{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:26:15Z","timestamp":1786994775329,"version":"build-2736575974"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:00:00Z","timestamp":1703203200000},"content-version":"vor","delay-in-days":355,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["421769\/2018\u20131"],"award-info":[{"award-number":["421769\/2018\u20131"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.neuro.2022.12.006","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T11:43:08Z","timestamp":1671018188000},"page":"223-234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats"],"prefix":"10.1016","volume":"94","author":[{"given":"Cristini Escobar","family":"Viana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandreza Cardoso","family":"Bortolotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00edfani Machado","family":"Araujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Munir Mustafa","family":"Dahleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franci\u00e9le Romero","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adson","family":"de Souza Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byanca Pereira","family":"Moreira de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Vit\u00f3ria","family":"Leimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odinei Hess","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Prigol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Petri","family":"Guerra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2022.12.006_bib1","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.3390\/antiox10091448","article-title":"Lutein as a modulator of oxidative stress-mediated inflammatory diseases","volume":"10","author":"Ahn","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.neuro.2022.12.006_bib2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.foodchem.2013.02.108","article-title":"Promising interaction between nanoencapsulated lutein with low molecular weight chitosan: characterization and bioavailability of lutein in vitro and in vivo","volume":"141","author":"Arunkumar","year":"2013","journal-title":"Food Chem."},{"key":"10.1016\/j.neuro.2022.12.006_bib3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/nutrit\/nuz096","article-title":"Nutraceutical approach to enhance lutein bioavailability via nanodelivery systems","volume":"78","author":"Bhat","year":"2020","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.neuro.2022.12.006_bib4","first-page":"934","article-title":"Neuroprotective Effect of Lutein Against 3-Nitropropionic Acid\u2013Induced Huntington\u2019s Disease\u2013Like Symptoms: Possible Behavioral, Biochemical, and Cellular Alterations","volume":"16","author":"Binawade","year":"2013"},{"key":"10.1016\/j.neuro.2022.12.006_bib5","first-page":"2314","article-title":"Oxidative stress in autism spectrum disorder","volume":"57","author":"Bj\u00f8rklund","year":"2020","journal-title":"Joanna Ka\u0142u\u017cna-Czapli\u0144ska"},{"key":"10.1016\/j.neuro.2022.12.006_bib6","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neuro.2022.12.006_bib7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/1028415X.2015.1133029","article-title":"The effect of ketogenic diet in an animal model of autism induced by prenatal exposure to valproic acid","volume":"20","author":"Castro","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.neuro.2022.12.006_bib8","doi-asserted-by":"crossref","first-page":"3761","DOI":"10.1007\/s10803-018-3639-1","article-title":"Autism diagnosis in the united kingdom: perspectives of autistic adults, parents and professionals","volume":"48","author":"Crane","year":"2018","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.neuro.2022.12.006_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109431","article-title":"Exposure to lutein-loaded nanoparticles attenuates Parkinson\u2019s model-induced damage in Drosophila melanogaster: Restoration of dopaminergic and cholinergic system and oxidative stress indicators","volume":"340","author":"Fernandes","year":"2021","journal-title":"Chem. -Biol. Interact."},{"key":"10.1016\/j.neuro.2022.12.006_bib10","doi-asserted-by":"crossref","first-page":"10863","DOI":"10.3748\/wjg.v20.i31.10851","article-title":"Noninvasive biomarkers in non-alcoholic fatty liver disease: Current status and a glimpse of the future","volume":"20","author":"Fitzpatrick","year":"2014","journal-title":"World J. Gastroenterol.: WJG"},{"key":"10.1016\/j.neuro.2022.12.006_bib11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.physbeh.2019.02.020","article-title":"Oral administration of lutein attenuates ethanol-induced memory deficit in rats by restoration of acetylcholinesterase activity","volume":"204","author":"Geiss","year":"2019","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuro.2022.12.006_bib12","first-page":"111","article-title":"Autism in Brazil: a systematic review of family challenges and coping strategies","volume":"91","author":"Gomes","year":"2015","journal-title":"Braz.: a Syst. Rev. Fam. Chall. coping Strateg. J. De. Pediatr."},{"key":"10.1016\/j.neuro.2022.12.006_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2019.125523","article-title":"Influence of nanoencapsulated lutein on acetylcholinesterase activity: In vitro determination, kinetic parameters, and in silico docking simulations","volume":"307","author":"Grella Miranda","year":"2020","journal-title":"Food Chem."},{"key":"10.1016\/j.neuro.2022.12.006_bib14","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1471-4159.2012.07778.x","article-title":"Spermidine-induced improvement of memory involves a cross-talk between protein kinases C and A","volume":"122","author":"Guerra","year":"2012","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuro.2022.12.006_bib15","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.bbr.2016.10.004","article-title":"Human adipose-derived stem cells ameliorate repetitive behavior, social deficit and anxiety in a VPA-induced autism mouse model","volume":"317","author":"Ha","year":"2017","journal-title":"Behav. brain Res."},{"key":"10.1016\/j.neuro.2022.12.006_bib16","doi-asserted-by":"crossref","first-page":"1161s","DOI":"10.3945\/ajcn.112.034611","article-title":"A possible role for lutein and zeaxanthin in cognitive function in the elderly 1-5","volume":"96","author":"Johnson","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neuro.2022.12.006_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S1461145711001714","article-title":"Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid","volume":"16","author":"Kataoka","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuro.2022.12.006_bib18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.beth.2014.03.005","article-title":"Not to be overshadowed or overlooked: functional impairments associated with comorbid anxiety disorders in youth with ASD","volume":"46","author":"Kerns","year":"2015","journal-title":"Behav. Ther."},{"key":"10.1016\/j.neuro.2022.12.006_bib19","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.phrs.2016.08.033","article-title":"Pharmacological inhibition of fatty acid amide hydrolase attenuates social behavioural deficits in male rats prenatally exposed to valproic acid","volume":"113","author":"Kerr","year":"2016","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neuro.2022.12.006_bib20","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1017\/S0007114513003188","article-title":"Carotenoid-rich dietary patterns during midlife and subsequent cognitive function","volume":"111","author":"Kesse-Guyot","year":"2014","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.neuro.2022.12.006_bib21","first-page":"247","article-title":"Plasma concentrations of selected antioxidants in autistic children and adolescents","volume":"110","author":"Krajcovicova-Kudlackova","year":"2009","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.neuro.2022.12.006_bib22","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3389\/fncel.2018.00422","article-title":"Molecular pathology and pharmacological treatment of autism spectrum disorder-like phenotypes using rodent models","volume":"12","author":"Kuo","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuro.2022.12.006_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13229-018-0251-3","article-title":"The valproic acid rat model of autism presents with gut bacterial dysbiosis similar to that in human autism","volume":"9","author":"Liu","year":"2018","journal-title":"Mol. Autism"},{"key":"10.1016\/j.neuro.2022.12.006_bib24","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.radphyschem.2004.06.011","article-title":"Spectrofluorometric determination of intracellular levels of reactive oxygen species in drug-sensitive and drug-resistant cancer cells using the 2\u2032,7\u2032-dichlorofluorescein diacetate assay","volume":"72","author":"Loetchutinat","year":"2005","journal-title":"Radiat. Phys. Chem."},{"key":"10.1016\/j.neuro.2022.12.006_bib25","first-page":"3658","volume":"62","author":"Maghsoudi","year":"2021"},{"key":"10.1016\/j.neuro.2022.12.006_bib26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/978-3-030-30402-7_7","article-title":"Role of oxidative stress and antioxidants in autism","volume":"24","author":"Manivasagam","year":"2020","journal-title":"Adv. Neurobiol."},{"key":"10.1016\/j.neuro.2022.12.006_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.107975","article-title":"5-aminolevulinic acid inhibits oxidative stress and ameliorates autistic-like behaviors in prenatal valproic acid-exposed rats","volume":"168","author":"Matsuo","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuro.2022.12.006_bib28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.bbi.2019.04.037","article-title":"The influence of neuroinflammation in Autism Spectrum Disorder","volume":"79","author":"Matta","year":"2019","journal-title":"Brain, Behav., Immun."},{"key":"10.1016\/j.neuro.2022.12.006_bib29","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1007\/s00213-021-05941-5","article-title":"Effects of catechin on a rodent model of autism spectrum disorder: implications for the role of nitric oxide in neuroinflammatory pathway","volume":"238","author":"Mehta","year":"2021","journal-title":"Psychopharmacol. (Berl. )"},{"key":"10.1016\/j.neuro.2022.12.006_bib30","doi-asserted-by":"crossref","first-page":"3699","DOI":"10.1111\/bph.14435","article-title":"Sex-specific autistic endophenotypes induced by prenatal exposure to valproic acid involve anandamide signalling","volume":"175","author":"Melancia","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.neuro.2022.12.006_bib31","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.cep.2007.07.008","article-title":"Precipitation of lutein and co-precipitation of lutein and poly-lactic acid with the supercritical anti-solvent process","volume":"47","author":"Miguel","year":"2008","journal-title":"Chem. Eng. Process."},{"key":"10.1016\/j.neuro.2022.12.006_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13229-017-0121-4","article-title":"Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses","volume":"8","author":"Modabbernia","year":"2017","journal-title":"Mol. Autism"},{"key":"10.1016\/j.neuro.2022.12.006_bib33","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.neuro.2022.12.006_bib34","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.neulet.2016.06.035","article-title":"Increased anxiety-like behaviour and altered GABAergic system in the amygdala and cerebellum of VPA rats \u2014 an animal model of autism","volume":"629","author":"Olexov\u00e1","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.neuro.2022.12.006_bib35","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ntt.2018.01.005","article-title":"S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice","volume":"71","author":"Ornoy","year":"2019","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.neuro.2022.12.006_bib36","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.3390\/ijms21093293","article-title":"Oxidative stress and immune system dysfunction in autism spectrum disorders","volume":"21","author":"Pangrazzi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuro.2022.12.006_bib37","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3390\/md19040188","article-title":"Xanthophylls from the sea: algae as source of bioactive carotenoids","volume":"19","author":"Pereira","year":"2021","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.neuro.2022.12.006_bib38","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.msec.2016.08.029","article-title":"Biocompatible lutein-polymer-lipid nanocapsules: acute and subacute toxicity and bioavailability in mice","volume":"69","author":"Ranganathan","year":"2016","journal-title":"Mater. Sci. Eng.: C."},{"key":"10.1016\/j.neuro.2022.12.006_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-39014-7","article-title":"Consequences of prenatal exposure to valproic acid in the socially monogamous prairie voles","volume":"9","author":"Sailer","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuro.2022.12.006_bib40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/sj.npp.1300518","article-title":"Behavioral alterations in rats prenatally exposed to valproic acid: animal model of autism","volume":"30","author":"Schneider","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuro.2022.12.006_bib41","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.psyneuen.2008.02.011","article-title":"Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid","volume":"33","author":"Schneider","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuro.2022.12.006_bib42","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.foodchem.2017.03.059","article-title":"Analytical validation of an ultraviolet\u2013visible procedure for determining lutein concentration and application to lutein-loaded nanoparticles","volume":"230","author":"Silva","year":"2017","journal-title":"Food Chem."},{"key":"10.1016\/j.neuro.2022.12.006_bib43","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.fct.2018.12.037","article-title":"In vitro and in vivo evaluation of enzymatic and antioxidant activity, cytotoxicity and genotoxicity of curcumin-loaded solid dispersions","volume":"125","author":"Silva de S\u00e1","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.neuro.2022.12.006_bib44","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1021\/acschemneuro.0c00672","article-title":"Inhibition of the ERK1\/2 phosphorylation by dextromethorphan protects against core autistic symptoms in VPA induced autistic rats: in silico and in vivo drug repurposition study","volume":"12","author":"Singla","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.neuro.2022.12.006_bib45","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.foodchem.2019.01.055","article-title":"Effect of temperature, oxygen and light on the degradation of \u03b2-carotene, lutein and \u03b1-tocopherol in spray-dried spinach juice powder during storage","volume":"284","author":"Syamila","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.neuro.2022.12.006_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112968","article-title":"Isoorientin, a GSK-3\u03b2 inhibitor, rescues synaptic dysfunction, spatial memory deficits and attenuates pathological progression in APP\/PS1 model mice","volume":"398","author":"Tan","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuro.2022.12.006_bib47","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/MPG.0000000000000389","article-title":"Lutein and preterm infants with decreased concentrations of brain carotenoids","volume":"59","author":"Vishwanathan","year":"2014","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.neuro.2022.12.006_bib48","doi-asserted-by":"crossref","first-page":"4303","DOI":"10.1007\/s00213-015-4058-z","article-title":"Modulation of social deficits and repetitive behaviors in a mouse model of autism: the role of the nicotinic cholinergic system","volume":"232","author":"Wang","year":"2015","journal-title":"Psychopharmacol. (Berl. )"},{"key":"10.1016\/j.neuro.2022.12.006_bib49","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2131\/jts.43.631","article-title":"Social behavior, neuroimmune markers and glutamic acid decarboxylase levels in a rat model of valproic acid-induced autism","volume":"43","author":"Win-Shwe","year":"2018","journal-title":"J. Toxicol. Sci."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X22001991?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X22001991?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T14:27:28Z","timestamp":1758983248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X22001991"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":49,"alternative-id":["S0161813X22001991"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2022.12.006","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lutein-loaded nanoparticles reverse oxidative stress, apoptosis, and autism spectrum disorder-like behaviors induced by prenatal valproic acid exposure in female rats","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2022.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}