{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:32:41Z","timestamp":1793053961141,"version":"4.5.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.neuro.2022.02.011","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T16:21:34Z","timestamp":1646238094000},"page":"62-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Jatamansinol from Nardostachys jatamansi (D.Don) DC. Protects A\u03b242-Induced Neurotoxicity in Alzheimer's Disease Drosophila Model"],"prefix":"10.1016","volume":"90","author":[{"given":"Kizhakke P.","family":"Anupama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olakkaran","family":"Shilpa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anet","family":"Antony","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamprasad V.","family":"Raghu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hunasanahally P.","family":"Gurushankara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2022.02.011_bib1","first-page":"21","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzym."},{"key":"10.1016\/j.neuro.2022.02.011_bib2","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.pbb.2006.01.005","article-title":"Attenuation by Nardostachys jatamansi of 6-hydroxydopamine-induced Parkinsonism in rats: behavioral, neurochemical, and immunohistochemical studies","volume":"83","author":"Ahmad","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.neuro.2022.02.011_bib3","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neulet.2018.10.053","article-title":"Therapeutic potential of luteolin in transgenic Drosophila model of Alzheimer's disease","volume":"692","author":"Ali","year":"2019","journal-title":"Neurosci. Lett."},{"issue":"3","key":"10.1016\/j.neuro.2022.02.011_bib4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/alz.12328","article-title":"Alzheimer's disease facts and figures 2021","volume":"17","author":"Alzheimer's Association","year":"2021","journal-title":"Alzheimer's Dement."},{"key":"10.1016\/j.neuro.2022.02.011_bib5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jhazmat.2018.07.050","article-title":"Bisphenol A-induced oxidative stress-mediated genotoxicity in Drosophila melanogaster","volume":"370","author":"Anet","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.neuro.2022.02.011_bib6","first-page":"115","article-title":"Convolvulus pluricaulis (Shankhapushpi) ameliorates human microtubule-associated protein tau (hMAP\u03c4) induced neurotoxicity in Alzheimer\u2019s disease Drosophila model","author":"Anupama","year":"2019","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.neuro.2022.02.011_bib7","first-page":"1","article-title":"Jatamansinol from Nardostachys jatamansi: a multi-targeted neuroprotective agent for Alzheimer's disease","author":"Anupama","year":"2021","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.neuro.2022.02.011_bib8","first-page":"289","article-title":"The molecular biology of senile plaques and neurofibrillary tangles in Alzheimer\u2019s disease","volume":"47","author":"Armstrong","year":"2009","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.neuro.2022.02.011_bib9","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1042\/BST0330591","article-title":"Mechanisms of memory loss in A\u03b2 and tau mouse models","volume":"33","author":"Ashe","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.neuro.2022.02.011_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21197290","article-title":"Retinal degeneration and Alzheimer\u2019s disease: an evolving link","volume":"21","author":"Ashok","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuro.2022.02.011_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1471-4159.1986.tb02858.x","article-title":"Molecular forms of acetylcholinesterase and butyrylcholinesterase in the aged human central nervous system","volume":"47","author":"Atack","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuro.2022.02.011_bib12","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.3389\/fphar.2019.01417","article-title":"Natural products-based drugs: potential therapeutics against Alzheimer\u2019s disease and other neurological disorders","volume":"10","author":"Ayaz","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuro.2022.02.011_bib13","doi-asserted-by":"crossref","first-page":"3806157","DOI":"10.1155\/2016\/3806157","article-title":"Getting to NO Alzheimer's disease: neuroprotection versus neurotoxicity mediated by nitric oxide","volume":"2016","author":"Balez","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.neuro.2022.02.011_bib14","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1152\/physrev.1998.78.2.547","article-title":"The free radical theory of aging matures","volume":"78","author":"Beckman","year":"1998","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuro.2022.02.011_bib15","series-title":"Handbook of Neurochemistry and Molecular Neurobiology","first-page":"543","article-title":"Protein carbonylation in neurodegenerative and demyelinating CNS diseases","author":"Bizzozero","year":"2009"},{"issue":"7","key":"10.1016\/j.neuro.2022.02.011_bib16","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1007\/s00204-015-1517-6","article-title":"Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update","volume":"89","author":"Bradley-Whitman","year":"2015","journal-title":"Arch. Toxicol."},{"issue":"2","key":"10.1016\/j.neuro.2022.02.011_bib17","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.neuro.2022.02.011_bib18","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive review on Alzheimer\u2019s disease","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.neuro.2022.02.011_bib19","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.freeradbiomed.2007.04.026","article-title":"Methods to detect nitric oxide and its metabolites in biological samples","volume":"43","author":"Bryan","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.neuro.2022.02.011_bib20","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1586\/ern.11.57","article-title":"Loss of motor function in preclinical Alzheimer's disease","volume":"11","author":"Buchman","year":"2011","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.neuro.2022.02.011_bib21","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S1471-4914(01)02173-6","article-title":"Evidence of oxidative damage in Alzheimer's disease brain: central role for amyloid \u03b2-peptide","volume":"7","author":"Butterfield","year":"2001","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neuro.2022.02.011_bib22","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1038\/aps.2017.28","article-title":"Amyloid-beta: structure, biology, and structure-based therapeutic development","volume":"38","author":"Chen","year":"2017","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.neuro.2022.02.011_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21134621","article-title":"Pharmacological treatment of Alzheimer\u2019s disease: Insights from Drosophila melanogaster","volume":"21","author":"Cheng","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.neuro.2022.02.011_bib24","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.12.4.564","article-title":"Plant products as antimicrobial agents","volume":"12","author":"Cowan","year":"1999","journal-title":"Clin. Microbiol. Rev."},{"issue":"1","key":"10.1016\/j.neuro.2022.02.011_bib25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.neuroscience.2004.12.025","article-title":"Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer\u2019s disease","volume":"132","author":"Crowther","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.neuro.2022.02.011_bib26","doi-asserted-by":"crossref","first-page":"21","DOI":"10.18388\/abp.2013_1946","article-title":"Cytoprotective effect of methanolic extract of Nardostachys jatamansi against hydrogen peroxide-induced oxidative damage in C6 glioma cells","volume":"60","author":"Dhuna","year":"2013","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.neuro.2022.02.011_bib27","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13321-016-0174-y","article-title":"ClassyFire: automated chemical classification with a comprehensive, computable taxonomy","volume":"8","author":"Djoumbou-Feunang","year":"2016","journal-title":"J. Cheminform."},{"issue":"2","key":"10.1016\/j.neuro.2022.02.011_bib28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0892-0362(99)00069-0","article-title":"Age-related changes in reactive oxygen species production in rat brain homogenates","volume":"22","author":"Driver","year":"2000","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.neuro.2022.02.011_bib29","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.neuro.2022.02.011_bib30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2583.2004.00529.x","article-title":"Insect glutathione transferases and insecticide resistance","volume":"14","author":"Enayati","year":"2005","journal-title":"Insect. Mol. Biol."},{"key":"10.1016\/j.neuro.2022.02.011_bib31","doi-asserted-by":"crossref","first-page":"2481076","DOI":"10.1155\/2018\/2481076","article-title":"Ayurvedic medicine for the treatment of dementia: mechanistic aspects","volume":"2018","author":"Farooqui","year":"2018","journal-title":"Evid.-Based Complement. Altern. Med."},{"key":"10.1016\/j.neuro.2022.02.011_bib32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2174\/1570159X13666150716165726","article-title":"Alzheimer\u2019s disease: targeting the cholinergic system","volume":"14","author":"Ferreira-Vieira","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.neuro.2022.02.011_bib33","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.mcn.2004.03.001","article-title":"A model for studying Alzheimer's A\u03b242-induced toxicity in Drosophila melanogaster","volume":"26","author":"Finelli","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.neuro.2022.02.011_bib34","series-title":"Probit Analysis","author":"Finney","year":"1971"},{"key":"10.1016\/j.neuro.2022.02.011_bib35","first-page":"265","article-title":"Effect of ashwagandha (Withania somnifera) root powder on lipid peroxidation in Drosophila melanogaster","volume":"19","author":"Gajare","year":"2005","journal-title":"Ind. J. Gerontol."},{"key":"10.1016\/j.neuro.2022.02.011_bib36","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0076-6879(81)77053-8","article-title":"Assays for differentiation of glutathione-S-transferases","volume":"77","author":"Habig","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.neuro.2022.02.011_bib37","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1073\/pnas.91.8.3270","article-title":"A model for \u03b2-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer\u2019s disease","volume":"91","author":"Hensley","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuro.2022.02.011_bib38","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.1021\/bi990438f","article-title":"The A\u03b2 peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction","volume":"38","author":"Huang","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.neuro.2022.02.011_bib39","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0006-8993(96)00156-4","article-title":"\u00df-Amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity","volume":"720","author":"Ii","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.neuro.2022.02.011_bib40","doi-asserted-by":"crossref","first-page":"6623","DOI":"10.1073\/pnas.0400895101","article-title":"Dissecting the pathological effects of human A\u03b240 and A\u03b242 in Drosophila: a potential model for Alzheimer\u2019s disease","volume":"101","author":"Iijima","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.neuro.2022.02.011_bib41","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1534\/g3.116.027060","article-title":"Quantitative assessment of eye phenotypes for functional genetic studies using Drosophila melanogaster","volume":"6","author":"Iyer","year":"2016","journal-title":"G3"},{"key":"10.1016\/j.neuro.2022.02.011_bib42","series-title":"Encyclopedia of Clinical Neuropsychology","article-title":"Cholinergic system","author":"Jackson","year":"2011"},{"key":"10.1016\/j.neuro.2022.02.011_bib43","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jneumeth.2011.01.026","article-title":"Detection of early locomotor abnormalities in a Drosophila model of Alzheimer's disease","volume":"197","author":"Jahn","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.neuro.2022.02.011_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0133272","article-title":"Systematic A\u03b2 analysis in Drosophila reveals high toxicity for the 1-42, 3-42, and 11-42 peptides and emphasizes N-and C-terminal residues","volume":"10","author":"Jonson","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.neuro.2022.02.011_bib45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1089\/jmf.2006.9.113","article-title":"Nardostachys jatamansi improves learning and memory in mice","volume":"9","author":"Joshi","year":"2006","journal-title":"J. Med. Food"},{"issue":"1","key":"10.1016\/j.neuro.2022.02.011_bib46","first-page":"33","article-title":"Alzheimer disease","volume":"7","author":"Knopman","year":"2021","journal-title":"Nat. Rev.: Dis. Prim."},{"key":"10.1016\/j.neuro.2022.02.011_bib47","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/ageing\/afx084","article-title":"Motor function and incident dementia: a systematic review and meta-analysis","volume":"46","author":"Kueper","year":"2017","journal-title":"Age Ageing"},{"key":"10.1016\/j.neuro.2022.02.011_bib48","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1017\/S1461145705005833","article-title":"Targeting acetylcholinesterase and butyrylcholinesterase in dementia","volume":"9","author":"Lane","year":"2006","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuro.2022.02.011_bib49","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.neuro.2022.02.011_bib50","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.mad.2011.07.008","article-title":"Curcumin-mediated lifespan extension in Caenorhabditis elegans","volume":"132","author":"Liao","year":"2011","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.neuro.2022.02.011_bib51","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1248\/bpb.b17-00750","article-title":"Nardostachys jatamansi ethanol extract ameliorates A\u03b242 cytotoxicity","volume":"41","author":"Liu","year":"2018","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neuro.2022.02.011_bib52","first-page":"5120230","article-title":"Multitarget Therapeutic Strategies for Alzheimer\u2019s Disease: Review on Emerging Target Combinations","author":"Maramai","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.neuro.2022.02.011_bib53","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1006\/exnr.1997.6750","article-title":"Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer\u2019s disease","volume":"150","author":"Marcus","year":"1998","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuro.2022.02.011_bib54","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/467180","article-title":"Oxidative stress in neurodegenerative diseases: mechanisms and therapeutic perspectives","volume":"2011","author":"Melo","year":"2011","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"2","key":"10.1016\/j.neuro.2022.02.011_bib55","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2165\/00002512-200421020-00002","article-title":"Role of hydrogen peroxide in the aetiology of Alzheimer's disease: implications for treatment","volume":"21","author":"Milton","year":"2004","journal-title":"Drugs Aging"},{"issue":"4","key":"10.1016\/j.neuro.2022.02.011_bib56","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tibs.2009.11.004","article-title":"Alzheimer\u2019s disease: insights from Drosophila melanogaster models","volume":"35","author":"Moloney","year":"2010","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.neuro.2022.02.011_bib57","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1124\/pr.110.003293","article-title":"Human disease models in Drosophila melanogaster and therole of the fly in therapeutic drug discovery","volume":"63","author":"Pandey","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.neuro.2022.02.011_bib58","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2990.1978.tb00545.x","article-title":"Changes in brain cholinesterase in senile dementia of Alzheimer\u2019s type","volume":"4","author":"Perry","year":"1978","journal-title":"Neuro. Pathol. Appl. Neurobiol."},{"key":"10.1016\/j.neuro.2022.02.011_bib59","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.bbadis.2011.10.003","article-title":"Elevation of glutathione as a therapeutic strategy in Alzheimer's disease","volume":"1822","author":"Pocernich","year":"2012","journal-title":"Biochim. Biophys. Acta - Mol. Basis Dis."},{"key":"10.1016\/j.neuro.2022.02.011_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-03397-2","article-title":"Amyloid \u03b2 peptides overexpression in retinal pigment epithelial cells via AAV-mediated gene transfer mimics AMD-like pathology in mice","volume":"7","author":"Prasad","year":"2017","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.neuro.2022.02.011_bib61","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13041-018-0390-7","article-title":"A zinc-finger fusion protein refines Gal4-defined neural circuits","volume":"11","author":"Raghu","year":"2018","journal-title":"Mol. Brain"},{"key":"10.1016\/j.neuro.2022.02.011_bib62","article-title":"Dietary intake of Curcuma longa and Emblica officinalis increases life span in Drosophila melanogaster","author":"Rawal","year":"2014","journal-title":"Bio. Med. Res. Int."},{"key":"10.1016\/j.neuro.2022.02.011_bib63","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3390\/antiox4010185","article-title":"Antioxidant, biomolecule oxidation protective activities of Nardostachys jatamansi DC and its phytochemical analysis by RP-HPLC and GC-MS","volume":"4","author":"Razack","year":"2015","journal-title":"Antioxidants"},{"key":"10.1016\/j.neuro.2022.02.011_bib64","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10059-010-0082-3","article-title":"Methods for detection and measurement of hydrogen peroxide inside and outside of cells","volume":"29","author":"Rhee","year":"2010","journal-title":"Mol. Cells"},{"key":"10.1016\/j.neuro.2022.02.011_bib65","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1111\/j.1460-9568.2009.06701.x","article-title":"Fenton chemistry and oxidative stress mediate the toxicity of the -amyloid peptide in a Drosophila model of Alzheimer\u2019s disease","volume":"29","author":"Rival","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuro.2022.02.011_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-31787-7","article-title":"A soy protein Lunasin can ameliorate amyloid-beta 42 mediated neurodegeneration in Drosophila eye","volume":"8","author":"Sarkar","year":"2018","journal-title":"Sci. Rep."},{"issue":"1965","key":"10.1016\/j.neuro.2022.02.011_bib67","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1016\/S0040-4020(01)96975-3","article-title":"Constituents of Nardostachys jatamansi and synthesis of (\u00b1) dihydrosamidin and visnadin from jatamansin","volume":"21","author":"Shanbhag","year":"1965","journal-title":"Tetrahedron"},{"key":"10.1016\/j.neuro.2022.02.011_bib68","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1007\/s11357-012-9438-2","article-title":"Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila","volume":"35","author":"Shen","year":"2013","journal-title":"Age"},{"key":"10.1016\/j.neuro.2022.02.011_bib69","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.scitotenv.2018.04.004","article-title":"Lead modulated heme synthesis inducing oxidative stress-mediated genotoxicity in Drosophila melanogaster","volume":"634","author":"Shilpa","year":"2018","journal-title":"Sci. Total. Environ."},{"issue":"12","key":"10.1016\/j.neuro.2022.02.011_bib70","doi-asserted-by":"crossref","first-page":"6378","DOI":"10.1007\/s12035-021-02546-z","article-title":"Lead (Pb)-induced oxidative stress mediates sex-specific autistic-like behaviour in Drosophila melanogaster","volume":"58","author":"Shilpa","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuro.2022.02.011_bib71","series-title":"Advances in Medicine and Biology","first-page":"179","article-title":"Drosophila melanogaster as a model organism for neurobehavioural studies","author":"Shilpa","year":"2021"},{"key":"10.1016\/j.neuro.2022.02.011_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152959","article-title":"Lead (Pb) induced oxidative stress as a mechanism to cause neurotoxicity in Drosophila melanogaster","volume":"462","author":"Shilpa","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.neuro.2022.02.011_bib73","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1248\/bpb.b19-00495","article-title":"Neuroprotective effects of limonene (+) against A\u03b242-induced neurotoxicity in a Drosophila model of Alzheimer's disease","volume":"43","author":"Shin","year":"2020","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.neuro.2022.02.011_bib74","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/35086072","article-title":"Alzheimer's disease and A toxicity: from top to bottom","volume":"2","author":"Small","year":"2001","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.neuro.2022.02.011_bib75","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/B978-0-12-804766-8.00013-3","article-title":"Alzheimer\u2019s disease","volume":"167","author":"Soria-Lopez","year":"2019","journal-title":"Handb. Clin. Neurol."},{"issue":"2","key":"10.1016\/j.neuro.2022.02.011_bib76","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3390\/molecules23020250","article-title":"Coumarin: A natural, privileged, and versatile scaffold for bioactive compounds","volume":"23","author":"Stefanachi","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.neuro.2022.02.011_bib77","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1001\/archneurol.2008.596","article-title":"Cerebrospinal fluid \u03b2-amyloid 42 and tau proteins as biomarkers of Alzheimer-type pathologic changes in the brain","volume":"66","author":"Tapiola","year":"2009","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.neuro.2022.02.011_bib78","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1523\/JNEUROSCI.22-02-00446.2002","article-title":"Repetitive mild brain trauma accelerates A\u03b2 deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer's amyloidosis","volume":"22","author":"Uryu","year":"2002","journal-title":"J. Neurosci."},{"issue":"2\u20133","key":"10.1016\/j.neuro.2022.02.011_bib79","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1006\/jsbi.2000.4274","article-title":"Review: Alzheimer\u2019s amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity","volume":"130","author":"Varadarajan","year":"2000","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.neuro.2022.02.011_bib80","unstructured":"Vasudev, V., Gurushankara, H.P., 2016. Understandings in cytogenetic techniques, Today and Tomorrow Publishers, New Delhi."},{"key":"10.1016\/j.neuro.2022.02.011_bib81","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/aps.2016.87","article-title":"DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against A\u03b2-induced neuronal damage via the Akt\/JNK signaling pathway","volume":"37","author":"Zhou","year":"2016","journal-title":"Acta Pharmacol. Sin."}],"updated-by":[{"DOI":"10.1016\/j.neuro.2023.04.002","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000}}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X22000304?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X22000304?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T13:04:56Z","timestamp":1704200696000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X22000304"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":81,"alternative-id":["S0161813X22000304"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2022.02.011","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.neuro.2023.04.002","asserted-by":"object"}]},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Jatamansinol from Nardostachys jatamansi (D.Don) DC. Protects A\u03b242-Induced Neurotoxicity in Alzheimer's Disease Drosophila Model","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2022.02.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}