu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.neuro.2019.08.006_bib0580","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1007\/s00253-018-9035-0","article-title":"Recent advances in glyphosate biodegradation","volume":"102","author":"Zhan","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0585","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1212\/WNL.0000000000003391","article-title":"Gram-negative bacterial molecules associate with Alzheimer disease pathology","volume":"87","author":"Zhan","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.neuro.2019.08.006_bib0590","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3233\/JAD-170020","article-title":"Altered gut microbiota in a mouse model of Alzheimer\u2019s disease","volume":"60","author":"Zhang","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.neuro.2019.08.006_bib0595","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jneuroim.2008.09.017","article-title":"Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)","volume":"206","author":"Zhang","year":"2009","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.neuro.2019.08.006_bib0600","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/mp.2016.44","article-title":"Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host\u2019s metabolism","volume":"21","author":"Zheng","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuro.2019.08.006_bib0605","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bbrc.2014.09.093","article-title":"Blood\u2013brain barrier dysfunction in mice induced by lipopolysaccharide is attenuated by dapsone","volume":"453","author":"Zhou","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X19300816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X19300816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:18:07Z","timestamp":1758982687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X19300816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":121,"alternative-id":["S0161813X19300816"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2019.08.006","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gut microbiota and neurological effects of glyphosate","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2019.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}