{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T06:27:58Z","timestamp":1793600878223,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.neuro.2026.103457","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T15:41:45Z","timestamp":1776440505000},"page":"103457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["A single nucleotide polymorphism that affects oligodendroglial lineage cells may augment the consequences of neurotoxicants"],"prefix":"10.1016","volume":"114","author":[{"given":"Ronald D.","family":"Poretz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2026.103457_bib1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1212\/WNL.0000000000208000","article-title":"What Are the Roles of Oligodendrocyte Precursor Cells in Normal and Pathologic Conditions?","volume":"101","author":"Benarroch","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.neuro.2026.103457_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0165-3806(02)00512-6","article-title":"Protein kinase C inhibitors counteract the ethanol effects on myelin basic protein expression in differentiating CG-4 oligodendrocytes","volume":"139","author":"Bichenkov","year":"2002","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.neuro.2026.103457_bib3","doi-asserted-by":"crossref","first-page":"eaba6905","DOI":"10.1126\/science.aba6905","article-title":"Myelin: A gatekeeper of activity-dependent circuit plasticity?","volume":"374","author":"Bonetto","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.neuro.2026.103457_bib4","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.neuro.2009.07.007","article-title":"Altered myelination and axonal integrity in adults with childhood lead exposure:A diffusion tensor imaging study","volume":"30","author":"Brubaker","year":"2009","journal-title":"NeuroToxicology"},{"key":"10.1016\/j.neuro.2026.103457_bib5","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1289\/ehp.1002176","article-title":"Proton magnetic resonance spectroscopy in adults with childhood lead exposure","volume":"119","author":"Cecil","year":"2011","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.neuro.2026.103457_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0300-483X(01)00387-0","article-title":"Lead causes human fibroblasts to mis-sort arylsulfatase A","volume":"163","author":"Chen","year":"2001","journal-title":"Toxicology"},{"key":"10.1016\/j.neuro.2026.103457_bib7","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/s41593-024-01599-2","article-title":"Pervasive environmental chemicals impair oligodendrocyte development","volume":"27","author":"Cohn","year":"2024","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.neuro.2026.103457_bib8","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/taap.2001.9142","article-title":"Lead exposure affects levels of galactolipid metabolic enzymes in the developing rat brain","volume":"172","author":"Deng","year":"2001","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.neuro.2026.103457_bib9","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0161-813X(02)00196-1","article-title":"Oligodendroglia in developmental neurotoxicity","volume":"24","author":"Deng","year":"2003","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2026.103457_bib10","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1002\/glia.24423","article-title":"Adult-onset depletion of sulfatide leads to axonal degeneration with relative myelin sparing","volume":"71","author":"Dustin","year":"2023","journal-title":"Glia"},{"key":"10.1016\/j.neuro.2026.103457_bib11","series-title":"GeneReviews\u00ae [Internet]","first-page":"1993","article-title":"Arylsulfatase A Deficiency","author":"Gomez-Ospina","year":"2006"},{"key":"10.1016\/j.neuro.2026.103457_bib12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/glia.10327","article-title":"Sulfatide Is a Negative Regulator of Oligodendrocyte Differentiation: Development in Sulfatide-Null Mice","volume":"45","author":"Hiraha","year":"2004","journal-title":"Glia"},{"key":"10.1016\/j.neuro.2026.103457_bib13","article-title":"Lead (Pb) exposure results in cell type specific changes in the mouse retina and optic nerve","author":"Khandokar","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.neuro.2026.103457_bib14","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1056\/NEJMra2402527","article-title":"Lead Poisoning","volume":"391","author":"Lanphear","year":"2024","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.neuro.2026.103457_bib15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/toxsci\/kfae100","article-title":"Demyelination and impaired oligodendrogenesis in the corpus callosum following lead exposure","volume":"202","author":"Liu","year":"2024","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.neuro.2026.103457_bib16","doi-asserted-by":"crossref","first-page":"651418","DOI":"10.3389\/fphar.2021.651418","article-title":"Expression of Oligodendrocyte and Oligoprogenitor Cell Proteins in Frontal Cortical White and GrayMatter: Impact of Adolescent Development and Ethanol Exposure","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Pharm."},{"key":"10.1016\/j.neuro.2026.103457_bib17","doi-asserted-by":"crossref","first-page":"19096","DOI":"10.3390\/ijms160819096","article-title":"Lead poisoning disturbs oligodendrocytes differentiation involved in decreased expression of NCX3 inducing intracellular calcium overload","volume":"16","author":"Ma","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuro.2026.103457_bib18","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/jcpp.14072","article-title":"Contribution of childhood lead exposure to psychopathology in the US population over the past 75 years","volume":"66","author":"McFarland","year":"2025","journal-title":"J. Child Psychol. Psychiat"},{"key":"10.1016\/j.neuro.2026.103457_bib19","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1126\/science.1254960","article-title":"Motor skill learning requires active central myelination","volume":"346","author":"McKenzie","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.neuro.2026.103457_bib20","first-page":"368","article-title":"Myelin is repaired by constitutive differentiation of oligodendrocyte progenitors","volume":"22","author":"Miranova","year":"2026","journal-title":"Science"},{"key":"10.1016\/j.neuro.2026.103457_bib21","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11065-007-9038-6","article-title":"Alcohol: Effects on Neurobehavioral Functions and the Brain","volume":"17","author":"Oscar-Berman","year":"2007","journal-title":"Neuropsychol. Rev."},{"key":"10.1016\/j.neuro.2026.103457_bib22","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1530-0277.1996.tb01634.x","article-title":"Association of alcoholism with the N-glycosylation polymorphism of pseudodeficient human arylsulfatase A","volume":"20","author":"Park","year":"1996","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.neuro.2026.103457_bib23","first-page":"379","article-title":"The interaction of lead exposure and arylsulfatase A genotype affects sulfatide catabolism in human fibroblasts","volume":"21","author":"Poretz","year":"2000","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.neuro.2026.103457_bib24","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.celrep.2016.12.053","article-title":"Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin","volume":"18","author":"Snaidero","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.neuro.2026.103457_bib25","unstructured":"Rees, N., Fuller R., The Toxic Truth: Children\u2019s Exposure to Lead Pollution Undermines a Generation of Future Potential. \u3008https:\/\/www.unicef.org\/reports\/toxic-truth childrens-exposure-to-lead-pollution-2020\u3009 [accessed May 9, 2025]."},{"key":"10.1016\/j.neuro.2026.103457_bib26","unstructured":"Substance Abuse and Mental Health Services Administration. (2025). Key substance use and mental health indicators in the United States: Results from the 2024 National Survey on Drug Use and Health (HHS Publication No. PEP25-07-007, NSDUH Series H-60). Center for Behavioral Health Statistics and Quality, Substance Abuse and Mental Health Services Administration."},{"key":"10.1016\/j.neuro.2026.103457_bib27","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1038\/s42003-021-02435-0","article-title":"Lead exposure is associated with functional and microstructural changes in the healthy human brain","volume":"4","author":"Takeuchi","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.neuro.2026.103457_bib28","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.tins.2023.04.003","article-title":"2023. Pathological potential of oligodendrocyte precursor cells: terra incognita","volume":"46","author":"Yi","year":"2023","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.neuro.2026.103457_bib29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.35946\/arcr.v38.2.04","article-title":"Alcohol\u2019s Effects on the Brain: Neuroimaging Results in Humans and Animal Models","volume":"38","author":"Zahr","year":"2017","journal-title":"Alcohol Res"}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X26000781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X26000781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T05:43:33Z","timestamp":1793598213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X26000781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":29,"alternative-id":["S0161813X26000781"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2026.103457","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A single nucleotide polymorphism that affects oligodendroglial lineage cells may augment the consequences of neurotoxicants","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2026.103457","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103457"}}