{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T19:57:31Z","timestamp":1781553451056,"version":"3.54.5"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["UBACYT-20020190100102BA"],"award-info":[{"award-number":["UBACYT-20020190100102BA"]}],"id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021778","name":"Agencia Nacional De Promoci\u00f3n Cient\u00edfica Y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT-2016-2202"],"award-info":[{"award-number":["PICT-2016-2202"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.neuro.2023.05.009","type":"journal-article","created":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T05:07:26Z","timestamp":1684300046000},"page":"89-100","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Social deficits in mice prenatally exposed to valproic acid are intergenerationally inherited and rescued by social enrichment"],"prefix":"10.1016","volume":"97","author":[{"given":"Cecilia","family":"Zappala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Dario","family":"Barrios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaicha Mara","family":"Depino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2023.05.009_bib1","series-title":"Diagnostic and Statistical Manual of Mental Disorders","article-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2013"},{"issue":"80","key":"10.1016\/j.neuro.2023.05.009_bib2","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.1108190","article-title":"Epigenetic transgenerational actions of endocrine disruptors and male fertility","volume":"308","author":"Anway","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.neuro.2023.05.009_bib3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.cell.2014.06.017","article-title":"Disruptive CHD8 mutations define a subtype of autism early in development","volume":"158","author":"Bernier","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.neuro.2023.05.009_bib4","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00018-018-2988-4","article-title":"The contribution of environmental exposure to the etiology of autism spectrum disorder","volume":"76","author":"B\u00f6lte","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.neuro.2023.05.009_bib5","first-page":"11","article-title":"Hippocampal SPARC regulates depression-related behavior","author":"Campolongo","year":"2012","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.neuro.2023.05.009_bib6","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13229-018-0221-9","article-title":"Sociability deficits after prenatal exposure to valproic acid are rescued by early social enrichment","volume":"9","author":"Campolongo","year":"2018","journal-title":"Mol. Autism"},{"key":"10.1016\/j.neuro.2023.05.009_bib7","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0022-3476(78)80921-4","article-title":"Behavioral consequences of congenital rubella","volume":"93","author":"Chess","year":"1978","journal-title":"J. Pedia"},{"key":"10.1016\/j.neuro.2023.05.009_bib8","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neuron.2015.06.022","article-title":"Oxytocin mediates entrainment of sensory stimuli to social cues of opposing valence","volume":"87","author":"Choe","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.neuro.2023.05.009_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep36250","article-title":"The transgenerational inheritance of autism-like phenotypes in mice exposed to valproic acid during pregnancy","volume":"6","author":"Choi","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuro.2023.05.009_bib10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1469-8749.1994.tb11858.x","article-title":"Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs","volume":"36","author":"Christianson","year":"2008","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.neuro.2023.05.009_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.semcdb.2017.09.010","article-title":"Perinatal inflammation and adult psychopathology: from preclinical models to humans","author":"Depino","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.neuro.2023.05.009_bib12","first-page":"25","article-title":"Early and adult hippocampal TGF-\u03b21 overexpression have opposite effects on behavior","author":"Depino","year":"2011","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.neuro.2023.05.009_bib13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.biopsych.2010.05.036","article-title":"Epigenetic transmission of the impact of early stress across generations","volume":"68","author":"Franklin","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuro.2023.05.009_bib14","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nn.3695","article-title":"Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice","volume":"17","author":"Gapp","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuro.2023.05.009_bib15","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1093\/emboj\/20.24.6969","article-title":"Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells","volume":"20","author":"G\u00f6ttlicher","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.neuro.2023.05.009_bib16","first-page":"12","article-title":"Hypomyelination and oligodendroglial alterations in a mouse model of autism spectrum disorder","author":"Graciarena","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.neuro.2023.05.009_bib17","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1001\/archgenpsychiatry.2011.76","article-title":"Genetic heritability and shared environmental factors among twin pairs with autism","volume":"68","author":"Hallmayer","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neuro.2023.05.009_bib18","first-page":"119","article-title":"Recruitment of CTCF to an Fto enhancer is responsible for transgenerational inheritance of BPA-induced obesity","author":"Jung","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuro.2023.05.009_bib19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S1461145711001714","article-title":"Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid","volume":"16","author":"Kataoka","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.neuro.2023.05.009_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.psyneuen.2016.06.001","article-title":"Postnatal behavioral and inflammatory alterations in female pups prenatally exposed to valproic acid","volume":"72","author":"Kazlauskas","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuro.2023.05.009_bib21","first-page":"110","article-title":"Sex-specific effects of prenatal valproic acid exposure on sociability and neuroinflammation: Relevance for susceptibility and resilience in autism","author":"Kazlauskas","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuro.2023.05.009_bib22","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/npp.2015.249","article-title":"Models of intergenerational and transgenerational transmission of risk for psychopathology in mice","volume":"41","author":"Klengel","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.neuro.2023.05.009_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fneur.2015.00107","article-title":"The role of epigenetic change in autism spectrum disorders","volume":"6","author":"Loke","year":"2015","journal-title":"Front. Neurol."},{"key":"10.1016\/j.neuro.2023.05.009_bib24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/aur.1338","article-title":"Altered Peripheral and Central Inflammatory Responses in a Mouse Model of Autism","volume":"7","author":"Lucchina","year":"2014","journal-title":"Autism Res"},{"key":"10.1016\/j.neuro.2023.05.009_bib25","first-page":"213","article-title":"Evaluating the interaction between early postnatal inflammation and maternal care in the programming of adult anxiety and depression-related behaviors","author":"Lucchina","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.neuro.2023.05.009_bib26","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1002\/dvdy.21626","article-title":"Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development","volume":"237","author":"MacDonald","year":"2008","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.neuro.2023.05.009_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss7011a1","article-title":"Prevalence and Characteristics of autism spectrum disorder among children aged 8 years \u2014 autism and developmental disabilities monitoring network, 11 sites, United States, 2018","volume":"70","author":"Maenner","year":"2021","journal-title":"Mmwr. Surveill. Summ."},{"key":"10.1016\/j.neuro.2023.05.009_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13229-017-0121-4","article-title":"Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses","volume":"8","author":"Modabbernia","year":"2017","journal-title":"Mol. Autism"},{"key":"10.1016\/j.neuro.2023.05.009_bib29","doi-asserted-by":"crossref","first-page":"11748","DOI":"10.1523\/JNEUROSCI.1887-11.2011","article-title":"Early prenatal stress epigenetically programs dysmasculinization in second-generation offspring via the paternal lineage","volume":"31","author":"Morgan","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuro.2023.05.009_bib30","first-page":"113","article-title":"The genetics of autism","author":"Muhle","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.neuro.2023.05.009_bib31","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4161\/epi.1.4.3514","article-title":"Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation","volume":"1","author":"Nagarajan","year":"2006","journal-title":"Epigenetics"},{"key":"10.1016\/j.neuro.2023.05.009_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpsyt.2022.889636","article-title":"Sex differences in autism spectrum disorder: diagnostic, neurobiological, and behavioral features","volume":"13","author":"Napolitano","year":"2022","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.neuro.2023.05.009_bib33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.expneurol.2017.04.017","article-title":"The valproic acid-induced rodent model of autism","volume":"299","author":"Nicolini","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.neuro.2023.05.009_bib34","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.trsl.2014.02.003","article-title":"Environmentally induced epigenetic transgenerational inheritance of disease susceptibility","volume":"165","author":"Nilsson","year":"2015","journal-title":"Transl. Res."},{"key":"10.1016\/j.neuro.2023.05.009_bib35","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.neuro.2023.05.009_bib36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41556-018-0242-9","article-title":"Intergenerational and transgenerational epigenetic inheritance in animals","volume":"21","author":"Perez","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.neuro.2023.05.009_bib37","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuro.2023.05.009_bib38","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1017\/S0012162205001076","article-title":"Characteristics of fetal anticonvulsant syndrome associated autistic disorder","volume":"47","author":"Rasalam","year":"2005","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.neuro.2023.05.009_bib39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.biopsych.2016.08.010","article-title":"Genome-wide DNA methylation changes in a mouse model of infection-mediated neurodevelopmental disorders","volume":"81","author":"Richetto","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuro.2023.05.009_bib40","doi-asserted-by":"crossref","first-page":"9003","DOI":"10.1523\/JNEUROSCI.0914-13.2013","article-title":"Paternal stress exposure alters sperm MicroRNA content and reprograms offspring HPA stress axis regulation","volume":"33","author":"Rodgers","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuro.2023.05.009_bib41","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1001\/jama.2014.4144","article-title":"The familial risk of autism","volume":"311","author":"Sandin","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.neuro.2023.05.009_bib42","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1073\/pnas.1619312114","article-title":"Sex-specific gene-environment interactions underlying ASD-like behaviors","volume":"114","author":"Schaafsma","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.neuro.2023.05.009_bib43","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.neuro.2023.05.009_bib44","first-page":"1","article-title":"Early estradiol exposure masculinizes disease\u2010relevant behaviors in female mice","author":"Seiffe","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.neuro.2023.05.009_bib45","first-page":"1","article-title":"Juvenile handling rescues autism \u2011 related effects of prenatal exposure to valproic acid","author":"Seiffe","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuro.2023.05.009_bib46","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1001\/archgenpsychiatry.2011.151","article-title":"Epigenetic signatures of autism: trimethylated H3K4 landscapes in prefrontal neurons","volume":"69","author":"Shulha","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.neuro.2023.05.009_bib47","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/s41580-018-0074-2","article-title":"Functions and mechanisms of epigenetic inheritance in animals","volume":"19","author":"Skvortsova","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.neuro.2023.05.009_bib48","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1469-8749.1994.tb11856.x","article-title":"Autism in thalidomide embryopathy: a population study","volume":"36","author":"Str\u00f6mland","year":"1994","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.neuro.2023.05.009_bib49","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.cell.2016.10.031","article-title":"Histone acetylome-wide association study of autism spectrum disorder","volume":"167","author":"Sun","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.neuro.2023.05.009_bib50","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molmed.2014.12.004","article-title":"Nongenetic inheritance and transgenerational epigenetics","volume":"21","author":"Szyf","year":"2015","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.neuro.2023.05.009_bib51","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.biopsych.2021.11.021","article-title":"Epigenetics of Autism Spectrum Disorder: Histone Deacetylases","volume":"91","author":"Tseng","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.neuro.2023.05.009_bib52","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1073\/pnas.0507526103","article-title":"Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood","volume":"103","author":"Weaver","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.neuro.2023.05.009_bib53","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/mp.2016.41","article-title":"Transgenerational transmission and modification of pathological traits induced by prenatal immune activation","volume":"22","author":"Weber-Stadlbauer","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuro.2023.05.009_bib54","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1023\/A:1025023131029","article-title":"Possible association between congenital cytomegalovirus infection and autistic disorder","volume":"33","author":"Yamashita","year":"2003","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.neuro.2023.05.009_bib55","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1093\/hmg\/ddt547","article-title":"Epigenetic dysregulation of SHANK3 in brain tissues from individuals with autism spectrum disorders","volume":"23","author":"Zhu","year":"2014","journal-title":"Hum. Mol. Genet"}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X2300075X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X2300075X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:55:10Z","timestamp":1777492510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X2300075X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":55,"alternative-id":["S0161813X2300075X"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2023.05.009","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Social deficits in mice prenatally exposed to valproic acid are intergenerationally inherited and rescued by social enrichment","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2023.05.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}