{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:12:34Z","timestamp":1769919154556,"version":"3.49.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:00:00Z","timestamp":1608768000000},"content-version":"am","delay-in-days":298,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.neuro.2019.12.012","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T12:30:41Z","timestamp":1576758641000},"page":"40-50","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Neurochemical and neuroinflammatory perturbations in two Gulf War Illness models: Modulation by the immunotherapeutic LNFPIII"],"prefix":"10.1016","volume":"77","author":[{"given":"J.M.","family":"Carpenter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.E.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.D.","family":"Ludwig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.J.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.A.","family":"Harn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Norberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.M.","family":"Filipov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.neuro.2019.12.012_bib0005","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s12017-011-8160-z","article-title":"Proteomic CNS profile of delayed cognitive impairment in mice exposed to Gulf War agents","volume":"13","author":"Abdullah","year":"2011","journal-title":"Neuromol. Med."},{"key":"10.1016\/j.neuro.2019.12.012_bib0010","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbr.2014.07.038","article-title":"The role of serotonin in adult hippocampal neurogenesis","volume":"277","author":"Alenina","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuro.2019.12.012_bib0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1017\/S1355617799533031","article-title":"Evidence of cognitive deficits in Persian Gulf War veterans: interim report from a population-based study","volume":"5","author":"Anger","year":"1999","journal-title":"J. Int. Neuropsychol. Soc."},{"issue":"1-2","key":"10.1016\/j.neuro.2019.12.012_bib0020","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jns.2015.06.062","article-title":"Temporal profile of M1 and M2 responses in the hippocampus following early 24h of neurotrauma","volume":"357","author":"Ansari","year":"2015","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.neuro.2019.12.012_bib0025","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2567.2008.02826.x","article-title":"The immunomodulatory glycan LNFPIII initiates alternative activation of murine macrophages in vivo","volume":"125","author":"Atochina","year":"2008","journal-title":"Immunology"},{"issue":"3","key":"10.1016\/j.neuro.2019.12.012_bib0030","doi-asserted-by":"crossref","first-page":"69","DOI":"10.5539\/gjhs.v5n3p69","article-title":"Carnosine treatment for gulf war illness: a randomized controlled trial","volume":"5","author":"Baraniuk","year":"2013","journal-title":"Glob. J. Health Sci."},{"issue":"12","key":"10.1016\/j.neuro.2019.12.012_bib0035","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/ijnp\/pyx056","article-title":"Dopamine system dysregulation in major depressive disorders","volume":"20","author":"Belujon","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"11","key":"10.1016\/j.neuro.2019.12.012_bib0040","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1038\/nm.2962","article-title":"Immunomodulatory glycan LNFPIII alleviates hepatosteatosis and insulin resistance through direct and indirect control of metabolic pathways","volume":"18","author":"Bhargava","year":"2012","journal-title":"Nat. Med."},{"issue":"1-2","key":"10.1016\/j.neuro.2019.12.012_bib0045","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jneuroim.2005.11.021","article-title":"The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1beta responses to stress","volume":"173","author":"Blandino","year":"2006","journal-title":"J. Neuroimmunol."},{"issue":"12","key":"10.1016\/j.neuro.2019.12.012_bib0050","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1097\/01.jom.0000099980.38936.09","article-title":"Reported exposures, stressors, and life events among gulf war registry veterans","volume":"45","author":"Boyd","year":"2003","journal-title":"J. Occup. Environ. Med."},{"key":"10.1016\/j.neuro.2019.12.012_bib0055","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbi.2012.11.007","article-title":"Altered immune pathway activity under exercise challenge in Gulf War Illness: an exploratory analysis","volume":"28","author":"Broderick","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuro.2019.12.012_bib0060","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-1-4939-7828-1_7","article-title":"Exploring the diagnostic potential of immune biomarker Co-expression in gulf war illness","volume":"1781","author":"Broderick","year":"2018","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.neuro.2019.12.012_bib0065","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.pharmthera.2011.01.014","article-title":"Immune system to brain signaling: neuropsychopharmacological implications","volume":"130","author":"Capuron","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.neuro.2019.12.012_bib0070","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainres.2017.12.030","article-title":"Anxiety, neuroinflammation, cholinergic and GABAergic abnormalities are early markers of Gulf War illness in a mouse model of the disease","volume":"1681","author":"Carreras","year":"2018","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.neuro.2019.12.012_bib0075","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.neuro.2010.05.006","article-title":"Effects of low-level exposure to sarin and cyclosarin during the 1991 Gulf War on brain function and brain structure in US veterans","volume":"31","author":"Chao","year":"2010","journal-title":"Neurotoxicology"},{"issue":"5","key":"10.1016\/j.neuro.2019.12.012_bib0080","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1136\/oem.58.5.299","article-title":"Health and exposures of United Kingdom Gulf war veterans. Part II: the relation of health to exposure","volume":"58","author":"Cherry","year":"2001","journal-title":"Occup. Environ. Med."},{"issue":"5","key":"10.1016\/j.neuro.2019.12.012_bib0085","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/j.1471-4159.2006.04294.x","article-title":"Dopaminergic toxicity associated with oral exposure to the herbicide atrazine in juvenile male C57BL\/6 mice","volume":"100","author":"Coban","year":"2007","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.neuro.2019.12.012_bib0090","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1172\/JCI58656","article-title":"The immunology of neurodegeneration","volume":"122","author":"Czirr","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.neuro.2019.12.012_bib0095","series-title":"The Gulf War Illness Landscape in: Programs","author":"DDGWIRP","year":"2018"},{"key":"10.1016\/j.neuro.2019.12.012_bib0100","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.molimm.2018.12.024","article-title":"Inflammasome activation and Th17 responses","volume":"107","author":"Deng","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.neuro.2019.12.012_bib0105","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3389\/fimmu.2013.00289","article-title":"Interleukin-18 and IL-18 binding protein","volume":"4","author":"Dinarello","year":"2013","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.neuro.2019.12.012_bib0110","doi-asserted-by":"crossref","first-page":"85","DOI":"10.7326\/0003-4819-141-2-200407200-00006","article-title":"Benefits and harms of doxycycline treatment for Gulf War veterans\u2019 illnesses: a randomized, double-blind, placebo-controlled trial","volume":"141","author":"Donta","year":"2004","journal-title":"Ann. Intern. Med."},{"issue":"1-2","key":"10.1016\/j.neuro.2019.12.012_bib0115","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cnr.2006.04.002","article-title":"Effects of cytokines and infections on brain neurochemistry","volume":"6","author":"Dunn","year":"2006","journal-title":"Clin. Neurosci. Res."},{"issue":"3","key":"10.1016\/j.neuro.2019.12.012_bib0120","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.yfrne.2012.09.003","article-title":"Cytokine effects on the basal ganglia and dopamine function: the subcortical source of inflammatory malaise","volume":"33","author":"Felger","year":"2012","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.neuro.2019.12.012_bib0125","first-page":"436813","article-title":"Parkinson\u2019s disease and systemic inflammation","volume":"2011","author":"Ferrari","year":"2011","journal-title":"Parkinsons Dis."},{"issue":"11","key":"10.1016\/j.neuro.2019.12.012_bib0130","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1162\/NECO_a_00659","article-title":"Coenzyme Q10 benefits symptoms in Gulf War veterans: results of a randomized double-blind study","volume":"26","author":"Golomb","year":"2014","journal-title":"Neural Comput."},{"key":"10.1016\/j.neuro.2019.12.012_bib0135","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3389\/fimmu.2015.00249","article-title":"Microglia versus myeloid cell nomenclature during brain inflammation","volume":"6","author":"Greter","year":"2015","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.neuro.2019.12.012_bib0140","doi-asserted-by":"crossref","first-page":"7","DOI":"10.31887\/DCNS.2016.18.1\/shaber","article-title":"Corticostriatal circuitry","volume":"18","author":"Haber","year":"2016","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.neuro.2019.12.012_bib0145","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fnbeh.2014.00078","article-title":"Object location and object recognition memory impairments, motivation deficits and depression in a model of Gulf War illness","volume":"8","author":"Hattiangady","year":"2014","journal-title":"Front. Behav. Neurosci."},{"issue":"2","key":"10.1016\/j.neuro.2019.12.012_bib0150","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neubiorev.2005.06.007","article-title":"Serotonergic modulation of the limbic system","volume":"30","author":"Hensler","year":"2006","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.neuro.2019.12.012_bib0155","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2017.00048","article-title":"The effects of serotonin in immune cells","volume":"4","author":"Herr","year":"2017","journal-title":"Front. Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.neuro.2019.12.012_bib0160","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1177\/2167702613506580","article-title":"Central executive dysfunction and deferred prefrontal processing in veterans with gulf war illness","volume":"2","author":"Hubbard","year":"2014","journal-title":"Clin. Psychol. Sci."},{"issue":"4","key":"10.1016\/j.neuro.2019.12.012_bib0165","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2006.02.016","article-title":"Innate immunity gone awry: linking microbial infections to chronic inflammation and Cancer","volume":"124","author":"Karin","year":"2006","journal-title":"Cell"},{"issue":"51","key":"10.1016\/j.neuro.2019.12.012_bib0170","doi-asserted-by":"crossref","first-page":"14835","DOI":"10.1073\/pnas.1616515114","article-title":"Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory","volume":"113","author":"Kempadoo","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1-2","key":"10.1016\/j.neuro.2019.12.012_bib0175","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jneuroim.2005.05.001","article-title":"Splenic norepinephrine depletion following acute stress suppresses in vivo antibody response","volume":"165","author":"Kennedy","year":"2005","journal-title":"J. Neuroimmunol."},{"issue":"334","key":"10.1016\/j.neuro.2019.12.012_bib0180","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3389\/fimmu.2018.00334","article-title":"Interleukin-18 amplifies macrophage polarization and morphological alteration, leading to excessive angiogenesis","volume":"9","author":"Kobori","year":"2018","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.neuro.2019.12.012_bib0185","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3390\/ph11030066","article-title":"Bacterial lipopolysaccharide increases serotonin metabolism in both medial prefrontal cortex and nucleus accumbens in male wild type rats, but not in serotonin transporter knockout rats","volume":"11","author":"Korte-Bouws","year":"2018","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.neuro.2019.12.012_bib0190","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.physbeh.2016.02.007","article-title":"Time-dependent behavioral, neurochemical, and metabolic dysregulation in female C57BL\/6 mice caused by chronic high-fat diet intake","volume":"157","author":"Krishna","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuro.2019.12.012_bib0195","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ntt.2013.06.002","article-title":"Short-term atrazine exposure causes behavioral deficits and disrupts monoaminergic systems in male C57BL\/6 mice","volume":"39","author":"Lin","year":"2013","journal-title":"Neurotoxicol. Teratol."},{"issue":"3","key":"10.1016\/j.neuro.2019.12.012_bib0200","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/jnc.14071","article-title":"Corticosterone primes the neuroinflammatory response to Gulf War Illness-relevant organophosphates independently of acetylcholinesterase inhibition","volume":"142","author":"Locker","year":"2017","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuro.2019.12.012_bib0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2019.04.015","article-title":"Pyridostigmine bromide and stress interact to impact immune function, cholinergic neurochemistry and behavior in a rat model of Gulf War Illness","author":"Macht","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuro.2019.12.012_bib0210","first-page":"447","article-title":"Parvalbumin and neuropeptide Y expressing hippocampal GABA-ergic inhibitory interneuron numbers decline in a model of Gulf War illness","volume":"8","author":"Megahed","year":"2014","journal-title":"Front. Cell. Neurosci."},{"issue":"2","key":"10.1016\/j.neuro.2019.12.012_bib0215","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/toxsci\/kfy130","article-title":"The neuroinflammatory phenotype in a mouse model of gulf war illness is unrelated to brain regional levels of acetylcholine as measured by quantitative HILIC-UPLC-MS\/MS","volume":"165","author":"Miller","year":"2018","journal-title":"Toxicol. Sci."},{"issue":"5","key":"10.1016\/j.neuro.2019.12.012_bib0220","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1111\/jnc.13088","article-title":"Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness","volume":"133","author":"O\u2019Callaghan","year":"2015","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.neuro.2019.12.012_bib0225","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/neup.12061","article-title":"Exposure to an organophosphate pesticide, individually or in combination with other Gulf War agents, impairs synaptic integrity and neuronal differentiation, and is accompanied by subtle microvascular injury in a mouse model of Gulf War agent exposure","volume":"34","author":"Ojo","year":"2014","journal-title":"Neuropathology"},{"issue":"12","key":"10.1016\/j.neuro.2019.12.012_bib0230","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1038\/npp.2013.158","article-title":"Mood and memory deficits in a model of Gulf War illness are linked with reduced neurogenesis, partial neuron loss, and mild inflammation in the hippocampus","volume":"38","author":"Parihar","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuro.2019.12.012_bib0235","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12865-015-0122-z","article-title":"Evidence for abnormal cytokine expression in Gulf War Illness: a preliminary analysis of daily immune monitoring data","volume":"16","author":"Parkitny","year":"2015","journal-title":"BMC Immunol."},{"issue":"11","key":"10.1016\/j.neuro.2019.12.012_bib0240","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1093\/brain\/awq268","article-title":"Fatigue in Parkinson\u2019s disease is linked to striatal and limbic serotonergic dysfunction","volume":"133","author":"Pavese","year":"2010","journal-title":"Brain"},{"issue":"1-2","key":"10.1016\/j.neuro.2019.12.012_bib0245","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jneuroim.2010.02.018","article-title":"Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression","volume":"222","author":"Pott Godoy","year":"2010","journal-title":"J. Neuroimmunol."},{"issue":"6","key":"10.1016\/j.neuro.2019.12.012_bib0250","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.neuro.2006.08.001","article-title":"Effects of sarin and cyclosarin exposure during the 1991 Gulf War on neurobehavioral functioning in US army veterans","volume":"27","author":"Proctor","year":"2006","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2019.12.012_bib0255","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fimmu.2014.00532","article-title":"Metabolism via Arginase or nitric oxide synthase: two competing arginine pathways in macrophages","volume":"5","author":"Rath","year":"2014","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.neuro.2019.12.012_bib0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058493","article-title":"Increased brain white matter axial diffusivity associated with fatigue, pain and hyperalgesia in Gulf War illness","volume":"8","author":"Rayhan","year":"2013","journal-title":"PLoS One"},{"issue":"7344","key":"10.1016\/j.neuro.2019.12.012_bib0265","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature09817","article-title":"Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation","volume":"472","author":"Sahay","year":"2011","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.neuro.2019.12.012_bib0270","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1128\/IAI.01293-13","article-title":"Immunomodulatory glycan lacto-N-fucopentaose III requires clathrin-mediated endocytosis to induce alternative activation of antigen-presenting cells","volume":"82","author":"Srivastava","year":"2014","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.neuro.2019.12.012_bib0275","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1289\/ehp.1003399","article-title":"Complex factors in the etiology of Gulf War illness: wartime exposures and risk factors in veteran subgroups","volume":"120","author":"Steele","year":"2012","journal-title":"Environ. Health Perspect."},{"issue":"6","key":"10.1016\/j.neuro.2019.12.012_bib0280","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/0031-9384(94)00369-G","article-title":"Stress-induced changes in regional monoamine metabolism and behavior in rats","volume":"57","author":"Sudha","year":"1995","journal-title":"Physiol. Behav."},{"issue":"5","key":"10.1016\/j.neuro.2019.12.012_bib0285","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1017\/S1355617709990294","article-title":"Neuropsychological functioning of U.S. Gulf War veterans 10 years after the war","volume":"15","author":"Toomey","year":"2009","journal-title":"J. Int. Neuropsychol. Soc."},{"issue":"9","key":"10.1016\/j.neuro.2019.12.012_bib0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137495","article-title":"A neoglycoconjugate containing the human milk sugar LNFPIII drives anti-inflammatory activation of antigen presenting cells in a CD14 dependent pathway","volume":"10","author":"Tundup","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neuro.2019.12.012_bib0295","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.cortex.2015.08.022","article-title":"Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: effects of toxicant exposures during deployment","volume":"74","author":"White","year":"2016","journal-title":"Cortex"},{"key":"10.1016\/j.neuro.2019.12.012_bib0300","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neuroscience.2015.05.068","article-title":"Differential degradation of motor deficits during gradual dopamine depletion with 6-hydroxydopamine in mice","volume":"301","author":"Willard","year":"2015","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.neuro.2019.12.012_bib0305","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.neuron.2014.12.064","article-title":"Immunotherapeutic approaches for Alzheimer\u2019s disease","volume":"85","author":"Wisniewski","year":"2015","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.neuro.2019.12.012_bib0310","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/j.biopsych.2013.11.029","article-title":"Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain","volume":"75","author":"Wohleb","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuro.2019.12.012_bib0315","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.phrs.2018.06.015","article-title":"Beyond a neurotransmitter: the role of serotonin in inflammation and immunity","volume":"140","author":"Wu","year":"2019","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.neuro.2019.12.012_bib0320","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbr.2011.07.006","article-title":"Pro- and anti-inflammatory cytokines expression in rat\u2019s brain and spleen exposed to chronic mild stress: involvement in depression","volume":"225","author":"You","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.neuro.2019.12.012_bib0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0119579","article-title":"Gulf War agent exposure causes impairment of long-term memory formation and neuropathological changes in a mouse model of Gulf War Illness","volume":"10","author":"Zakirova","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.neuro.2019.12.012_bib0330","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s40120-018-0122-z","article-title":"Emerging immunotherapies for Parkinson disease","volume":"8","author":"Zella","year":"2019","journal-title":"Neurol. Ther."},{"issue":"3","key":"10.1016\/j.neuro.2019.12.012_bib0335","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.clim.2011.12.006","article-title":"Immune modulation by Lacto-N-fucopentaose III in experimental autoimmune encephalomyelitis","volume":"142","author":"Zhu","year":"2012","journal-title":"Clin. Immunol."},{"issue":"6","key":"10.1016\/j.neuro.2019.12.012_bib0340","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00415-015-7986-y","article-title":"Optimizing treatment success in multiple sclerosis","volume":"263","author":"Ziemssen","year":"2016","journal-title":"J. Neurol."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X19301494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X19301494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:20:08Z","timestamp":1758982808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X19301494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":68,"alternative-id":["S0161813X19301494"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2019.12.012","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurochemical and neuroinflammatory perturbations in two Gulf War Illness models: Modulation by the immunotherapeutic LNFPIII","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2019.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}