{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:19:01Z","timestamp":1789841941690,"version":"4.0.1"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020582","name":"National Institute of Pharmaceutical Education and Research, Raebareli","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.neuro.2025.04.009","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T11:57:17Z","timestamp":1745409437000},"page":"246-262","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Urolithin improves \u03b1-synuclein aggregation and DNMT1 expression in rotenone model of Parkinson\u2019s disease"],"prefix":"10.1016","volume":"108","author":[{"given":"Ankita","family":"Devi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Munagalasetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pardeep","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasundhra","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-9365","authenticated-orcid":false,"given":"Manoj P.","family":"Dandekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2025.04.009_bib1","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1523\/JNEUROSCI.3047-16.2016","article-title":"Hippocampal \u03b1-synuclein in dementia with Lewy bodies contributes to memory impairment and is consistent with spread of pathology","volume":"37","author":"Adamowicz","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuro.2025.04.009_bib2","doi-asserted-by":"crossref","first-page":"2698","DOI":"10.1039\/D2FO03310K","article-title":"Walnut polyphenols and the active metabolite urolithin A improve oxidative damage in SH-SY5Y cells by up-regulating PKA\/CREB\/BDNF signaling","volume":"14","author":"An","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.neuro.2025.04.009_bib3","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.3390\/nu11112678","article-title":"5-(Hydroxyphenyl)-\u03b3-valerolactone-sulfate, a key microbial metabolite of flavan-3-ols, is able to reach the brain: evidence from different in silico, in vitro and in vivo experimental models","volume":"11","author":"Angelino","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.neuro.2025.04.009_bib4","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1002\/2211-5463.13023","article-title":"Interaction of amyloid beta with humanin and acetylcholinesterase is modulated by ATP","volume":"10","author":"Atali","year":"2020","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.neuro.2025.04.009_bib5","first-page":"140","article-title":"Molecular Dynamics Simulations of Acetylcholinesterase\u2013Beta-Amyloid Peptide Complex","volume":"20","author":"Atanasova","year":"2020","journal-title":"Cybern. Inf. Technol."},{"key":"10.1016\/j.neuro.2025.04.009_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiolchem.2019.107096","article-title":"In silico and in vitro identification of candidate SIRT1 activators from Indonesian medicinal plants compounds database","volume":"83","author":"Azminah","year":"2019","journal-title":"Comput. Biol. Chem."},{"key":"10.1016\/j.neuro.2025.04.009_bib7","doi-asserted-by":"crossref","first-page":"W257","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: a webserver for the prediction of toxicity of chemicals","volume":"46","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.neuro.2025.04.009_bib8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1042\/BJ20081276","article-title":"Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions","volume":"417","author":"Barak","year":"2009","journal-title":"Biochem. J."},{"key":"10.1016\/j.neuro.2025.04.009_bib9","doi-asserted-by":"crossref","first-page":"17187","DOI":"10.1074\/jbc.M501250200","article-title":"Mechanism of human SIRT1 activation by resveratrol","volume":"280","author":"Borra","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.neuro.2025.04.009_bib10","doi-asserted-by":"crossref","unstructured":"Bowers, K.J., E. Chow, H. Xu, R.O. Dror, M.P. Eastwood, B.A. Gregersen, J.L. Klepeis, I. Kolossvary, M.A. Moraes, and F.D. Sacerdoti. 2006. Scalable algorithms for molecular dynamics simulations on commodity clusters. In Proceedings of the 2006 ACM\/IEEE Conference on Supercomputing. 84-es.","DOI":"10.1145\/1188455.1188544"},{"key":"10.1016\/j.neuro.2025.04.009_bib11","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1007\/s13311-020-00890-x","article-title":"Current management and emerging therapies in multiple system atrophy","volume":"17","author":"Burns","year":"2020","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.neuro.2025.04.009_bib12","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41419-023-05672-9","article-title":"Alpha-synuclein in Parkinson\u2019s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction","volume":"14","author":"Calabresi","year":"2023","journal-title":"Cell death Dis."},{"key":"10.1016\/j.neuro.2025.04.009_bib13","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1101\/gad.265462.115","article-title":"Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol","volume":"29","author":"Cao","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.neuro.2025.04.009_bib14","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3390\/antiox9020177","article-title":"The metabolite urolithin-A ameliorates oxidative stress in neuro-2a cells, becoming a potential neuroprotective agent","volume":"9","author":"C\u00e1sedas","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.neuro.2025.04.009_bib15","article-title":"The gut microbiota metabolite urolithin B improves cognitive deficits by inhibiting Cyt C-mediated apoptosis and promoting the survival of neurons through the PI3K pathway in aging mice","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuro.2025.04.009_bib16","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s12640-021-00392-4","article-title":"SIRT1 protects dopaminergic neurons in parkinson\u2019s disease models via PGC-1\u03b1-mediated mitochondrial biogenesis","volume":"39","author":"Chen","year":"2021","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.neuro.2025.04.009_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113151","article-title":"The ellagitannin metabolite urolithin C attenuated cognitive impairment by inhibiting neuroinflammation via downregulation of MAPK\/NF-kB signaling pathways in aging mice","volume":"142","author":"Chen","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.neuro.2025.04.009_bib18","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s12035-016-0276-6","article-title":"Curcumin attenuates colistin-induced neurotoxicity in N2a cells via anti-inflammatory activity, suppression of oxidative stress, and apoptosis","volume":"55","author":"Dai","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuro.2025.04.009_bib19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41594-020-0384-x","article-title":"A short motif in the N-terminal region of \u03b1-synuclein is critical for both aggregation and function","volume":"27","author":"Doherty","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.neuro.2025.04.009_bib20","article-title":"Salivary acetylcholinesterase activity is increased in Parkinson\u2019s disease: a potential marker of parasympathetic dysfunction","volume":"2015","author":"Fedorova","year":"2015","journal-title":"Park. \u2019S. Dis."},{"key":"10.1016\/j.neuro.2025.04.009_bib21","doi-asserted-by":"crossref","first-page":"872","DOI":"10.4161\/cc.24061","article-title":"Resveratrol activates SIRT1 in a Lamin A-dependent manner","volume":"12","author":"Ghosh","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1016\/j.neuro.2025.04.009_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.715618","article-title":"Increased Sodium Concentration in Substantia Nigra in Early Parkinson's Disease: A Preliminary Study With Ultra-High Field (7T) MRI","volume":"12","author":"Grimaldi","year":"2021","journal-title":"Front Neurol."},{"key":"10.1016\/j.neuro.2025.04.009_bib23","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0005-2728(96)00163-6","article-title":"Interaction of the mitochondrial NADH-ubiquinone reductase with rotenone as related to the enzyme active\/inactive transition","volume":"1319","author":"Grivennikova","year":"1997","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Bioenerg."},{"key":"10.1016\/j.neuro.2025.04.009_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144290","article-title":"Resveratrol directly binds to mitochondrial complex I and increases oxidative stress in brain mitochondria of aged mice","volume":"10","author":"Gueguen","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.neuro.2025.04.009_bib25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.7324\/JAPS.2017.70116","article-title":"In silico ADME\/T and 3D QSAR analysis of KDR inhibitors","volume":"7","author":"Hosen","year":"2017","journal-title":"J. Appl. Pharm. Sci."},{"key":"10.1016\/j.neuro.2025.04.009_bib26","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2169\/internalmedicine.4836-20","article-title":"Effectiveness of levodopa in patients with multiple system atrophy and associated clinicopathological features","volume":"60","author":"Ishida","year":"2021","journal-title":"Intern. Med."},{"key":"10.1016\/j.neuro.2025.04.009_bib27","article-title":"An In Silico Study to Explore the Role of EGFR in Ovarian Cancer","volume":"14","author":"Jakhmola","year":"2022","journal-title":"Pharmacogn. J."},{"key":"10.1016\/j.neuro.2025.04.009_bib28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.biomag.2014.01.002","article-title":"In silico identification of potent inhibitors of alpha-synuclein aggregation and its in vivo evaluation using MPTP induced Parkinson mice model","volume":"4","author":"Jayaraj","year":"2014","journal-title":"Biomed. Aging Pathol."},{"key":"10.1016\/j.neuro.2025.04.009_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0211935","article-title":"Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer\u2019s disease","volume":"14","author":"Junaid","year":"2019","journal-title":"PloS One"},{"key":"10.1016\/j.neuro.2025.04.009_bib30","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1038\/s41467-022-34779-4","article-title":"Structural basis for activation of DNMT1","volume":"13","author":"Kikuchi","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuro.2025.04.009_bib31","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3390\/ijms21010202","article-title":"Neuroprotective effects of pomegranate juice against Parkinson\u2019s disease and presence of ellagitannins-derived metabolite\u2014urolithin A\u2014in the brain","volume":"21","author":"Kujawska","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuro.2025.04.009_bib32","doi-asserted-by":"crossref","first-page":"12483","DOI":"10.1021\/acs.jpcb.4c04719","article-title":"Solid-state NMR validation of OPLS4: Structure of pc-lipid bilayers and its modulation by dehydration","volume":"128","author":"Kurki","year":"2024","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.neuro.2025.04.009_bib33","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.biopha.2018.09.054","article-title":"Cadmium nitrate-induced neuronal apoptosis is protected by N-acetyl-l-cysteine via reducing reactive oxygen species generation and mitochondria dysfunction","volume":"108","author":"Lee","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.neuro.2025.04.009_bib34","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jafc.4c06542","article-title":"Comparative Study on the Antioxidative Effects and \u03b1-Glucosidase Inhibitory Potential In Vitro among Ellagic Acid and Its Metabolites Urolithins","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.neuro.2025.04.009_bib35","article-title":"Identification of ellagic acid and urolithins as natural inhibitors of A\u03b225\u201335-induced neurotoxicity and the mechanism predication using network pharmacology analysis and molecular docking","volume":"9","author":"Li","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.neuro.2025.04.009_bib36","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ddtec.2004.11.007","article-title":"Lead-and drug-like compounds: the rule-of-five revolution","volume":"1","author":"Lipinski","year":"2004","journal-title":"Drug Discov. Today.: Technol."},{"key":"10.1016\/j.neuro.2025.04.009_bib37","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1039\/D1FO02534A","article-title":"Urolithin A protects dopaminergic neurons in experimental models of Parkinson's disease by promoting mitochondrial biogenesis through the SIRT1\/PGC-1\u03b1 signaling pathway","volume":"13","author":"Liu","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.neuro.2025.04.009_bib38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S1474-4422(18)30032-2","article-title":"The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson's disease: a cross-sectional PET study","volume":"17","author":"Liu","year":"2018","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.neuro.2025.04.009_bib39","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1021\/acs.jctc.1c00302","article-title":"OPLS4: Improving force field accuracy on challenging regimes of chemical space","volume":"17","author":"Lu","year":"2021","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.neuro.2025.04.009_bib40","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1111\/bcp.12169","article-title":"Structure-based drug design of catechol-O-methyltransferase inhibitors for CNS disorders","volume":"77","author":"Ma","year":"2014","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.neuro.2025.04.009_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.867","article-title":"Serum sodium and chloride are inversely associated with dyskinesia in Parkinson's disease patients","volume":"7","author":"Mao","year":"2017","journal-title":"Brain Behav."},{"key":"10.1016\/j.neuro.2025.04.009_bib42","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.3390\/molecules28124814","article-title":"Structure-based design of novel MAO-B inhibitors: a review","volume":"28","author":"Mateev","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.neuro.2025.04.009_bib43","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fphar.2013.00038","article-title":"Lazar: a modular predictive toxicology framework","volume":"4","author":"Maunz","year":"2013","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.neuro.2025.04.009_bib44","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.neuro.2025.04.009_bib45","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/s41598-020-57417-9","article-title":"Design and molecular dynamic investigations of 7, 8-dihydroxyflavone derivatives as potential neuroprotective agents against alpha-synuclein","volume":"10","author":"Mohankumar","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuro.2025.04.009_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7912765","article-title":"Computational studies applied to flavonoids against Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"2018","author":"Monteiro","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.neuro.2025.04.009_bib47","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1111\/psyg.13091","article-title":"Efficacy and safety of donepezil in patients with dementia with Lewy bodies: results from a 12-week multicentre, randomised, double-blind, and placebo-controlled phase IV study","volume":"24","author":"Mori","year":"2024","journal-title":"Psychogeriatrics"},{"key":"10.1016\/j.neuro.2025.04.009_bib48","doi-asserted-by":"crossref","first-page":"11059","DOI":"10.3390\/ijms231911059","article-title":"Neuroprotective function of rasagiline and selegiline, inhibitors of type B monoamine oxidase, and role of monoamine oxidases in synucleinopathies","volume":"23","author":"Naoi","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuro.2025.04.009_bib49","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/s41531-022-00428-2","article-title":"Gut microbiota in dementia with Lewy bodies","volume":"8","author":"Nishiwaki","year":"2022","journal-title":"npj Park. 'S. Dis."},{"key":"10.1016\/j.neuro.2025.04.009_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2193-1801-2-353","article-title":"An in silico evaluation of the ADMET profile of the StreptomeDB database","volume":"2","author":"Ntie-Kang","year":"2013","journal-title":"Springerplus"},{"key":"10.1016\/j.neuro.2025.04.009_bib51","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2021.776847","article-title":"Global trends in the incidence, prevalence, and years lived with disability of Parkinson's disease in 204 countries\/territories from 1990 to 2019","volume":"9","author":"Ou","year":"2021","journal-title":"Front. Public Health"},{"key":"10.1016\/j.neuro.2025.04.009_bib52","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3389\/fnmol.2019.00306","article-title":"ZPD-2, a small compound that inhibits \u03b1-synuclein amyloid aggregation and its seeded polymerization","volume":"12","author":"Pe\u00f1a-D\u00edaz","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.neuro.2025.04.009_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2022.108963","article-title":"Urolithin A promotes mitophagy and suppresses NLRP3 inflammasome activation in lipopolysaccharide-induced BV2 microglial cells and MPTP-induced Parkinson's disease model","volume":"207","author":"Qiu","year":"2022","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.neuro.2025.04.009_bib54","doi-asserted-by":"crossref","first-page":"5200","DOI":"10.1021\/acs.biomac.0c01292","article-title":"Unraveling the NaCl Concentration Effect on the First Stages of alpha-Synuclein Aggregation","volume":"21","author":"Ramis","year":"2020","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.neuro.2025.04.009_bib55","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00702-023-02623-8","article-title":"Clinical benefit of MAO-B and COMT inhibition in Parkinson\u2019s disease: practical considerations","volume":"130","author":"Regensburger","year":"2023","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.neuro.2025.04.009_bib56","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1039\/D2FO00552B","article-title":"Urolithins: potential biomarkers of gut dysbiosis and disease stage in Parkinson's patients","volume":"13","author":"Romo-Vaquero","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.neuro.2025.04.009_bib57","article-title":"Rotenone induced neurodegeneration is mediated via cytoskeleton degradation and necroptosis","volume":"1870","author":"Roy","year":"2023","journal-title":"Biochim. Et. Biophys. Acta (BBA)-Mol. Cell Res."},{"key":"10.1016\/j.neuro.2025.04.009_bib58","unstructured":"S. Release, \"2: Prime; Schr\u00f6dinger, LLC,\" New York, NY, 2022."},{"key":"10.1016\/j.neuro.2025.04.009_bib59","unstructured":"S. Release, \"4: Schr\u00f6dinger,\" LLC, New York, NY, 2021."},{"key":"10.1016\/j.neuro.2025.04.009_bib60","doi-asserted-by":"crossref","first-page":"10756","DOI":"10.1523\/JNEUROSCI.23-34-10756.2003","article-title":"Mechanism of toxicity in rotenone models of Parkinson's disease","volume":"23","author":"Sherer","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.neuro.2025.04.009_bib61","article-title":"Patterning amyloid-beta aggregation under the effect of acetylcholinesterase using a biological nanopore - an in vitro study","volume":"6","author":"Subramanian","year":"2023","journal-title":"Sens Actuators Rep."},{"key":"10.1016\/j.neuro.2025.04.009_bib62","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1023\/B:JCAM.0000021831.47952.a7","article-title":"A structure-activity relationship study of catechol-O-methyltransferase inhibitors combining molecular docking and 3D QSAR methods","volume":"17","author":"Tervo","year":"2003","journal-title":"J. Comput. -Aided Mol. Des."},{"key":"10.1016\/j.neuro.2025.04.009_bib63","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41531-023-00561-6","article-title":"Transient exposure to rotenone causes degeneration and progressive parkinsonian motor deficits, neuroinflammation, and synucleinopathy","volume":"9","author":"Van Laar","year":"2023","journal-title":"npj Park. 'S. Dis."},{"key":"10.1016\/j.neuro.2025.04.009_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/cddiscovery.2017.7","article-title":"Malathion increases apoptotic cell death by inducing lysosomal membrane permeabilization in N2a neuroblastoma cells: a model for neurodegeneration in Alzheimer\u2019s disease","volume":"3","author":"Venkatesan","year":"2017","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.neuro.2025.04.009_bib65","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3389\/fnins.2019.01102","article-title":"Alterations of the gut microbiota in multiple system atrophy patients","volume":"13","author":"Wan","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.neuro.2025.04.009_bib66","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1002\/ar.23781","article-title":"Resveratrol suppresses rotenone-induced neurotoxicity through activation of SIRT1\/Akt1 signaling pathway","volume":"301","author":"Wang","year":"2018","journal-title":"Anat. Rec."},{"key":"10.1016\/j.neuro.2025.04.009_bib67","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/cns.12059","article-title":"A DNA Methyltransferase Inhibitor, 5-Aza-2\u2032-Deoxycytidine, Exacerbates Neurotoxicity and Upregulates P arkinson's Disease-Related Genes in Dopaminergic Neurons","volume":"19","author":"Wang","year":"2013","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.neuro.2025.04.009_bib68","doi-asserted-by":"crossref","first-page":"6740","DOI":"10.1002\/alz.14118","article-title":"Long-term effects of cholinesterase inhibitors and memantine on cognitive decline, cardiovascular events, and mortality in dementia with Lewy bodies: An up to 10-year follow-up study","volume":"20","author":"Xu","year":"2024","journal-title":"Alzheimer'S. Dement."},{"key":"10.1016\/j.neuro.2025.04.009_bib69","doi-asserted-by":"crossref","unstructured":"Xu JiaLin, X.J., Y.C. Yuan ChunHui, W.G. Wang GuiHua, L.J. Luo JiaMing, M.H. Ma Hang, X.L. Xu Li, M.Y. Mu Yu, L.Y. Li YuanYuan, N. Seeram, and H.X. Huang XueShi. 2018. Urolithins attenuate LPS-induced neuroinflammation in BV2 microglia via MAPK, Akt, and NF-\u03baB signaling pathways.","DOI":"10.1021\/acs.jafc.7b03285"},{"key":"10.1016\/j.neuro.2025.04.009_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.137953","article-title":"Oral supplementation of Gordonibacter urolithinfaciens promotes ellagic acid metabolism and urolithin bioavailability in mice","volume":"437","author":"Yang","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.neuro.2025.04.009_bib71","doi-asserted-by":"crossref","first-page":"11045","DOI":"10.1038\/s41598-023-38210-w","article-title":"Stressed neuronal cells can recover from profound membrane blebbing, nuclear condensation and mitochondrial fragmentation, but not from cytochrome c release","volume":"13","author":"You","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.neuro.2025.04.009_bib72","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.toxlet.2014.11.029","article-title":"The molecular mechanism of rotenone-induced \u03b1-synuclein aggregation: emphasizing the role of the calcium\/GSK3\u03b2 pathway","volume":"233","author":"Yuan","year":"2015","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.neuro.2025.04.009_bib73","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1007\/s12035-021-02298-w","article-title":"DNA methyltransferase 1 is dysregulated in Parkinson\u2019s disease via mediation of miR-17","volume":"58","author":"Zhang","year":"2021","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.neuro.2025.04.009_bib74","first-page":"4989","article-title":"Neuroprotective effects of lithium on a chronic MPTP mouse model of Parkinson's disease via regulation of \u03b1-synuclein methylation","volume":"19","author":"Zhao","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.neuro.2025.04.009_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.890168","article-title":"The \u201cBlack Straight-Line Sign\u201d in the Putamen in Diffusion-Weighted Imaging: A Potential Diagnostic MRI Marker for Multiple System Atrophy","volume":"13","author":"Zheng","year":"2022","journal-title":"Front. Neurol."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X25000440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X25000440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T08:43:13Z","timestamp":1778143393000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X25000440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":75,"alternative-id":["S0161813X25000440"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2025.04.009","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urolithin improves \u03b1-synuclein aggregation and DNMT1 expression in rotenone model of Parkinson\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2025.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}