{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T00:22:18Z","timestamp":1794356538866,"version":"4.9.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["NeuroToxicology"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.neuro.2026.103572","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:03:18Z","timestamp":1789023798000},"page":"103572","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Identification and validation of condition-specific candidate reference genes for accurate RT-qPCR normalization in acute and chronic methamphetamine-exposed cynomolgus monkeys"],"prefix":"10.1016","volume":"117","author":[{"given":"Sang-Je","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se-Hee","family":"Choe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon-Mu","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ja-Rang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Ri","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Gyeong","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Jung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Won","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.neuro.2026.103572_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1471-2199-9-78","article-title":"Selection of internal reference genes for SYBR green qRT-PCR studies of rhesus monkey (Macaca mulatta) tissues","volume":"9","author":"Ahn","year":"2008","journal-title":"BMC Mol. Biol."},{"issue":"15","key":"10.1016\/j.neuro.2026.103572_bib2","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","article-title":"Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets","volume":"64","author":"Andersen","year":"2004","journal-title":"Cancer Res."},{"issue":"6","key":"10.1016\/j.neuro.2026.103572_bib3","doi-asserted-by":"crossref","first-page":"390","DOI":"10.5607\/en22034","article-title":"Claustral MeCP2 regulates methamphetamine-induced conditioned place preference in cynomolgus monkey","volume":"31","author":"Bae","year":"2022","journal-title":"Exp. Neurobiol."},{"issue":"2","key":"10.1016\/j.neuro.2026.103572_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1017\/S0967199411000748","article-title":"Validation of reference genes for ovarian tissue from capuchin monkeys (Cebus apella)","volume":"21","author":"Brito","year":"2013","journal-title":"Zygote"},{"issue":"4","key":"10.1016\/j.neuro.2026.103572_bib5","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1373\/clinchem.2008.112797","article-title":"The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments","volume":"55","author":"Bustin","year":"2009","journal-title":"Clin. Chem."},{"issue":"6","key":"10.1016\/j.neuro.2026.103572_bib6","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/clinchem\/hvaf043","article-title":"MIQE 2.0: revision of the minimum information for publication of quantitative real-time PCR experiments guidelines","volume":"71","author":"Bustin","year":"2025","journal-title":"Clin. Chem."},{"key":"10.1016\/j.neuro.2026.103572_bib7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1186\/1471-2164-14-545","article-title":"Genome-wide profiling identifies a subset of methamphetamine (METH)-induced genes associated with METH-induced increased H4K5Ac binding in the rat striatum","volume":"14","author":"Cadet","year":"2013","journal-title":"BMC Genom."},{"issue":"9","key":"10.1016\/j.neuro.2026.103572_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/biom13091428","article-title":"Analysis of acute and chronic methamphetamine treatment in mice on gdnf system expression reveals a potential mechanism of schizophrenia susceptibility","volume":"13","author":"Casserly","year":"2023","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.neuro.2026.103572_bib9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ab.2010.07.021","article-title":"Microarray-driven validation of reference genes for quantitative real-time polymerase chain reaction in a rat vocal fold model of mucosal injury","volume":"406","author":"Chang","year":"2010","journal-title":"Anal. Biochem."},{"issue":"4","key":"10.1016\/j.neuro.2026.103572_bib10","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11481-008-9113-7","article-title":"Chronic methamphetamine induces structural changes in frontal cortex neurons and upregulates type I interferons","volume":"3","author":"Coutinho","year":"2008","journal-title":"J. Neuroimmune Pharmacol."},{"issue":"5","key":"10.1016\/j.neuro.2026.103572_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019434","article-title":"Selection and validation of reference genes for quantitative real-time PCR in buckwheat (Fagopyrum esculentum) based on transcriptome sequence data","volume":"6","author":"Demidenko","year":"2011","journal-title":"PLoS. One"},{"issue":"1","key":"10.1016\/j.neuro.2026.103572_bib12","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1038\/s41598-024-52415-7","article-title":"Selection of suitable reference genes for gene expression studies in HMC3 cell line by quantitative real-time RT-PCR","volume":"14","author":"Fazzina","year":"2024","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.neuro.2026.103572_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012545","article-title":"A pipeline to determine RT-QPCR control genes for evolutionary studies: application to primate gene expression across multiple tissues","volume":"5","author":"Fedrigo","year":"2010","journal-title":"PLoS. One"},{"issue":"2","key":"10.1016\/j.neuro.2026.103572_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056296","article-title":"Immune-related gene expression profile in laboratory common marmosets assessed by an accurate quantitative real-time PCR using selected reference genes","volume":"8","author":"Fujii","year":"2013","journal-title":"PLoS. One"},{"key":"10.1016\/j.neuro.2026.103572_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/srep38513","article-title":"Evaluation of candidate reference genes for RT-qPCR studies in three metabolism related tissues of mice after caloric restriction","volume":"6","author":"Gong","year":"2016","journal-title":"Sci. Rep."},{"issue":"17","key":"10.1016\/j.neuro.2026.103572_bib16","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1523\/JNEUROSCI.0029-12.2012","article-title":"Dysregulation of D(2)-mediated dopamine transmission in monkeys after chronic escalating methamphetamine exposure","volume":"32","author":"Groman","year":"2012","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.neuro.2026.103572_bib17","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1038\/s41598-021-82800-5","article-title":"Assessment of common housekeeping genes as reference for gene expression studies using RT-qPCR in mouse choroid plexus","volume":"11","author":"Ho","year":"2021","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.neuro.2026.103572_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/1471-2164-13-163","article-title":"Large-scale transcriptome sequencing and gene analyses in the crab-eating macaque (Macaca fascicularis) for biomedical research","volume":"13","author":"Huh","year":"2012","journal-title":"BMC Genom."},{"issue":"1","key":"10.1016\/j.neuro.2026.103572_bib19","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1038\/s41598-017-02078-4","article-title":"Validation of reference genes for the normalization of the RT-qPCR gene expression of virulence genes of Erwinia amylovora in apple shoots","volume":"7","author":"Kaluzna","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.neuro.2026.103572_bib20","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1046\/j.1471-4159.2000.0752095.x","article-title":"Age-dependent differential responses of monoaminergic systems to high doses of methamphetamine","volume":"75","author":"Kokoshka","year":"2000","journal-title":"J. Neurochem."},{"issue":"2","key":"10.1016\/j.neuro.2026.103572_bib21","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/sj.npp.1300575","article-title":"Modeling human methamphetamine exposure in nonhuman primates: chronic dosing in the rhesus macaque leads to behavioral and physiological abnormalities","volume":"30","author":"Madden","year":"2005","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.neuro.2026.103572_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-43892-3","article-title":"Evaluation and validation of reference genes for RT-qPCR gene expression in Naegleria gruberi","volume":"13","author":"Martin-Perez","year":"2023","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.neuro.2026.103572_bib23","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00213-010-2146-7","article-title":"Chronic methamphetamine exposure suppresses the striatal expression of members of multiple families of immediate early genes (IEGs) in the rat: normalization by an acute methamphetamine injection","volume":"215","author":"McCoy","year":"2011","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"6","key":"10.1016\/j.neuro.2026.103572_bib24","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/sj.npp.1301502","article-title":"Long-term methamphetamine administration in the vervet monkey models aspects of a human exposure: brain neurotoxicity and behavioral profiles","volume":"33","author":"Melega","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"1-2","key":"10.1016\/j.neuro.2026.103572_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0006-8993(97)00548-9","article-title":"Recovery of striatal dopamine function after acute amphetamine- and methamphetamine-induced neurotoxicity in the vervet monkey","volume":"766","author":"Melega","year":"1997","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.neuro.2026.103572_bib26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12865-016-0145-0","article-title":"Methamphetamine abuse affects gene expression in brain-derived microglia of SIV-infected macaques to enhance inflammation and promote virus targets","volume":"17","author":"Najera","year":"2016","journal-title":"BMC Immunol."},{"issue":"1","key":"10.1016\/j.neuro.2026.103572_bib27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s40850-022-00159-0","article-title":"Selection and validation of reference genes for the normalization of quantitative real-time PCR in different muscle tissues of rabbits","volume":"7","author":"Ni","year":"2022","journal-title":"BMC Zool."},{"key":"10.1016\/j.neuro.2026.103572_bib28","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2199-11-47","article-title":"Microarray analysis of relative gene expression stability for selection of internal reference genes in the rhesus macaque brain","volume":"11","author":"Noriega","year":"2010","journal-title":"BMC Mol. Biol."},{"issue":"4","key":"10.1016\/j.neuro.2026.103572_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060758","article-title":"Selection of new appropriate reference genes for RT-qPCR analysis via transcriptome sequencing of cynomolgus monkeys (Macaca fascicularis)","volume":"8","author":"Park","year":"2013","journal-title":"PLoS. One"},{"issue":"2","key":"10.1016\/j.neuro.2026.103572_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0056034","article-title":"Selection of appropriate reference genes for RT-qPCR analysis in a streptozotocin-induced Alzheimer's disease model of cynomolgus monkeys (Macaca fascicularis)","volume":"8","author":"Park","year":"2013","journal-title":"PLoS. One"},{"issue":"9","key":"10.1016\/j.neuro.2026.103572_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.neuro.2026.103572_bib32","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1023\/B:BILE.0000019559.84305.47","article-title":"Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper--Excel-based tool using pair-wise correlations","volume":"26","author":"Pfaffl","year":"2004","journal-title":"Biotechnol. Lett."},{"issue":"9","key":"10.1016\/j.neuro.2026.103572_bib33","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/ajp.22281","article-title":"Why primate models matter","volume":"76","author":"Phillips","year":"2014","journal-title":"Am. J. Primatol."},{"key":"10.1016\/j.neuro.2026.103572_bib34","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.phrs.2017.03.009","article-title":"Methamphetamine: Effects on the brain, gut and immune system","volume":"120","author":"Prakash","year":"2017","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.neuro.2026.103572_bib35","first-page":"365","article-title":"Primer3 on the WWW for general users and for biologist programmers","volume":"132","author":"Rozen","year":"2000","journal-title":"Methods Mol. Biol."},{"issue":"1","key":"10.1016\/j.neuro.2026.103572_bib36","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41598-017-00043-9","article-title":"Reference genes for gene expression studies in the mouse heart","volume":"7","author":"Ruiz-Villalba","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.neuro.2026.103572_bib37","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.1007\/s11033-013-2791-0","article-title":"Selection of suitable reference genes for mRNA quantification studies using common marmoset tissues","volume":"40","author":"Shimamoto","year":"2013","journal-title":"Mol. Biol. Rep."},{"issue":"7","key":"10.1016\/j.neuro.2026.103572_bib38","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1080\/17460441.2017.1323863","article-title":"Nonhuman primates as models for the discovery and development of radiation countermeasures","volume":"12","author":"Singh","year":"2017","journal-title":"Expert. Opin. Drug. Discov."},{"issue":"1","key":"10.1016\/j.neuro.2026.103572_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15145-7","article-title":"Comparison of Transcriptomic Platforms for Analysis of Whole Blood from Ebola-Infected Cynomolgus Macaques","volume":"7","author":"Speranza","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.neuro.2026.103572_bib40","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1124\/jpet.105.085951","article-title":"Age-dependent methamphetamine-induced alterations in vesicular monoamine transporter-2 function: implications for neurotoxicity","volume":"314","author":"Truong","year":"2005","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"7","key":"10.1016\/j.neuro.2026.103572_bib41","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.neuro.2026.103572_bib42","article-title":"Systematic selection and validation of suitable reference genes for quantitative real-time PCR normalization studies of gene expression in Nitraria tangutorum","volume":"10","author":"Wang","year":"2020","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.neuro.2026.103572_bib43","article-title":"Selection and evaluation of new reference genes for RT-qPCR analysis in Epinephelus akaara based on transcriptome data","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS. One"},{"issue":"1","key":"10.1016\/j.neuro.2026.103572_bib44","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s11427-019-1553-5","article-title":"Public-transcriptome-database-assisted selection and validation of reliable reference genes for qRT-PCR in rice","volume":"63","author":"Zhao","year":"2020","journal-title":"Sci. China Life Sci."}],"container-title":["NeuroToxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X26001932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0161813X26001932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T23:39:16Z","timestamp":1794353956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0161813X26001932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":44,"alternative-id":["S0161813X26001932"],"URL":"https:\/\/doi.org\/10.1016\/j.neuro.2026.103572","relation":{},"ISSN":["0161-813X"],"issn-type":[{"value":"0161-813X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification and validation of condition-specific candidate reference genes for accurate RT-qPCR normalization in acute and chronic methamphetamine-exposed cynomolgus monkeys","name":"articletitle","label":"Article Title"},{"value":"NeuroToxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.neuro.2026.103572","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"103572"}}