{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:52:05Z","timestamp":1791280325341,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Bumsuk Academic Research Fund in 2017"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.neuro.2020.03.005","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T12:27:16Z","timestamp":1583843236000},"page":"134-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Analysis of behavioral changes in zebrafish (Danio rerio) larvae caused by aminoglycoside-induced damage to the lateral line and muscles"],"prefix":"10.1016","volume":"78","author":[{"given":"Eunjung","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung","family":"Ho Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saemi","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon","family":"Chan Rah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae-Chul","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soonil","family":"Koun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6330-279X","authenticated-orcid":false,"given":"June","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2020.03.005_bib0005","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ydbio.2013.06.026","article-title":"The zebrafish amyloid precursor protein-b is required for motor neuron guidance and synapse formation","volume":"318","author":"Abramsson","year":"2013","journal-title":"Dev. Biol."},{"issue":"9","key":"10.1016\/j.neuro.2020.03.005_bib0010","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1345\/aph.1L001","article-title":"Aminoglycoside-induced vestibular injury: maintaining a sense of balance","volume":"42","author":"Ariano","year":"2008","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.neuro.2020.03.005_bib0015","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.pneurobio.2014.03.001","article-title":"Zebrafish models of human motor neuron diseases: advantages and limitations","volume":"118","author":"Babin","year":"2014","journal-title":"Prog. Neurobiol."},{"issue":"6167","key":"10.1016\/j.neuro.2020.03.005_bib0020","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1126\/science.1245629","article-title":"Modular organization of axial microcircuits in zebrafish","volume":"343","author":"Bagnall","year":"2014","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.neuro.2020.03.005_bib0025","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nn788","article-title":"Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo","volume":"5","author":"Behra","year":"2002","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuro.2020.03.005_bib0030","doi-asserted-by":"crossref","first-page":"40905","DOI":"10.1038\/srep40905","article-title":"Maternal cortisol stimulates neurogenesis and affects larval behaviour in zebrafish","volume":"7","author":"Best","year":"2017","journal-title":"Sci. Rep."},{"issue":"Pt 22","key":"10.1016\/j.neuro.2020.03.005_bib0035","doi-asserted-by":"crossref","first-page":"5181","DOI":"10.1242\/jcs.02625","article-title":"Acetylcholine and calcium signalling regulates muscle fibre formation in the zebrafish embryo","volume":"118","author":"Brennan","year":"2005","journal-title":"J. Cell. Sci."},{"issue":"1-2","key":"10.1016\/j.neuro.2020.03.005_bib0040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.heares.2011.12.001","article-title":"Ototoxin-induced cellular damage in neuromasts disrupts lateral line function in larval zebrafish","volume":"284","author":"Buck","year":"2012","journal-title":"Hear. Res."},{"issue":"18","key":"10.1016\/j.neuro.2020.03.005_bib0045","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.1523\/JNEUROSCI.0615-07.2007","article-title":"Sensorimotor gating in larval zebrafish","volume":"27","author":"Burgess","year":"2007","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.neuro.2020.03.005_bib0050","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/tox.21873","article-title":"Exposure to benzidine caused apoptosis and malformation of telencephalon region in zebrafish","volume":"29","author":"Chen","year":"2014","journal-title":"Environ. Toxicol."},{"issue":"2","key":"10.1016\/j.neuro.2020.03.005_bib0055","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1007\/s10162-008-0118-y","article-title":"Using the zebrafish lateral line to screen for ototoxicity","volume":"9","author":"Chiu","year":"2008","journal-title":"J. Assoc. Res. Otolaryngol."},{"issue":"5","key":"10.1016\/j.neuro.2020.03.005_bib0060","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/jat.2964","article-title":"Protective role of edaravone against neomycin-induced ototoxicity in zebrafish","volume":"34","author":"Choi","year":"2014","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.neuro.2020.03.005_bib0065","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/978-3-319-21059-9_18","article-title":"Chemical ototoxicity of the fish inner ear and lateral line","volume":"877","author":"Coffin","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.neuro.2020.03.005_bib0070","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/zeb.2009.0639","article-title":"Chemical screening for hair cell loss and protection in the zebrafish lateral line","volume":"7","author":"Coffin","year":"2010","journal-title":"Zebrafish"},{"issue":"1","key":"10.1016\/j.neuro.2020.03.005_bib0075","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1515\/rns.2011.008","article-title":"Imaging escape and avoidance behavior in zebrafish larvae","volume":"22","author":"Colwill","year":"2011","journal-title":"Rev. Neurosci."},{"issue":"12","key":"10.1016\/j.neuro.2020.03.005_bib0080","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1242\/dev.015719","article-title":"Expression of multiple slow myosin heavy chain genes reveals a diversity of zebrafish slow twitch muscle fibres with differing requirements for Hedgehog and Prdm1 activity","volume":"135","author":"Elworthy","year":"2008","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.neuro.2020.03.005_bib0085","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.conb.2004.01.012","article-title":"Development of the zebrafish lateral line","volume":"14","author":"Ghysen","year":"2004","journal-title":"Curr. Opin. Neurobiol."},{"issue":"10","key":"10.1016\/j.neuro.2020.03.005_bib0090","doi-asserted-by":"crossref","first-page":"e1001409","DOI":"10.1371\/journal.pbio.1001409","article-title":"NAD+ biosynthesis ameliorates a zebrafish model of muscular dystrophy","volume":"10","author":"Goody","year":"2012","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.neuro.2020.03.005_bib0095","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/(SICI)1096-9861(19960129)365:1<113::AID-CNE9>3.0.CO;2-6","article-title":"Early ear development in the embryo of the zebrafish, Danio rerio","volume":"365","author":"Haddon","year":"1996","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.neuro.2020.03.005_bib0100","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/nyas.13522","article-title":"Myasthenia gravis: the role of complement at the neuromuscular junction","volume":"1412","author":"Howard","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.neuro.2020.03.005_bib0105","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/937861","article-title":"Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection","volume":"2011","author":"Huth","year":"2011","journal-title":"Int. J. Otolaryngol."},{"issue":"14","key":"10.1016\/j.neuro.2020.03.005_bib0110","doi-asserted-by":"crossref","first-page":"E1383","DOI":"10.1073\/pnas.1402898111","article-title":"Gene-expression analysis of hair cell regeneration in the zebrafish lateral line","volume":"111","author":"Jiang","year":"2014","journal-title":"Proc. Nati. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuro.2020.03.005_bib0115","series-title":"Basic & Clinical Pharmacology","first-page":"699","author":"Katzung","year":"1998"},{"key":"10.1016\/j.neuro.2020.03.005_bib0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ntt.2015.12.003","article-title":"Trimethyltin chloride inhibits neuronal cell differentiation in zebrafish embryo neurodevelopment","volume":"54","author":"Kim","year":"2016","journal-title":"Neurotoxicol. Teratol."},{"issue":"3","key":"10.1016\/j.neuro.2020.03.005_bib0125","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"issue":"42","key":"10.1016\/j.neuro.2020.03.005_bib0130","doi-asserted-by":"crossref","first-page":"10641","DOI":"10.1523\/JNEUROSCI.1435-08.2008","article-title":"Initiation of Mauthner- or non-Mauthner-mediated fast escape evoked by different modes of sensory input","volume":"28","author":"Kohashi","year":"2008","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.neuro.2020.03.005_bib0135","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/cpt.603","article-title":"Drug-induced ototoxicity: mechanisms, pharmacogenetics, and protective strategies","volume":"101","author":"Lanvers-Kaminsky","year":"2017","journal-title":"Clin. Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.neuro.2020.03.005_bib0140","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s10162-013-0386-z","article-title":"Early development of hearing in zebrafish","volume":"14","author":"Lu","year":"2013","journal-title":"J. Assoc. Res. Otolaryngol."},{"issue":"2","key":"10.1016\/j.neuro.2020.03.005_bib0145","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.bbr.2012.07.014","article-title":"The immediate and the delayed effects of buspirone on zebrafish (Danio rerio) in an open field test: a 3-D approach","volume":"234","author":"Maaswinkel","year":"2012","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.neuro.2020.03.005_bib0150","doi-asserted-by":"crossref","DOI":"10.1136\/oem.54.1.69","article-title":"The pharmacological basis of therapeutics. 9th ed","volume":"54","author":"Maynard","year":"1997","journal-title":"Occup. Environ. Med."},{"issue":"4","key":"10.1016\/j.neuro.2020.03.005_bib0155","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.aanat.2014.01.005","article-title":"Topographical and drug specific sensitivity of hair cells of the zebrafish larvae to aminoglycoside-induced toxicity","volume":"196","author":"Montalbano","year":"2014","journal-title":"Ann. Anat."},{"issue":"5","key":"10.1016\/j.neuro.2020.03.005_bib0160","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.trsl.2015.05.002","article-title":"Zebrafish swimming behavior as a biomarker for ototoxicity-induced hair cell damage: a high-throughput drug development platform targeting hearing loss","volume":"166","author":"Niihori","year":"2015","journal-title":"Transl. Res."},{"issue":"1-2","key":"10.1016\/j.neuro.2020.03.005_bib0165","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.heares.2012.01.009","article-title":"Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line","volume":"288","author":"Ou","year":"2012","journal-title":"Hear. Res."},{"issue":"2","key":"10.1016\/j.neuro.2020.03.005_bib0170","doi-asserted-by":"crossref","first-page":"e1000020","DOI":"10.1371\/journal.pgen.1000020","article-title":"Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death","volume":"4","author":"Owens","year":"2008","journal-title":"PLoS Genet."},{"issue":"1\u20132","key":"10.1016\/j.neuro.2020.03.005_bib0175","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.heares.2009.03.001","article-title":"Response of mechanosensory hair cells of the zebrafish lateral line to aminoglycosides reveals distinct cell death pathways","volume":"253","author":"Owens","year":"2009","journal-title":"Hear. Res."},{"issue":"2","key":"10.1016\/j.neuro.2020.03.005_bib0180","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1006\/dbio.2000.9898","article-title":"Analysis of upstream elements in the HuC promoter leads to the establishment of transgenic zebrafish with fluorescent neurons","volume":"227","author":"Park","year":"2000","journal-title":"Dev. Biol."},{"issue":"1","key":"10.1016\/j.neuro.2020.03.005_bib0185","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000113821","article-title":"Sound detection and processing by fish: critical review and major research questions","volume":"41","author":"Popper","year":"1993","journal-title":"Brain Behav. Evol."},{"key":"10.1016\/j.neuro.2020.03.005_bib0190","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.freeradbiomed.2015.11.007","article-title":"Ecabet sodium alleviates neomycin-induced hair cell damage","volume":"89","author":"Rah","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"3\u20134","key":"10.1016\/j.neuro.2020.03.005_bib0195","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.aquatox.2011.08.014","article-title":"Developmental lead exposure causes startle response deficits in zebrafish","volume":"105","author":"Rice","year":"2011","journal-title":"Aquat. Toxicol."},{"issue":"1","key":"10.1016\/j.neuro.2020.03.005_bib0200","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbr.2011.11.041","article-title":"On the edge: pharmacological evidence for anxiety-related behavior in zebrafish larvae","volume":"228","author":"Richendrfer","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuro.2020.03.005_bib0205","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fnagi.2014.00099","article-title":"Degeneration of neuromuscular junction in age and dystrophy","volume":"6","author":"Rudolf","year":"2014","journal-title":"Front. Aging Neurosci."},{"issue":"9","key":"10.1016\/j.neuro.2020.03.005_bib0210","doi-asserted-by":"crossref","first-page":"R353","DOI":"10.1016\/j.cub.2009.02.025","article-title":"Mauthner cells","volume":"19","author":"Sillar","year":"2009","journal-title":"Curr. Biol."},{"issue":"4","key":"10.1016\/j.neuro.2020.03.005_bib0215","doi-asserted-by":"crossref","first-page":"e94227","DOI":"10.1371\/journal.pone.0094227","article-title":"PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae","volume":"9","author":"Spulber","year":"2014","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.neuro.2020.03.005_bib0220","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1534\/g3.116.030080","article-title":"Cilia-associated genes play differing roles in aminoglycoside-induced hair cell death in zebrafish","volume":"6","author":"Stawicki","year":"2016","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.neuro.2020.03.005_bib0225","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cbpc.2016.11.001","article-title":"An optimized method to assess ototoxic effects in the lateral line of zebrafish (Danio rerio) embryos","volume":"193","author":"Stengel","year":"2017","journal-title":"Comp. Biochem. Physiol. C Toxicol. Pharmacol."},{"key":"10.1016\/j.neuro.2020.03.005_bib0230","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.heares.2017.04.001","article-title":"A non-toxic dose of cobalt chloride blocks hair cells of the zebrafish lateral line","volume":"350","author":"Stewart","year":"2017","journal-title":"Hear. Res."},{"issue":"2","key":"10.1016\/j.neuro.2020.03.005_bib0235","doi-asserted-by":"crossref","first-page":"e29727","DOI":"10.1371\/journal.pone.0029727","article-title":"Rheotaxis in larval zebrafish is mediated by lateral line mechanosensory hair cells","volume":"7","author":"Suli","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.neuro.2020.03.005_bib0240","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1089\/zeb.2016.1412","article-title":"A fully automated high-throughput zebrafish behavioral ototoxicity assay","volume":"14","author":"Todd","year":"2017","journal-title":"Zebrafish"},{"issue":"1","key":"10.1016\/j.neuro.2020.03.005_bib0245","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1113\/JP272466","article-title":"Intensity-dependent timing and precision of startle response latency in larval zebrafish","volume":"595","author":"Troconis","year":"2017","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.neuro.2020.03.005_bib0250","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/dgd.12345","article-title":"From neuron to behavior: sensory-motor coordination of zebrafish turning behavior","volume":"59","author":"Umeda","year":"2017","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.neuro.2020.03.005_bib0255","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8283075","article-title":"Evaluation of the hair cell regeneration in zebrafish larvae by measuring and quantifying the startle responses","volume":"2017","author":"Wang","year":"2017","journal-title":"Neural Plast."},{"issue":"Pt 23","key":"10.1016\/j.neuro.2020.03.005_bib0260","doi-asserted-by":"crossref","first-page":"4788","DOI":"10.1242\/jeb.02582","article-title":"Correlation of C-start behaviors with neural activity recorded from the hindbrain in free-swimming goldfish (Carassius auratus)","volume":"209","author":"Weiss","year":"2006","journal-title":"J. Exp. Biol."},{"issue":"1\u20132","key":"10.1016\/j.neuro.2020.03.005_bib0265","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.heares.2011.05.008","article-title":"New developments in aminoglycoside therapy and ototoxicity","volume":"281","author":"Xie","year":"2011","journal-title":"Hear. Res."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X20300474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X20300474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:21:00Z","timestamp":1758982860000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X20300474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":53,"alternative-id":["S0161813X20300474"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2020.03.005","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of behavioral changes in zebrafish (Danio rerio) larvae caused by aminoglycoside-induced damage to the lateral line and muscles","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2020.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}