{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:09:24Z","timestamp":1789016964791,"version":"build-2803163510"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.neuro.2026.103527","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:41:44Z","timestamp":1785307304000},"page":"103527","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Gestational NO\u2082 exposure induces anxiety\u2010 and depression-like behaviors in mice via hippocampal PTGDS-PGD2 activation and tryptophan metabolism reprogramming"],"prefix":"10.1016","volume":"116","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sixuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuzi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruicheng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenchen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2026.103527_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2019.105448","article-title":"Air pollution is associated with depressive symptoms in elderly women with cognitive impairment","volume":"136","author":"Altu\u011f","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.neuro.2026.103527_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2025.127062","article-title":"Associations of ambient particulate matter and nitrogen dioxide with hospital admissions for Parkinson's disease: A nationwide case-crossover study in China","volume":"385","author":"Bai","year":"2025","journal-title":"Environ. Pollut. (Barking Essex 1987)"},{"issue":"2","key":"10.1016\/j.neuro.2026.103527_bib3","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neuron.2020.06.002","article-title":"The bidirectional relationship of depression and inflammation: double trouble","volume":"107","author":"Beurel","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.neuro.2026.103527_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2026.128461","article-title":"Machine-learning-based estimation of ground-level NO2 concentrations across Southeastern Europe using multi-source satellite, reanalysis, and emission data","volume":"403","author":"Bilgi\u00e7","year":"2026","journal-title":"Environ. Pollut."},{"issue":"14","key":"10.1016\/j.neuro.2026.103527_bib5","doi-asserted-by":"crossref","first-page":"6949","DOI":"10.1021\/acs.est.4c10981","article-title":"The associations of short-term ambient nitrogen dioxide pollution with major cause-specific morbidities and the modifying effects by ambient temperature: a nationwide case-crossover study","volume":"59","author":"Chen","year":"2025","journal-title":"Environ. Sci. & Technol."},{"key":"10.1016\/j.neuro.2026.103527_bib6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.bbi.2022.10.022","article-title":"Minocycline, a classic antibiotic, exerts psychotropic effects by normalizing microglial neuroinflammation-evoked tryptophan-kynurenine pathway dysregulation in chronically stressed male mice","volume":"107","author":"Cheng","year":"2023","journal-title":"Brain Behav. Immun."},{"issue":"6276","key":"10.1016\/j.neuro.2026.103527_bib7","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1126\/science.aad0314","article-title":"The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring","volume":"351","author":"Choi","year":"2016","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.neuro.2026.103527_bib8","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jaac.2020.07.895","article-title":"Associations of childhood and adolescent depression with adult psychiatric and functional outcomes","volume":"60","author":"Copeland","year":"2021","journal-title":"J. Am. Acad. Child. Adolesc. Psychiatry"},{"issue":"1","key":"10.1016\/j.neuro.2026.103527_bib9","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s12974-018-1305-3","article-title":"Prostaglandin D2\/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets","volume":"15","author":"Corwin","year":"2018","journal-title":"J. Neuroinflamm."},{"issue":"12","key":"10.1016\/j.neuro.2026.103527_bib10","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1429-24.2025","article-title":"From circuits to lifespan: translating mouse and human timelines with neuroimaging-based tractography","volume":"45","author":"Cottam","year":"2025","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.neuro.2026.103527_bib11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.tips.2008.05.004","article-title":"Serotonin and depression: pathophysiological mechanism or marketing myth?","volume":"29","author":"Cowen","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.neuro.2026.103527_bib12","author":"Cs\u00e1rdi","year":"2006","journal-title":"igraph Softw. Package Complex. Netw. Res."},{"issue":"1","key":"10.1016\/j.neuro.2026.103527_bib13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000484238","article-title":"Effects of early-life adversity on hippocampal structures and associated HPA Axis functions","volume":"40","author":"Dahmen","year":"2017","journal-title":"Dev. Neurosci."},{"issue":"1","key":"10.1016\/j.neuro.2026.103527_bib14","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-022-02400-6","article-title":"Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1\/Nrf2\/HO-1\/Gpx4 pathway","volume":"19","author":"Dang","year":"2022","journal-title":"J. Neuroinflamm."},{"issue":"3","key":"10.1016\/j.neuro.2026.103527_bib15","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.psyneuen.2010.09.012","article-title":"Inflammation-associated depression: from serotonin to kynurenine","volume":"36","author":"Dantzer","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.neuro.2026.103527_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111487","article-title":"Effects of air pollution on health: A mapping review of systematic reviews and meta-analyses","volume":"201","author":"Dominski","year":"2021","journal-title":"Environ. Res."},{"key":"10.1016\/j.neuro.2026.103527_bib17","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3389\/fped.2017.00202","article-title":"Prenatal Maternal Stress and the Risk of Asthma in Children","volume":"5","author":"Douros","year":"2017","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.neuro.2026.103527_bib18","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ecoenv.2018.10.090","article-title":"Exposure to nanoscale diesel exhaust particles: Oxidative stress, neuroinflammation, anxiety and depression on adult male mice","volume":"168","author":"Ehsanifar","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.neuro.2026.103527_bib19","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s13148-016-0296-0","article-title":"Assessment of global DNA methylation in the first trimester fetal tissues exposed to maternal cigarette smoking","volume":"8","author":"Fa","year":"2016","journal-title":"Clin. Epigenetics"},{"key":"10.1016\/j.neuro.2026.103527_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175966","article-title":"The key roles of reactive oxygen species in microglial inflammatory activation: Regulation by endogenous antioxidant system and exogenous sulfur-containing compounds","volume":"956","author":"Fan","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.neuro.2026.103527_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134721","article-title":"Ambient air pollution and depression: A systematic review with meta-analysis up to 2019","volume":"701","author":"Fan","year":"2020","journal-title":"Sci. Total. Environ."},{"issue":"10132","key":"10.1016\/j.neuro.2026.103527_bib22","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/S0140-6736(18)30312-X","article-title":"Origins of lifetime health around the time of conception: causes and consequences","volume":"391","author":"Fleming","year":"2018","journal-title":"Lancet (Lond. Engl. )"},{"issue":"4","key":"10.1016\/j.neuro.2026.103527_bib23","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/nar\/gkq890","article-title":"Redundant or separate entities?\u2014roles of Twist1 and Twist2 as molecular switches during gene transcription","volume":"39","author":"Franco","year":"2011","journal-title":"Nucleic Acids Res."},{"issue":"13","key":"10.1016\/j.neuro.2026.103527_bib24","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jpsychires.2010.01.006","article-title":"Interaction of childhood stress with hippocampus and prefrontal cortex volume reduction in major depression","volume":"44","author":"Frodl","year":"2010","journal-title":"J. Psychiatr. Res."},{"issue":"9","key":"10.1016\/j.neuro.2026.103527_bib25","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/intimm\/dxz023","article-title":"Roles of multiple lipid mediators in stress and depression","volume":"31","author":"Furuyashiki","year":"2019","journal-title":"Int. Immunol."},{"issue":"2","key":"10.1016\/j.neuro.2026.103527_bib26","doi-asserted-by":"crossref","first-page":"118","DOI":"10.2174\/1871527320666210208130412","article-title":"Arachidonic Acid Derivatives and Neuroinflammation","volume":"21","author":"Gorica","year":"2022","journal-title":"CNS & Neurol. Disord. Drug. Targets"},{"key":"10.1016\/j.neuro.2026.103527_bib27","article-title":"TROPOMI CO and NO2 as Observational Constraints on the Sources of Air Pollution Inequalities in US Cities","author":"Guo","year":"2026","journal-title":"Environ. Sci. & Technol."},{"issue":"9","key":"10.1016\/j.neuro.2026.103527_bib28","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1038\/s41380-025-03044-7","article-title":"Implications of neurogenesis in depression through BDNF: rodent models, regulatory pathways, gut microbiota, and potential therapy","volume":"30","author":"Han","year":"2025","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.neuro.2026.103527_bib29","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1152\/physrev.00029.2013","article-title":"Early developmental conditioning of later health and disease: physiology or pathophysiology?","volume":"94","author":"Hanson","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuro.2026.103527_bib30","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jad.2020.03.131","article-title":"Major depression accompanied with inflammation and multiple cytokines alterations: Evidences from clinical patients to Macaca fascicularis and LPS-induced depressive mice model","volume":"271","author":"He","year":"2020","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neuro.2026.103527_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105998","article-title":"Long-term exposure to NO(2) and O(3) and all-cause and respiratory mortality: A systematic review and meta-analysis","volume":"144","author":"Huangfu","year":"2020","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.neuro.2026.103527_bib32","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s12974-021-02361-2","article-title":"A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD(2)-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus","volume":"18","author":"Iwasa","year":"2021","journal-title":"J. Neuroinflamm."},{"issue":"11","key":"10.1016\/j.neuro.2026.103527_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113695","article-title":"Prenatal Programming of Neuroendocrine System Development by Lipopolysaccharide: Long-Term Effects","volume":"19","author":"Izvolskaia","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.neuro.2026.103527_bib34","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fncel.2020.00011","article-title":"Indoleamine-2,3-Dioxygenase Mediates Emotional Deficits by the Kynurenine\/Tryptophan Pathway in the Ethanol Addiction\/Withdrawal Mouse Model","volume":"14","author":"Jiang","year":"2020","journal-title":"Front. Cell. Neurosci."},{"issue":"4","key":"10.1016\/j.neuro.2026.103527_bib35","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/mp.2016.120","article-title":"HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition","volume":"22","author":"Keller","year":"2016","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuro.2026.103527_bib36","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tox.2017.08.010","article-title":"Gender-specific association of exposure to non-dioxin-like polychlorinated biphenyls during pregnancy with methylation levels of H19 and long interspersed nuclear element-1 in cord blood in the Hokkaido study [Article]","volume":"390","author":"Kobayashi","year":"2017","journal-title":"Toxicology"},{"issue":"9820","key":"10.1016\/j.neuro.2026.103527_bib37","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/S0140-6736(11)60602-8","article-title":"Major depressive disorder: new clinical, neurobiological, and treatment perspectives","volume":"379","author":"Kupfer","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.neuro.2026.103527_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124801","article-title":"Association of phenol exposure during pregnancy and asthma development in children: The Japan Environment and Children's study","volume":"361","author":"Kuraoka","year":"2024","journal-title":"Environ. Pollut."},{"issue":"5","key":"10.1016\/j.neuro.2026.103527_bib39","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1210\/jc.2013-1016","article-title":"Gender Difference in the Relationship between Passive Smoking Exposure and HDL-Cholesterol Levels in Late Adolescence","volume":"98","author":"Le-Ha","year":"2013","journal-title":"J. Clin. Endocrinol. & Metab."},{"issue":"3","key":"10.1016\/j.neuro.2026.103527_bib40","first-page":"306","article-title":"A starring role for microglia in brain sex differences","volume":"21","author":"Lenz","year":"2014","journal-title":"Neurosci. a Rev. J. Bringing Neurobiol. Neurol. Psychiatry"},{"key":"10.1016\/j.neuro.2026.103527_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.118385","article-title":"Single-cell RNA sequencing identifies cellular heterogeneity in endothelial and epithelial cells associated with nitrogen dioxide-induced acute lung injury","volume":"299","author":"Li","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"16","key":"10.1016\/j.neuro.2026.103527_bib42","doi-asserted-by":"crossref","first-page":"11536","DOI":"10.1021\/acs.est.2c03037","article-title":"New Insights into Prenatal NO2 Exposure and Behavioral Abnormalities in Male Offspring: Disturbed Serotonin Metabolism and Delayed Oligodendrocyte Development","volume":"56","author":"Li","year":"2022","journal-title":"Environ. Sci. & Technol."},{"issue":"16","key":"10.1016\/j.neuro.2026.103527_bib43","doi-asserted-by":"crossref","first-page":"11536","DOI":"10.1021\/acs.est.2c03037","article-title":"New Insights into Prenatal NO2 Exposure and Behavioral Abnormalities in Male Offspring: Disturbed Serotonin Metabolism and Delayed Oligodendrocyte Development","volume":"56","author":"Li","year":"2022","journal-title":"Environ. Sci. & Technol."},{"key":"10.1016\/j.neuro.2026.103527_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2026.128062","article-title":"Nanoplastics exacerbated renal injury amid hypertension: Rethinking health hazards in disease and implication of renal senescence and EMT associated with Sirt1 downregulation","volume":"398","author":"Liu","year":"2026","journal-title":"Environ. Pollut. (Barking Essex 1987)"},{"issue":"17","key":"10.1016\/j.neuro.2026.103527_bib45","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.3390\/healthcare12171721","article-title":"Estimation of the Global Disease Burden of Depression and Anxiety between 1990 and 2044: An Analysis of the Global Burden of Disease Study 2019 [Article]","volume":"12","author":"Liu","year":"2024","journal-title":"Healthcare"},{"key":"10.1016\/j.neuro.2026.103527_bib46","article-title":"The efficacy and safety of complementary and alternative medicine for depression: an umbrella review","volume":"46","author":"Liu","year":"2024","journal-title":"Braz. J. Psychiatry"},{"key":"10.1016\/j.neuro.2026.103527_bib47","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jad.2016.11.039","article-title":"Biological mechanisms of depression following treatment with interferon for chronic hepatitis C: A critical systematic review","volume":"209","author":"Machado","year":"2017","journal-title":"J. Affect. Disord."},{"issue":"10161","key":"10.1016\/j.neuro.2026.103527_bib48","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.neuro.2026.103527_bib49","doi-asserted-by":"crossref","DOI":"10.1152\/physrev.00010.2007","article-title":"Estradiol and the developing brain","volume":"88","author":"McCarthy","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.neuro.2026.103527_bib50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jad.2013.10.043","article-title":"Treatment-resistant depression: definitions, review of the evidence, and algorithmic approach","volume":"156","author":"McIntyre","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.neuro.2026.103527_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.105109","article-title":"Prenatal and childhood stress exposure and the sex specific response to psychosocial stress in adulthood","volume":"125","author":"McLaughlin","year":"2021","journal-title":"Psychoneuroendocrinology"},{"issue":"16","key":"10.1016\/j.neuro.2026.103527_bib52","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1523\/JNEUROSCI.4531-05.2006","article-title":"Prostaglandin D2-mediated microglia\/astrocyte interaction enhances astrogliosis and demyelination in twitcher","volume":"26","author":"Mohri","year":"2006","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.neuro.2026.103527_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2022.173372","article-title":"Transmission of the adverse consequences of childhood maltreatment across generations: Focus on gestational biology","volume":"215","author":"Moog","year":"2022","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.neuro.2026.103527_bib54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","article-title":"Neurobiology of Depression","volume":"34","author":"Nestler","year":"2002","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.neuro.2026.103527_bib55","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.12169","article-title":"Air and Noise Pollution Exposure in Early Life and Mental Health From Adolescence to Young Adulthood","volume":"7","author":"Newbury","year":"2024","journal-title":"Jama Netw. Open."},{"issue":"4","key":"10.1016\/j.neuro.2026.103527_bib56","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0006-3223(88)90283-1","article-title":"Increased level of salivary prostaglandins in patients with major depression","volume":"23","author":"Ohishi","year":"1988","journal-title":"Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.neuro.2026.103527_bib57","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1038\/s41380-025-02953-x","article-title":"Large-scale plasma proteomics uncovers novel targets linking ambient air pollution and depression","volume":"30","author":"Pan","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.neuro.2026.103527_bib58","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.neubiorev.2021.05.005","article-title":"Anxiety and Alzheimer's disease: Behavioral analysis and neural basis in rodent models of Alzheimer's-related neuropathology","volume":"127","author":"Pentkowski","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.neuro.2026.103527_bib59","article-title":"Health risk evaluation of nitrogen oxides. Epidemiologic studies [; Review]","volume":"19","author":"Pershagen","year":"1993","journal-title":"Scand. J. Work. Environ. & Health"},{"key":"10.1016\/j.neuro.2026.103527_bib60","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.bbi.2024.07.020","article-title":"Maternal high-fat diet-induced microbiota changes are associated with alterations in embryonic brain metabolites and adolescent behaviour","volume":"121","author":"Ratsika","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.neuro.2026.103527_bib61","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.anbehav.2018.01.018","article-title":"Testing experience and environmental enrichment potentiated open-field habituation and grooming behaviour in rats","volume":"137","author":"Rojas-Carvajal","year":"2018","journal-title":"Anim. Behav."},{"issue":"1","key":"10.1016\/j.neuro.2026.103527_bib62","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2014.06.008","article-title":"Sublime microglia: expanding roles for the guardians of the CNS","volume":"158","author":"Salter","year":"2014","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.neuro.2026.103527_bib63","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0060316","article-title":"Twist-2 Controls Myeloid Lineage Development and Function","volume":"6","author":"Sharabi","year":"2008","journal-title":"PLOS Biol."},{"issue":"1","key":"10.1016\/j.neuro.2026.103527_bib64","doi-asserted-by":"crossref","first-page":"6754","DOI":"10.1038\/s41467-021-27049-2","article-title":"A national cohort study (2000-2018) of long-term air pollution exposure and incident dementia in older adults in the United States","volume":"12","author":"Shi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.neuro.2026.103527_bib65","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neubiorev.2020.01.034","article-title":"Revisiting the validity of the mouse tail suspension test: Systematic review and meta-analysis of the effects of prototypic antidepressants","volume":"112","author":"Stukalin","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"4","key":"10.1016\/j.neuro.2026.103527_bib66","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s00204-025-04289-5","article-title":"Chronic melamine cyanurate exposure impairs spatial learning and memory by altering autophagy-mediated synaptic plasticity and oxidative stress in the hippocampus of adolescent rats","volume":"100","author":"Sun","year":"2026","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.neuro.2026.103527_bib67","author":"US.EPA","year":"2026","journal-title":"Prim. Natl. Ambient. Air Qual. Stand. (NAAQS) Nitrogen. Dioxide"},{"key":"10.1016\/j.neuro.2026.103527_bib68","unstructured":"B. Wang. (2021). The Air Pollution Impact to Maternal Mice and Offspring. <Go to ISI>:\/\/PQDT:85661256."},{"key":"10.1016\/j.neuro.2026.103527_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2025.119658","article-title":"The effect and mechanism of atrazine induced depression-like in mice","volume":"309","author":"Wang","year":"2026","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"10","key":"10.1016\/j.neuro.2026.103527_bib70","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1007\/s11064-007-9339-4","article-title":"Gender differences in the effects of prenatal stress on brain development and behaviour","volume":"32","author":"Weinstock","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.neuro.2026.103527_bib71","unstructured":"WHO. (2021). WHO global air quality guidelines. Particulate matter (PM2.5 and PM10), ozone, nitrogen dioxide, sulfur dioxide and carbon monoxide. (C\u00a0BY-NC-SA\u00a03.0\u00a0IGO.). https:\/\/www.who.int\/publications\/i\/item\/9789240034228."},{"issue":"2","key":"10.1016\/j.neuro.2026.103527_bib72","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nrd1303","article-title":"From monoamines to genomic targets: a paradigm shift for drug discovery in depression","volume":"3","author":"Wong","year":"2004","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"2","key":"10.1016\/j.neuro.2026.103527_bib73","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3934\/environsci.2015.2.353","article-title":"Traffic-related air pollution and brain development","volume":"2","author":"Woodward","year":"2015","journal-title":"AIMS Environ. Sci."},{"issue":"3","key":"10.1016\/j.neuro.2026.103527_bib74","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innov. (Camb. (Mass. ))"},{"key":"10.1016\/j.neuro.2026.103527_bib75","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.chemosphere.2016.09.063","article-title":"NO2 inhalation causes tauopathy by disturbing the insulin signaling pathway","volume":"165","author":"Yan","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.neuro.2026.103527_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105659","article-title":"Prenatal NO2 exposure and neurodevelopmental disorders in offspring mice: Transcriptomics reveals sex-dependent changes in cerebral gene expression","volume":"138","author":"Yan","year":"2020","journal-title":"Environ. Int."},{"key":"10.1016\/j.neuro.2026.103527_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2020.105659","article-title":"Prenatal NO(2) exposure and neurodevelopmental disorders in offspring mice: Transcriptomics reveals sex-dependent changes in cerebral gene expression","volume":"138","author":"Yan","year":"2020","journal-title":"Environ. Int."},{"issue":"2","key":"10.1016\/j.neuro.2026.103527_bib78","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1192\/bjp.2024.69","article-title":"Global, regional and national burdens of depression in adolescents and young adults aged 10-24 years, from 1990 to 2019: findings from the 2019 Global Burden of Disease study [Article]","volume":"225","author":"Yang","year":"2024","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.neuro.2026.103527_bib79","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jes.2025.08.058","article-title":"Ambient NO2 induces premature pulmonary senescence in rats: The role of the ROS-DRG1\/CDK5 axis","volume":"164","author":"Ye","year":"2025","journal-title":"J. Environ. Sci. (China)"},{"key":"10.1016\/j.neuro.2026.103527_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131755","article-title":"Ambient NO2 hinders neutrophil extracellular trap formation in rats: Assessment of the role of neutrophil autophagy","volume":"457","author":"Ye","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.neuro.2026.103527_bib81","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.chemosphere.2018.02.116","article-title":"Maternal exposure to NO(2) enhances airway sensitivity to allergens in BALB\/c mice through the JAK-STAT6 pathway","volume":"200","author":"Yue","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.neuro.2026.103527_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2021.105625","article-title":"Cortisol and development of depression in adolescence and young adulthood \u2013 a systematic review and meta-analysis","volume":"136","author":"Zajkowska","year":"2022","journal-title":"Psychoneuroendocrinology"},{"issue":"12","key":"10.1016\/j.neuro.2026.103527_bib83","doi-asserted-by":"crossref","first-page":"14254","DOI":"10.1096\/fj.201901347RR","article-title":"KLF15-activating Twist2 ameliorated hepatic steatosis by inhibiting inflammation and improving mitochondrial dysfunction via NF-\u03baB-FGF21 or SREBP1c-FGF21 pathway","volume":"33","author":"Zhou","year":"2019","journal-title":"FASEB J."},{"issue":"1","key":"10.1016\/j.neuro.2026.103527_bib84","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12951-023-01807-4","article-title":"Melanin-like polydopamine nanoparticles mediating anti-inflammatory and rescuing synaptic loss for inflammatory depression therapy","volume":"21","author":"Zhu","year":"2023","journal-title":"J. Nanobiotechnology"}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X26001488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X26001488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:27:47Z","timestamp":1789014467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X26001488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":84,"alternative-id":["S0161813X26001488"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2026.103527","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gestational NO\u2082 exposure induces anxiety\u2010 and depression-like behaviors in mice via hippocampal PTGDS-PGD2 activation and tryptophan metabolism reprogramming","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2026.103527","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103527"}}