{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:01:36Z","timestamp":1788454896944,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Science and Technology Program Key Projects","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.neuro.2021.05.004","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T11:39:19Z","timestamp":1620819559000},"page":"90-98","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Vitamin A supplementation ameliorates motor incoordination via modulating ROR\u03b1 in the cerebellum in a valproic acid-treated rat autism model with vitamin A deficiency"],"prefix":"10.1016","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1079-089X","authenticated-orcid":false,"given":"Si","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boli","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qionghui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisha","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nali","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1940-7076","authenticated-orcid":false,"given":"Tingyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2021.05.004_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-418700-9.00001-0","article-title":"Autism spectrum disorder and the cerebellum","volume":"113","author":"Becker","year":"2013","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.neuro.2021.05.004_bib0010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/14734220600750184","article-title":"RORalpha, a pivotal nuclear receptor for Purkinje neuron survival and differentiation: from development to ageing","volume":"5","author":"Boukhtouche","year":"2006","journal-title":"Cerebellum (London, England)"},{"key":"10.1016\/j.neuro.2021.05.004_bib0015","first-page":"251","article-title":"Cerebellar functions in motor control","volume":"2","author":"Brooks","year":"1984","journal-title":"Hum. Neurobiol."},{"key":"10.1016\/j.neuro.2021.05.004_bib0020","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.neuroscience.2006.01.027","article-title":"Vitamin A deficiency induces motor impairments and striatal cholinergic dysfunction in rats","volume":"139","author":"Carta","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuro.2021.05.004_bib0025","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuro.2020.06.004","article-title":"Vitamin A deficiency exacerbates autism-like behaviors and abnormalities of the enteric nervous system in a valproic acid-induced rat model of autism","volume":"79","author":"Cheng","year":"2020","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2021.05.004_bib0030","article-title":"From movement kinematics to social cognition: the case of autism","volume":"371","author":"Cook","year":"2016","journal-title":"Philos. Trans. R. Soc. Lond. Series B Biol. Sci."},{"key":"10.1016\/j.neuro.2021.05.004_bib0035","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0306-4522(99)00464-9","article-title":"Regional brain variations of cytochrome oxidase activity and motor coordination in staggerer mutant mice","volume":"95","author":"Deiss","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuro.2021.05.004_bib0040","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0165-3806(01)00131-6","article-title":"A comparative study of Purkinje cells in two RORalpha gene mutant mice: staggerer and RORalpha(-\/-)","volume":"127","author":"Doulazmi","year":"2001","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.neuro.2021.05.004_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00343800","article-title":"Effect of sodium valproate on mania. The GABA-hypothesis of affective disorders","volume":"229","author":"Emrich","year":"1980","journal-title":"Arch. Psychiatr. Nervenkr."},{"key":"10.1016\/j.neuro.2021.05.004_bib0050","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s12311-012-0355-9","article-title":"Consensus paper: pathological role of the cerebellum in autism","volume":"11","author":"Fatemi","year":"2012","journal-title":"Cerebellum (London, England)"},{"key":"10.1016\/j.neuro.2021.05.004_bib0055","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fendo.2015.00099","article-title":"Editorial: \u201cthyroid hormone in brain and brain cells\u201d","volume":"6","author":"Flamant","year":"2015","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.neuro.2021.05.004_bib0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainres.2005.11.080","article-title":"ROR alpha in genetic control of cerebellum development: 50 staggering years","volume":"1140","author":"Gold","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.neuro.2021.05.004_bib0065","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1080\/1028415X.2017.1423268","article-title":"Vitamin A, and vitamin D deficiencies exacerbate symptoms in children with autism spectrum disorders","volume":"22","author":"Guo","year":"2019","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.neuro.2021.05.004_bib0070","doi-asserted-by":"crossref","first-page":"25848","DOI":"10.1074\/jbc.M111.253674","article-title":"Optogenetic control of motor coordination by Gi\/o protein-coupled vertebrate rhodopsin in cerebellar Purkinje cells","volume":"286","author":"Gutierrez","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuro.2021.05.004_bib0075","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1001\/archgenpsychiatry.2011.76","article-title":"Genetic heritability and shared environmental factors among twin pairs with autism","volume":"68","author":"Hallmayer","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neuro.2021.05.004_bib0080","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0165-3806(96)00069-7","article-title":"The numerical matching of source and target populations in the CNS: the inferior olive to Purkinje cell projection","volume":"96","author":"Herrup","year":"1996","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.neuro.2021.05.004_bib0085","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s12035-014-8741-6","article-title":"Vitamin A deficiency impairs spatial learning and memory: the mechanism of abnormal CBP-dependent histone acetylation regulated by retinoic acid receptor alpha","volume":"51","author":"Hou","year":"2015","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuro.2021.05.004_bib0090","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3389\/fnbeh.2018.00182","article-title":"A developmental study of abnormal behaviors and altered GABAergic signaling in the VPA-treated rat model of autism","volume":"12","author":"Hou","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.neuro.2021.05.004_bib0095","article-title":"Cerebellar Differentiation from Human Stem Cells Through Retinoid, Wnt, and Sonic Hedgehog Pathways","author":"Hua","year":"2020","journal-title":"Tissue Eng. Part A"},{"key":"10.1016\/j.neuro.2021.05.004_bib0100","doi-asserted-by":"crossref","first-page":"e003","DOI":"10.1621\/nrs.07003","article-title":"Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism","volume":"7","author":"Jetten","year":"2009","journal-title":"Nucl. Recept. Signal."},{"key":"10.1016\/j.neuro.2021.05.004_bib0105","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/nutrit\/nuz092","article-title":"Nutritional interventions for autism spectrum disorder","volume":"78","author":"Karhu","year":"2020","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.neuro.2021.05.004_bib0110","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700754","article-title":"Vitamin a deficiency induces autistic-like behaviors in rats by regulating the RAR\u03b2-CD38-oxytocin axis in the hypothalamus","volume":"62","author":"Lai","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.neuro.2021.05.004_bib0115","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1089\/neu.2019.6679","article-title":"Histological and behavioral evaluation after traumatic brain injury in mice: a ten months follow-up study","volume":"37","author":"Leconte","year":"2020","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.neuro.2021.05.004_bib0120","doi-asserted-by":"crossref","DOI":"10.3390\/nu8050294","article-title":"Correlation between nutrition and symptoms: nutritional survey of children with autism spectrum disorder in Chongqing, China","volume":"8","author":"Liu","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.neuro.2021.05.004_bib0125","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/s12866-017-1096-1","article-title":"Effect of vitamin A supplementation on gut microbiota in children with autism spectrum disorders - a pilot study","volume":"17","author":"Liu","year":"2017","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.neuro.2021.05.004_bib0130","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2165\/00023210-200216100-00003","article-title":"Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy","volume":"16","author":"L\u00f6scher","year":"2002","journal-title":"CNS Drugs"},{"key":"10.1016\/j.neuro.2021.05.004_bib0135","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1095-6433(98)00022-1","article-title":"Role of retinoic acid in regulation of mRNA expression of CaBP-D28k in the cerebellum of the chicken","volume":"120","author":"Matsumoto","year":"1998","journal-title":"Comp. Biochem. Physiol. Part A Mol. Integr. Physiol."},{"key":"10.1016\/j.neuro.2021.05.004_bib0140","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.expneurol.2017.04.017","article-title":"The valproic acid-induced rodent model of autism","volume":"299","author":"Nicolini","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuro.2021.05.004_bib0145","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1210\/me.2013-1414","article-title":"Deciphering direct and indirect influence of thyroid hormone with mouse genetics","volume":"28","author":"Picou","year":"2014","journal-title":"Mol. Endocrinol. (Baltimore, Md.)"},{"key":"10.1016\/j.neuro.2021.05.004_bib0150","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.physbeh.2014.11.047","article-title":"Impaired gait pattern as a sensitive tool to assess hypoxic brain damage in a novel mouse model of atherosclerotic plaque rupture","volume":"139","author":"Roth","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuro.2021.05.004_bib0155","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2040-2392-4-14","article-title":"Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder","volume":"4","author":"Sarachana","year":"2013","journal-title":"Mol. Autism"},{"key":"10.1016\/j.neuro.2021.05.004_bib0160","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cca.2019.12.009","article-title":"Biomarkers in autism spectrum disorders: current progress","volume":"502","author":"Shen","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.neuro.2021.05.004_bib0165","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1073\/pnas.95.7.3960","article-title":"staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice","volume":"95","author":"Steinmayr","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.neuro.2021.05.004_bib0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118688","article-title":"Maternal vitamin A deficiency impairs cholinergic and nitrergic neurons, leading to gastrointestinal dysfunction in rat offspring via RAR\u03b2","volume":"264","author":"Tan","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.neuro.2021.05.004_bib0175","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.neuron.2014.07.016","article-title":"The cerebellum, sensitive periods, and autism","volume":"83","author":"Wang","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.neuro.2021.05.004_bib0180","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jnutbio.2018.04.012","article-title":"Maternal iodine supplementation improves motor coordination in offspring by modulating the mGluR1 signaling pathway in mild iodine deficiency-induced hypothyroxinemia rats","volume":"58","author":"Wang","year":"2018","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.neuro.2021.05.004_bib0185","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3389\/fncel.2018.00500","article-title":"Aberrant development and synaptic transmission of cerebellar cortex in a VPA induced mouse autism model","volume":"12","author":"Wang","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuro.2021.05.004_bib0190","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fcell.2020.00231","article-title":"Abnormal cerebellar development is involved in dystonia-like behaviors and motor dysfunction of autistic BTBR mice","volume":"8","author":"Xiao","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.neuro.2021.05.004_bib0195","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3389\/fped.2020.00469","article-title":"Nutritional status and symptoms in preschool children with autism spectrum disorder: a two-center comparative study in Chongqing and Hainan Province, China","volume":"8","author":"Zhu","year":"2020","journal-title":"Front. Pediatr."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X21000498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X21000498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:24:12Z","timestamp":1758983052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X21000498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":39,"alternative-id":["S0161813X21000498"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2021.05.004","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin A supplementation ameliorates motor incoordination via modulating ROR\u03b1 in the cerebellum in a valproic acid-treated rat autism model with vitamin A deficiency","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2021.05.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}