{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:02:27Z","timestamp":1788238947436,"version":"build-2803163510"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,7]],"date-time":"2024-01-07T00:00:00Z","timestamp":1704585600000},"content-version":"am","delay-in-days":312,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009633","name":"NICHD","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"NIEHS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001454","name":"American Epilepsy Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001454","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.neuro.2023.01.002","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T16:39:46Z","timestamp":1672936786000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Acute manganese exposure impairs glutamatergic function in a young mouse model of Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"95","author":[{"given":"Brittany D.","family":"Spitznagel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca A.","family":"Buchanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Consoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan K.","family":"Thibert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron B.","family":"Bowman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William P.","family":"Nobis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona E.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2023.01.002_bib1","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1046\/j.1471-4159.2001.00668.x","article-title":"Differing effects of substrate and non-substrate transport inhibitors on glutamate uptake reversal","volume":"79","author":"Anderson","year":"2001","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neuro.2023.01.002_bib2","doi-asserted-by":"crossref","unstructured":"Asadollahi, M., Atazadeh, M., and Noroozian, M. Seizure in Alzheimer\u2019s Disease: An Underestimated Phenomenon. https:\/\/doi.org\/10.1177\/1533317518813551.","DOI":"10.1177\/1533317518813551"},{"key":"10.1016\/j.neuro.2023.01.002_bib3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.mam.2005.07.003","article-title":"Nutritional aspects of manganese homeostasis","volume":"26","author":"Aschner","year":"2005","journal-title":"Mol. Asp. Med"},{"key":"10.1016\/j.neuro.2023.01.002_bib4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/exnr.1993.1042","article-title":"Manganese injection into the rat striatum produces excitotoxic lesions by impairing energy metabolism","volume":"120","author":"Brouillet","year":"1993","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuro.2023.01.002_bib5","first-page":"5","article-title":"Metals and neurodegeneration","author":"Chen","year":"2016","journal-title":"F1000Res"},{"key":"10.1016\/j.neuro.2023.01.002_bib6","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.2741\/4665","article-title":"Manganese metabolism in humans","volume":"23","author":"Chen","year":"2018","journal-title":"Front. Biosci. - Landmark"},{"key":"10.1016\/j.neuro.2023.01.002_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF02784167","article-title":"Effects of iron deficiency and iron overload on manganese uptake and deposition in the brain and other organs of the rat","volume":"55","author":"Chua","year":"1996","journal-title":"Biol. Trace Elem. Res"},{"key":"10.1016\/j.neuro.2023.01.002_bib8","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1097\/JOM.0000000000001634","article-title":"MRI signal intensity and Parkinsonism in manganese-exposed workers","volume":"61","author":"Criswell","year":"2019","journal-title":"J. Occup. Environ. Med"},{"key":"10.1016\/j.neuro.2023.01.002_bib9","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/10915810500366500","article-title":"Basal Ganglia accumulation and motor assessment following manganese chloride exposure in the C57BL\/6 mouse","volume":"24","author":"Dodd","year":"2005","journal-title":"Int J. Toxicol."},{"key":"10.1016\/j.neuro.2023.01.002_bib10","unstructured":"Erikson, K., Aschner, M. Manganese Causes Differential Regulation of Glutamate Transporter (GLAST) Taurine Transporter and Metallothionein in Cultured Rat Astrocytes."},{"key":"10.1016\/j.neuro.2023.01.002_bib11","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0161-813X(02)00012-8","article-title":"Manganese causes differential regulation of glutamate transporter (GLAST) taurine transporter and metallothionein in cultured rat astrocytes","author":"Erikson","year":"2002","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2023.01.002_bib12","first-page":"11","article-title":"Regulation of the metal transporters ZIP14 and ZnT10 by manganese intake in mice","author":"Felber","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.neuro.2023.01.002_bib13","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.neuint.2005.10.012","article-title":"The effects of manganese on glutamate, dopamine and \u03b3-aminobutyric acid regulation","volume":"48","author":"Fitsanakis","year":"2006","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuro.2023.01.002_bib14","first-page":"5","article-title":"Synaptic plasticity in the hippocampus of a APP\/PS1 mouse model of Alzheimer\u2019s disease is impaired in old but not young mice","author":"Gengler","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neuro.2023.01.002_bib15","first-page":"5","article-title":"Synaptic plasticity in the hippocampus of a APP\/PS1 mouse model of Alzheimer\u2019s disease is impaired in old but not young mice","author":"Gengler","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.neuro.2023.01.002_bib16","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1289\/ehp.0901748","article-title":"Manganese and Parkinson\u2019s disease: a critical review and new findings","volume":"118","author":"Guilarte","year":"2010","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.neuro.2023.01.002_bib17","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1023\/A:1021994126329","article-title":"Manganese decreases glutamate uptake in cultured astrocytes","volume":"22","author":"Hazell","year":"1997","journal-title":"Neurochem Res"},{"key":"10.1016\/j.neuro.2023.01.002_bib18","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.stemcr.2020.05.003","article-title":"Pro-maturational effects of human iPSC-derived cortical astrocytes upon iPSC-derived cortical neurons","volume":"15","author":"Hedegaard","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.neuro.2023.01.002_bib19","first-page":"7","article-title":"Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding A\u03b2 plaques by iGluSnFR two-photon imaging","author":"Hefendehl","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuro.2023.01.002_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.bbr.2015.02.002","article-title":"Chronic exercise dampens hippocampal glutamate overflow induced by kainic acid in rats","volume":"284","author":"Holmes","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuro.2023.01.002_bib21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuro.2018.05.001","article-title":"Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity","volume":"67","author":"Johnson","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2023.01.002_bib22","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.neuro.2018.05.001","article-title":"Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity","volume":"67","author":"Johnson","year":"2018","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2023.01.002_bib23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neuint.2014.08.002","article-title":"Role of transcription factor yin yang 1 in manganese-induced reduction of astrocytic glutamate transporters: putative mechanism for manganese-induced neurotoxicity","volume":"88","author":"Karki","year":"2015","journal-title":"Neurochem Int"},{"key":"10.1016\/j.neuro.2023.01.002_bib24","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1111\/j.1471-4159.2006.03935.x","article-title":"Down-regulation of vesicular glutamate transporters precedes cell loss and pathology in Alzheimer\u2019s disease","volume":"98","author":"Kirvell","year":"2006","journal-title":"J. Neurochem"},{"key":"10.1016\/j.neuro.2023.01.002_bib25","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0387-7604(98)00074-6","article-title":"Tremor and seizures associated with chronic manganese intoxication","volume":"21","author":"Komaki","year":"1999","journal-title":"Brain Dev."},{"key":"10.1016\/j.neuro.2023.01.002_bib26","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/00005072-199708000-00008","article-title":"Glutamate transporter alterations in Alzheimer disease are possibly associated with abnormal APP expression","volume":"56","author":"Li","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.neuro.2023.01.002_bib27","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.neuron.2009.05.012","article-title":"Soluble oligomers of Amyloid \u03b2 protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake","volume":"62","author":"Li","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.neuro.2023.01.002_bib28","first-page":"287","article-title":"Long-term exposure to \u201clow levels\u201d of manganese oxides and neurofunctional changes in ferroalloy workers","volume":"20","author":"Lucchini","year":"1999","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2023.01.002_bib29","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.physbeh.2009.09.005","article-title":"A revised Racine\u2019s scale for PTZ-induced seizures in rats","volume":"98","author":"L\u00fcttjohann","year":"2009","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.neuro.2023.01.002_bib30","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ana.410400512","article-title":"Deficient glutamate transport is associated with neurodegeneration in Alzheimer\u2019s disease","volume":"40","author":"Masliah","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuro.2023.01.002_bib31","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/ana.410400512","article-title":"Deficient glutamate transport is associated with neurodegeneration in Alzheimer\u2019s disease","volume":"40","author":"Masliah","year":"1996","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.neuro.2023.01.002_bib32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuro.2016.09.001","article-title":"Severity scoring of manganese health effects for categorical regression","volume":"58","author":"Mattison","year":"2017","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2023.01.002_bib33","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/toxsci\/kfm095","article-title":"Manganese induces oxidative impairment in cultured rat astrocytes","volume":"98","author":"Milatovic","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.neuro.2023.01.002_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.taap.2009.07.004","article-title":"Oxidative damage and neurodegeneration in manganese-induced neurotoxicity","volume":"240","author":"Milatovic","year":"2009","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.neuro.2023.01.002_bib35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1039\/c2tx20064c","article-title":"Mechanisms of lead and manganese neurotoxicity","volume":"2","author":"Neal","year":"2013","journal-title":"Toxicol. Res (Camb. )"},{"key":"10.1016\/j.neuro.2023.01.002_bib36","doi-asserted-by":"crossref","first-page":"261.e3","DOI":"10.1016\/j.ajem.2020.08.087","article-title":"Toxic boost: acute, reversible neurotoxicity after ingestion of methylcyclopentadienyl manganese tricarbonyl (MMT) mistaken for an energy drink","volume":"42","author":"Nemanich","year":"2021","journal-title":"Am. J. Emergency Med."},{"key":"10.1016\/j.neuro.2023.01.002_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101372","article-title":"Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity","volume":"297","author":"Pajarillo","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuro.2023.01.002_bib38","series-title":"Molecular Sciences Iron Homeostasis Disorder and Alzheimer\u2019s Disease","author":"Peng","year":"2021"},{"key":"10.1016\/j.neuro.2023.01.002_bib39","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1039\/d0mt00081g","article-title":"Huntington\u2019s disease genotype suppresses global manganese-responsive processes in pre-manifest and manifest YAC128 mice","volume":"12","author":"Pfalzer","year":"2020","journal-title":"Metallomics"},{"key":"10.1016\/j.neuro.2023.01.002_bib40","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1039\/d0mt00081g","article-title":"Huntington\u2019s disease genotype suppresses global manganese-responsive processes in pre-manifest and manifest YAC128 mice","volume":"12","author":"Pfalzer","year":"2020","journal-title":"Metallomics"},{"key":"10.1016\/j.neuro.2023.01.002_bib41","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1212\/WNL.0000000000003533","article-title":"Dose-dependent progression of parkinsonism in manganese-exposed welders","volume":"88","author":"Racette","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.neuro.2023.01.002_bib42","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/sj.embor.7400784","article-title":"Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology","volume":"7","author":"Radde","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/j.neuro.2023.01.002_bib43","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.yrtph.2019.03.005","article-title":"Sex differences in subacute manganese intoxication: oxidative parameters and metal deposition in peripheral organs of adult Wistar rats","volume":"104","author":"Richter Schmitz","year":"2019","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.neuro.2023.01.002_bib44","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/ajim.4700110308","article-title":"Epidemiological survey among workers exposed to manganese: effects on lung, central nervous system, and some biological indices","volume":"11","author":"Roels","year":"1987","journal-title":"Am. J. Ind. Med"},{"key":"10.1016\/j.neuro.2023.01.002_bib45","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1093\/ajcn\/54.1.152","article-title":"Competitive inhibition of iron absorption by manganese and zinc in humans","volume":"54","author":"Rossander-Hulten","year":"1991","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.neuro.2023.01.002_bib46","doi-asserted-by":"crossref","unstructured":"Roth, J., Ponzoni, S., Aschner, M., Roth, J., Ponzoni, S., and Aschner, M.. Manganese Homeostasis and Transport. https:\/\/doi.org\/10.1007\/978\u201394-007\u20135561-1_6.","DOI":"10.1007\/978-94-007-5561-1_6"},{"key":"10.1016\/j.neuro.2023.01.002_bib47","first-page":"50079","article-title":"Isolation and culture of mouse cortical astrocytes","author":"Schildge","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.neuro.2023.01.002_bib48","doi-asserted-by":"crossref","unstructured":"Scott, H.A., Gebhardt, F.M., Mitrovic, A.D., Vandenberg, R.J., and Dodd, P.R. (2011). Glutamate transporter variants reduce glutamate uptake in Alzheimer\u2019s disease. Neurobiol. Aging 32, 553.e1\u2013553.e11. https:\/\/doi.org\/10.1016\/J.NEUROBIOLAGING.2010.03.008.","DOI":"10.1016\/j.neurobiolaging.2010.03.008"},{"key":"10.1016\/j.neuro.2023.01.002_bib49","doi-asserted-by":"crossref","first-page":"377","DOI":"10.5114\/fn.2014.47838","article-title":"Impairment of glutamine\/glutamate-\u03b3-aminobutyric acid cycle in manganese toxicity in the central nervous system","volume":"52","author":"Sidoryk-Wegrzynowicz","year":"2014","journal-title":"Folia Neuropathol."},{"key":"10.1016\/j.neuro.2023.01.002_bib50","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1471-4159.2009.06172.x","article-title":"Manganese disrupts astrocyte glutamine transporter expression and function","volume":"110","author":"Sidoryk-W\u0327grzynowicz","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.neuro.2023.01.002_bib51","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0022-510X(02)00026-6","article-title":"Scavenger receptor class B type I expression and elemental analysis in cerebellum and parietal cortex regions of the Alzheimer\u2019s disease brain","author":"Srivastava","year":"2002","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.neuro.2023.01.002_bib52","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3233\/JAD-140534","article-title":"High manganese, a risk for Alzheimer\u2019s disease: high manganese induces amyloid-\u03b2 related cognitive impairment","volume":"42","author":"Tong","year":"2014","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.neuro.2023.01.002_bib53","first-page":"333","article-title":"Iron and Alzheimer\u2019s disease: from pathology to imaging","volume":"0","author":"Tran","year":"2022","journal-title":"Front Hum. Neurosci."},{"key":"10.1016\/j.neuro.2023.01.002_bib54","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1001\/jamaneurol.2013.136","article-title":"Seizures and epileptiform activity in the early stages of Alzheimer disease","volume":"70","author":"Vossel","year":"2013","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.neuro.2023.01.002_bib55","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/ana.24794","article-title":"Incidence and impact of subclinical epileptiform activity in Alzheimer\u2019s disease","volume":"80","author":"Vossel","year":"2016","journal-title":"ANN NEUROL"},{"key":"10.1016\/j.neuro.2023.01.002_bib56","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1474-4422(17)30044-3","article-title":"Epileptic activity in Alzheimer\u2019s disease: causes and clinical relevance","volume":"16","author":"Vossel","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuro.2023.01.002_bib57","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.eplepsyres.2014.11.017","article-title":"Low brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer\u2019s disease","volume":"110","author":"Warner","year":"2015","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.neuro.2023.01.002_bib58","first-page":"158","article-title":"Altered synaptic glutamate homeostasis contributes to cognitive decline in young APP\/PSEN1 mice","author":"Wilcox","year":"2021","journal-title":"Neurobiol. Dis."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X23000025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X23000025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T13:27:29Z","timestamp":1736342849000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X23000025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":58,"alternative-id":["S0161813X23000025"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2023.01.002","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acute manganese exposure impairs glutamatergic function in a young mouse model of Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2023.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}