{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:37:51Z","timestamp":1790415471994,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.neuro.2020.05.007","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T04:11:07Z","timestamp":1590725467000},"page":"142-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Prenatal exposure to alcohol impairs social play behavior in adolescent male mice"],"prefix":"10.1016","volume":"79","author":[{"given":"Mara A.P.","family":"de \u00c1vila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca M.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisandra C.C.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layla D.M.","family":"Cabral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana C.","family":"Vilela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5059-9988","authenticated-orcid":false,"given":"Alexandre","family":"Giusti-Paiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.neuro.2020.05.007_bib0005","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/S0022-3565(25)31495-3","article-title":"Effects of prenatal alcohol exposure on growth and development in rats","volume":"207","author":"Abel","year":"1978","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"1","key":"10.1016\/j.neuro.2020.05.007_bib0010","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1523\/JNEUROSCI.2945-14.2015","article-title":"Methylphenidate and atomoxetine inhibit social play behavior through prefrontal and subcortical limbic mechanisms in rats","volume":"35","author":"Achterberg","year":"2015","journal-title":"J. Neurosci."},{"issue":"11","key":"10.1016\/j.neuro.2020.05.007_bib0015","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/14833","article-title":"Impairment of social and moral behavior related to early damage in human prefrontal cortex","volume":"2","author":"Anderson","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuro.2020.05.007_bib0020","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.alcohol.2016.05.002","article-title":"Effect of prenatal ethanol exposure on sexual motivation in adult rats","volume":"54","author":"\u00c1vila","year":"2016","journal-title":"Alcohol."},{"issue":"2","key":"10.1016\/j.neuro.2020.05.007_bib0025","first-page":"283","article-title":"Identifying maternal self-reported alcohol use associated with fetal alcohol spectrum disorders","volume":"25","author":"Barr","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"4","key":"10.1016\/j.neuro.2020.05.007_bib0030","doi-asserted-by":"crossref","first-page":"228","DOI":"10.2307\/1309460","article-title":"Social play behavior","volume":"34","author":"Bekoff","year":"1984","journal-title":"Bioscience."},{"key":"10.1016\/j.neuro.2020.05.007_bib0035","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ijdevneu.2016.07.005","article-title":"Early life overnutrition induced by litter size manipulation decreases social play behavior in adolescent male rats","volume":"53","author":"Carvalho","year":"2016","journal-title":"Int. J. Dev. Neurosci."},{"issue":"1","key":"10.1016\/j.neuro.2020.05.007_bib0040","doi-asserted-by":"crossref","first-page":"e54924","DOI":"10.1371\/journal.pone.0054924","article-title":"Low dose prenatal ethanol exposure induces anxiety-like behaviour and alters dendritic morphology in the basolateral amygdala of rat offspring","volume":"8","author":"Cullen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.neuro.2020.05.007_bib0045","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbr.2016.05.003","article-title":"Acute prenatal exposure to ethanol on gestational day 12 elicits opposing deficits in social behaviors and anxiety-like behaviors in Sprague Dawley rats","volume":"310","author":"Diaz","year":"2016","journal-title":"Behav. Brain Res."},{"issue":"6","key":"10.1016\/j.neuro.2020.05.007_bib0050","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.neuron.2012.12.002","article-title":"The role of medial prefrontal cortex in memory and decision making","volume":"76","author":"Euston","year":"2012","journal-title":"Neuron."},{"key":"10.1016\/j.neuro.2020.05.007_bib0055","first-page":"140","article-title":"Low-dose chronic prenatal alcohol exposure abolishes the pro-cognitive effects of angiotensin IV. Behav","volume":"329","author":"Fidalgo","year":"2017","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.neuro.2020.05.007_bib0060","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.bbr.2009.10.012","article-title":"Prenatal exposure to moderate levels of ethanol alters social behavior in adult rats: relationship to structural plasticity and immediate early gene expression in frontal cortex","volume":"207","author":"Hamilton","year":"2010","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.neuro.2020.05.007_bib0065","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/syn.20711","article-title":"Postnatal binge-like alcohol exposure decreases dendritic complexity while increasing the density of mature spines in mPFC Layer II\/III pyramidal neurons","volume":"64","author":"Hamilton","year":"2010","journal-title":"Synapse."},{"key":"10.1016\/j.neuro.2020.05.007_bib0070","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbr.2014.04.029","article-title":"Effects of moderate prenatal ethanol exposure and age on social behavior, spatial response perseveration errors and motor behavior","volume":"269","author":"Hamilton","year":"2014","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.neuro.2020.05.007_bib0075","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/ddrr.69","article-title":"Animal models of fetal alcohol spectrum disorders: impact of the social environment","volume":"15","author":"Kelly","year":"2009","journal-title":"Dev. Disabil. Res. Rev."},{"issue":"5","key":"10.1016\/j.neuro.2020.05.007_bib0080","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1177\/0013164496056005002","article-title":"Practical significance: a concept whose time has come","volume":"56","author":"Kirk","year":"1996","journal-title":"Educ. Psychol. Meas."},{"issue":"10","key":"10.1016\/j.neuro.2020.05.007_bib0085","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1001\/jamapediatrics.2017.1919","article-title":"Global prevalence of fetal alcohol spectrum disorder among children and youth: a systematic review and meta-analysis","volume":"171","author":"Lange","year":"2017","journal-title":"JAMA Pediatr."},{"issue":"1","key":"10.1016\/j.neuro.2020.05.007_bib0090","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbr.2007.10.028","article-title":"Effects of alcohol exposure during development on play behavior and c-Fos expression in response to play behavior","volume":"188","author":"Lawrence","year":"2008","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.neuro.2020.05.007_bib0095","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ntt.2011.08.002","article-title":"Selective effects of perinatal ethanol exposure in medial prefrontal cortex and nucleus accumbens","volume":"34","author":"Lawrence","year":"2012","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.neuro.2020.05.007_bib0100","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1471-2202-14-37","article-title":"Improving basic and translational science by accounting for litter-to-litter variation in animal models","volume":"14","author":"Lazic","year":"2013","journal-title":"BMC Neurosci."},{"issue":"2","key":"10.1016\/j.neuro.2020.05.007_bib0105","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1097\/00007691-200304000-00002","article-title":"Children of alcoholic parents--observed anomalies: discussion of 127 cases","volume":"25","author":"Lemoine","year":"2003","journal-title":"Ther. Drug Monit."},{"issue":"1","key":"10.1016\/j.neuro.2020.05.007_bib0110","first-page":"84","article-title":"Alcohol and the liver: metabolism of alcohol and its role in hepatic and extrahepatic diseases","volume":"67","author":"Lieber","year":"2000","journal-title":"Mt. Sinai J. Med."},{"issue":"7","key":"10.1016\/j.neuro.2020.05.007_bib0115","doi-asserted-by":"crossref","first-page":"e015410","DOI":"10.1136\/bmjopen-2016-015410","article-title":"Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently\u2019 safe\u2019 levels of alcohol during pregnancy? A systematic review and meta-analyses","volume":"7","author":"Mamluk","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.neuro.2020.05.007_bib0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.alcohol.2015.12.002","article-title":"The impact of prenatal alcohol exposure on social, cognitive and affective behavioral domains: insights from rodent models","volume":"51","author":"Marquardt","year":"2016","journal-title":"Alcohol."},{"issue":"1","key":"10.1016\/j.neuro.2020.05.007_bib0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/tera.1420340102","article-title":"Social play in juvenile rats prenatally exposed to alcohol","volume":"34","author":"Meyer","year":"1986","journal-title":"Teratology."},{"issue":"1","key":"10.1016\/j.neuro.2020.05.007_bib0130","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.bbr.2010.08.014","article-title":"Acute prenatal exposure to ethanol and social behavior: effects of age, sex, and timing of exposure","volume":"216","author":"Mooney","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"Suppl 2","key":"10.1016\/j.neuro.2020.05.007_bib0135","first-page":"3","article-title":"Nutrition and chronic alcohol abuse","volume":"23","author":"Moreno Otero","year":"2008","journal-title":"Nutr. Hosp."},{"issue":"3","key":"10.1016\/j.neuro.2020.05.007_bib0140","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3758\/BF03195394","article-title":"EthoVision: a versatile video tracking system for automation of behavioral experiments","volume":"33","author":"Noldus","year":"2001","journal-title":"Behav. Res. Methods Instrum. Comput."},{"issue":"1","key":"10.1016\/j.neuro.2020.05.007_bib0145","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/s41598-018-38355-z","article-title":"Neurometabolic and functional connectivity basis of prosocial behavior in early adolescence","volume":"9","author":"Okada","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.neuro.2020.05.007_bib0150","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0163-1047(80)91077-8","article-title":"Social deprivation and play in rats","volume":"30","author":"Panksepp","year":"1980","journal-title":"Behav. Neural Biol."},{"key":"10.1016\/j.neuro.2020.05.007_bib0155","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"issue":"1-2","key":"10.1016\/j.neuro.2020.05.007_bib0160","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0166-4328(98)00111-9","article-title":"Developmental brain injury associated with abnormal play behavior in neonatally Borna disease virus-infected Lewis rats: a model of autism","volume":"100","author":"Pletnikov","year":"1999","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuro.2020.05.007_bib0165","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.physbeh.2015.01.001","article-title":"Can low-level ethanol exposure during pregnancy influence maternal care? An investigation using two strains of rat across two generations","volume":"148","author":"Popoola","year":"2015","journal-title":"Physiol. Behav."},{"issue":"6","key":"10.1016\/j.neuro.2020.05.007_bib0170","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1071\/RD11200","article-title":"A rodent model of low- to moderate-dose ethanol consumption during pregnancy: patterns of ethanol consumption and effects on fetal and offspring growth","volume":"24","author":"Probyn","year":"2012","journal-title":"Reprod. Fertil. Dev."},{"issue":"1","key":"10.1016\/j.neuro.2020.05.007_bib0175","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/acer.12939","article-title":"Worldwide prevalence of fetal alcohol spectrum disorders: a systematic literature review including meta-analysis","volume":"40","author":"Roozen","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.neuro.2020.05.007_bib0180","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuro.2018.08.006","article-title":"Effects of prenatal ethanol exposure on acoustic characteristics of ultrasonic vocalizations in rat pups","volume":"69","author":"Shahrier","year":"2018","journal-title":"Neurotoxicology."},{"issue":"7","key":"10.1016\/j.neuro.2020.05.007_bib0185","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/acer.13107","article-title":"Chronic gestational exposure to ethanol leads to enduring aberrances in cortical form and function in the medial prefrontal cortex","volume":"40","author":"Skorput","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"31","key":"10.1016\/j.neuro.2020.05.007_bib0190","doi-asserted-by":"crossref","first-page":"10977","DOI":"10.1523\/JNEUROSCI.1462-15.2015","article-title":"Persistent interneuronopathy in the prefrontal cortex of young adult offspring exposed to ethanol in utero","volume":"35","author":"Skorput","year":"2015","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.neuro.2020.05.007_bib0195","doi-asserted-by":"crossref","first-page":"E34","DOI":"10.1542\/peds.108.2.e34","article-title":"Prenatal alcohol exposure and childhood behavior at age 6 to 7 years: I. dose-response effect","volume":"108","author":"Sood","year":"2001","journal-title":"Pediatrics."},{"key":"10.1016\/j.neuro.2020.05.007_bib0200","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.alcohol.2017.08.006","article-title":"Implications of altered maternal cytokine concentrations on infant outcomes in children with prenatal alcohol exposure","volume":"68","author":"Sowell","year":"2018","journal-title":"Alcohol"},{"issue":"8","key":"10.1016\/j.neuro.2020.05.007_bib0205","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/dev.420260805","article-title":"Ontogeny of amicable social behavior in the mouse: gender differences and ongoing isolation outcomes","volume":"26","author":"Terranova","year":"1993","journal-title":"Dev. Psychobiol."},{"issue":"5","key":"10.1016\/j.neuro.2020.05.007_bib0210","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.tins.2012.01.006","article-title":"Does moderate drinking harm the fetal brain? Insights from animal models","volume":"35","author":"Valenzuela","year":"2012","journal-title":"Trends Neurosci."},{"issue":"10","key":"10.1016\/j.neuro.2020.05.007_bib0215","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1038\/npp.2013.83","article-title":"Social play behavior in adolescent rats is mediated by functional activity in medial prefrontal cortex and striatum","volume":"38","author":"van Kerkhof","year":"2013","journal-title":"Neuropsychopharmacology."},{"issue":"3","key":"10.1016\/j.neuro.2020.05.007_bib0220","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0149-7634(96)00020-6","article-title":"The neurobiology of social play behavior in rats","volume":"21","author":"Vanderschuren","year":"1997","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.neuro.2020.05.007_bib0225","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0031-9384(98)00285-6","article-title":"Social behavior and social motivation in adolescent rats: role of housing conditions and partner\u2019s activity","volume":"67","author":"Varlinskaya","year":"1999","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuro.2020.05.007_bib0230","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.physbeh.2013.08.027","article-title":"Lactational exposure to sulpiride: assessment of maternal care and reproductive and behavioral parameters of male rat pups","volume":"122","author":"Vieira","year":"2013","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuro.2020.05.007_bib0235","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.bbr.2014.01.037","article-title":"Cannabinoid receptor agonist disrupts behavioral and neuroendocrine responses during lactation","volume":"263","author":"Vilela","year":"2014","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.neuro.2020.05.007_bib0240","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/brainsci6040043","article-title":"Prenatal ethanol exposure and whisker clipping disrupt ultrasonic vocalizations and play behavior in adolescent rats","volume":"6","author":"Waddell","year":"2016","journal-title":"Brain Sci."},{"issue":"8","key":"10.1016\/j.neuro.2020.05.007_bib0245","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/syn.20532","article-title":"Postnatal binge-like alcohol exposure reduces spine density without affecting dendritic morphology in rat mPFC","volume":"62","author":"Whitcher","year":"2008","journal-title":"Synapse."},{"issue":"3","key":"10.1016\/j.neuro.2020.05.007_bib0250","first-page":"295","article-title":"Which effect size measure is appropriate for one-way and two-way ANOVA models? A Monte Carlo simulation study","volume":"16","author":"Yigit","year":"2018","journal-title":"Revstat Stat. J."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X20300875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X20300875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:22:04Z","timestamp":1758982924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X20300875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":50,"alternative-id":["S0161813X20300875"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2020.05.007","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal exposure to alcohol impairs social play behavior in adolescent male mice","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2020.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}