{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:54:21Z","timestamp":1791309261961,"version":"4.3.1"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.neuro.2019.12.004","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T12:17:49Z","timestamp":1575634669000},"page":"94-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Ropinirole induces neuroprotection following reperfusion-promoted mitochondrial dysfunction after focal cerebral ischemia in Wistar rats"],"prefix":"10.1016","volume":"77","author":[{"given":"Syed Suhail","family":"Andrabi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8699-5309","authenticated-orcid":false,"given":"Heena","family":"Tabassum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabiha","family":"Parveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhel","family":"Parvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.neuro.2019.12.004_bib0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.15407\/fz58.01.003","article-title":"Cytochrome C as an amplifier of ROS release in mitochondria","volume":"58","author":"Akopova","year":"2012","journal-title":"Fiziol. Zh."},{"issue":"3","key":"10.1016\/j.neuro.2019.12.004_bib0010","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/1941874412441802","article-title":"Impact of protocol deviations in acute ischemic stroke treated with intravenous rt-PA within 4.5 hours after symptom onset","volume":"2","author":"Alderazi","year":"2012","journal-title":"Neurohospitalist"},{"key":"10.1016\/j.neuro.2019.12.004_bib0015","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.033860","article-title":"Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke","author":"Andrabi","year":"2019","journal-title":"Dis. Model. Mech."},{"issue":"6","key":"10.1016\/j.neuro.2019.12.004_bib0020","first-page":"787","article-title":"Progesterone induces neuroprotection following reperfusion-promoted mitochondrial dysfunction after focal cerebral ischemia in rats","volume":"10","author":"Andrabi","year":"2017","journal-title":"Dis. Model. Mech."},{"issue":"7","key":"10.1016\/j.neuro.2019.12.004_bib0025","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s10072-014-2061-5","article-title":"Dopamine agonists can improve pure apathy associated with lesions of the prefrontal-basal ganglia functional system","volume":"36","author":"Blundo","year":"2015","journal-title":"Neurol. Sci."},{"issue":"3","key":"10.1016\/j.neuro.2019.12.004_bib0030","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.nbd.2011.12.022","article-title":"The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: the importance of free oxygen radicals and mitochondrial integrity","volume":"45","author":"Boscolo","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.neuro.2019.12.004_bib0035","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.etap.2015.06.002","article-title":"The role of multifunctional drug therapy against carbamate induced neuronal toxicity during acute and chronic phase in rats","volume":"40","author":"Chahal","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"5","key":"10.1016\/j.neuro.2019.12.004_bib0040","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.febslet.2008.01.028","article-title":"D2\/D3 receptor agonist ropinirole protects dopaminergic cell line against rotenone-induced apoptosis through inhibition of caspase- and JNK-dependent pathways","volume":"582","author":"Chen","year":"2008","journal-title":"FEBS Lett."},{"issue":"2","key":"10.1016\/j.neuro.2019.12.004_bib0045","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s00702-016-1616-4","article-title":"Gene therapy targeting mitochondrial pathway in Parkinson\u2019s disease","volume":"124","author":"Choong","year":"2017","journal-title":"J. Neural Transm."},{"issue":"1","key":"10.1016\/j.neuro.2019.12.004_bib0050","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1124\/jpet.105.092312","article-title":"Targeted antioxidative and neuroprotective properties of the dopamine agonist pramipexole and its nondopaminergic enantiomer SND919CL2x [(+)2-amino-4,5,6,7-tetrahydro-6-Lpropylamino-benzathiazole dihydrochloride]","volume":"316","author":"Danzeisen","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"12","key":"10.1016\/j.neuro.2019.12.004_bib0055","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1038\/sj.jcbfm.9600298","article-title":"Bench to bedside: the quest for quality in experimental stroke research","volume":"26","author":"Dirnagl","year":"2006","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.neuro.2019.12.004_bib0060","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2210-10-2","article-title":"Mitochondria-targeted antioxidant effects of S(-) and R(+) pramipexole","volume":"10","author":"Ferrari-Toninelli","year":"2010","journal-title":"BMC Pharmacol."},{"issue":"5","key":"10.1016\/j.neuro.2019.12.004_bib0065","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1080\/10749357.2017.1304865","article-title":"Post-stroke hemiparesis: Does chronicity, etiology, and lesion side are associated with gait pattern?","volume":"24","author":"Gama","year":"2017","journal-title":"Top. Stroke Rehabil."},{"issue":"1","key":"10.1016\/j.neuro.2019.12.004_bib0070","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/cns.12655","article-title":"Mitochondrial dysfunction and biogenesis in neurodegenerative diseases: pathogenesis and treatment","volume":"23","author":"Golpich","year":"2017","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neuro.2019.12.004_bib0075","doi-asserted-by":"crossref","first-page":"355","DOI":"10.3389\/fphys.2014.00355","article-title":"Bcl-xL in neuroprotection and plasticity","volume":"5","author":"Jonas","year":"2014","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.neuro.2019.12.004_bib0080","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/j.2040-4603.2017.tb00741.x","article-title":"Ischemia\/Reperfusion","volume":"7","author":"Kalogeris","year":"2016","journal-title":"Compr. Physiol."},{"issue":"12","key":"10.1016\/j.neuro.2019.12.004_bib0085","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1002\/jps.10502","article-title":"In vivo iontophoretic administration of ropinirole hydrochloride","volume":"92","author":"Luzardo-Alvarez","year":"2003","journal-title":"J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.neuro.2019.12.004_bib0090","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1161\/STROKEAHA.108.525386","article-title":"Good laboratory practice: preventing introduction of bias at the bench","volume":"40","author":"Macleod","year":"2009","journal-title":"Stroke"},{"issue":"9","key":"10.1016\/j.neuro.2019.12.004_bib0095","doi-asserted-by":"crossref","first-page":"11753","DOI":"10.3390\/ijms130911753","article-title":"Neuroprotection for stroke: current status and future perspectives","volume":"13","author":"Minnerup","year":"2012","journal-title":"Int. J. Mol. Sci."},{"issue":"22","key":"10.1016\/j.neuro.2019.12.004_bib0100","doi-asserted-by":"crossref","first-page":"15469","DOI":"10.1074\/jbc.M707238200","article-title":"Differential modulation of Akt\/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responses","volume":"283","author":"Nair","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuro.2019.12.004_bib0105","article-title":"Efficacy of ropinirole-loaded PLGA microspheres for the reversion of rotenone-induced Parkinsonism","author":"Negro","year":"2016","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.neuro.2019.12.004_bib0110","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pbb.2013.01.017","article-title":"Ropinirole protects against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced neurotoxicity in mice via anti-apoptotic mechanism","volume":"104","author":"Park","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"6-7","key":"10.1016\/j.neuro.2019.12.004_bib0115","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.bbabio.2010.02.001","article-title":"The dopamine-D2-receptor agonist ropinirole dose-dependently blocks the Ca2+-triggered permeability transition of mitochondria","volume":"1797","author":"Parvez","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"issue":"9","key":"10.1016\/j.neuro.2019.12.004_bib0120","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.euroneuro.2015.07.012","article-title":"Pharmacological targeting of dopamine D3 receptors: possible clinical applications of selective drugs","volume":"25","author":"Pich","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.neuro.2019.12.004_bib0125","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2592935","article-title":"The injury and therapy of reactive oxygen species in intracerebral hemorrhage looking at mitochondria","volume":"2016","author":"Qu","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.neuro.2019.12.004_bib0130","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00709-015-0930-2","article-title":"Mitochondrial permeability transition pore: a promising target for the treatment of Parkinson\u2019s disease","volume":"254","author":"Rasheed","year":"2017","journal-title":"Protoplasma"},{"issue":"9","key":"10.1016\/j.neuro.2019.12.004_bib0135","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrm3412","article-title":"Mitochondria as sensors and regulators of calcium signalling","volume":"13","author":"Rizzuto","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"11","key":"10.1016\/j.neuro.2019.12.004_bib0140","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078627","article-title":"Cytochrome C is tyrosine 97 phosphorylated by neuroprotective insulin treatment","volume":"8","author":"Sanderson","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.neuro.2019.12.004_bib0145","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1096\/fj.05-4748fje","article-title":"Patch clamp reveals powerful blockade of the mitochondrial permeability transition pore by the D2-receptor agonist pramipexole","volume":"20","author":"Sayeed","year":"2006","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.neuro.2019.12.004_bib0150","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tips.2015.11.006","article-title":"Drug repurposing for the development of novel analgesics","volume":"37","author":"Sisignano","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"issue":"6","key":"10.1016\/j.neuro.2019.12.004_bib0155","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nm.3595","article-title":"Overcoming drug development bottlenecks with repurposing: old drugs learn new tricks","volume":"20","author":"Strittmatter","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.neuro.2019.12.004_bib0160","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuint.2016.12.010","article-title":"Role of melatonin in mitigating nonylphenol-induced toxicity in frontal cortex and hippocampus of rat brain","volume":"104","author":"Tabassum","year":"2017","journal-title":"Neurochem. Int."},{"issue":"4","key":"10.1016\/j.neuro.2019.12.004_bib0165","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1177\/0271678X16654921","article-title":"Systematic and detailed analysis of behavioural tests in the rat middle cerebral artery occlusion model of stroke: tests for long-term assessment","volume":"37","author":"Trueman","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"Pt 2","key":"10.1016\/j.neuro.2019.12.004_bib0170","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/brain\/awt319","article-title":"Progesterone in experimental permanent stroke: a dose-response and therapeutic time-window study","volume":"137","author":"Wali","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.neuro.2019.12.004_bib0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mito.2016.08.005","article-title":"Melatonin modulates permeability transition pore and 5-hydroxydecanoate induced KATP channel inhibition in isolated brain mitochondria","volume":"31","author":"Waseem","year":"2016","journal-title":"Mitochondrion"},{"issue":"24","key":"10.1016\/j.neuro.2019.12.004_bib0180","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1212\/WNL.0000000000003388","article-title":"Practice guideline summary: treatment of restless legs syndrome in adults: report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology","volume":"87","author":"Winkelman","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.neuro.2019.12.004_bib0185","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/978-1-61779-382-0_15","article-title":"Mitochondrial permeability transition pore and calcium handling","volume":"810","author":"Wong","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.neuro.2019.12.004_bib0190","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.brainres.2015.05.009","article-title":"Decreased HCN2 expression in STN contributes to abnormal high-voltage spindles in the cortex and globus pallidus of freely moving rats","volume":"1618","author":"Yang","year":"2015","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.neuro.2019.12.004_bib0195","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0185-16.2016","article-title":"High-content genome-wide RNAi screen reveals CCR3 as a key mediator of neuronal cell death","volume":"3","author":"Zhang","year":"2016","journal-title":"eNeuro"},{"issue":"13","key":"10.1016\/j.neuro.2019.12.004_bib0200","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.4103\/0366-6999.159349","article-title":"Dopamine Agonists Exert Nurr1-inducing Effect in Peripheral Blood Mononuclear Cells of Patients with Parkinson\u2019s disease","volume":"128","author":"Zhang","year":"2015","journal-title":"Chin. Med. J."},{"issue":"9","key":"10.1016\/j.neuro.2019.12.004_bib0205","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1161\/STROKEAHA.115.009792","article-title":"Activation of dopamine D2 receptor suppresses neuroinflammation through alphaB-Crystalline by inhibition of NF-kappaB nuclear translocation in experimental ICH mice model","volume":"46","author":"Zhang","year":"2015","journal-title":"Stroke"}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X1930141X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X1930141X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:20:49Z","timestamp":1758982849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X1930141X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":41,"alternative-id":["S0161813X1930141X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2019.12.004","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ropinirole induces neuroprotection following reperfusion-promoted mitochondrial dysfunction after focal cerebral ischemia in Wistar rats","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2019.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}