{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T06:27:24Z","timestamp":1793600844424,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["HYDSYTB202301"],"award-info":[{"award-number":["HYDSYTB202301"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010722","name":"Harbin Medical University","doi-asserted-by":"publisher","award":["HYDSYXKJC202402\\u20132"],"award-info":[{"award-number":["HYDSYXKJC202402\\u20132"]}],"id":[{"id":"10.13039\/100010722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.neuro.2026.103432","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:24:14Z","timestamp":1773825854000},"page":"103432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Nociceptive stimulation activates NR2B-mediated DISC1\/GSK-3\u03b2 and ERK\/CREB signaling alleviates sevoflurane induced neurotoxicity in neonatal rats"],"prefix":"10.1016","volume":"114","author":[{"given":"Ting-Ting","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Wen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Qing","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Qiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan-Feng","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Hua","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Jun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Ren","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.neuro.2026.103432_bib1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/00000542-200408000-00033","article-title":"Anesthetic agents and the immature brain: are these toxic or therapeutic?","volume":"101","author":"Anand","year":"2004","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.neuro.2026.103432_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpa.2022.11.003","article-title":"Introduction and history of anaesthesia-induced neurotoxicity and overview of animal models","volume":"37","author":"Bleeser","year":"2023","journal-title":"Best. Pr. Res Clin. Anaesthesiol."},{"issue":"6","key":"10.1016\/j.neuro.2026.103432_bib3","first-page":"Cd006837","article-title":"High initial concentration versus low initial concentration sevoflurane for inhalational induction of anaesthesia","volume":"2016","author":"Boonmak","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"issue":"8","key":"10.1016\/j.neuro.2026.103432_bib4","article-title":"Early cognitive function after deep sedation using different anesthetic agents in pediatric patients: a prospective, randomized controlled trial","volume":"60","author":"Chae","year":"2024","journal-title":"Med. (Kaunas. )"},{"key":"10.1016\/j.neuro.2026.103432_bib5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neuroscience.2023.03.019","article-title":"Preoperative pain facilitates postoperative cognitive dysfunction via periaqueductal gray matter-dorsal raphe circuit","volume":"524","author":"Deng","year":"2023","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.neuro.2026.103432_bib6","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0896-6273(00)80602-9","article-title":"Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation","volume":"21","author":"Impey","year":"1998","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.neuro.2026.103432_bib7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0896-6273(00)80747-3","article-title":"Making new connections: role of ERK\/MAP kinase signaling in neuronal plasticity","volume":"23","author":"Impey","year":"1999","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.neuro.2026.103432_bib8","first-page":"669","article-title":"Synergistic antinociceptive effects of N-methyl-D-aspartate receptor antagonist and electroacupuncture in the complete Freund's adjuvant-induced pain model","volume":"28","author":"Jang","year":"2011","journal-title":"Int J. Mol. Med"},{"key":"10.1016\/j.neuro.2026.103432_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114062","article-title":"Down-regulation of NR2B receptors contributes to the analgesic and antianxiety effects of enriched environment mediated by endocannabinoid system in the inflammatory pain mice","volume":"435","author":"Jiang","year":"2022","journal-title":"Behav. Brain Res"},{"issue":"5","key":"10.1016\/j.neuro.2026.103432_bib10","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1007\/s43440-023-00526-9","article-title":"Therapeutic implications of phosphorylation- and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration","volume":"75","author":"Khakha","year":"2023","journal-title":"Pharm. Rep."},{"issue":"1-3","key":"10.1016\/j.neuro.2026.103432_bib11","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.ejphar.2013.07.039","article-title":"Mechanism underlying anti-hyperalgesic and anti-allodynic properties of anomalin in both acute and chronic inflammatory pain models in mice through inhibition of NF-\u03baB, MAPKs and CREB signaling cascades","volume":"718","author":"Khan","year":"2013","journal-title":"Eur. J. Pharm."},{"issue":"3","key":"10.1016\/j.neuro.2026.103432_bib12","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jep.2014.01.028","article-title":"Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model","volume":"152","author":"Khan","year":"2014","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.neuro.2026.103432_bib13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s11064-024-04252-3","article-title":"Neuroprotective effects of STAT3 inhibitor on hydrogen peroxide-induced neuronal cell death via the ERK\/CREB signaling pathway","volume":"50","author":"Kim","year":"2024","journal-title":"Neurochem. Res"},{"issue":"3","key":"10.1016\/j.neuro.2026.103432_bib14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.21307\/ane-2021-025","article-title":"Role of NR2B\/ERK signaling in the neuroprotective effect of dexmedetomidine against sevoflurane induced neurological dysfunction in the developing rat brain","volume":"81","author":"Li","year":"2021","journal-title":"Acta Neurobiol. Exp. (Wars. )"},{"issue":"2","key":"10.1016\/j.neuro.2026.103432_bib15","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1159\/000485008","article-title":"Roscovitine, a CDK5 inhibitor, alleviates sevoflurane-induced cognitive dysfunction via regulation Tau\/GSK3\u03b2 and ERK\/PPAR\u03b3\/CREB signaling","volume":"44","author":"Liu","year":"2017","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.neuro.2026.103432_bib16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.freeradbiomed.2022.01.031","article-title":"Sevoflurane induced neurotoxicity in neonatal mice links to a GSK3\u03b2\/Drp1-dependent mitochondrial fission and apoptosis","volume":"181","author":"Liu","year":"2022","journal-title":"Free Radic. Biol. Med"},{"issue":"1","key":"10.1016\/j.neuro.2026.103432_bib17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/ALN.0b013e31825ae693","article-title":"Noxious stimulation attenuates ketamine-induced neuroapoptosis in the developing rat brain","volume":"117","author":"Liu","year":"2012","journal-title":"Anesthesiology"},{"issue":"1","key":"10.1016\/j.neuro.2026.103432_bib18","doi-asserted-by":"crossref","first-page":"i3","DOI":"10.1093\/bja\/aet057","article-title":"Role of glycogen synthase kinase-3beta in ketamine-induced developmental neuroapoptosis in rats","volume":"110","author":"Liu","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.neuro.2026.103432_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1342233","article-title":"Ketamine modulates disrupted in schizophrenia-1\/glycogen synthase kinase-3\u03b2 interaction","volume":"17","author":"Liu","year":"2024","journal-title":"Front Mol. Neurosci."},{"issue":"9","key":"10.1016\/j.neuro.2026.103432_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.1023","article-title":"The effect of TEMPOL pretreatment on postoperative cognitive function, inflammatory response, and oxidative stress in aged rats under sevoflurane anesthesia","volume":"11","author":"Liu","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.neuro.2026.103432_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107689","article-title":"The ERK\/CREB\/PTN\/syndecan-3 pathway involves in heparin-mediated neuro-protection and neuro-regeneration against cerebral ischemia-reperfusion injury following cardiac arrest","volume":"98","author":"Liu","year":"2021","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.neuro.2026.103432_bib22","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.biopha.2016.01.034","article-title":"Neuronal apoptosis may not contribute to the long-term cognitive dysfunction induced by a brief exposure to 2% sevoflurane in developing rats","volume":"78","author":"Lu","year":"2016","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.neuro.2026.103432_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114804","article-title":"Sevoflurane causes neurotoxicity and cognitive impairment by regulating Hippo signaling pathway-mediated ferroptosis via upregulating PRKCD","volume":"377","author":"Lv","year":"2024","journal-title":"Exp. Neurol."},{"issue":"6","key":"10.1016\/j.neuro.2026.103432_bib24","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.cell.2008.12.044","article-title":"Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta\/beta-catenin signaling","volume":"136","author":"Mao","year":"2009","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.neuro.2026.103432_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1742-4658.2009.07369.x","article-title":"ERK and cell death: cadmium toxicity, sustained ERK activation and cell death","volume":"277","author":"Martin","year":"2010","journal-title":"Febs J."},{"key":"10.1016\/j.neuro.2026.103432_bib26","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.2147\/JPR.S367982","article-title":"Role of N-methyl-D-aspartate receptor NR2B Subunit in inflammatory arthritis-induced chronic pain and peripheral sensitized neuropathic pain: a systematic review","volume":"15","author":"Meng","year":"2022","journal-title":"J. Pain. Res"},{"issue":"9","key":"10.1016\/j.neuro.2026.103432_bib27","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1073\/pnas.91.9.3954","article-title":"The major tyrosine-phosphorylated protein in the postsynaptic density fraction is N-methyl-D-aspartate receptor subunit 2B","volume":"91","author":"Moon","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.neuro.2026.103432_bib28","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1471-4159.2011.07282.x","article-title":"NMDA receptor regulates migration of newly generated neurons in the adult hippocampus via disrupted-in-schizophrenia 1 (DISC1)","volume":"118","author":"Namba","year":"2011","journal-title":"J. Neurochem."},{"issue":"5","key":"10.1016\/j.neuro.2026.103432_bib29","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/1073858412470168","article-title":"DISC1: a key lead in studying cortical development and associated brain disorders","volume":"19","author":"Narayan","year":"2013","journal-title":"Neuroscientist"},{"issue":"12","key":"10.1016\/j.neuro.2026.103432_bib30","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1001\/archpsyc.1995.03950240016004","article-title":"Farber NB. Glutamate receptor dysfunction and schizophrenia","volume":"52","author":"Olney","year":"1995","journal-title":"Arch. Gen. Psychiatry"},{"issue":"5","key":"10.1016\/j.neuro.2026.103432_bib31","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1097\/ALN.0b013e3181d692c2","article-title":"Implicit memory formation during routine anesthesia in children: a double-masked randomized controlled trial","volume":"112","author":"Pham","year":"2010","journal-title":"Anesthesiology"},{"issue":"14","key":"10.1016\/j.neuro.2026.103432_bib32","doi-asserted-by":"crossref","first-page":"5795","DOI":"10.1073\/pnas.1012621108","article-title":"Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner","volume":"108","author":"Ramsey","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"21","key":"10.1016\/j.neuro.2026.103432_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399404008385","article-title":"Lithium neuroprotection: molecular mechanisms and clinical implications","volume":"6","author":"Rowe","year":"2004","journal-title":"Expert Rev. Mol. Med"},{"issue":"7","key":"10.1016\/j.neuro.2026.103432_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/mtomcs\/mfae031","article-title":"Enhanced axon guidance and synaptic markers in rat brains using ferric-tannic nanoparticles","volume":"16","author":"Sanit","year":"2024","journal-title":"Metallomics"},{"issue":"1633","key":"10.1016\/j.neuro.2026.103432_bib35","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0163","article-title":"GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity","volume":"369","author":"Shipton","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.neuro.2026.103432_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102231","article-title":"Lithium and disease modification: a systematic review and meta-analysis in Alzheimer's and Parkinson's disease","volume":"95","author":"Singulani","year":"2024","journal-title":"Ageing Res Rev."},{"issue":"18","key":"10.1016\/j.neuro.2026.103432_bib37","doi-asserted-by":"crossref","first-page":"6800","DOI":"10.1523\/JNEUROSCI.5616-10.2011","article-title":"PSD-95 and PSD-93 play critical but distinct roles in synaptic scaling up and down","volume":"31","author":"Sun","year":"2011","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.neuro.2026.103432_bib38","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.conb.2004.04.001","article-title":"Mitogen-activated protein kinases in synaptic plasticity and memory","volume":"14","author":"Sweatt","year":"2004","journal-title":"Curr. Opin. Neurobiol."},{"issue":"3","key":"10.1016\/j.neuro.2026.103432_bib39","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00109-023-02285-9","article-title":"Inhibition of ERK\/CREB signaling contributes to postoperative learning and memory dysfunction in neonatal rats","volume":"101","author":"Wang","year":"2023","journal-title":"J. Mol. Med (Berl. )"},{"issue":"3","key":"10.1016\/j.neuro.2026.103432_bib40","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0092-8674(85)80082-9","article-title":"Identification and localization of synaptophysin, an integral membrane glycoprotein of Mr 38,000 characteristic of presynaptic vesicles","volume":"41","author":"Wiedenmann","year":"1985","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.neuro.2026.103432_bib41","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.gene.2013.01.015","article-title":"DISC1-related signaling pathways in adult neurogenesis of the hippocampus","volume":"518","author":"Wu","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.neuro.2026.103432_bib42","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.brainresbull.2020.08.003","article-title":"Research progress and treatment strategies for anesthetic neurotoxicity","volume":"164","author":"Yang","year":"2020","journal-title":"Brain Res Bull."},{"key":"10.1016\/j.neuro.2026.103432_bib43","article-title":"Dexmedetomidine alleviates the long-term neurodevelopmental toxicity induced by sevoflurane in the developing brain","volume":"1","author":"Yang","year":"2024","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.neuro.2026.103432_bib44","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.toxlet.2025.02.012","article-title":"Lithium attenuates ketamine-induced long-term neurotoxicity through DISC1-mediated GSK-3\u03b2\/\u03b2-catenin and ERK\/CREB pathways","volume":"406","author":"Yang","year":"2025","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.neuro.2026.103432_bib45","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jad.2022.05.115","article-title":"Prolonged sevoflurane exposure causes abnormal synapse development and dysregulates beta-neurexin and neuroligins in the hippocampus in neonatal rats","volume":"312","author":"Zhang","year":"2022","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.neuro.2026.103432_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1156674","article-title":"Mechanism of ERK\/CREB pathway in pain and analgesia","volume":"16","author":"Zhen","year":"2023","journal-title":"Front Mol. Neurosci."},{"issue":"5","key":"10.1016\/j.neuro.2026.103432_bib47","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/1073858410386384","article-title":"MAGUKs, synaptic development, and synaptic plasticity","volume":"17","author":"Zheng","year":"2011","journal-title":"Neuroscientist"},{"issue":"8","key":"10.1016\/j.neuro.2026.103432_bib48","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1007\/s11064-016-1909-x","article-title":"Lithium treatment prevents apoptosis in neonatal rat hippocampus resulting from sevoflurane exposure","volume":"41","author":"Zhou","year":"2016","journal-title":"Neurochem. Res"},{"issue":"1","key":"10.1016\/j.neuro.2026.103432_bib49","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3892\/mmr.2016.5336","article-title":"Subclinical concentrations of sevoflurane reduce oxidative stress but do not prevent hippocampal apoptosis","volume":"14","author":"Zhou","year":"2016","journal-title":"Mol. Med Rep."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X26000537?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X26000537?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T05:37:23Z","timestamp":1793597843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X26000537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":49,"alternative-id":["S0161813X26000537"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2026.103432","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nociceptive stimulation activates NR2B-mediated DISC1\/GSK-3\u03b2 and ERK\/CREB signaling alleviates sevoflurane induced neurotoxicity in neonatal rats","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2026.103432","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103432"}}